ATE298577T1 - Präparate auf purinbasis - Google Patents
Präparate auf purinbasisInfo
- Publication number
- ATE298577T1 ATE298577T1 AT95904103T AT95904103T ATE298577T1 AT E298577 T1 ATE298577 T1 AT E298577T1 AT 95904103 T AT95904103 T AT 95904103T AT 95904103 T AT95904103 T AT 95904103T AT E298577 T1 ATE298577 T1 AT E298577T1
- Authority
- AT
- Austria
- Prior art keywords
- purine
- catecholamine
- compound
- administered
- counteracting agent
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title 1
- KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 9
- -1 purine compound Chemical class 0.000 abstract 7
- OIRDTQYFTABQOQ-KQYNXXCUSA-N Adenosine Natural products C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 abstract 5
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 230000000694 effects Effects 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 4
- 239000002126 C01EB10 - Adenosine Substances 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 3
- 229960005305 adenosine Drugs 0.000 abstract 3
- 150000003943 catecholamines Chemical class 0.000 abstract 3
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000001766 physiological effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15801293A | 1993-11-24 | 1993-11-24 | |
| US08/341,668 US5679650A (en) | 1993-11-24 | 1994-11-17 | Pharmaceutical compositions including mixtures of an adenosine compound and a catecholamine |
| PCT/US1994/013412 WO1995014478A1 (en) | 1993-11-24 | 1994-11-21 | Purine compositions and methods for administration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE298577T1 true ATE298577T1 (de) | 2005-07-15 |
Family
ID=26854668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95904103T ATE298577T1 (de) | 1993-11-24 | 1994-11-21 | Präparate auf purinbasis |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US5679650A (de) |
| EP (1) | EP0735888B1 (de) |
| JP (1) | JP3836128B2 (de) |
| AT (1) | ATE298577T1 (de) |
| AU (1) | AU688835B2 (de) |
| CA (1) | CA2175828A1 (de) |
| DE (1) | DE69434416T2 (de) |
| DK (1) | DK0735888T3 (de) |
| ES (1) | ES2244962T3 (de) |
| WO (1) | WO1995014478A1 (de) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6004945A (en) | 1990-05-10 | 1999-12-21 | Fukunaga; Atsuo F. | Use of adenosine compounds to relieve pain |
| US6180616B1 (en) | 1990-05-10 | 2001-01-30 | Atsuo F. Fukunaga | Use of purine receptor agonists to alleviate or normalize physiopathologically excited sensory nerve function |
| US5679650A (en) * | 1993-11-24 | 1997-10-21 | Fukunaga; Atsuo F. | Pharmaceutical compositions including mixtures of an adenosine compound and a catecholamine |
| IL121272A (en) * | 1997-07-10 | 2000-06-01 | Can Fite Technologies Ltd | Pharmaceutical compositions comprising adenosine and their use for treating or preventing leukopenia |
| DE69912441T2 (de) | 1998-08-19 | 2004-08-19 | Skyepharma Canada Inc., Verdun | Injizierbare wässerige propofoldispersionen |
| US6025362A (en) * | 1998-08-31 | 2000-02-15 | Fukunaga; Atsuo F. | Uses of xanthine compounds |
| US20030166605A1 (en) * | 1999-04-27 | 2003-09-04 | Edward Leung | Method of minimizing damage to heart tissue during cardiac surgery and cardiac transplantation |
| EP1326642A2 (de) * | 2000-09-29 | 2003-07-16 | Board of Trustees operating Michigan State University | Catecholamin pharmazeutische zusammensetzungen und verfahren |
| US7157103B2 (en) | 2001-08-06 | 2007-01-02 | Euro-Celtique S.A. | Pharmaceutical formulation containing irritant |
| US20030068375A1 (en) | 2001-08-06 | 2003-04-10 | Curtis Wright | Pharmaceutical formulation containing gelling agent |
| US7332182B2 (en) | 2001-08-06 | 2008-02-19 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant |
| US7842307B2 (en) * | 2001-08-06 | 2010-11-30 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and gelling agent |
| US8183350B2 (en) | 2002-05-04 | 2012-05-22 | Acorda Therapeutics, Inc. | Compositions and methods for promoting neuronal outgrowth |
| CN1713926B (zh) | 2002-11-21 | 2010-12-22 | 兴和株式会社 | 腹膜透析法 |
| GB0228723D0 (en) * | 2002-12-09 | 2003-01-15 | Cambridge Biotechnology Ltd | Treatment of pain |
| GB0305149D0 (en) * | 2003-03-07 | 2003-04-09 | Cambridge Biotechnology Ltd | Compounds for the treatment of pain |
| GB0305150D0 (en) * | 2003-03-07 | 2003-04-09 | Cambridge Biotechnology Ltd | Use of therapeutic compounds |
| GB0305153D0 (en) * | 2003-03-07 | 2003-04-09 | Cambridge Biotechnology Ltd | Identification of therapeutic compounds |
| EP1631234B1 (de) * | 2003-05-16 | 2011-09-14 | Acorda Therapeutics, Inc. | Zusammensetzungen und verfahren zur behandlung von zns-schäden |
| EP3211084B1 (de) | 2003-05-16 | 2019-03-27 | Acorda Therapeutics, Inc. | Proteoglycan-abbauende mutanten zur behandlung des zns |
| US7959914B2 (en) | 2003-05-16 | 2011-06-14 | Acorda Therapeutics, Inc. | Methods of reducing extravasation of inflammatory cells |
| WO2004103263A2 (en) * | 2003-05-22 | 2004-12-02 | Yeda Research And Development Co. Ltd. | Dopamine and agonists and antagonists thereof for treatment of neurodegenerative diseases |
| US20080221060A1 (en) * | 2004-03-05 | 2008-09-11 | Martyn Pritchard | Therapeutic Compounds |
| CA2916869A1 (en) | 2004-06-12 | 2005-12-29 | Jane C. Hirsh | Abuse-deterrent drug formulations |
| US20060079479A1 (en) * | 2004-10-13 | 2006-04-13 | Italo Biaggioni | Methods of inducing vasodilation |
| JP5189985B2 (ja) | 2005-09-26 | 2013-04-24 | アコーダ セラピューティクス、インク. | コンドロイチナーゼabci変異体を用いた組成物およびその使用方法 |
| US7811549B2 (en) * | 2006-07-05 | 2010-10-12 | Adenobio N.V. | Methods, compositions, unit dosage forms, and kits for pharmacologic stress testing with reduced side effects |
| CA2663857C (en) * | 2006-09-20 | 2017-10-31 | The Board Of Regents Of The University Of Texas System | Methods for delivering volatile anesthetics for regional anesthesia and/or pain relief |
| CA3009034C (en) | 2006-10-10 | 2020-08-18 | Acorda Therapeutics, Inc. | Compositions and methods of using chondroitinase abci mutants |
| WO2009092516A2 (en) * | 2008-01-22 | 2009-07-30 | Adenobio N.V. | Methods, compositions, unit dosage forms, and kits for pharmacologic stress testing with reduced side effects |
| PL2244737T3 (pl) | 2008-01-22 | 2020-05-18 | The Board Of Regents Of The University Of Texas System | Kompozycje lotnego środka znieczulającego zawierające rozpuszczalniki ekstrakcyjne do znieczulania miejscowego i / albo zwalczania bólu |
| WO2011057199A1 (en) * | 2009-11-06 | 2011-05-12 | Adenios, Inc. | Compositions for treating cns disorders |
| WO2011066412A1 (en) * | 2009-11-24 | 2011-06-03 | University Of Rochester | Enhancing the therapeutic effect of acupuncture with adenosine |
| US10668060B2 (en) | 2009-12-10 | 2020-06-02 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs |
| WO2011130599A1 (en) * | 2010-04-16 | 2011-10-20 | Enzon Pharmaceuticals, Inc. | Polymeric conjugates of adenine nucleoside analogs |
| US20130324461A1 (en) * | 2010-08-26 | 2013-12-05 | Michail V. Sitkovsky | Methods and compositions for preventing or treating obesity |
| ME02874B (de) | 2010-12-22 | 2018-04-20 | Purdue Pharma Lp | Gekapselte manipulationssichere Darreichungsformen mit gesteuerter Freisetzung |
| PH12013501345A1 (en) | 2010-12-23 | 2022-10-24 | Purdue Pharma Lp | Tamper resistant solid oral dosage forms |
| CN104363757B (zh) * | 2012-02-11 | 2017-05-24 | 中央研究院 | 治疗疼痛的方法及组合物 |
| AU2013201465B2 (en) * | 2012-10-24 | 2016-03-03 | Rayner Intraocular Lenses Limited | Stable preservative-free mydriatic and anti-inflammatory solutions for injection |
| MX2015010041A (es) | 2013-02-05 | 2015-10-30 | Purdue Pharma Lp | Formulacion farmaceuticas resistentes a la alteracion. |
| US10751287B2 (en) | 2013-03-15 | 2020-08-25 | Purdue Pharma L.P. | Tamper resistant pharmaceutical formulations |
| SG11201507140PA (en) * | 2013-03-15 | 2015-10-29 | Galleon Pharmaceuticals Inc | Novel breathing control modulating compounds, and methods of using same |
| TWI705812B (zh) | 2014-12-01 | 2020-10-01 | 奥默羅斯公司 | 用於抑制術後眼睛炎性病況的抗炎和散瞳前房溶液 |
| US9737530B1 (en) | 2016-06-23 | 2017-08-22 | Collegium Pharmaceutical, Inc. | Process of making stable abuse-deterrent oral formulations |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB797237A (en) * | 1955-07-26 | 1958-06-25 | Sterling Drug Inc | Composition for reducing period of anesthesia |
| ZA7468B (en) * | 1973-01-16 | 1974-11-27 | J Voorhees | Compositions and treatment of proliferatave skin diseases with phosphodiesterase inhibitors |
| DE3019322A1 (de) * | 1980-05-21 | 1981-12-03 | Merck Patent Gmbh, 6100 Darmstadt | Psychopharmakon sowie verwendung von adenosinderivaten |
| US4673563A (en) * | 1980-10-14 | 1987-06-16 | The University Of Virginia Alumni Patents Foundation | Adenosine in the treatment of supraventricular tachycardia |
| US4514405A (en) * | 1981-09-17 | 1985-04-30 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Use of adenosine derivatives as anticonvulsants |
| US4880918A (en) * | 1982-07-13 | 1989-11-14 | Eliezer Rapaport | Arrest and killing of tumor cells by adenosine 5-diphosphate and adenosine-5-triphosphate |
| US5049372A (en) * | 1982-07-13 | 1991-09-17 | Eliezer Rapaport | Anticancer activities in a host by increasing blood and plasma adenosine 5'-triphosphate (ATP) levels |
| US4605644A (en) * | 1985-02-07 | 1986-08-12 | Regents Of The University Of Minnesota | Method for stimulating recovery from ischemia employing ribose and adenine |
| FR2577422B1 (fr) * | 1985-02-14 | 1988-10-28 | Roussel Uclaf | Association renfermant a titre de principes actifs, un analgesique central et l'adenine ou l'adenosine ou l'un des analogues de l'adenosine |
| US5104859A (en) * | 1985-09-24 | 1992-04-14 | Solimedco Aktiebolag | Continuous administration of adenosine to reduce pulmonary vascular resistance |
| US4693996A (en) * | 1985-12-23 | 1987-09-15 | Warner-Lambert Company | Method of treating heart failure and medicaments therefor |
| JP2930589B2 (ja) * | 1986-10-06 | 1999-08-03 | ザ ユニバーシィティ オブ バージニア アルミニ パテンツ ファンデーション | 外科手術中における改善された心臓保護のためのアデノシン,ヒポキサンチン及びリボース含有溶液の使用 |
| US4980379A (en) * | 1988-06-30 | 1990-12-25 | The University Of Virginia | Use of adenosine antagonists in the treatment of bradyarrhythmias and hemodynamic depression associated with cardiopulmonary resucitation and/or cardiovascular collapse |
| US5070877A (en) * | 1988-08-11 | 1991-12-10 | Medco Research, Inc. | Novel method of myocardial imaging |
| US5020356A (en) * | 1989-08-25 | 1991-06-04 | Process Automation Business, Inc. | Method and apparatus for measuring characteristics of a multilayer product |
| US5679650A (en) * | 1993-11-24 | 1997-10-21 | Fukunaga; Atsuo F. | Pharmaceutical compositions including mixtures of an adenosine compound and a catecholamine |
| US5137712A (en) * | 1990-08-31 | 1992-08-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of s-adenosyl-l-methionine (SAMe) to reverse and/or prevent supersensitivity, tolerance and extrapyramidal side effects induced by neuroleptic treatment |
| AU654507B2 (en) * | 1990-09-25 | 1994-11-10 | Rhone-Poulenc Rorer International (Holdings) Inc. | Compounds having antihypertensive and anti-ischemic properties |
| US5206222A (en) * | 1991-05-22 | 1993-04-27 | Vanderbilt University | Methods for the reduction of myocardial reperfusion injury |
| US5236908A (en) * | 1991-06-07 | 1993-08-17 | Gensia Pharmaceuticals, Inc. | Methods of treating injury to the central nervous system |
| AU3071992A (en) * | 1991-11-13 | 1993-06-15 | Gensia, Inc. | Methods for increasing the sensitivity and decreasing the side effects of pharmacological stress testing for coronary artery disease |
-
1994
- 1994-11-17 US US08/341,668 patent/US5679650A/en not_active Expired - Fee Related
- 1994-11-21 DE DE69434416T patent/DE69434416T2/de not_active Expired - Fee Related
- 1994-11-21 CA CA002175828A patent/CA2175828A1/en not_active Abandoned
- 1994-11-21 AU AU12920/95A patent/AU688835B2/en not_active Ceased
- 1994-11-21 DK DK95904103T patent/DK0735888T3/da active
- 1994-11-21 JP JP51516795A patent/JP3836128B2/ja not_active Expired - Fee Related
- 1994-11-21 ES ES95904103T patent/ES2244962T3/es not_active Expired - Lifetime
- 1994-11-21 AT AT95904103T patent/ATE298577T1/de not_active IP Right Cessation
- 1994-11-21 WO PCT/US1994/013412 patent/WO1995014478A1/en not_active Ceased
- 1994-11-21 EP EP95904103A patent/EP0735888B1/de not_active Expired - Lifetime
-
1997
- 1997-06-02 US US08/867,370 patent/US5942497A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP3836128B2 (ja) | 2006-10-18 |
| JPH09505807A (ja) | 1997-06-10 |
| AU1292095A (en) | 1995-06-13 |
| US5942497A (en) | 1999-08-24 |
| ES2244962T3 (es) | 2005-12-16 |
| EP0735888A1 (de) | 1996-10-09 |
| CA2175828A1 (en) | 1995-06-01 |
| EP0735888B1 (de) | 2005-06-29 |
| DE69434416D1 (de) | 2005-08-04 |
| WO1995014478A1 (en) | 1995-06-01 |
| AU688835B2 (en) | 1998-03-19 |
| US5679650A (en) | 1997-10-21 |
| DE69434416T2 (de) | 2006-05-18 |
| EP0735888A4 (de) | 1999-05-12 |
| DK0735888T3 (da) | 2005-10-10 |
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