ATE295T1 - Vitamin b12 derivate, verfahren zu deren herstellung und ihre verwendung bei radioimmun-testen. - Google Patents

Vitamin b12 derivate, verfahren zu deren herstellung und ihre verwendung bei radioimmun-testen.

Info

Publication number
ATE295T1
ATE295T1 AT79101668T AT79101668T ATE295T1 AT E295 T1 ATE295 T1 AT E295T1 AT 79101668 T AT79101668 T AT 79101668T AT 79101668 T AT79101668 T AT 79101668T AT E295 T1 ATE295 T1 AT E295T1
Authority
AT
Austria
Prior art keywords
derivatives
vitamin
radioimmune
testing
processes
Prior art date
Application number
AT79101668T
Other languages
English (en)
Inventor
Jack Bernstein
Ravi K. Varma
Berthold R. Vogt
Frank L. Weisenborn
Original Assignee
E.R. Squibb & Sons, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E.R. Squibb & Sons, Inc. filed Critical E.R. Squibb & Sons, Inc.
Application granted granted Critical
Publication of ATE295T1 publication Critical patent/ATE295T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
AT79101668T 1978-05-30 1979-05-30 Vitamin b12 derivate, verfahren zu deren herstellung und ihre verwendung bei radioimmun-testen. ATE295T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/910,568 US4209614A (en) 1978-05-30 1978-05-30 Vitamin B12 derivative suitable for radiolabeling
EP79101668A EP0005834B1 (de) 1978-05-30 1979-05-30 Vitamin B12 Derivate, Verfahren zu deren Herstellung und ihre Verwendung bei Radioimmun-Testen

Publications (1)

Publication Number Publication Date
ATE295T1 true ATE295T1 (de) 1981-10-15

Family

ID=25428998

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79101668T ATE295T1 (de) 1978-05-30 1979-05-30 Vitamin b12 derivate, verfahren zu deren herstellung und ihre verwendung bei radioimmun-testen.

Country Status (9)

Country Link
US (1) US4209614A (de)
EP (1) EP0005834B1 (de)
JP (1) JPS54157600A (de)
AT (1) ATE295T1 (de)
AU (1) AU4649179A (de)
CA (1) CA1109464A (de)
DE (1) DE2960982D1 (de)
IL (1) IL57385A0 (de)
ZA (1) ZA792064B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2437398A1 (fr) * 1978-06-20 1980-04-25 Commissariat Energie Atomique Compose iode utilisable comme traceur en radio-immunologie
US4355018A (en) * 1980-05-21 1982-10-19 Hoffmann-La Roche Inc. Assay for vitamin B12
EP0069450B1 (de) * 1981-06-22 1985-04-10 TECHNICON INSTRUMENTS CORPORATION (a New York corporation) Markierte Vitamin-B12-Derivate, ihre Herstellung und Verwendung
US4465776A (en) * 1982-09-27 1984-08-14 Research Corporation Monoclonal antibodies to vitamin B6 and immunoassay method
NZ217821A (en) * 1985-10-10 1989-07-27 Biotech Australia Pty Ltd Oral delivery system; complex of active agent and vitamin b12 or analogue thereof
US5807832A (en) * 1987-06-09 1998-09-15 Biotech Australia Pty Limited Oral delivery of biologically active substances bound to vitamin B12
HK1002252A1 (en) * 1991-04-02 1998-08-07 Biotech Australia Pty. Limited Oral delivery systems for microparticles
JPH06336494A (ja) * 1993-05-27 1994-12-06 Nippon Oil Co Ltd 疎水性ビタミンｂ１２誘導体
US5739313A (en) * 1995-11-13 1998-04-14 Regents Of The University Of Minnesota Radionuclide labeling of vitamin B12 and coenzymes thereof
AUPP405098A0 (en) * 1998-06-12 1998-07-02 Access Pharmaceuticals Australia Pty Limited Novel methods of preparation of vitamin b12 derivatives suitable for conjugation to pharmaceuticals
US6806363B1 (en) * 1999-04-16 2004-10-19 Mayo Foundation For Medical Education & Research Cobalamin conjugates useful as antitumor agents
MXPA02003771A (es) * 1999-10-15 2005-04-28 Mayo Foundation Conjugados de cobalamina, utiles como agentes para obtencion de imagen y como agentes anti-tumor.
JP2003531105A (ja) 1999-10-15 2003-10-21 メイオウ・フアウンデーシヨン・フオー・メデイカル・エジユケイシヨン・アンド・リサーチ 造影剤および治療薬として有用なコバラミン結合体
US7591995B2 (en) * 1999-10-15 2009-09-22 Mayo Foundation For Medical Education And Research Cobalamin conjugates useful as imaging and therapeutic agents
EP1754712A3 (de) * 2000-10-25 2009-01-14 Mayo Foundation For Medical Education And Research Transcobalamin-bindende Konjugate zur Behandlung abnormaler zellulärer Proliferation
CA2427146A1 (en) * 2000-10-25 2002-07-18 Mayo Foundation For Medical Education And Research Transcobalamin binding conjugates useful for treating abnormal cellular proliferation
WO2003000010A2 (en) * 2001-06-20 2003-01-03 Mayo Foundation For Medical Education And Research Adenosyl-cobalamin fortified compositions
US20060074034A1 (en) * 2001-09-17 2006-04-06 Collins Douglas A Cobalamin mediated delivery of nucleic acids, analogs and derivatives thereof
JP2005508332A (ja) * 2001-09-28 2005-03-31 メイオウ・フアウンデーシヨン・フオー・メデイカル・エジユケイシヨン・アンド・リサーチ 薬剤を送達するための、輸送タンパク質とコンジュゲートコバラミンとの同時投与
KR100440725B1 (ko) * 2002-06-20 2004-07-15 주식회사 그린진 바이오텍 비생물성 스트레스에 대한 단자엽 식물의 내성을증가시키는 방법
KR101126138B1 (ko) * 2003-12-22 2012-04-12 솔리다고 아게 비정상적 세포 증식의 진단 및 치료에 유용한 코발아민유도체
EP1893038A1 (de) * 2005-05-17 2008-03-05 Cargill, Incorporated Granulatförmige lecithine, granulatförmige lysolecithine, verfahren zu ihrer herstellung und sie enthaltende zusammensetzungen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5372M (de) * 1966-02-10 1967-10-16
US3981863A (en) * 1975-02-25 1976-09-21 Micromedic Diagonistics, Inc. Cyanocobalamin derivatives
CA1118409A (en) * 1977-08-12 1982-02-16 Jack Bernstein Steroid derivatives and their use in radioimmunoassays

Also Published As

Publication number Publication date
JPS54157600A (en) 1979-12-12
EP0005834A1 (de) 1979-12-12
US4209614A (en) 1980-06-24
AU4649179A (en) 1979-12-06
EP0005834B1 (de) 1981-10-14
CA1109464A (en) 1981-09-22
IL57385A0 (en) 1979-09-30
DE2960982D1 (en) 1981-12-24
ZA792064B (en) 1980-05-28

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