ATE299028T1 - Behandlung von krebserkrankungen mit aplidin in kombination mit carnitin oder acetylcarnitin - Google Patents

Behandlung von krebserkrankungen mit aplidin in kombination mit carnitin oder acetylcarnitin

Info

Publication number: ATE299028T1
Authority: AT; Austria
Prior art keywords: aplidine; carnitine; acetylcarnitine; treatment; combination
Prior art date: 2000-10-12

Application number

AT01974510T

Other languages

English (en)

Inventor

Lazaro Luis Lopez

Sousa Jose Maria Fernandez

Jean-Pierre Armand

Eric Raymond

Original Assignee

Pharma Mar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-12

Filing date

2001-10-12

Publication date

2005-07-15

2000-10-12 Priority claimed from GB0025044A external-priority patent/GB0025044D0/en

2000-10-13 Priority claimed from GB0025209A external-priority patent/GB0025209D0/en

2000-11-15 Priority claimed from PCT/GB2000/004349 external-priority patent/WO2001035974A2/en

2001-03-23 Priority claimed from GB0107373A external-priority patent/GB0107373D0/en

2001-10-12 Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa

2001-10-12 Priority claimed from PCT/GB2001/004555 external-priority patent/WO2002030441A2/en

2005-07-15 Application granted granted Critical

2005-07-15 Publication of ATE299028T1 publication Critical patent/ATE299028T1/de

Links

UUSZLLQJYRSZIS-LXNNNBEUSA-N plitidepsin Chemical compound CN([C@H](CC(C)C)C(=O)N[C@@H]1C(=O)N[C@@H]([C@H](CC(=O)O[C@H](C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(OC)=CC=2)C(=O)O[C@@H]1C)C(C)C)O)[C@@H](C)CC)C(=O)[C@@H]1CCCN1C(=O)C(C)=O UUSZLLQJYRSZIS-LXNNNBEUSA-N 0.000 title abstract 3
PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 title abstract 2
229960004203 carnitine Drugs 0.000 title abstract 2
229950008499 plitidepsin Drugs 0.000 title abstract 2
108010049948 plitidepsin Proteins 0.000 title abstract 2
206010028980 Neoplasm Diseases 0.000 title 1
RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 title 1
229960001009 acetylcarnitine Drugs 0.000 title 1
201000011510 cancer Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
230000000694 effects Effects 0.000 abstract 1
210000003205 muscle Anatomy 0.000 abstract 1
230000001012 protector Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Steroid Compounds (AREA)

AT01974510T 2000-10-12 2001-10-12 Behandlung von krebserkrankungen mit aplidin in kombination mit carnitin oder acetylcarnitin ATE299028T1 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GB0025044A GB0025044D0 (en)	2000-10-12	2000-10-12	Toxicity protection
GB0025209A GB0025209D0 (en)	2000-10-13	2000-10-13	Treatment of cancers
PCT/GB2000/004349 WO2001035974A2 (en)	1999-11-15	2000-11-15	Aplidine treatment of cancers
GB0107373A GB0107373D0 (en)	2001-03-23	2001-03-23	Aplidine
PCT/GB2001/004555 WO2002030441A2 (en)	2000-10-12	2001-10-12	Treatment of cancers by aplidine in conjunction with a myoprotector

Publications (1)

Publication Number	Publication Date
ATE299028T1 true ATE299028T1 (de)	2005-07-15

Family

ID=27255931

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01974510T ATE299028T1 (de)	2000-10-12	2001-10-12	Behandlung von krebserkrankungen mit aplidin in kombination mit carnitin oder acetylcarnitin

Country Status (14)

Country	Link
US (1)	US7507766B2 (de)
JP (1)	JP2010031043A (de)
KR (1)	KR20030038812A (de)
CN (1)	CN1479622A (de)
AT (1)	ATE299028T1 (de)
BR (1)	BR0114604A (de)
CZ (1)	CZ2003993A3 (de)
ES (1)	ES2243555T3 (de)
HK (1)	HK1054191A1 (de)
IL (1)	IL155273A0 (de)
NO (1)	NO20031673L (de)
NZ (1)	NZ525196A (de)
PL (1)	PL361179A1 (de)
RU (1)	RU2003113210A (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100518986B1 (ko) *	1999-11-15	2005-10-06	파르마 마르, 에스.에이.	아플리딘을 사용하여 암을 치료하는 방법
RU2341283C2 (ru) *	2003-03-12	2008-12-20	Фарма Мар, С.А.	Усовершенствованное лечение опухолей
WO2007100385A2 (en) *	2005-10-31	2007-09-07	Genentech, Inc.	Macrocyclic depsipeptide antibody-drug conjugates and methods
US8258098B2 (en) *	2006-02-28	2012-09-04	Pharma Mar, S.A.	Antitumoral treatments
JP2011500650A (ja) *	2007-10-19	2011-01-06	ファルマ・マール・ソシエダード・アノニマ	改良された抗腫瘍治療
AU2009221720A1 (en) *	2008-03-07	2009-09-11	Pharma Mar, S.A.	Improved anticancer treatments
CA2838387A1 (en)	2011-06-06	2012-12-13	Chevron Phillips Chemical Company Lp	Use of metallocene compounds for cancer treatment
US11332480B2 (en)	2017-04-27	2022-05-17	Pharma Mar, S.A.	Antitumoral compounds

Family Cites Families (31)

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US4950649A (en)	1980-09-12	1990-08-21	University Of Illinois	Didemnins and nordidemnins
DE3161556D1 (en)	1980-09-12	1984-01-05	Univ Illinois	Novel antibiotics, derivatives thereof, processes for their extraction, and compositions containing them
US4493796A (en)	1980-09-12	1985-01-15	Board Of Trustees, Univ. Of Ill.	Didemnins A, B, C, and derivatives thereof, as antiviral agents
IT1153974B (it)	1982-09-23	1987-01-21	Erba Farmitalia	Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento
US4948791A (en)	1989-04-10	1990-08-14	The Board Of Trustees Of The University Of Illinois	Novel Cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum
GB8922026D0 (en)	1989-09-29	1989-11-15	Pharma Mar Sa	Novel anti-viral and cytotoxic agent
DE4120327A1 (de)	1991-06-20	1992-12-24	Basf Ag	Neue peptide, ihre herstellung und verwendung
US5462726A (en)	1993-12-17	1995-10-31	Bristol-Myers Squibb Company	Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A2 receptor antagonist and pharmaceutical compositions containing such solvents
US5861439A (en)	1994-11-14	1999-01-19	Alza Corporation	Method for enhanced electrotransport agent delivery
ES2102322B1 (es)	1995-07-13	1998-03-01	Pharma Mar Sa	Procedimiento de preparacion de didemnina a.
JP4172726B2 (ja)	1996-05-22	2008-10-29	ルイトポルド・ファーマシューティカルズ・インコーポレーテッド	シス―ドコサヘキサエン酸とドセタキセルとの共有複合体を含有する製剤
US6156724A (en)	1996-06-07	2000-12-05	Rinehart; Kenneth L.	Uses of didemnins as immunomodulating agents
ATE208323T1 (de)	1996-07-03	2001-11-15	Paxton C G Ltd	Behälter
JP2001503746A (ja)	1996-10-24	2001-03-21	ザ・ボード・オブ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・イリノイ	ジデムニン類似体の半合成法
ES2202644T3 (es)	1996-10-24	2004-04-01	The Board Of Trustees Of The University Of Illinois	Sintesis total del analogo hip amino de la didemnin a.
US6034058A (en)	1997-04-15	2000-03-07	Rinehart; Kenneth L.	Semi-synthetic alanyl dilemnin analogs
EP0981352B8 (de)	1997-05-07	2009-06-17	Pharma Mar, S.A.	Verwendung von Aplidine zur Behandlung von kardiovaskulären Erkrankungen
GB9803448D0 (en)	1998-02-18	1998-04-15	Pharma Mar Sa	Pharmaceutical formulation
PT1100589E (pt)	1998-07-30	2005-05-31	Sigma Tau Ind Farmaceuti	Utilizacao de propionil-l-carnitina e acetil-l-carnitina na preparacao de medicamentos com actividade anticancerigena
US20010021380A1 (en)	1999-04-19	2001-09-13	Pluenneke John D.	Soluble tumor necrosis factor receptor treatment of medical disorders
CA2373643A1 (en)	1999-05-25	2000-11-30	Point Therapeutics, Inc.	Anti-tumor comprising boroproline compounds
US6890904B1 (en)	1999-05-25	2005-05-10	Point Therapeutics, Inc.	Anti-tumor agents
KR100518986B1 (ko)	1999-11-15	2005-10-06	파르마 마르, 에스.에이.	아플리딘을 사용하여 암을 치료하는 방법
US6509315B1 (en)	2000-04-07	2003-01-21	The Trustees Of The University Of Pennsylvania	Didemnin analogs and fragments and methods of making and using them
IL152111A0 (en)	2000-04-07	2003-07-31	Univ Pennsylvania	Tamandarin and didemnin analogs and methods of making and using them
UA76718C2 (uk)	2000-06-30	2006-09-15	Фарма Мар, С.А.	Протипухлинні похідні аплідину
CA2423462A1 (en)	2000-10-05	2002-04-11	Immunex Corporation	Nectin polypeptides, polynucleotides, methods of making and use thereof
AU2001294024C1 (en)	2000-10-12	2006-11-23	Pharma Mar, S.A.	Treatment of cancers by aplidine in conjunction with a myoprotector
AU2002224417A1 (en)	2000-10-18	2002-04-29	Immunex Corporation	Methods for treating il-18 mediated disorders
ES2315404T3 (es)	2001-10-19	2009-04-01	Pharma Mar, S.A.	Uso de aplidina para el tratamiento de cancer de pancreas.
RU2341283C2 (ru)	2003-03-12	2008-12-20	Фарма Мар, С.А.	Усовершенствованное лечение опухолей

2001
- 2001-10-12 HK HK03106440.0A patent/HK1054191A1/zh unknown
- 2001-10-12 PL PL01361179A patent/PL361179A1/xx not_active Application Discontinuation
- 2001-10-12 NZ NZ525196A patent/NZ525196A/en unknown
- 2001-10-12 KR KR10-2003-7005081A patent/KR20030038812A/ko not_active Withdrawn
- 2001-10-12 CN CNA018204740A patent/CN1479622A/zh active Pending
- 2001-10-12 RU RU2003113210/14A patent/RU2003113210A/ru not_active Application Discontinuation
- 2001-10-12 US US10/398,835 patent/US7507766B2/en not_active Expired - Fee Related
- 2001-10-12 BR BR0114604-1A patent/BR0114604A/pt not_active IP Right Cessation
- 2001-10-12 IL IL15527301A patent/IL155273A0/xx unknown
- 2001-10-12 ES ES01974510T patent/ES2243555T3/es not_active Expired - Lifetime
- 2001-10-12 AT AT01974510T patent/ATE299028T1/de not_active IP Right Cessation
- 2001-10-12 CZ CZ2003993A patent/CZ2003993A3/cs unknown
2003
- 2003-04-11 NO NO20031673A patent/NO20031673L/no not_active Application Discontinuation
2009
- 2009-11-06 JP JP2009255266A patent/JP2010031043A/ja active Pending

Also Published As

Publication number	Publication date
NZ525196A (en)	2004-09-24
CN1479622A (zh)	2004-03-03
NO20031673D0 (no)	2003-04-11
BR0114604A (pt)	2003-10-14
IL155273A0 (en)	2003-11-23
RU2003113210A (ru)	2004-11-27
US7507766B2 (en)	2009-03-24
ES2243555T3 (es)	2005-12-01
PL361179A1 (en)	2004-09-20
KR20030038812A (ko)	2003-05-16
CZ2003993A3 (cs)	2004-02-18
NO20031673L (no)	2003-06-12
HK1054191A1 (zh)	2003-11-21
US20040010043A1 (en)	2004-01-15
JP2010031043A (ja)	2010-02-12

Legal Events

Date	Code	Title	Description
2006-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ES543862A0 (es)	1986-12-16	Procedimiento para apreciar variaciones en el tiempo de caracteristicas somaticas de personas sometidas a tratamiento deadelgazamiento, cicatrizacion y otros.
EA200700684A1 (ru)	2007-10-26	Полиаминные композиции
DE69505962D1 (de)	1998-12-17	Mittel zur künstlichen bräunung mit verbesserter stabilität
ATE303156T1 (de)	2005-09-15	Verwendung von gnrh-analogue zur behandlung der harninkontinenz
DE60315964D1 (de)	2007-10-11	Verbesserung der herstellung von endogenen gonadotropin
MX9400434A (es)	1994-07-29	Potenciamiento de temozolomida en celulas de tumores humanos.
ECSP045153A (es)	2004-08-27	Metodo y composición para aumentar la potencia de un analgésico de narcotico.
ES2103854T3 (es)	1997-10-01	Peptidos con actividad organo protectiva, procedimiento para la preparacion de los mismos y su utilizacion en la terapia.
DK1689404T3 (da)	2009-01-26	Kombination af et-743 med 5-fluoracil-prodrugs til behandling af cancer
ZA200004260B (en)	2001-07-25	Treatment of skin disorders.
IL138290A0 (en)	2001-10-31	Use of selegiline or desmethylselegiline for treating wounds, burns and dermatological damage
BR0114604A (pt)	2003-10-14	Tratamento de cnceres
ES2068714T3 (es)	1995-04-16	Derivados de pirimidina para aumentar la actividad antitumoral.
ATE399558T1 (de)	2008-07-15	Anti-tumorale formulierungen mit defibrotid allein oder in kombination mit anderen antitumoralen mitteln
DE60111858D1 (de)	2005-08-11	BEHANDLUNG VON KREBSERKRANKUNGEN mit APLIDIN IN KOMBINATION MIT CARNITIN ODER ACETYLCARNITIN
AR015956A1 (es)	2001-05-30	Composiciones de citoquinas oromucosales y usos de las mismas
ATE359808T1 (de)	2007-05-15	Verwendung von sarp-1 zur behandlung und/oder vorbeugung von scleroderma
DE60216292D1 (de)	2007-01-04	Calciumtrifluoracetat mit zytotoxischer wirkung
ATE236633T1 (de)	2003-04-15	Topische verwendung von loperamid zur behandlung mikrobieller infektionen
DK0572549T3 (da)	2003-01-06	Behandling af ikke-småcellet lungecarcinom
ATE466587T1 (de)	2010-05-15	Valeriana officinalis extrakt zur behandlung von schlafapnoe oder hypopnoe
ES2168772T3 (es)	2002-06-16	Uso de hormona del crecimiento en composiciones para el tratamiento de la resistencia del corazon a la insulina.
EA200500773A1 (ru)	2005-12-29	СПОСОБЫ ЗАЩИТЫ ОТ РАДИАЦИОННОГО ПОРАЖЕНИЯ С ПРИМЕНЕНИЕМ α-ТИМОЗИНА
MXPA04000418A (es)	2004-03-18	Tratamiento de dolor cronico con 3-heterocicloxi- y -cicloalquiloxi-3-fenilpropanaminas.
ES1044515U (es)	2000-05-01	Pantalon para el tratamiento topico de la celulitis