ES2095960T3 - Compuestos que tienen propiedades antihipertensivas y antiisquemicas. - Google Patents

Compuestos que tienen propiedades antihipertensivas y antiisquemicas.

Info

Publication number
ES2095960T3
ES2095960T3 ES91917927T ES91917927T ES2095960T3 ES 2095960 T3 ES2095960 T3 ES 2095960T3 ES 91917927 T ES91917927 T ES 91917927T ES 91917927 T ES91917927 T ES 91917927T ES 2095960 T3 ES2095960 T3 ES 2095960T3
Authority
ES
Spain
Prior art keywords
compounds
hypertensive
ischemical
properties
adenosine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91917927T
Other languages
English (en)
Inventor
Alfred P Spada
Cynthia A Fink
Michael R Myers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Rorer International Holdings Inc
Original Assignee
Rhone Poulenc Rorer International Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer International Holdings Inc filed Critical Rhone Poulenc Rorer International Holdings Inc
Application granted granted Critical
Publication of ES2095960T3 publication Critical patent/ES2095960T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA INVENCION SE REFIERE A DERIVADOS DE LA ADENOSINA Y A ANALOGOS DE LA MISMA QUE POSEEN ACTIVIDAD ANTAGONISTA PARA LA ADENOSINA Y SON UTILES COMO AGENTES ANTIHIPERTENSIVOS Y ANTIISQUEMICOS, ASI COMO A LAS COMPOSICIONES FARMACEUTICAS QUE INCLUYEN TALES COMPUESTOS, Y A SU USO EN EL TRATAMIENTO DE LA HIPERTENSION Y DE LA ISQUEMIA DE MIORCARDIO, Y A METODOS Y PRODUCTOS INTERMEDIOS USADOS EN LA PREPARACION DE TALES COMPUESTOS.
ES91917927T 1990-09-25 1991-09-25 Compuestos que tienen propiedades antihipertensivas y antiisquemicas. Expired - Lifetime ES2095960T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58788490A 1990-09-25 1990-09-25

Publications (1)

Publication Number Publication Date
ES2095960T3 true ES2095960T3 (es) 1997-03-01

Family

ID=24351576

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91917927T Expired - Lifetime ES2095960T3 (es) 1990-09-25 1991-09-25 Compuestos que tienen propiedades antihipertensivas y antiisquemicas.

Country Status (13)

Country Link
US (1) US5364862A (es)
EP (1) EP0550631B1 (es)
JP (1) JP2505085B2 (es)
AT (1) ATE147074T1 (es)
AU (1) AU654507B2 (es)
CA (1) CA2092305C (es)
DE (1) DE69123974T2 (es)
DK (1) DK0550631T3 (es)
ES (1) ES2095960T3 (es)
GR (1) GR3022207T3 (es)
MX (1) MX9203771A (es)
SG (1) SG80526A1 (es)
WO (1) WO1992005177A1 (es)

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EP0550631B1 (en) 1997-01-02
HK1002031A1 (en) 1998-07-24
CA2092305A1 (en) 1992-03-26
GR3022207T3 (en) 1997-04-30
ATE147074T1 (de) 1997-01-15
AU654507B2 (en) 1994-11-10
JP2505085B2 (ja) 1996-06-05
DE69123974D1 (de) 1997-02-13
EP0550631A4 (en) 1994-08-10
SG80526A1 (en) 2001-05-22
DK0550631T3 (da) 1997-01-20
CA2092305C (en) 2003-02-11
EP0550631A1 (en) 1993-07-14
JPH05508864A (ja) 1993-12-09
US5364862A (en) 1994-11-15
MX9203771A (es) 1992-09-01
AU8726691A (en) 1992-04-15
DE69123974T2 (de) 1997-05-07
WO1992005177A1 (en) 1992-04-02

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