ATE258181T1 - Verfahren zur herstellung von dinatrium pamidronat - Google Patents

Verfahren zur herstellung von dinatrium pamidronat

Info

Publication number: ATE258181T1
Authority: AT; Austria
Prior art keywords: pamidronate; disodium pamidronate; resulting; solution; water
Prior art date: 2001-02-23

Application number

AT02003891T

Other languages

English (en)

Inventor

Nicola Caraccia

Franco Castellari

Pier Andrea Gatti

Cristiana Giordani

Roberto Tarditi

Original Assignee

Bioindustria Lab Italiano Medi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-23

Filing date

2002-02-21

Publication date

2004-02-15

2002-02-21 Application filed by Bioindustria Lab Italiano Medi filed Critical Bioindustria Lab Italiano Medi

2004-02-15 Application granted granted Critical

2004-02-15 Publication of ATE258181T1 publication Critical patent/ATE258181T1/de

Links

WRUUGTRCQOWXEG-UHFFFAOYSA-N pamidronate Chemical compound NCCC(O)(P(O)(O)=O)P(O)(O)=O WRUUGTRCQOWXEG-UHFFFAOYSA-N 0.000 title abstract 4
238000004519 manufacturing process Methods 0.000 title 1
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
239000000243 solution Substances 0.000 abstract 3
238000000034 method Methods 0.000 abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
239000007900 aqueous suspension Substances 0.000 abstract 1
238000001816 cooling Methods 0.000 abstract 1
238000004821 distillation Methods 0.000 abstract 1
238000001914 filtration Methods 0.000 abstract 1
229940046231 pamidronate Drugs 0.000 abstract 1
229960003978 pamidronic acid Drugs 0.000 abstract 1
238000001556 precipitation Methods 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
239000011734 sodium Substances 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Electric Double-Layer Capacitors Or The Like (AREA)
Superconductors And Manufacturing Methods Therefor (AREA)
General Factory Administration (AREA)
Prostheses (AREA)
Water Treatment By Sorption (AREA)

AT02003891T 2001-02-23 2002-02-21 Verfahren zur herstellung von dinatrium pamidronat ATE258181T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT2001MI000364A ITMI20010364A1 (it)	2001-02-23	2001-02-23	Procedimento per la preparazione del pamidronato disodico

Publications (1)

Publication Number	Publication Date
ATE258181T1 true ATE258181T1 (de)	2004-02-15

Family

ID=11446985

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02003891T ATE258181T1 (de)	2001-02-23	2002-02-21	Verfahren zur herstellung von dinatrium pamidronat

Country Status (4)

Country	Link
EP (1)	EP1236733B1 (de)
AT (1)	ATE258181T1 (de)
DE (1)	DE60200171D1 (de)
IT (1)	ITMI20010364A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITMI20012634A1 (it) *	2001-12-13	2003-06-13	Istituto Biochimico Pavese Pha	Metodo di preparazione del panidronato disodico anidro
WO2005054260A1 (en) *	2003-12-04	2005-06-16	Mustafa Nevzat Ilac Sanayii A.S.	Method for producing pure disodium pamidronate
CN104072538A (zh) *	2014-07-10	2014-10-01	陕西汉江药业集团股份有限公司	一种双膦酸盐类药物的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE238315T1 (de) *	1998-12-10	2003-05-15	Aesgen Inc	Verfahren zur herstellung von dinatriumpamidronat
KR100343232B1 (ko) *	1999-12-10	2002-07-10	김재윤	결정성 파미드론산 이나트륨염 수화물과 그의 제조방법

2001
- 2001-02-23 IT IT2001MI000364A patent/ITMI20010364A1/it unknown
2002
- 2002-02-21 AT AT02003891T patent/ATE258181T1/de not_active IP Right Cessation
- 2002-02-21 DE DE60200171T patent/DE60200171D1/de not_active Expired - Lifetime
- 2002-02-21 EP EP02003891A patent/EP1236733B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP1236733B1 (de)	2004-01-21
EP1236733A1 (de)	2002-09-04
DE60200171D1 (de)	2004-02-26
ITMI20010364A1 (it)	2002-08-23

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Legal Events

Date	Code	Title	Description
2004-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties