ATE297202T1 - Verwendung von nichtimmununterdruckende verbindungen zur förderung von nervenregeneration - Google Patents
Verwendung von nichtimmununterdruckende verbindungen zur förderung von nervenregenerationInfo
- Publication number
- ATE297202T1 ATE297202T1 AT98950843T AT98950843T ATE297202T1 AT E297202 T1 ATE297202 T1 AT E297202T1 AT 98950843 T AT98950843 T AT 98950843T AT 98950843 T AT98950843 T AT 98950843T AT E297202 T1 ATE297202 T1 AT E297202T1
- Authority
- AT
- Austria
- Prior art keywords
- nerve regeneration
- promote nerve
- immune suppressive
- hsp90
- receptor complexes
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 210000005036 nerve Anatomy 0.000 title abstract 2
- 230000008929 regeneration Effects 0.000 title abstract 2
- 238000011069 regeneration method Methods 0.000 title abstract 2
- 101100016370 Danio rerio hsp90a.1 gene Proteins 0.000 abstract 3
- 101100285708 Dictyostelium discoideum hspD gene Proteins 0.000 abstract 3
- 101100071627 Schizosaccharomyces pombe (strain 972 / ATCC 24843) swo1 gene Proteins 0.000 abstract 3
- 108010085012 Steroid Receptors Proteins 0.000 abstract 3
- 102000005969 steroid hormone receptors Human genes 0.000 abstract 3
- JRZJKWGQFNTSRN-UHFFFAOYSA-N Geldanamycin Natural products C1C(C)CC(OC)C(O)C(C)C=C(C)C(OC(N)=O)C(OC)CCC=C(C)C(=O)NC2=CC(=O)C(OC)=C1C2=O JRZJKWGQFNTSRN-UHFFFAOYSA-N 0.000 abstract 1
- 102100020739 Peptidyl-prolyl cis-trans isomerase FKBP4 Human genes 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000010494 dissociation reaction Methods 0.000 abstract 1
- 230000005593 dissociations Effects 0.000 abstract 1
- QTQAWLPCGQOSGP-GBTDJJJQSA-N geldanamycin Chemical compound N1C(=O)\C(C)=C/C=C\[C@@H](OC)[C@H](OC(N)=O)\C(C)=C/[C@@H](C)[C@@H](O)[C@H](OC)C[C@@H](C)CC2=C(OC)C(=O)C=C1C2=O QTQAWLPCGQOSGP-GBTDJJJQSA-N 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000003270 steroid hormone Substances 0.000 abstract 1
- 108010067247 tacrolimus binding protein 4 Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1883—Neuregulins, e.g.. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5058—Neurological cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/743—Steroid hormones
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/956,691 US5968921A (en) | 1997-10-24 | 1997-10-24 | Compositions and methods for promoting nerve regeneration |
| PCT/US1998/020658 WO1999021552A1 (en) | 1997-10-24 | 1998-10-02 | Use of non-immunosuppressive compounds for promoting nerve regeneration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE297202T1 true ATE297202T1 (de) | 2005-06-15 |
Family
ID=25498557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98950843T ATE297202T1 (de) | 1997-10-24 | 1998-10-02 | Verwendung von nichtimmununterdruckende verbindungen zur förderung von nervenregeneration |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US5968921A (de) |
| EP (1) | EP1024806B1 (de) |
| JP (1) | JP2001520995A (de) |
| AT (1) | ATE297202T1 (de) |
| AU (1) | AU759011B2 (de) |
| CA (1) | CA2308216C (de) |
| DE (1) | DE69830509T2 (de) |
| WO (1) | WO1999021552A1 (de) |
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|---|---|---|---|---|
| CA2287387C (en) * | 1997-05-14 | 2010-02-16 | Sloan-Kettering Institute For Cancer Research | Methods and compositions for destruction of selected proteins |
| US6852496B1 (en) * | 1997-08-12 | 2005-02-08 | Oregon Health And Science University | Methods of screening for agents that promote nerve cell growth |
| US5968921A (en) | 1997-10-24 | 1999-10-19 | Orgegon Health Sciences University | Compositions and methods for promoting nerve regeneration |
| MXPA01003376A (es) | 1998-10-02 | 2002-11-07 | Kosan Biosciences Inc | Enzimas policetido sintetasa y construcciones de acido desoxirribonucleico recombinante para las mismas. |
| US20040120891A1 (en) | 1998-12-21 | 2004-06-24 | Craig Hill | Compounds for intracellular delivery of therapeutic moieties to nerve cells |
| US6652864B1 (en) | 1998-12-21 | 2003-11-25 | Asilomar Pharmaceuticals, Inc. | Compounds for intracellular delivery of therapeutic moieties to nerve cells |
| US7238682B1 (en) | 1999-04-09 | 2007-07-03 | Sloan-Kettering Institute For Cancer Research | Methods and compositions for degradation and/or inhibition of HER-family tyrosine kinases |
| JP2002541255A (ja) | 1999-04-09 | 2002-12-03 | スローン − ケッタリング インスティチュート フォー キャンサー リサーチ | Ｈｅｒ族チロシンキナーゼの分解および／または阻害方法および組成物 |
| US6734211B1 (en) * | 1999-07-09 | 2004-05-11 | Oregon Health & Sciences University | Compositions and methods for promoting nerve regeneration |
| CA2377918A1 (en) * | 1999-07-09 | 2001-01-18 | Bruce G. Gold | Compositions and methods for promoting nerve regeneration |
| US6979574B1 (en) * | 1999-08-06 | 2005-12-27 | Institut Fuer Diagnostik Forshung Gmbh | Process for detecting binding reactions with use of the measurement of the relaxation of the double refraction of magnetic particles |
| EP1225906B1 (de) * | 1999-08-17 | 2008-11-19 | The Trustees Of The University Of Pennsylvania | Mechanisch verlängerte neuronale zellen und methoden zur herstellung und verwendung dieser zellen |
| US6569867B2 (en) | 1999-10-01 | 2003-05-27 | Kosan Biosciences, Inc. | Polyketide derivatives |
| US6818643B1 (en) | 1999-12-08 | 2004-11-16 | Bristol-Myers Squibb Company | Neurotrophic bicyclic diamides |
| ATE526019T1 (de) * | 2000-07-28 | 2011-10-15 | Sloan Kettering Inst Cancer | Verfahren zur behandlung von zellproliferationen störungen und virusinfektionen |
| US7439359B2 (en) * | 2000-11-02 | 2008-10-21 | Sloan-Kettering Institute For Cancer Research | Small molecule compositions for binding to hsp90 |
| AR035411A1 (es) * | 2000-12-29 | 2004-05-26 | Fujisawa Pharmaceutical Co | Uso de un derivado de tacrolimus para fabricar un agente neurotrofico, composiciones y articulos de fabricacion o kits que lo comprenden, metodo para fabricar un agente que lo comprende y tejidos e injertos con una celula nerviosa tratada con este compuesto |
| DK1373215T3 (da) * | 2001-03-30 | 2006-11-13 | Us Health | Gelanamycinderivater egnet til behandling af cancer |
| WO2002094259A1 (en) * | 2001-05-03 | 2002-11-28 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Compounds that inhibit hsp90 and stimulate hsp70 and hsp40, useful in the prevention or treatment of diseases associated with protein aggregation and amyloid formation |
| WO2002094196A2 (en) * | 2001-05-23 | 2002-11-28 | Sloan Kettering Institute For Cancer Research | Method of treatment for cancers associated with elevated |
| US7169564B1 (en) * | 2001-06-26 | 2007-01-30 | Anaderm Research Corporation | FKBP51/52 and CyP40-mediated mammalian hair growth |
| US6872715B2 (en) * | 2001-08-06 | 2005-03-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
| WO2003037860A2 (en) | 2001-10-30 | 2003-05-08 | Conforma Therapeutics Corporation | Purine analogs having hsp90-inhibiting activity |
| US20070129334A1 (en) * | 2001-10-30 | 2007-06-07 | Conforma Therapeutics Corporation | Orally Active Purine-Based Inhibitors of Heat Shock Protein 90 |
| WO2003066005A2 (en) * | 2002-02-08 | 2003-08-14 | Conforma Therapeutics Corporation | Ansamycins having improved pharmacological and biological properties |
| CA2481683A1 (en) * | 2002-04-10 | 2003-10-23 | Conforma Therapeutics Corporation | Ansamycin formulations and methods for producing and using same |
| WO2004022156A2 (en) * | 2002-09-04 | 2004-03-18 | Washington University | Methods for treating central nervous system damage |
| US20060148776A1 (en) * | 2003-03-13 | 2006-07-06 | Conforma Therapeutics Corporation | Drug formulations having long and medium chain triglycerides |
| MXPA06002997A (es) * | 2003-09-18 | 2007-02-08 | Conforma Therapeutics Corp | Novedosos compuestos heterociclicos como inhibidores- hsp90. |
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|---|---|---|---|---|
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| KR100244372B1 (ko) * | 1991-05-09 | 2000-03-02 | 조슈아 에스.보저 | 신규한 면역 억제성 화합물 |
| WO1992021213A1 (en) | 1991-05-15 | 1992-11-26 | Videonics Incorporated | An improved digital video image adjusting circuit and a method therefor |
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| AU2803692A (en) * | 1991-10-11 | 1993-05-03 | Vertex Pharmaceuticals Incorporated | Isolation of an mr 52,000 fk506 binding protein and molecular cloning of a corresponding human cdna |
| WO1993023548A2 (en) * | 1992-05-20 | 1993-11-25 | Vertex Pharmaceuticals Incorporated | METHOD OF DETECTING TISSUE-SPECIFIC FK506 BINDING PROTEIN MESSENGER RNAs AND USES THEREOF |
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| WO1996034525A1 (en) * | 1995-05-02 | 1996-11-07 | The Regents Of The University Of California | Inducement of thermotolerance with benzoquinonoid ansamycins |
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| HUP9903684A3 (en) | 1995-12-22 | 2001-12-28 | Lilly Co Eli | Use of olanzapine for the preparation of pharmaceutical compositions treating depression |
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-
1997
- 1997-10-24 US US08/956,691 patent/US5968921A/en not_active Expired - Fee Related
-
1998
- 1998-10-02 EP EP98950843A patent/EP1024806B1/de not_active Expired - Lifetime
- 1998-10-02 DE DE69830509T patent/DE69830509T2/de not_active Expired - Fee Related
- 1998-10-02 AU AU96783/98A patent/AU759011B2/en not_active Ceased
- 1998-10-02 CA CA002308216A patent/CA2308216C/en not_active Expired - Fee Related
- 1998-10-02 AT AT98950843T patent/ATE297202T1/de not_active IP Right Cessation
- 1998-10-02 JP JP2000517710A patent/JP2001520995A/ja active Pending
- 1998-10-02 WO PCT/US1998/020658 patent/WO1999021552A1/en not_active Ceased
-
1999
- 1999-04-07 US US09/288,061 patent/US6210974B1/en not_active Expired - Fee Related
-
2001
- 2001-04-02 US US09/825,243 patent/US6641810B2/en not_active Expired - Fee Related
-
2003
- 2003-09-04 US US10/656,701 patent/US6881409B2/en not_active Expired - Fee Related
-
2005
- 2005-04-18 US US11/109,463 patent/US20050226871A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1024806A1 (de) | 2000-08-09 |
| EP1024806B1 (de) | 2005-06-08 |
| US6881409B2 (en) | 2005-04-19 |
| AU9678398A (en) | 1999-05-17 |
| CA2308216A1 (en) | 1999-05-06 |
| WO1999021552A1 (en) | 1999-05-06 |
| US6641810B2 (en) | 2003-11-04 |
| JP2001520995A (ja) | 2001-11-06 |
| DE69830509D1 (de) | 2005-07-14 |
| AU759011B2 (en) | 2003-04-03 |
| CA2308216C (en) | 2009-09-01 |
| DE69830509T2 (de) | 2005-11-03 |
| US20050226871A1 (en) | 2005-10-13 |
| US20020086015A1 (en) | 2002-07-04 |
| US20040063610A1 (en) | 2004-04-01 |
| US5968921A (en) | 1999-10-19 |
| US6210974B1 (en) | 2001-04-03 |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |