ATE298755T1 - Verfahren zur herstellung von natriumsalz der d-6-((alpha-4-(ethyl-2,3-dioxo-1-piperazinocarb nyl- amino)phenylacetamido)-penicillansäure - Google Patents
Verfahren zur herstellung von natriumsalz der d-6-((alpha-4-(ethyl-2,3-dioxo-1-piperazinocarb nyl- amino)phenylacetamido)-penicillansäureInfo
- Publication number
- ATE298755T1 ATE298755T1 AT02017375T AT02017375T ATE298755T1 AT E298755 T1 ATE298755 T1 AT E298755T1 AT 02017375 T AT02017375 T AT 02017375T AT 02017375 T AT02017375 T AT 02017375T AT E298755 T1 ATE298755 T1 AT E298755T1
- Authority
- AT
- Austria
- Prior art keywords
- sodium salt
- dioxo
- alpha
- ethyl
- piperazinocarb
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- NOJNFULGOQGBKB-UHFFFAOYSA-M sodium;3-[3-tert-butylsulfanyl-1-[[4-(6-ethoxypyridin-3-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoate Chemical compound [Na+].C1=NC(OCC)=CC=C1C(C=C1)=CC=C1CN1C2=CC=C(OCC=3N=CC(C)=CC=3)C=C2C(SC(C)(C)C)=C1CC(C)(C)C([O-])=O NOJNFULGOQGBKB-UHFFFAOYSA-M 0.000 title 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 229910052708 sodium Inorganic materials 0.000 abstract 2
- 239000011734 sodium Substances 0.000 abstract 2
- 159000000000 sodium salts Chemical class 0.000 abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- -1 sodium carboxylates Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001MI001718A ITMI20011718A1 (it) | 2001-08-03 | 2001-08-03 | Processo per la preparazione del sale sodico dell'acido-6(d-(-)-alpha-(4-etil-2,3-diosso-1-piperazinocarbonilammino)fenilacetammido)penicill |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE298755T1 true ATE298755T1 (de) | 2005-07-15 |
Family
ID=11448237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02017375T ATE298755T1 (de) | 2001-08-03 | 2002-08-02 | Verfahren zur herstellung von natriumsalz der d-6-((alpha-4-(ethyl-2,3-dioxo-1-piperazinocarb nyl- amino)phenylacetamido)-penicillansäure |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6828438B2 (de) |
| EP (1) | EP1281713B1 (de) |
| AT (1) | ATE298755T1 (de) |
| DE (1) | DE60204826T2 (de) |
| ES (1) | ES2244704T3 (de) |
| IT (1) | ITMI20011718A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007246514A (ja) * | 2006-02-14 | 2007-09-27 | Toyama Chem Co Ltd | ピペラシリンナトリウムの新規な結晶 |
| MX2009008124A (es) * | 2007-01-31 | 2009-10-08 | Toyama Chemical Co Ltd | Cristal nuevo de piperacilina sodica. |
| WO2011040386A1 (ja) * | 2009-09-30 | 2011-04-07 | 富山化学工業株式会社 | ピペラシリンナトリウム・１水和物の新規な結晶 |
| CN102977119A (zh) * | 2012-12-14 | 2013-03-20 | 江西富祥药业股份有限公司 | 一种用溶媒法制备哌拉西林钠的工艺 |
| CN111377948A (zh) * | 2020-04-20 | 2020-07-07 | 山东二叶制药有限公司 | 哌拉西林钠的制备工艺 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4112090A (en) * | 1974-05-09 | 1978-09-05 | Toyama Chemical Co., Ltd. | Novel penicillins and cephalosporins and process for producing the same |
| BG46664A1 (en) | 1985-08-16 | 1990-02-15 | Druzhestven N Izsledovatelski | Method for preparing of 6- /d (-)- alpha- (4- ethyl- 2, 3- dioxo- 1- piperazine carbonylamino)- phenylacetamido/- penicillanic acid |
| IT1213352B (it) * | 1986-10-06 | 1989-12-20 | Valleambrosia Di Rozzano Milan | Procedimento per la preparazione dell'acido 6-[d(-)-alfa-(4-etil-2,3-diossipiperazin-1-ilcarbonilamino)-alfa-fenilace tamido]penicillanico e intermedi utili in detto procedimento. |
| SI8711089A8 (en) | 1987-06-11 | 1996-08-31 | Krka Tovarna Zdravil | Process for preparation of 6-/d(-)-alpha-(4-ethyl-2,3-dioxo-1- piperazine-carboxyamido)-phenylacetamido/-penicillanic acid |
| IT1255716B (it) | 1992-10-05 | 1995-11-10 | Procedimento per la preparazione di antibiotici beta-lattamici sterili | |
| US6207661B1 (en) * | 1999-02-22 | 2001-03-27 | Baxter International Inc. | Premixed formulation of piperacillin sodium and tazobactam sodium injection |
-
2001
- 2001-08-03 IT IT2001MI001718A patent/ITMI20011718A1/it unknown
-
2002
- 2002-08-01 US US10/210,563 patent/US6828438B2/en not_active Expired - Lifetime
- 2002-08-02 EP EP02017375A patent/EP1281713B1/de not_active Expired - Lifetime
- 2002-08-02 ES ES02017375T patent/ES2244704T3/es not_active Expired - Lifetime
- 2002-08-02 DE DE60204826T patent/DE60204826T2/de not_active Expired - Lifetime
- 2002-08-02 AT AT02017375T patent/ATE298755T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI20011718A1 (it) | 2003-02-03 |
| ITMI20011718A0 (it) | 2001-08-03 |
| DE60204826D1 (de) | 2005-08-04 |
| ES2244704T3 (es) | 2005-12-16 |
| EP1281713A1 (de) | 2003-02-05 |
| EP1281713B1 (de) | 2005-06-29 |
| US6828438B2 (en) | 2004-12-07 |
| US20030028016A1 (en) | 2003-02-06 |
| DE60204826T2 (de) | 2006-04-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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