ATE451380T1 - Verfahren zur herstellung von bisphosphonsäureverbindungen - Google Patents
Verfahren zur herstellung von bisphosphonsäureverbindungenInfo
- Publication number
- ATE451380T1 ATE451380T1 AT04816640T AT04816640T ATE451380T1 AT E451380 T1 ATE451380 T1 AT E451380T1 AT 04816640 T AT04816640 T AT 04816640T AT 04816640 T AT04816640 T AT 04816640T AT E451380 T1 ATE451380 T1 AT E451380T1
- Authority
- AT
- Austria
- Prior art keywords
- acid compounds
- bisphosphonic acid
- producing
- producing bisphosphonic
- acid
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 229960004343 alendronic acid Drugs 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Vending Machines For Individual Products (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN837MU2003 | 2003-08-21 | ||
| PCT/IN2004/000238 WO2005044831A2 (en) | 2003-08-21 | 2004-08-10 | A process for preparation of bisphosphonic acid compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE451380T1 true ATE451380T1 (de) | 2009-12-15 |
Family
ID=34566872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04816640T ATE451380T1 (de) | 2003-08-21 | 2004-08-10 | Verfahren zur herstellung von bisphosphonsäureverbindungen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7411087B2 (de) |
| EP (1) | EP1656386B1 (de) |
| JP (1) | JP4642762B2 (de) |
| AT (1) | ATE451380T1 (de) |
| CA (1) | CA2536229C (de) |
| DE (1) | DE602004024545D1 (de) |
| DK (1) | DK1656386T3 (de) |
| ES (1) | ES2337063T3 (de) |
| PL (1) | PL1656386T3 (de) |
| PT (1) | PT1656386E (de) |
| SI (1) | SI1656386T1 (de) |
| WO (1) | WO2005044831A2 (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100681282B1 (ko) * | 2002-05-17 | 2007-02-12 | 테바 파마슈티컬 인더스트리즈 리미티드 | 특정 희석제를 사용하는 비스포스폰산 및 그 염의 제조방법 |
| HUP0300227A2 (hu) * | 2003-01-28 | 2004-09-28 | Richter Gedeon Vegyészeti Gyár Rt. | Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására |
| MX2007000087A (es) | 2004-06-23 | 2007-11-06 | Teva Pharma | Acido ibandronico solido y cristalino. |
| WO2006051553A1 (en) * | 2004-11-09 | 2006-05-18 | Jubilant Organosys Limited | Process for preparing a pure polymorphic form of 3-pyridyl-1-hydroxyethylidine-1,1-bisphosphonic acid sodium salt |
| US8071574B2 (en) | 2005-02-22 | 2011-12-06 | John Dennis Bobyn | Implant improving local bone formation |
| WO2006134603A1 (en) * | 2005-06-13 | 2006-12-21 | Jubilant Organosys Limited | Process for producing bisphosphonic acids and forms thereof |
| WO2007010556A1 (en) * | 2005-07-20 | 2007-01-25 | Lupin Limited | Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| CN101262856A (zh) * | 2005-09-12 | 2008-09-10 | 雷迪博士实验室有限公司 | 唑来膦酸的结晶三水合物 |
| US8003820B2 (en) | 2005-10-20 | 2011-08-23 | Dr. Reddy's Laboratories Limited | Process for preparing bisphosphonic acids |
| WO2007083240A2 (en) | 2006-01-20 | 2007-07-26 | Aurobindo Pharma Limited | An improved process for the preparation of bisphosphonic acids |
| US20090137808A1 (en) * | 2006-03-21 | 2009-05-28 | Albemarle Corporation | Process for manufacturing bisphosphonic acids |
| WO2007125521A2 (en) * | 2006-05-02 | 2007-11-08 | Ranbaxy Laboratories Limited | Polymorphic form of zoledronic acid and processes for their preparation |
| JP5354858B2 (ja) * | 2006-05-09 | 2013-11-27 | 株式会社Ａｄｅｋａ | スルホンアミド化合物の金属塩を含有するポリエステル樹脂組成物 |
| WO2007132478A2 (en) * | 2006-05-11 | 2007-11-22 | Ind-Swift Laboratories Limited | Process for the preparation of pure risedronic acid or salts |
| US8178712B2 (en) | 2006-06-23 | 2012-05-15 | Cipla Ltd. | Process for the synthesis of Ibandronate sodium |
| WO2008004000A1 (en) * | 2006-07-03 | 2008-01-10 | Generics [Uk] Limited | Novel process for the preparation of bisphosphonic acids |
| PT103600B (pt) * | 2006-11-06 | 2009-01-30 | Hovione Farmaciencia Sa | Processo para a preparação de ácidos biosfónicos e seus sais farmaceuticamente aceitáveis |
| BRPI0809548A8 (pt) * | 2007-04-11 | 2018-10-16 | Hoffmann La Roche | processo para a preparação do sal ácido- (mono-hidratado)-3- (n-metil-n-pentil) amino-1-hidroxipropano-1, 1-difosfônico monossódico |
| US20100317859A1 (en) * | 2007-05-16 | 2010-12-16 | Actavis Group Ptc Ehf | Process for the Preparation of Risedronate Sodium |
| WO2009050731A2 (en) * | 2007-06-20 | 2009-04-23 | Alkem Laboratories Ltd | Novel process for preparing risedronic acid |
| JP5258370B2 (ja) * | 2008-05-08 | 2013-08-07 | ダイト株式会社 | リセドロン酸の工業的製造方法 |
| PL213599B1 (pl) | 2008-10-31 | 2013-03-29 | Politechnika Gdanska | Sposób otrzymywania kwasu [1-hydroksy-2-(1H-imidazol-1-ilo)-etylideno] bisfosfonowego |
| GB0906068D0 (en) | 2009-04-07 | 2009-05-20 | King S College London | Bisphosphonate Compounds for chelating radionuclides |
| CA2769633C (en) | 2009-07-31 | 2017-06-06 | Thar Pharma, Llc | Crystallization method and bioavailability |
| US9169279B2 (en) | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| WO2011016738A1 (en) | 2009-08-05 | 2011-02-10 | Zaklady Farmaceutyczne Polpharma Sa | A process for the synthesis of 1-hydroxy-3-(n-methylpentylamino) propylidene bisphosphonic acid monosodium salt, monohydrate |
| US8882740B2 (en) * | 2009-12-23 | 2014-11-11 | Stryker Trauma Gmbh | Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone |
| WO2012071517A2 (en) | 2010-11-24 | 2012-05-31 | Thar Pharmaceuticals, Inc. | Novel crystalline forms |
| CN102276650A (zh) * | 2011-06-22 | 2011-12-14 | 苏州莱克施德药业有限公司 | 一种唑来膦酸的制备方法 |
| WO2017208070A1 (en) | 2016-05-31 | 2017-12-07 | Grünenthal GmbH | Bisphosphonic acid and coformers with lysin, glycin, nicotinamide for treating psoriatic arthritis |
| CN116253759B (zh) * | 2022-12-14 | 2026-04-07 | 仁合益康集团有限公司 | 一种一锅法制备帕米膦酸二钠的方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3016289A1 (de) * | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
| US4304734A (en) * | 1980-10-16 | 1981-12-08 | Vysoka Skola Chemicko-Technologicka | 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof |
| IT1196315B (it) * | 1984-10-29 | 1988-11-16 | Gentili Ist Spa | Procedimento per la preparazione di acidi difosfonici |
| DE3623397A1 (de) * | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| DE3822650A1 (de) * | 1988-07-05 | 1990-02-01 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| DE3917153A1 (de) * | 1989-05-26 | 1990-11-29 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US4922007A (en) | 1989-06-09 | 1990-05-01 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| US5019651A (en) * | 1990-06-20 | 1991-05-28 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof |
| CA2197267C (en) | 1997-02-11 | 2000-02-08 | Yong Tao | Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| PE20011065A1 (es) | 2000-02-01 | 2001-11-21 | Procter & Gamble | Proceso para fabricar bisfosfonatos geminales |
| TR200101250A2 (tr) | 2001-05-10 | 2003-04-21 | E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. | 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses |
| GB0115824D0 (en) * | 2001-06-28 | 2001-08-22 | Rhodia Cons Spec Ltd | Improved solvent systems |
| KR100681282B1 (ko) | 2002-05-17 | 2007-02-12 | 테바 파마슈티컬 인더스트리즈 리미티드 | 특정 희석제를 사용하는 비스포스폰산 및 그 염의 제조방법 |
-
2004
- 2004-08-10 JP JP2006523750A patent/JP4642762B2/ja not_active Expired - Fee Related
- 2004-08-10 SI SI200431349T patent/SI1656386T1/sl unknown
- 2004-08-10 DK DK04816640.9T patent/DK1656386T3/da active
- 2004-08-10 AT AT04816640T patent/ATE451380T1/de not_active IP Right Cessation
- 2004-08-10 WO PCT/IN2004/000238 patent/WO2005044831A2/en not_active Ceased
- 2004-08-10 ES ES04816640T patent/ES2337063T3/es not_active Expired - Lifetime
- 2004-08-10 US US10/569,308 patent/US7411087B2/en not_active Expired - Fee Related
- 2004-08-10 DE DE602004024545T patent/DE602004024545D1/de not_active Expired - Lifetime
- 2004-08-10 EP EP04816640A patent/EP1656386B1/de not_active Expired - Lifetime
- 2004-08-10 CA CA2536229A patent/CA2536229C/en not_active Expired - Fee Related
- 2004-08-10 PT PT04816640T patent/PT1656386E/pt unknown
- 2004-08-10 PL PL04816640T patent/PL1656386T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004024545D1 (de) | 2010-01-21 |
| US7411087B2 (en) | 2008-08-12 |
| JP4642762B2 (ja) | 2011-03-02 |
| SI1656386T1 (sl) | 2010-04-30 |
| CA2536229A1 (en) | 2005-05-19 |
| JP2007502810A (ja) | 2007-02-15 |
| WO2005044831A3 (en) | 2005-07-28 |
| DK1656386T3 (da) | 2010-04-19 |
| PL1656386T3 (pl) | 2010-05-31 |
| PT1656386E (pt) | 2010-03-05 |
| ES2337063T3 (es) | 2010-04-20 |
| EP1656386A2 (de) | 2006-05-17 |
| WO2005044831A2 (en) | 2005-05-19 |
| EP1656386B1 (de) | 2009-12-09 |
| US20060293524A1 (en) | 2006-12-28 |
| CA2536229C (en) | 2012-09-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1656386 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |