ATE297683T1 - Darstellung von krankhaft verändertem gewebe mittels autofluoreszenz - Google Patents

Darstellung von krankhaft verändertem gewebe mittels autofluoreszenz

Info

Publication number
ATE297683T1
ATE297683T1 AT98952301T AT98952301T ATE297683T1 AT E297683 T1 ATE297683 T1 AT E297683T1 AT 98952301 T AT98952301 T AT 98952301T AT 98952301 T AT98952301 T AT 98952301T AT E297683 T1 ATE297683 T1 AT E297683T1
Authority
AT
Austria
Prior art keywords
light
tissue
endoscope
autofluorescence
processing unit
Prior art date
Application number
AT98952301T
Other languages
English (en)
Inventor
Peter P Gombrich
Richard A Domanik
Norman J Pressman
Original Assignee
Monogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monogen Inc filed Critical Monogen Inc
Application granted granted Critical
Publication of ATE297683T1 publication Critical patent/ATE297683T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/06Devices, other than using radiation, for detecting or locating foreign bodies ; Determining position of diagnostic devices within or on the body of the patient
    • A61B5/065Determining position of the probe employing exclusively positioning means located on or in the probe, e.g. using position sensors arranged on the probe
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/43Detecting, measuring or recording for evaluating the reproductive systems
    • A61B5/4306Detecting, measuring or recording for evaluating the reproductive systems for evaluating the female reproductive systems, e.g. gynaecological evaluations
    • A61B5/4318Evaluation of the lower reproductive system
    • A61B5/4331Evaluation of the lower reproductive system of the cervix
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A61B5/0086Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Human Computer Interaction (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Endoscopes (AREA)
AT98952301T 1997-10-15 1998-10-14 Darstellung von krankhaft verändertem gewebe mittels autofluoreszenz ATE297683T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/951,018 US6081740A (en) 1997-04-23 1997-10-15 Method and apparatus for imaging and sampling diseased tissue
PCT/US1998/021710 WO1999018847A1 (en) 1997-10-15 1998-10-14 Imaging diseased tissue using autofluorescence

Publications (1)

Publication Number Publication Date
ATE297683T1 true ATE297683T1 (de) 2005-07-15

Family

ID=25491161

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98952301T ATE297683T1 (de) 1997-10-15 1998-10-14 Darstellung von krankhaft verändertem gewebe mittels autofluoreszenz

Country Status (7)

Country Link
US (1) US6081740A (de)
EP (1) EP0944349B1 (de)
AT (1) ATE297683T1 (de)
AU (1) AU9803598A (de)
CA (1) CA2268956C (de)
DE (1) DE69830564T2 (de)
WO (1) WO1999018847A1 (de)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6847490B1 (en) 1997-01-13 2005-01-25 Medispectra, Inc. Optical probe accessory device for use in vivo diagnostic procedures
US6364829B1 (en) 1999-01-26 2002-04-02 Newton Laboratories, Inc. Autofluorescence imaging system for endoscopy
CA2356195A1 (en) 1998-12-23 2000-06-29 Medispectra, Inc. Optical methods and systems for cervical screening
EP1148810B1 (de) 1999-01-26 2005-11-16 Newton Laboratories, Inc. Vorrichtung zur autofluoreszensbildgebung für ein endoskop
EP1089067B1 (de) * 1999-09-29 2004-12-08 Fuji Photo Film Co., Ltd. Vorrichtung zur Erfassung eines Fluoreszenzbildes
US6544041B1 (en) * 1999-10-06 2003-04-08 Fonar Corporation Simulator for surgical procedures
US6902935B2 (en) 1999-12-15 2005-06-07 Medispectra, Inc. Methods of monitoring effects of chemical agents on a sample
US7187810B2 (en) 1999-12-15 2007-03-06 Medispectra, Inc. Methods and systems for correcting image misalignment
US7260248B2 (en) 1999-12-15 2007-08-21 Medispectra, Inc. Image processing using measures of similarity
US20010047136A1 (en) * 2000-01-21 2001-11-29 Domanik Richard A. In-vivo tissue inspection and sampling
GR1004180B (el) * 2000-03-28 2003-03-11 ����������� ����� ��������� (����) Μεθοδος και συστημα χαρακτηρισμου και χαρτογραφησης αλλοιωσεων των ιστων
US6377841B1 (en) 2000-03-31 2002-04-23 Vanderbilt University Tumor demarcation using optical spectroscopy
US6678398B2 (en) * 2000-09-18 2004-01-13 Sti Medical Systems, Inc. Dual mode real-time screening and rapid full-area, selective-spectral, remote imaging and analysis device and process
DE10056384C2 (de) * 2000-11-14 2003-06-05 Leica Microsystems Vorrichtung zur Messung der Lebensdauer eines angeregten Zustandes in einer Probe und Verwendung der Vorrichtung
US6839661B2 (en) 2000-12-15 2005-01-04 Medispectra, Inc. System for normalizing spectra
US6600947B2 (en) * 2001-03-16 2003-07-29 Nymox Corporation Method of detecting amyloid-containing lesions by autofluorescence
DE10124340A1 (de) * 2001-05-18 2002-12-05 Fraunhofer Ges Forschung Verfahren zur Analyse einer biologischen Probe
US7170677B1 (en) 2002-01-25 2007-01-30 Everest Vit Stereo-measurement borescope with 3-D viewing
CN100405976C (zh) * 2002-04-14 2008-07-30 王念勇 利用固有荧光诊断早期肿瘤的诊断仪
US7309867B2 (en) 2003-04-18 2007-12-18 Medispectra, Inc. Methods and apparatus for characterization of tissue samples
US7469160B2 (en) 2003-04-18 2008-12-23 Banks Perry S Methods and apparatus for evaluating image focus
US6933154B2 (en) 2002-07-09 2005-08-23 Medispectra, Inc. Optimal windows for obtaining optical data for characterization of tissue samples
US7136518B2 (en) 2003-04-18 2006-11-14 Medispectra, Inc. Methods and apparatus for displaying diagnostic data
US7282723B2 (en) 2002-07-09 2007-10-16 Medispectra, Inc. Methods and apparatus for processing spectral data for use in tissue characterization
US7459696B2 (en) 2003-04-18 2008-12-02 Schomacker Kevin T Methods and apparatus for calibrating spectral data
US6768918B2 (en) 2002-07-10 2004-07-27 Medispectra, Inc. Fluorescent fiberoptic probe for tissue health discrimination and method of use thereof
US7103401B2 (en) 2002-07-10 2006-09-05 Medispectra, Inc. Colonic polyp discrimination by tissue fluorescence and fiberoptic probe
US7660440B2 (en) * 2002-11-07 2010-02-09 Frito-Lay North America, Inc. Method for on-line machine vision measurement, monitoring and control of organoleptic properties of products for on-line manufacturing processes
US8634607B2 (en) 2003-09-23 2014-01-21 Cambridge Research & Instrumentation, Inc. Spectral imaging of biological samples
US7321791B2 (en) 2003-09-23 2008-01-22 Cambridge Research And Instrumentation, Inc. Spectral imaging of deep tissue
DE102004006960B4 (de) * 2004-02-10 2021-03-18 Heidelberg Engineering Gmbh Verfahren und Anordnung zur Gewinnung und Auswertung kontrastreicher Bilder der zeitaufgelösten Fluoreszenz von bewegten Objekten, beispielsweise des Augenhintergrundes
JP4631057B2 (ja) * 2004-02-18 2011-02-16 国立大学法人大阪大学 内視鏡システム
US11832793B2 (en) 2004-03-23 2023-12-05 Boston Scientific Scimed, Inc. Vivo visualization system
US7922654B2 (en) * 2004-08-09 2011-04-12 Boston Scientific Scimed, Inc. Fiber optic imaging catheter
ES2552252T3 (es) 2004-03-23 2015-11-26 Boston Scientific Limited Sistema de visualización in vivo
CN101907622A (zh) * 2004-11-24 2010-12-08 巴特尔纪念研究所 用于检测稀有细胞的方法和装置
US20060161076A1 (en) * 2005-01-06 2006-07-20 Diamics, Inc. Systems and methods for collection of cell clusters
US20060189893A1 (en) * 2005-01-06 2006-08-24 Diamics, Inc. Systems and methods for detecting abnormal cells
CN101151623B (zh) 2005-01-27 2010-06-23 剑桥研究和仪器设备股份有限公司 对样本图像的特征进行分类的方法和设备
US8050746B2 (en) 2005-02-02 2011-11-01 Voyage Medical, Inc. Tissue visualization device and method variations
US8078266B2 (en) 2005-10-25 2011-12-13 Voyage Medical, Inc. Flow reduction hood systems
US7918787B2 (en) 2005-02-02 2011-04-05 Voyage Medical, Inc. Tissue visualization and manipulation systems
US10064540B2 (en) 2005-02-02 2018-09-04 Intuitive Surgical Operations, Inc. Visualization apparatus for transseptal access
US7930016B1 (en) 2005-02-02 2011-04-19 Voyage Medical, Inc. Tissue closure system
US11478152B2 (en) 2005-02-02 2022-10-25 Intuitive Surgical Operations, Inc. Electrophysiology mapping and visualization system
US7860556B2 (en) 2005-02-02 2010-12-28 Voyage Medical, Inc. Tissue imaging and extraction systems
US20080015569A1 (en) 2005-02-02 2008-01-17 Voyage Medical, Inc. Methods and apparatus for treatment of atrial fibrillation
US7860555B2 (en) 2005-02-02 2010-12-28 Voyage Medical, Inc. Tissue visualization and manipulation system
US8137333B2 (en) 2005-10-25 2012-03-20 Voyage Medical, Inc. Delivery of biological compounds to ischemic and/or infarcted tissue
US9510732B2 (en) 2005-10-25 2016-12-06 Intuitive Surgical Operations, Inc. Methods and apparatus for efficient purging
US7901441B2 (en) * 2005-10-18 2011-03-08 Boston Scientific Scimed, Inc. Method of using an imaging catheter to conduct photodynamic procedures
US8221310B2 (en) 2005-10-25 2012-07-17 Voyage Medical, Inc. Tissue visualization device and method variations
US9055906B2 (en) 2006-06-14 2015-06-16 Intuitive Surgical Operations, Inc. In-vivo visualization systems
EP2063781A4 (de) 2006-09-01 2010-07-28 Voyage Medical Inc System zur zuordnung und visualisierung elektrophysiologischer daten
US20080097476A1 (en) 2006-09-01 2008-04-24 Voyage Medical, Inc. Precision control systems for tissue visualization and manipulation assemblies
US10004388B2 (en) 2006-09-01 2018-06-26 Intuitive Surgical Operations, Inc. Coronary sinus cannulation
US10335131B2 (en) 2006-10-23 2019-07-02 Intuitive Surgical Operations, Inc. Methods for preventing tissue migration
US20080183036A1 (en) 2006-12-18 2008-07-31 Voyage Medical, Inc. Systems and methods for unobstructed visualization and ablation
US8131350B2 (en) 2006-12-21 2012-03-06 Voyage Medical, Inc. Stabilization of visualization catheters
US9226648B2 (en) 2006-12-21 2016-01-05 Intuitive Surgical Operations, Inc. Off-axis visualization systems
WO2008134457A1 (en) 2007-04-27 2008-11-06 Voyage Medical, Inc. Complex shape steerable tissue visualization and manipulation catheter
US8657805B2 (en) 2007-05-08 2014-02-25 Intuitive Surgical Operations, Inc. Complex shape steerable tissue visualization and manipulation catheter
US8709008B2 (en) 2007-05-11 2014-04-29 Intuitive Surgical Operations, Inc. Visual electrode ablation systems
US20090048610A1 (en) * 2007-08-14 2009-02-19 Bme Capital Holdings Ltd. Medical probe introducer
US8235985B2 (en) 2007-08-31 2012-08-07 Voyage Medical, Inc. Visualization and ablation system variations
US8858609B2 (en) 2008-02-07 2014-10-14 Intuitive Surgical Operations, Inc. Stent delivery under direct visualization
US9101735B2 (en) 2008-07-07 2015-08-11 Intuitive Surgical Operations, Inc. Catheter control systems
US8894643B2 (en) 2008-10-10 2014-11-25 Intuitive Surgical Operations, Inc. Integral electrode placement and connection systems
US8333012B2 (en) 2008-10-10 2012-12-18 Voyage Medical, Inc. Method of forming electrode placement and connection systems
US9468364B2 (en) 2008-11-14 2016-10-18 Intuitive Surgical Operations, Inc. Intravascular catheter with hood and image processing systems
WO2011066149A1 (en) * 2009-11-30 2011-06-03 Laura Weller-Brophy Method and apparatus for cervical cancer screening
US8694071B2 (en) 2010-02-12 2014-04-08 Intuitive Surgical Operations, Inc. Image stabilization techniques and methods
US9814522B2 (en) 2010-04-06 2017-11-14 Intuitive Surgical Operations, Inc. Apparatus and methods for ablation efficacy
JP5371946B2 (ja) * 2010-12-24 2013-12-18 富士フイルム株式会社 内視鏡診断装置
US9179844B2 (en) 2011-11-28 2015-11-10 Aranz Healthcare Limited Handheld skin measuring or monitoring device
KR101352769B1 (ko) * 2012-05-09 2014-01-22 서강대학교산학협력단 배경과 관심조직을 구별하는 방법 및 장치
US9550072B2 (en) * 2012-08-03 2017-01-24 Cerca Solutions, LLC Diagnostic device, therapeutic device, and uses thereof
WO2014118601A1 (en) * 2013-01-31 2014-08-07 Universidade Do Minho Optical system for parameter characterization of an element of body fluid or tissue
US10743750B2 (en) 2014-04-28 2020-08-18 Massachusetts Institute Of Technology Multi-link modular continuum robotic endoscope system
US10206581B2 (en) * 2014-10-29 2019-02-19 Zoll Medical Corporation Transesophageal or transtracheal cardiac monitoring by optical spectroscopy
US20200046211A1 (en) * 2016-03-10 2020-02-13 Biop - Medical Ltd Device for diagnosing a tissue
US20240011969A1 (en) * 2021-01-05 2024-01-11 Cytoveris Inc. Multi-Modal Multi-Spectral Imaging System and Method for Characterizing Tissue Types in Bladder Specimens
US20240299017A1 (en) * 2021-01-06 2024-09-12 Regents Of The University Of Michigan Examination Scope With Tissue Sample Collection Brush
JP2024517549A (ja) 2021-03-12 2024-04-23 ストライカー・ユーロピアン・オペレーションズ・リミテッド 腫瘍組織を検出および除去するための神経外科的方法およびシステム
DE102021001955B4 (de) 2021-04-14 2023-03-23 Baumer Inspection Gmbh Vorrichtung und Verfahren zur fluoreszenzbasierten Inspektion sowie Prüfanordung mit einer solchen Vorrichtung

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4269192A (en) * 1977-12-02 1981-05-26 Olympus Optical Co., Ltd. Stabbing apparatus for diagnosis of living body
US4566438A (en) * 1984-10-05 1986-01-28 Liese Grover J Fiber-optic stylet for needle tip localization
US4718417A (en) * 1985-03-22 1988-01-12 Massachusetts Institute Of Technology Visible fluorescence spectral diagnostic for laser angiosurgery
US4930516B1 (en) * 1985-11-13 1998-08-04 Laser Diagnostic Instr Inc Method for detecting cancerous tissue using visible native luminescence
US5042494A (en) * 1985-11-13 1991-08-27 Alfano Robert R Method and apparatus for detecting cancerous tissue using luminescence excitation spectra
US4905670A (en) * 1988-12-28 1990-03-06 Adair Edwin Lloyd Apparatus for cervical videoscopy
US5131398A (en) * 1990-01-22 1992-07-21 Mediscience Technology Corp. Method and apparatus for distinguishing cancerous tissue from benign tumor tissue, benign tissue or normal tissue using native fluorescence
US5217023A (en) * 1991-04-03 1993-06-08 Langdon Medical, Inc. Cytology collection device and method
CA2042075C (en) * 1991-05-08 2001-01-23 Branko Palcic Endoscopic imaging system
US5217456A (en) * 1992-02-24 1993-06-08 Pdt Cardiovascular, Inc. Device and method for intra-vascular optical radial imaging
US5762609A (en) * 1992-09-14 1998-06-09 Sextant Medical Corporation Device and method for analysis of surgical tissue interventions
US5421339A (en) * 1993-05-12 1995-06-06 Board Of Regents, The University Of Texas System Diagnosis of dysplasia using laser induced fluoroescence
US5596992A (en) * 1993-06-30 1997-01-28 Sandia Corporation Multivariate classification of infrared spectra of cell and tissue samples
US5697373A (en) * 1995-03-14 1997-12-16 Board Of Regents, The University Of Texas System Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies

Also Published As

Publication number Publication date
DE69830564T2 (de) 2006-05-11
EP0944349B1 (de) 2005-06-15
US6081740A (en) 2000-06-27
CA2268956A1 (en) 1999-04-22
AU9803598A (en) 1999-05-03
EP0944349A1 (de) 1999-09-29
CA2268956C (en) 2004-09-21
DE69830564D1 (de) 2005-07-21
WO1999018847A1 (en) 1999-04-22

Similar Documents

Publication Publication Date Title
ATE297683T1 (de) Darstellung von krankhaft verändertem gewebe mittels autofluoreszenz
JP3236085B2 (ja) 内視鏡装置
US5827190A (en) Endoscope having an integrated CCD sensor
US5687730A (en) Apparatus for detecting the presence of abnormal tissue within a target tissue beneath the skin of a patient
US6016440A (en) Device for infrared (IR) spectroscopic investigations of internal surfaces of a body
AU759282B2 (en) Systems and methods for optical examination of samples
EP2100551B1 (de) Endoskopisches Beobachtungssystem
JPS6053918A (ja) 内視鏡装置
US20040245350A1 (en) Methods and apparatus for fluorescence imaging using multiple excitation-emission pairs and simultaneous multi-channel image detection
US20030156788A1 (en) Method and device for recognizing dental caries, plaque, concrements or bacterial attacks
US20110213252A1 (en) Autofluorescence imaging system for endoscopy
Liang Biomedical optical imaging technologies: design and applications
JPS62247232A (ja) 蛍光測定装置
WO2002063269A3 (en) Layered calibration standard for tissue sampling
DE69212382D1 (de) Endoskopisches Bilderzeugungssystem für erkranktes Gewebe
WO2004051242A1 (en) Use of high wavenumber raman spectroscopy for measuring tissue
WO2003032808A3 (en) Tissue oxygen measurement system
JPH09189659A (ja) 歯の状態の認識装置
ATE429850T1 (de) Verfahren und vorrichtung zur digitalen diagnostischen multispectralabbildung
FR2791548B1 (fr) Dispositif d'observation d'un corps a haute resolution
WO2010024397A1 (ja) ラマン散乱測定装置
ATE361699T1 (de) Analyse einer zusammenstellung mit beobachtung
KR20180066645A (ko) 형광 내시경 시스템
JP2005319212A (ja) 蛍光内視鏡装置
JP2002336187A (ja) 規格化蛍光画像生成方法および装置

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties