ATE451380T1 - Verfahren zur herstellung von bisphosphonsäureverbindungen - Google Patents
Verfahren zur herstellung von bisphosphonsäureverbindungenInfo
- Publication number
- ATE451380T1 ATE451380T1 AT04816640T AT04816640T ATE451380T1 AT E451380 T1 ATE451380 T1 AT E451380T1 AT 04816640 T AT04816640 T AT 04816640T AT 04816640 T AT04816640 T AT 04816640T AT E451380 T1 ATE451380 T1 AT E451380T1
- Authority
- AT
- Austria
- Prior art keywords
- acid compounds
- bisphosphonic acid
- producing
- producing bisphosphonic
- acid
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 229960004343 alendronic acid Drugs 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Vending Machines For Individual Products (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN837MU2003 | 2003-08-21 | ||
| PCT/IN2004/000238 WO2005044831A2 (en) | 2003-08-21 | 2004-08-10 | A process for preparation of bisphosphonic acid compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE451380T1 true ATE451380T1 (de) | 2009-12-15 |
Family
ID=34566872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04816640T ATE451380T1 (de) | 2003-08-21 | 2004-08-10 | Verfahren zur herstellung von bisphosphonsäureverbindungen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7411087B2 (de) |
| EP (1) | EP1656386B1 (de) |
| JP (1) | JP4642762B2 (de) |
| AT (1) | ATE451380T1 (de) |
| CA (1) | CA2536229C (de) |
| DE (1) | DE602004024545D1 (de) |
| DK (1) | DK1656386T3 (de) |
| ES (1) | ES2337063T3 (de) |
| PL (1) | PL1656386T3 (de) |
| PT (1) | PT1656386E (de) |
| SI (1) | SI1656386T1 (de) |
| WO (1) | WO2005044831A2 (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL165227A0 (en) * | 2002-05-17 | 2005-12-18 | Tva Pharmaceutical Ind Ltd | Cus of certain diluents for making bisphosphonic acids |
| HUP0300227A2 (hu) * | 2003-01-28 | 2004-09-28 | Richter Gedeon Vegyészeti Gyár Rt. | Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására |
| WO2006002348A2 (en) * | 2004-06-23 | 2006-01-05 | Teva Pharmaceutical Industies Ltd. | Solid and crystalline ibandronic acid |
| EP1828214A4 (de) * | 2004-11-09 | 2008-08-13 | Jubilant Organosys Ltd | Verfahren zur herstellung einer reinen polymorphen form von 3-pyridyl-1-hydroxyethylidin-1,1-bisphosphonsäure-natriumsalz |
| US8071574B2 (en) | 2005-02-22 | 2011-12-06 | John Dennis Bobyn | Implant improving local bone formation |
| EP1891081B1 (de) * | 2005-06-13 | 2014-08-20 | Jubilant Organosys Limited | Verfahren zur herstellung von bisphosphonsäuren und formen davon |
| WO2007010556A1 (en) * | 2005-07-20 | 2007-01-25 | Lupin Limited | Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| EP1931326A4 (de) * | 2005-09-12 | 2009-12-16 | Reddys Lab Ltd Dr | Kristallines trihydrat von zoledronsäure |
| US8003820B2 (en) | 2005-10-20 | 2011-08-23 | Dr. Reddy's Laboratories Limited | Process for preparing bisphosphonic acids |
| WO2007083240A2 (en) | 2006-01-20 | 2007-07-26 | Aurobindo Pharma Limited | An improved process for the preparation of bisphosphonic acids |
| CA2646418A1 (en) * | 2006-03-21 | 2007-09-27 | Albemarle Corporation | Process for manufacturing bisphosphonic acids |
| WO2007125521A2 (en) * | 2006-05-02 | 2007-11-08 | Ranbaxy Laboratories Limited | Polymorphic form of zoledronic acid and processes for their preparation |
| JP5354858B2 (ja) * | 2006-05-09 | 2013-11-27 | 株式会社Ａｄｅｋａ | スルホンアミド化合物の金属塩を含有するポリエステル樹脂組成物 |
| BRPI0710421A2 (pt) * | 2006-05-11 | 2011-08-09 | Ind Swift Ltd | processo para a preparação de ácido risedrÈnico puro ou sais |
| KR101425429B1 (ko) * | 2006-06-23 | 2014-08-01 | 씨아이피엘에이 엘티디. | 이반드로네이트 나트륨 합성을 위한 향상된 공정 |
| AU2007270897A1 (en) * | 2006-07-03 | 2008-01-10 | Generics [Uk] Limited | Novel process for the preparation of bisphosphonic acids |
| PT103600B (pt) * | 2006-11-06 | 2009-01-30 | Hovione Farmaciencia Sa | Processo para a preparação de ácidos biosfónicos e seus sais farmaceuticamente aceitáveis |
| AU2008238058B2 (en) * | 2007-04-11 | 2010-12-02 | F. Hoffmann-La Roche Ag | Multi step synthesis of ibandronate |
| WO2008152518A2 (en) * | 2007-05-16 | 2008-12-18 | Actavis Group Ptc Ehf | Process for the preparation of risedronic acid or risedronate sodium |
| WO2009050731A2 (en) * | 2007-06-20 | 2009-04-23 | Alkem Laboratories Ltd | Novel process for preparing risedronic acid |
| JP5258370B2 (ja) * | 2008-05-08 | 2013-08-07 | ダイト株式会社 | リセドロン酸の工業的製造方法 |
| PL213599B1 (pl) | 2008-10-31 | 2013-03-29 | Politechnika Gdanska | Sposób otrzymywania kwasu [1-hydroksy-2-(1H-imidazol-1-ilo)-etylideno] bisfosfonowego |
| GB0906068D0 (en) | 2009-04-07 | 2009-05-20 | King S College London | Bisphosphonate Compounds for chelating radionuclides |
| EP2459176B1 (de) | 2009-07-31 | 2017-09-27 | Grünenthal GmbH | Kristallisationsverfahren und bioverfügbarkeit |
| US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| US9169279B2 (en) | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| WO2011016738A1 (en) | 2009-08-05 | 2011-02-10 | Zaklady Farmaceutyczne Polpharma Sa | A process for the synthesis of 1-hydroxy-3-(n-methylpentylamino) propylidene bisphosphonic acid monosodium salt, monohydrate |
| US8882740B2 (en) * | 2009-12-23 | 2014-11-11 | Stryker Trauma Gmbh | Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone |
| US9340565B2 (en) | 2010-11-24 | 2016-05-17 | Thar Pharmaceuticals, Inc. | Crystalline forms |
| CN102276650A (zh) * | 2011-06-22 | 2011-12-14 | 苏州莱克施德药业有限公司 | 一种唑来膦酸的制备方法 |
| US10195218B2 (en) | 2016-05-31 | 2019-02-05 | Grunenthal Gmbh | Crystallization method and bioavailability |
| CN116253759A (zh) * | 2022-12-14 | 2023-06-13 | 仁合益康集团有限公司 | 一种一锅法制备帕米膦酸二钠的方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3016289A1 (de) * | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
| US4304734A (en) * | 1980-10-16 | 1981-12-08 | Vysoka Skola Chemicko-Technologicka | 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof |
| IT1196315B (it) | 1984-10-29 | 1988-11-16 | Gentili Ist Spa | Procedimento per la preparazione di acidi difosfonici |
| DE3623397A1 (de) * | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| DE3822650A1 (de) * | 1988-07-05 | 1990-02-01 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| DE3917153A1 (de) * | 1989-05-26 | 1990-11-29 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US4922007A (en) * | 1989-06-09 | 1990-05-01 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| US5019651A (en) * | 1990-06-20 | 1991-05-28 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof |
| CA2197267C (en) * | 1997-02-11 | 2000-02-08 | Yong Tao | Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| US6562974B2 (en) | 2000-02-01 | 2003-05-13 | The Procter & Gamble Company | Process for making geminal bisphosphonates |
| TR200101250A2 (tr) | 2001-05-10 | 2003-04-21 | E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. | 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses |
| GB0115824D0 (en) * | 2001-06-28 | 2001-08-22 | Rhodia Cons Spec Ltd | Improved solvent systems |
| IL165227A0 (en) * | 2002-05-17 | 2005-12-18 | Tva Pharmaceutical Ind Ltd | Cus of certain diluents for making bisphosphonic acids |
-
2004
- 2004-08-10 EP EP04816640A patent/EP1656386B1/de not_active Expired - Lifetime
- 2004-08-10 CA CA2536229A patent/CA2536229C/en not_active Expired - Fee Related
- 2004-08-10 PT PT04816640T patent/PT1656386E/pt unknown
- 2004-08-10 ES ES04816640T patent/ES2337063T3/es not_active Expired - Lifetime
- 2004-08-10 US US10/569,308 patent/US7411087B2/en not_active Expired - Fee Related
- 2004-08-10 DK DK04816640.9T patent/DK1656386T3/da active
- 2004-08-10 JP JP2006523750A patent/JP4642762B2/ja not_active Expired - Fee Related
- 2004-08-10 SI SI200431349T patent/SI1656386T1/sl unknown
- 2004-08-10 AT AT04816640T patent/ATE451380T1/de not_active IP Right Cessation
- 2004-08-10 DE DE602004024545T patent/DE602004024545D1/de not_active Expired - Lifetime
- 2004-08-10 WO PCT/IN2004/000238 patent/WO2005044831A2/en not_active Ceased
- 2004-08-10 PL PL04816640T patent/PL1656386T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL1656386T3 (pl) | 2010-05-31 |
| US20060293524A1 (en) | 2006-12-28 |
| ES2337063T3 (es) | 2010-04-20 |
| EP1656386A2 (de) | 2006-05-17 |
| PT1656386E (pt) | 2010-03-05 |
| DE602004024545D1 (de) | 2010-01-21 |
| CA2536229C (en) | 2012-09-25 |
| JP4642762B2 (ja) | 2011-03-02 |
| US7411087B2 (en) | 2008-08-12 |
| CA2536229A1 (en) | 2005-05-19 |
| WO2005044831A2 (en) | 2005-05-19 |
| WO2005044831A3 (en) | 2005-07-28 |
| DK1656386T3 (da) | 2010-04-19 |
| JP2007502810A (ja) | 2007-02-15 |
| SI1656386T1 (sl) | 2010-04-30 |
| EP1656386B1 (de) | 2009-12-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1656386 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |