ATE298793T1 - Transgene tiermodelle für herz-hypertrophie und deren verwendungen - Google Patents

Transgene tiermodelle für herz-hypertrophie und deren verwendungen

Info

Publication number
ATE298793T1
ATE298793T1 AT98953672T AT98953672T ATE298793T1 AT E298793 T1 ATE298793 T1 AT E298793T1 AT 98953672 T AT98953672 T AT 98953672T AT 98953672 T AT98953672 T AT 98953672T AT E298793 T1 ATE298793 T1 AT E298793T1
Authority
AT
Austria
Prior art keywords
cardiac hypertrophy
animal models
transgenic animal
heart hypertrophy
activity
Prior art date
Application number
AT98953672T
Other languages
English (en)
Inventor
Stephen R Grant
Eric N Olson
Jeffrey D Molkentin
Original Assignee
Univ Texas
Univ North Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, Univ North Texas filed Critical Univ Texas
Application granted granted Critical
Publication of ATE298793T1 publication Critical patent/ATE298793T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0375—Animal model for cardiovascular diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Environmental Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Animal Husbandry (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT98953672T 1997-10-16 1998-10-16 Transgene tiermodelle für herz-hypertrophie und deren verwendungen ATE298793T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6286497P 1997-10-16 1997-10-16
US6517897P 1997-11-10 1997-11-10
US8185398P 1998-04-15 1998-04-15
US6141798A 1998-04-16 1998-04-16
PCT/US1998/021988 WO1999019473A1 (en) 1997-10-16 1998-10-16 Transgenic animal models for cardiac hypertrophy and uses thereof

Publications (1)

Publication Number Publication Date
ATE298793T1 true ATE298793T1 (de) 2005-07-15

Family

ID=27490205

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98953672T ATE298793T1 (de) 1997-10-16 1998-10-16 Transgene tiermodelle für herz-hypertrophie und deren verwendungen

Country Status (9)

Country Link
US (3) US6673768B1 (de)
EP (3) EP1023441A1 (de)
JP (3) JP2001520170A (de)
AT (1) ATE298793T1 (de)
AU (2) AU748334B2 (de)
CA (2) CA2306448A1 (de)
DE (1) DE69830737T2 (de)
ES (1) ES2241173T3 (de)
WO (2) WO1999019471A1 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6673768B1 (en) * 1997-10-16 2004-01-06 Board Of Regents, The University Of Texas System Transgenic animal models for cardiac hypertrophy and methods of use thereof (treating)
CA2352599A1 (en) * 1998-11-24 2000-06-02 Gerald R. Crabtree Nf-at mediates cardiac hypertrophy, methods and reagents related thereto
WO2001014581A2 (en) * 1999-08-20 2001-03-01 Board Of Regents, The University Of Texas System Hdac4 and hdac5 in the regulation of cardiac gene expression
US20070032853A1 (en) 2002-03-27 2007-02-08 Hossainy Syed F 40-O-(2-hydroxy)ethyl-rapamycin coated stent
EP1311704A2 (de) * 2000-05-30 2003-05-21 Medigene AG Neuartige zielgene für herzerkrankungen
JP2002078483A (ja) * 2000-06-28 2002-03-19 Takeda Chem Ind Ltd 心筋細胞の調製法および心疾患治療薬の探索法
US20030175847A1 (en) * 2000-06-28 2003-09-18 Haruhide Kimura Method of preparing heart muscle cells and method of searching for remedy for heart diseases
US7629308B2 (en) * 2000-07-07 2009-12-08 Board Of Regents, The University Of Texas System Methods relating to muscle selective calcineurin interacting protein (MCIP)
US8568766B2 (en) 2000-08-24 2013-10-29 Gattadahalli M. Anantharamaiah Peptides and peptide mimetics to treat pathologies associated with eye disease
JP2004528822A (ja) * 2000-11-07 2004-09-24 ボード・オブ・リージェンツ，ザ・ユニヴァーシティ・オヴ・テキサス・システム 筋特異的筋節カルシニューリン結合タンパク質（カルサルシン）に関する方法および組成物
US7526112B2 (en) * 2001-04-30 2009-04-28 Chase Medical, L.P. System and method for facilitating cardiac intervention
US7327862B2 (en) * 2001-04-30 2008-02-05 Chase Medical, L.P. System and method for facilitating cardiac intervention
DE10126371A1 (de) * 2001-05-30 2003-02-27 Medigene Ag Verfahren zur Identifizierung von Substanzen gegen Herzmuskelzellen-Hypertrophie
EP1605262A1 (de) * 2001-09-27 2005-12-14 Board Of Regents The University Of Texas System Methode zur Idenfitikation von Inhibitoren der Herzhypertrophie
US20030186289A1 (en) * 2002-01-22 2003-10-02 Myogen, Inc. Model cell systems for screening of anti-hypertrophic therapeutics
US20030221207A1 (en) * 2002-02-13 2003-11-27 Pharmacia Corporation, Global Patent Department Cardiac-specific 11beta hydroxysteroid dehydrogenase type 2 transgenic mice
US20040106647A1 (en) * 2002-06-28 2004-06-03 Schneider Michael D. Modulators of Cdk9 as a therapeutic target in cardiac hypertrophy
US20040082613A1 (en) * 2002-06-28 2004-04-29 Schneider Michael D. Modulators of Cdk9 as a therapeutic target in cardiac hypertrophy
CA2514303C (en) * 2002-11-13 2012-09-18 The Uab Research Foundation Synthetic single domain polypeptides mimicking apolipoprotein e and methods of use
WO2004068406A2 (en) * 2003-01-30 2004-08-12 Chase Medical, L.P. A method and system for image processing and contour assessment
US20040229360A1 (en) * 2003-03-13 2004-11-18 Jeffrey Robbins Cardiac-preferred genetic alteration of transgenic rabbits
US20050118344A1 (en) 2003-12-01 2005-06-02 Pacetti Stephen D. Temperature controlled crimping
US7951532B2 (en) * 2003-11-12 2011-05-31 Children's Hospital Medical Center Method of screening a midkine modulating agent
US7333643B2 (en) * 2004-01-30 2008-02-19 Chase Medical, L.P. System and method for facilitating cardiac intervention
EP1740945B1 (de) 2004-04-07 2018-09-19 Ncardia AG Nichtinvasive, in-vitro-funktionelle gewebetestsysteme
US8318488B1 (en) 2004-05-11 2012-11-27 Axiogenesis Ag Assay for drug discovery based on in vitro differentiated cells
JP4682310B2 (ja) * 2004-12-28 2011-05-11 独立行政法人産業技術総合研究所 天然型ｌ−システインまたはその誘導体を用いたホタル発光基質の生合成システム及び本システムを含んだ発光基質溶液
JP2008526816A (ja) * 2005-01-10 2008-07-24 デビオファーム ソシエテ アノニム 心筋虚血状態の間の投与のための薬剤の製造のための環状ウンデカペプチドの使用
WO2007014029A2 (en) * 2005-07-22 2007-02-01 The Regents Of The University Of Colorado, A Body Corporate Yin yang 1 as a treatment for cardiac hypertrophy and heart failure
JP2009508596A (ja) 2005-09-19 2009-03-05 ヒストジェニックス コーポレイション 細胞支持基材及びその調製方法
CA2673863A1 (en) * 2006-12-28 2008-07-10 Limerick Biopharma, Inc. Methods and compositions for therapeutic treatment
JP2011500512A (ja) * 2007-07-31 2011-01-06 リメリック バイオファーマ，インコーポレイティド リン酸化ピロン類似体および方法
WO2009032702A2 (en) 2007-08-28 2009-03-12 Uab Research Foundation Synthetic apolipoprotein e mimicking polypeptides and methods of use
EP2195331B1 (de) 2007-08-28 2013-11-20 Uab Research Foundation Synthetische, apolipoprotein e nachahmende polypeptide und anwendungsverfahren
US20110218253A1 (en) * 2010-01-26 2011-09-08 Lange Nicholas T Imaging-based identification of a neurological disease or a neurological disorder
WO2016018665A1 (en) 2014-07-31 2016-02-04 Uab Research Foundation Apoe mimetic peptides and higher potency to clear plasma cholesterol
WO2016085876A1 (en) 2014-11-25 2016-06-02 The Broad Institute Inc. Clonal haematopoiesis
EP3224381B1 (de) 2014-11-25 2019-09-04 The Brigham and Women's Hospital, Inc. Verfahren zur identifizierung von personen mit einer prädisposition für eine kardiometabolische krankheit oder davon betroffenen personen
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
KR102634017B1 (ko) * 2018-10-26 2024-02-05 고려대학교 산학협력단 심비대증 동물 모델 제작용 재조합 벡터, 상기 재조합 벡터로 형질전환된 심비대증 동물 모델 및 이의 제작 방법
US20230134859A1 (en) * 2020-03-31 2023-05-04 Sky Pharma Co., Ltd. Method for screening for, method for producing, and method for designing drug active ingredients
IL313426A (en) * 2021-12-10 2024-08-01 Aavantibio Inc Methods and preparations for treating MYBPC3-associated hypertrophic cardiomyopathy with a viral vector
CN115969959A (zh) * 2022-11-07 2023-04-18 孙英贤 多肽gl42的制药用途

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
DE3884470T2 (de) 1987-06-17 1994-03-10 Sandoz Ag Cyclosporine und deren Benutzung als Arzneimittel.
US5284826A (en) 1989-07-24 1994-02-08 Sandoz Ltd. 0-hydroxyethyl and acyloxyethyl derivatives of [ser]8 cyclosporins
GB9113872D0 (en) 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
TW215434B (de) 1992-03-07 1993-11-01 Hoechst Ag
GB9206874D0 (en) 1992-03-30 1992-05-13 Connaught Lab Generation of improved inducible mammalian expression vectors
EP0642589A4 (de) 1992-05-11 1997-05-21 Ribozyme Pharm Inc Methode und reagenz zur inhibierung der viralen replikation.
WO1994021634A1 (en) 1993-03-17 1994-09-29 Abbott Laboratories Substituted alicyclic-aliphatic amine-containing macrocyclic immunomodulators
MY110603A (en) 1993-05-27 1998-08-29 Novartis Ag Tetrahydropyran derivatives
US5866755A (en) 1993-06-14 1999-02-02 Basf Aktiengellschaft Animals transgenic for a tetracycline-regulated transcriptional inhibitor
JPH09500526A (ja) 1993-06-14 1997-01-21 ベーアーエスエフ アクツィエンゲゼルシャフト テトラサイクリン反応性プロモーターによる真核細胞の遺伝子発現の厳密な制御
US5589362A (en) 1993-06-14 1996-12-31 Basf Aktiengesellschaft Tetracycline regulated transcriptional modulators with altered DNA binding specificities
DK0756489T3 (da) 1994-06-01 1999-12-06 Yuhan Corp Cyclosporinholdigt præparat og fremgangsmåde til fremstillingen af dette
ATE225647T1 (de) 1994-06-13 2002-10-15 Alza Corp Dosierungsform zur verabreichung von flüssige arzneimittel formulierung
US5612455A (en) * 1994-07-05 1997-03-18 Tularik, Inc. Nuclear factors and binding assay
IE75744B1 (en) 1995-04-03 1997-09-24 Elan Corp Plc Controlled release biodegradable micro- and nanospheres containing cyclosporin
SG68529A1 (en) * 1995-05-25 1999-11-16 Univ Singapore The use of des-aspartate-angiotensin i (agr-val-tyr-ile-his-pro-phe-his-leu) as an anti-cardiac hypertrophic agent
WO1997007787A1 (en) 1995-08-25 1997-03-06 Sangstat Medical Corporation Oral cyclosporin formulations
JP4117027B2 (ja) 1996-04-19 2008-07-09 コルパン メチン パルボウイルス感染のための核酸予防接種
US6147080A (en) 1996-12-18 2000-11-14 Vertex Pharmaceuticals Incorporated Inhibitors of p38
JP2002514199A (ja) 1997-02-04 2002-05-14 ブリストル−マイヤーズ スクイブ カンパニー Ｎｐｙ拮抗剤としてのジヒドロピリミドン誘導体
US6673768B1 (en) * 1997-10-16 2004-01-06 Board Of Regents, The University Of Texas System Transgenic animal models for cardiac hypertrophy and methods of use thereof (treating)

Also Published As

Publication number Publication date
EP1645634A2 (de) 2006-04-12
AU1099299A (en) 1999-05-03
CA2306448A1 (en) 1999-04-22
US6673768B1 (en) 2004-01-06
JP2001520010A (ja) 2001-10-30
EP1025216A1 (de) 2000-08-09
AU755428B2 (en) 2002-12-12
EP1645634A3 (de) 2009-06-17
JP2001520170A (ja) 2001-10-30
DE69830737D1 (de) 2005-08-04
EP1023441A1 (de) 2000-08-02
WO1999019473A1 (en) 1999-04-22
AU748334B2 (en) 2002-05-30
JP2008253274A (ja) 2008-10-23
US6657104B1 (en) 2003-12-02
AU9805898A (en) 1999-05-03
ES2241173T3 (es) 2005-10-16
CA2315244A1 (en) 1999-04-22
US6201165B1 (en) 2001-03-13
WO1999019471A1 (en) 1999-04-22
DE69830737T2 (de) 2006-06-01
EP1025216B1 (de) 2005-06-29

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