ATE329606T1 - Peptidantagonisten von zonulin und methoden zu deren verwendung - Google Patents

Peptidantagonisten von zonulin und methoden zu deren verwendung

Info

Publication number
ATE329606T1
ATE329606T1 AT99940809T AT99940809T ATE329606T1 AT E329606 T1 ATE329606 T1 AT E329606T1 AT 99940809 T AT99940809 T AT 99940809T AT 99940809 T AT99940809 T AT 99940809T AT E329606 T1 ATE329606 T1 AT E329606T1
Authority
AT
Austria
Prior art keywords
peptide antagonists
zonulin
methods
peptide
opening
Prior art date
Application number
AT99940809T
Other languages
English (en)
Inventor
Alessio Fasano
Original Assignee
Univ Maryland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Maryland filed Critical Univ Maryland
Application granted granted Critical
Publication of ATE329606T1 publication Critical patent/ATE329606T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4716—Muscle proteins, e.g. myosin, actin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT99940809T 1998-08-03 1999-07-28 Peptidantagonisten von zonulin und methoden zu deren verwendung ATE329606T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/127,815 US6458925B1 (en) 1998-08-03 1998-08-03 Peptide antagonists of zonulin and methods for use of the same

Publications (1)

Publication Number Publication Date
ATE329606T1 true ATE329606T1 (de) 2006-07-15

Family

ID=22432094

Family Applications (2)

Application Number Title Priority Date Filing Date
AT06006483T ATE480252T1 (de) 1998-08-03 1999-07-28 Peptidantagonist von zonulin und dessen verwendung
AT99940809T ATE329606T1 (de) 1998-08-03 1999-07-28 Peptidantagonisten von zonulin und methoden zu deren verwendung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT06006483T ATE480252T1 (de) 1998-08-03 1999-07-28 Peptidantagonist von zonulin und dessen verwendung

Country Status (18)

Country Link
US (10) US6458925B1 (de)
EP (2) EP1698345B1 (de)
JP (1) JP4822585B2 (de)
KR (1) KR100610389B1 (de)
CN (2) CN1217697C (de)
AT (2) ATE480252T1 (de)
AU (1) AU745507B2 (de)
CA (1) CA2338005C (de)
DE (2) DE69931929T2 (de)
DK (1) DK1102596T3 (de)
ES (1) ES2267282T3 (de)
HU (1) HU228079B1 (de)
IL (2) IL141082A0 (de)
NO (1) NO326552B1 (de)
NZ (1) NZ509579A (de)
RU (1) RU2214267C2 (de)
WO (1) WO2000007609A1 (de)
ZA (1) ZA200100829B (de)

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US6458925B1 (en) * 1998-08-03 2002-10-01 University Of Maryland, Baltimore Peptide antagonists of zonulin and methods for use of the same
US7026294B2 (en) * 2000-05-19 2006-04-11 University Of Maryland Method of use of peptide antagonists of zonulin to prevent or delay the onset of diabetes
FR2844201A1 (fr) * 2002-09-06 2004-03-12 Rytek Compositions pour le traitement de pathologies fonctionnelles digestives
JP2005526772A (ja) * 2002-03-15 2005-09-08 リテック 消化機能病理を処置するための組成物
CA2531491A1 (en) * 2003-07-15 2005-02-03 University Of Maryland, Baltimore Agonist polypeptide of receptor for zot and zonulin
US7067385B2 (en) * 2003-09-04 2006-06-27 Micron Technology, Inc. Support for vertically oriented capacitors during the formation of a semiconductor device
US7125781B2 (en) * 2003-09-04 2006-10-24 Micron Technology, Inc. Methods of forming capacitor devices
US20080038843A1 (en) * 2006-08-11 2008-02-14 University Of Maryland - Baltimore Method of diagnosing celiac disease
US7387939B2 (en) * 2004-07-19 2008-06-17 Micron Technology, Inc. Methods of forming semiconductor structures and capacitor devices
US7202127B2 (en) * 2004-08-27 2007-04-10 Micron Technology, Inc. Methods of forming a plurality of capacitors
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FR2879100B1 (fr) 2004-12-09 2007-07-06 Lionel Bueno Compositions pour le traitement des pathologies oculaires de surface et de la retine
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US7517753B2 (en) * 2005-05-18 2009-04-14 Micron Technology, Inc. Methods of forming pluralities of capacitors
TW200716159A (en) * 2005-06-09 2007-05-01 Univ Maryland Method of use of antagonists of zonulin to prevent the loss of or to regenerate pancreatic cells
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US7199005B2 (en) * 2005-08-02 2007-04-03 Micron Technology, Inc. Methods of forming pluralities of capacitors
US7867851B2 (en) 2005-08-30 2011-01-11 Micron Technology, Inc. Methods of forming field effect transistors on substrates
US7700441B2 (en) 2006-02-02 2010-04-20 Micron Technology, Inc. Methods of forming field effect transistors, methods of forming field effect transistor gates, methods of forming integrated circuitry comprising a transistor gate array and circuitry peripheral to the gate array, and methods of forming integrated circuitry comprising a transistor gate array including first gates and second grounded isolation gates
AR060103A1 (es) * 2006-02-09 2008-05-28 Alba Therapeutics Corp Formulaciones para un efector de uniones apretadas
US7557013B2 (en) 2006-04-10 2009-07-07 Micron Technology, Inc. Methods of forming a plurality of capacitors
US7602001B2 (en) 2006-07-17 2009-10-13 Micron Technology, Inc. Capacitorless one transistor DRAM cell, integrated circuitry comprising an array of capacitorless one transistor DRAM cells, and method of forming lines of capacitorless one transistor DRAM cells
US7772632B2 (en) 2006-08-21 2010-08-10 Micron Technology, Inc. Memory arrays and methods of fabricating memory arrays
US7589995B2 (en) 2006-09-07 2009-09-15 Micron Technology, Inc. One-transistor memory cell with bias gate
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US7902081B2 (en) 2006-10-11 2011-03-08 Micron Technology, Inc. Methods of etching polysilicon and methods of forming pluralities of capacitors
US8034776B2 (en) * 2006-10-26 2011-10-11 Alba Therapeutics Corporation Materials and methods for the treatment of celiac disease
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Also Published As

Publication number Publication date
US20090082279A1 (en) 2009-03-26
KR100610389B1 (ko) 2006-08-09
EP1102596A4 (de) 2002-08-14
US20110183923A1 (en) 2011-07-28
IL141082A0 (en) 2002-02-10
CN1679915A (zh) 2005-10-12
DE69931929D1 (de) 2006-07-27
HUP0103321A3 (en) 2006-01-30
KR20010072245A (ko) 2001-07-31
ES2267282T3 (es) 2007-03-01
CN1313772A (zh) 2001-09-19
US20140128328A1 (en) 2014-05-08
NZ509579A (en) 2003-07-25
ATE480252T1 (de) 2010-09-15
RU2214267C2 (ru) 2003-10-20
JP4822585B2 (ja) 2011-11-24
US20060276399A1 (en) 2006-12-07
ZA200100829B (en) 2002-06-26
US6458925B1 (en) 2002-10-01
US6670448B2 (en) 2003-12-30
WO2000007609A1 (en) 2000-02-17
JP2002524393A (ja) 2002-08-06
IL141082A (en) 2012-09-24
NO20010567D0 (no) 2001-02-02
US20040082512A1 (en) 2004-04-29
HU228079B1 (en) 2012-10-29
EP1698345B1 (de) 2010-09-08
US7582603B2 (en) 2009-09-01
US7531504B2 (en) 2009-05-12
US6936689B2 (en) 2005-08-30
CA2338005A1 (en) 2000-02-17
US7189696B2 (en) 2007-03-13
NO326552B1 (no) 2009-01-05
EP1698345A3 (de) 2006-09-13
US20050209161A1 (en) 2005-09-22
CN1217697C (zh) 2005-09-07
US20080051349A1 (en) 2008-02-28
CA2338005C (en) 2012-05-29
US20020115825A1 (en) 2002-08-22
DK1102596T3 (da) 2006-10-09
NO20010567L (no) 2001-04-02
CN100348266C (zh) 2007-11-14
EP1102596B1 (de) 2006-06-14
AU5459099A (en) 2000-02-28
EP1102596A1 (de) 2001-05-30
AU745507B2 (en) 2002-03-21
HUP0103321A2 (hu) 2001-12-28
DE69931929T2 (de) 2007-02-08
DE69942753D1 (de) 2010-10-21
US20130190247A1 (en) 2013-07-25
EP1698345A2 (de) 2006-09-06
HK1082210A1 (zh) 2006-06-02

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