ATE297403T1 - Verfahren zur herstellung von risedronsäure - Google Patents
Verfahren zur herstellung von risedronsäureInfo
- Publication number
- ATE297403T1 ATE297403T1 AT02004222T AT02004222T ATE297403T1 AT E297403 T1 ATE297403 T1 AT E297403T1 AT 02004222 T AT02004222 T AT 02004222T AT 02004222 T AT02004222 T AT 02004222T AT E297403 T1 ATE297403 T1 AT E297403T1
- Authority
- AT
- Austria
- Prior art keywords
- acid
- risedronic acid
- risedronic
- producing
- solvent
- Prior art date
Links
- IIDJRNMFWXDHID-UHFFFAOYSA-N Risedronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CC1=CC=CN=C1 IIDJRNMFWXDHID-UHFFFAOYSA-N 0.000 title abstract 4
- 229960000759 risedronic acid Drugs 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- WGNUNYPERJMVRM-UHFFFAOYSA-N 3-pyridylacetic acid Chemical compound OC(=O)CC1=CC=CN=C1 WGNUNYPERJMVRM-UHFFFAOYSA-N 0.000 abstract 2
- 239000001099 ammonium carbonate Substances 0.000 abstract 2
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 abstract 2
- 229950007593 homonicotinic acid Drugs 0.000 abstract 2
- FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 abstract 2
- 239000011541 reaction mixture Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 abstract 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 235000012538 ammonium bicarbonate Nutrition 0.000 abstract 1
- 235000012501 ammonium carbonate Nutrition 0.000 abstract 1
- 239000000908 ammonium hydroxide Substances 0.000 abstract 1
- 235000011114 ammonium hydroxide Nutrition 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- PYLWMHQQBFSUBP-UHFFFAOYSA-N monofluorobenzene Chemical compound FC1=CC=CC=C1 PYLWMHQQBFSUBP-UHFFFAOYSA-N 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL346517A PL194770B1 (pl) | 2001-03-19 | 2001-03-19 | Sposób wytwarzania kwasu rizedronowego |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE297403T1 true ATE297403T1 (de) | 2005-06-15 |
Family
ID=20078443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02004222T ATE297403T1 (de) | 2001-03-19 | 2002-02-26 | Verfahren zur herstellung von risedronsäure |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1243592B1 (de) |
| AT (1) | ATE297403T1 (de) |
| DE (1) | DE60204498D1 (de) |
| ES (1) | ES2243609T3 (de) |
| PL (1) | PL194770B1 (de) |
| PT (1) | PT1243592E (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602004032577D1 (de) | 2003-12-23 | 2011-06-16 | Alchymars S P A | Amorphe Form das Natriumsalzes der Ibandronsäure |
| PL199215B1 (pl) | 2004-12-28 | 2008-08-29 | Politechnika Gdanska | Sposób wytwarzania kwasu [1-hydroksy-2-(3-pirydylo)etylidenobisfosfonowego] oraz jego soli monosodowej dwu i pół wodnej |
| EP1888606A2 (de) * | 2005-05-28 | 2008-02-20 | PLIVA HRVATSKA d.o.o. | Verfahren und neues salz |
| EP1775302A1 (de) | 2005-10-11 | 2007-04-18 | Sandoz A/S | Methode zur Herstellung von kristallinem Natriumrisedronat |
| WO2007083243A2 (en) * | 2006-01-20 | 2007-07-26 | Aurobindo Pharma Limited | An improved process for the preparation of risedronate sodium hemi-pentahydrate |
| PT103600B (pt) | 2006-11-06 | 2009-01-30 | Hovione Farmaciencia Sa | Processo para a preparação de ácidos biosfónicos e seus sais farmaceuticamente aceitáveis |
| DE102007030370A1 (de) | 2007-06-29 | 2009-01-02 | Ratiopharm Gmbh | Essigsäure-Solvate von Risedronat, Polymorph hiervon, deren Herstellung und Verwendung sowie pharmazeutische Zusammensetzung, enthaltend diese |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2745083C2 (de) * | 1977-10-07 | 1985-05-02 | Henkel KGaA, 4000 Düsseldorf | Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung |
| IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| DK0646119T3 (da) * | 1992-05-29 | 1998-12-14 | Procter & Gamble Pharma | Phosphonatforbindelser indeholdende kvaternært nitrogen til behandling af unormalt calcium- og phosphatstofskifte samt tan |
-
2001
- 2001-03-19 PL PL346517A patent/PL194770B1/pl not_active IP Right Cessation
-
2002
- 2002-02-26 ES ES02004222T patent/ES2243609T3/es not_active Expired - Lifetime
- 2002-02-26 PT PT02004222T patent/PT1243592E/pt unknown
- 2002-02-26 EP EP02004222A patent/EP1243592B1/de not_active Expired - Lifetime
- 2002-02-26 DE DE60204498T patent/DE60204498D1/de not_active Expired - Lifetime
- 2002-02-26 AT AT02004222T patent/ATE297403T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60204498D1 (de) | 2005-07-14 |
| EP1243592A3 (de) | 2003-05-07 |
| PL346517A1 (en) | 2002-09-23 |
| PL194770B1 (pl) | 2007-07-31 |
| EP1243592A2 (de) | 2002-09-25 |
| ES2243609T3 (es) | 2005-12-01 |
| EP1243592B1 (de) | 2005-06-08 |
| PT1243592E (pt) | 2005-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1243592 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |