BRPI0416546A - produção de ácido 3-hidroxipropiÈnico usando beta-alanina/piruvato aminotransferase - Google Patents

produção de ácido 3-hidroxipropiÈnico usando beta-alanina/piruvato aminotransferase

Info

Publication number
BRPI0416546A
BRPI0416546A BRPI0416546-2A BRPI0416546A BRPI0416546A BR PI0416546 A BRPI0416546 A BR PI0416546A BR PI0416546 A BRPI0416546 A BR PI0416546A BR PI0416546 A BRPI0416546 A BR PI0416546A
Authority
BR
Brazil
Prior art keywords
alanine
beta
acid production
hydroxypropionic acid
pyruvate aminotransferase
Prior art date
Application number
BRPI0416546-2A
Other languages
English (en)
Inventor
Hans H Liao
Ravi R Gokarn
Holly Jean Jessen
Steven John Gort
Olga V Selifonova
Original Assignee
Cargill Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cargill Inc filed Critical Cargill Inc
Publication of BRPI0416546A publication Critical patent/BRPI0416546A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C12P7/625—Polyesters of hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01018—Beta-alanine-pyruvate transaminase (2.6.1.18)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"PRODUçãO DE áCIDO 3-HIDROXIPROPIÈNICO USANDO BETA -ALANINA/ PIRUVATO AMINOTRANSFERASE". Métodos de usar beta-alanina/piruvato aminotransferase para produzir ácido 3-hidroxipropiónico e derivados desse, a partir de beta-alanina, são divulgados. Células e ácidos nucléicos recombinantes que podem ser usados para praticar os métodos também são divulgados.
BRPI0416546-2A 2003-12-04 2004-12-06 produção de ácido 3-hidroxipropiÈnico usando beta-alanina/piruvato aminotransferase BRPI0416546A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52735703P 2003-12-04 2003-12-04
PCT/US2004/040827 WO2005118719A2 (en) 2003-12-04 2004-12-06 Production of 3-hydroxypropionic acid using beta-alanine/pyruvate aminotransferase

Publications (1)

Publication Number Publication Date
BRPI0416546A true BRPI0416546A (pt) 2007-01-09

Family

ID=35463438

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416546-2A BRPI0416546A (pt) 2003-12-04 2004-12-06 produção de ácido 3-hidroxipropiÈnico usando beta-alanina/piruvato aminotransferase

Country Status (6)

Country Link
US (3) US7700319B2 (pt)
EP (1) EP1706457B1 (pt)
AT (1) ATE543873T1 (pt)
BR (1) BRPI0416546A (pt)
DK (1) DK1706457T3 (pt)
WO (1) WO2005118719A2 (pt)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0115877A (pt) 2000-11-20 2003-10-07 Cargill Inc ácido 3-hidroxipropiÈnico e outros compostos orgánicos
DE60327804D1 (de) * 2002-01-18 2009-07-09 Novozymes As Alanin-2,3-aminomutase
MX2007001195A (es) * 2004-07-30 2007-10-03 Cargill Inc Alanina 2,3-aminomutasas.
CN101068923A (zh) 2004-10-25 2007-11-07 科德克希思公司 改良的丙氨酸2,3－氨基变位酶和相关多核苷酸
US8030051B2 (en) 2005-10-14 2011-10-04 Codexis, Inc. Alanine 2,3-aminomutases and related polynucleotides
US7988883B2 (en) 2006-02-10 2011-08-02 Dupont Tate & Lyle Bio Products Company, Llc Heat transfer compositions comprising renewably-based biodegradable 1,3-propanediol
WO2007106524A2 (en) 2006-03-13 2007-09-20 Cargill Inc. Yeast cells having disrupted pathway from dihydroxyacetone phosphate to glycerol
US8030045B2 (en) 2006-08-30 2011-10-04 Cargill, Incorporated Beta-alanine/alpha-ketoglutarate aminotransferase for 3-hydroxypropionic acid production
CA2675026A1 (en) * 2007-01-12 2008-07-24 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for enhancing tolerance for the production of organic chemicals produced by microorganisms
US8048624B1 (en) 2007-12-04 2011-11-01 Opx Biotechnologies, Inc. Compositions and methods for 3-hydroxypropionate bio-production from biomass
DE102008020688B3 (de) 2008-04-24 2009-11-05 Evonik Stockhausen Gmbh Verfahren zur Herstellung und Aufreinigung wässriger Phasen
CN102317436B (zh) * 2008-07-23 2014-06-25 Opx生物工艺学公司 用于增加微生物对3-羟基丙酸(3-hp)的耐受性以及增加3-羟基丙酸产量的方法、系统和组合物
EP2326709A4 (en) * 2008-09-15 2013-01-23 Opx Biotechnologies Inc METHODS, SYSTEMS AND COMPOSITIONS RELATED TO REDUCED MICROBIAL PRODUCTION OF 3-HYDROXYPROPIONIC ACID (3-HP) IN ALDEHYDMETABOLITE
MX2012003604A (es) 2009-09-27 2012-09-12 Opx Biotechnologies Inc Metodo para producir acido 3-hidroxipropionico y otros productos.
US8809027B1 (en) 2009-09-27 2014-08-19 Opx Biotechnologies, Inc. Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase
US20110125118A1 (en) * 2009-11-20 2011-05-26 Opx Biotechnologies, Inc. Production of an Organic Acid and/or Related Chemicals
EP2529023A4 (en) * 2010-01-27 2015-06-10 Opx Biotechnologies Inc MICRO-ORGANISM MANUFACTURE FROM HIGH-FLOW CHEMICAL PRODUCTS AND CORRESPONDING COMPOSITIONS, METHODS AND SYSTEMS
MX2012009134A (es) 2010-02-11 2012-11-30 Metabolix Inc Proceso para producir componente monomerico de biomasa de polihidroxialcanoato geneticamente modificado.
EP2588598B1 (en) 2010-07-02 2016-03-09 Metabolic Explorer Method for the preparation of hydroxy acids
US9090918B2 (en) 2010-11-22 2015-07-28 Novozymes A/A Compositions and methods for 3-hydroxypropionic acid production
CA2849303C (en) 2011-09-30 2019-09-17 Novozymes, Inc. Dehydrogenase variants and polynucleotides encoding same
US20150159184A1 (en) * 2012-03-20 2015-06-11 Metabolix, Inc. Genetically Engineered Microorganisms for the Production of Poly-4-Hydroxybutyrate
WO2013173711A1 (en) 2012-05-18 2013-11-21 Novozymes A/S Bacterial mutants with improved transformation efficiency
US9850192B2 (en) 2012-06-08 2017-12-26 Cj Cheiljedang Corporation Renewable acrylic acid production and products made therefrom
MX2015001780A (es) 2012-08-10 2015-09-28 Opx Biotechnologies Inc Microorganismos y métodos para la producción de ácidos grasos y productos derivados de ácidos grasos.
CN104619721A (zh) 2012-09-27 2015-05-13 诺维信股份有限公司 具有改进的转化效率的细菌突变体
CA2888093A1 (en) * 2012-10-11 2014-04-17 Technical University Of Denmark Genetically engineered yeast
CN105209626B (zh) 2012-11-30 2019-09-03 诺维信股份有限公司 通过重组酵母生产3-羟基丙酸
US10442749B2 (en) 2013-03-15 2019-10-15 Cargill, Incorporated Recovery of 3-hydroxypropionic acid
EP2976141A4 (en) 2013-03-15 2016-10-05 Cargill Inc FLASHING FOR PRODUCTION CLEANING AND RECOVERY
US20150119601A1 (en) 2013-03-15 2015-04-30 Opx Biotechnologies, Inc. Monofunctional mcr + 3-hp dehydrogenase
BR112015030208A2 (pt) * 2013-06-05 2017-08-22 Lanzatech New Zealand Ltd Métodos para produzir um produto de fermentação e um micro-organismo, e, micro-organismo recombinante
EP3008179A1 (en) 2013-06-14 2016-04-20 Technical University of Denmark 3hp tolerance
EP3022310B1 (en) 2013-07-19 2019-10-16 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
KR101730035B1 (ko) 2015-03-20 2017-04-26 한국과학기술원 L-아스파르트산 유도체를 생산하는 변이미생물 및 이를 이용한 l-아스파르트산 유도체의 제조방법
US11345938B2 (en) 2017-02-02 2022-05-31 Cargill, Incorporated Genetically modified cells that produce C6-C10 fatty acid derivatives
WO2018190398A1 (ja) * 2017-04-13 2018-10-18 協和発酵バイオ株式会社 テアニンの製造方法
US11788092B2 (en) * 2021-02-08 2023-10-17 Lanzatech, Inc. Recombinant microorganisms and uses therefor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0008355A (pt) 1999-08-30 2002-07-16 Wisconsin Alumni Res Found Produção de ácido 3-hidroxipropionico em organismos recombinantes
BR0115877A (pt) * 2000-11-20 2003-10-07 Cargill Inc ácido 3-hidroxipropiÈnico e outros compostos orgánicos
DE60327804D1 (de) 2002-01-18 2009-07-09 Novozymes As Alanin-2,3-aminomutase
MX2007001195A (es) 2004-07-30 2007-10-03 Cargill Inc Alanina 2,3-aminomutasas.

Also Published As

Publication number Publication date
US8124388B2 (en) 2012-02-28
EP1706457A2 (en) 2006-10-04
WO2005118719A3 (en) 2006-09-21
US7700319B2 (en) 2010-04-20
EP1706457B1 (en) 2012-02-01
DK1706457T3 (da) 2012-05-21
ATE543873T1 (de) 2012-02-15
US20070107080A1 (en) 2007-05-10
US7785837B2 (en) 2010-08-31
WO2005118719A2 (en) 2005-12-15
US20100267115A1 (en) 2010-10-21
US20100136638A1 (en) 2010-06-03

Similar Documents

Publication Publication Date Title
BRPI0416546A (pt) produção de ácido 3-hidroxipropiÈnico usando beta-alanina/piruvato aminotransferase
ATE432338T1 (de) Alanin-2,3-aminomutase
BR0316927A (pt) Proteìna, métodos para produzir um derivado de ácido glutâmico oticamente ativo e para produzir uma proteìna tendo uma atividade de d-aminotransferase, dna, célula
CR20110356A (es) Bioconversion estereoselectiva de dinitrilos alifaticos en acidos cianocarboxilicos (divisional exp. 8686)
BRPI0411475A (pt) adições de código genético de aminoácido reativo não natural
EA200300647A1 (ru) Изотермическая амплификация нуклеиновых кислот на твердой подложке
ATA165999A (de) Medium zur protein- und serumfreien kultivierung von zellen
DK1870417T3 (da) Peptidacceptor-ligeringsmetoder
BR0000897A (pt) Processo para a produção fermentativa de l-aminoácidos usando-se bactéria corineforme
BR0215469A (pt) Método aperfeiçoado de produção de licopeno pela fermentação de cepas selecionadas de blakeslea trispora, formulações e usos do licopeno obtido
UY27618A1 (es) Ésteres hidroxamato de ácido n-(4-fenil-sustituido)-antranílico
MX2007008980A (es) Acidos nucleicos para apoptosis de celulas cancerigenas.
BR9908797A (pt) Aperfeiçoamento na sìntese enzimática de aminas quirais e método de preparação de (s)-1- metoxi-2-aminopropano
BR9816106A (pt) Carboxilase de piruvato de corynebacterium glutamicum
DK1191106T3 (da) Fremgangsmåde til fermentativ fremstilling af ikke-proteinogene L-aminosyrer
BR0315055A (pt) Diamidas de ácido pirimidin-4,6-dicarboxìilco para a inibição seletiva de colagenases
BR0312348A (pt) Processo para a preparação de copolìmeros em bloco e copolìmeros em bloco
ATE435205T1 (de) Kristalline formen von imidoalkanpercarbonsäuren
BR0002493A (pt) Processo para a preparação de l-aminoácidos por fermentação e sequências de nucleotìdeos que codificam o gene accda
BR0005307A (pt) Processo para a produção fermentativa de l-lisina usando bactérias coryneform
BR0008586A (pt) Processo de preparação de aminoácidos quirais e processo de preparação de compostos a partir destes
ITMI20041271A1 (it) Processo di preparazione di gabapentina
BRPI0507353A (pt) métodos de produção de l-treonina e de microrganismo produtor de l-treonina e microrganismo
EP1334176A4 (en) L-GLUTAMATE-PRODUCING MICRO-ORGANISMS AND METHOD FOR THE PREPARATION OF L-GLUTAMATE USING THE SAME
DE60015559D1 (de) Sentrin-spezifische menschliche protease senp1

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements