IL155273A0 - Pharmaceutical compositions comprising an aplidine compound - Google Patents

Pharmaceutical compositions comprising an aplidine compound

Info

Publication number: IL155273A0
Authority: IL; Israel
Prior art keywords: pharmaceutical compositions; aplidine; aplidine compound; compound; carnitine
Prior art date: 2000-10-12

Application number

IL15527301A

Other languages

English (en)

Original Assignee

Pharma Mar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-12

Filing date

2001-10-12

Publication date

2003-11-23

2000-10-12 Priority claimed from GB0025044A external-priority patent/GB0025044D0/en

2000-10-13 Priority claimed from GB0025209A external-priority patent/GB0025209D0/en

2000-11-15 Priority claimed from PCT/GB2000/004349 external-priority patent/WO2001035974A2/en

2001-03-23 Priority claimed from GB0107373A external-priority patent/GB0107373D0/en

2001-10-12 Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa

2001-10-12 Priority claimed from PCT/GB2001/004555 external-priority patent/WO2002030441A2/en

2003-11-23 Publication of IL155273A0 publication Critical patent/IL155273A0/xx

Links

229950008499 plitidepsin Drugs 0.000 title abstract 2
108010049948 plitidepsin Proteins 0.000 title abstract 2
-1 aplidine compound Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
UUSZLLQJYRSZIS-LXNNNBEUSA-N plitidepsin Chemical compound CN([C@H](CC(C)C)C(=O)N[C@@H]1C(=O)N[C@@H]([C@H](CC(=O)O[C@H](C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(OC)=CC=2)C(=O)O[C@@H]1C)C(C)C)O)[C@@H](C)CC)C(=O)[C@@H]1CCCN1C(=O)C(C)=O UUSZLLQJYRSZIS-LXNNNBEUSA-N 0.000 abstract 2
PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 abstract 1
229960004203 carnitine Drugs 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
210000003205 muscle Anatomy 0.000 abstract 1
230000001012 protector Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Steroid Compounds (AREA)

IL15527301A 2000-10-12 2001-10-12 Pharmaceutical compositions comprising an aplidine compound IL155273A0 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GB0025044A GB0025044D0 (en)	2000-10-12	2000-10-12	Toxicity protection
GB0025209A GB0025209D0 (en)	2000-10-13	2000-10-13	Treatment of cancers
PCT/GB2000/004349 WO2001035974A2 (en)	1999-11-15	2000-11-15	Aplidine treatment of cancers
GB0107373A GB0107373D0 (en)	2001-03-23	2001-03-23	Aplidine
PCT/GB2001/004555 WO2002030441A2 (en)	2000-10-12	2001-10-12	Treatment of cancers by aplidine in conjunction with a myoprotector

Publications (1)

Publication Number	Publication Date
IL155273A0 true IL155273A0 (en)	2003-11-23

Family

ID=27255931

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL15527301A IL155273A0 (en)	2000-10-12	2001-10-12	Pharmaceutical compositions comprising an aplidine compound

Country Status (14)

Country	Link
US (1)	US7507766B2 (de)
JP (1)	JP2010031043A (de)
KR (1)	KR20030038812A (de)
CN (1)	CN1479622A (de)
AT (1)	ATE299028T1 (de)
BR (1)	BR0114604A (de)
CZ (1)	CZ2003993A3 (de)
ES (1)	ES2243555T3 (de)
HK (1)	HK1054191A1 (de)
IL (1)	IL155273A0 (de)
NO (1)	NO20031673L (de)
NZ (1)	NZ525196A (de)
PL (1)	PL361179A1 (de)
RU (1)	RU2003113210A (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100518986B1 (ko) *	1999-11-15	2005-10-06	파르마 마르, 에스.에이.	아플리딘을 사용하여 암을 치료하는 방법
RU2341283C2 (ru) *	2003-03-12	2008-12-20	Фарма Мар, С.А.	Усовершенствованное лечение опухолей
WO2007100385A2 (en) *	2005-10-31	2007-09-07	Genentech, Inc.	Macrocyclic depsipeptide antibody-drug conjugates and methods
US8258098B2 (en) *	2006-02-28	2012-09-04	Pharma Mar, S.A.	Antitumoral treatments
JP2011500650A (ja) *	2007-10-19	2011-01-06	ファルマ・マール・ソシエダード・アノニマ	改良された抗腫瘍治療
AU2009221720A1 (en) *	2008-03-07	2009-09-11	Pharma Mar, S.A.	Improved anticancer treatments
CA2838387A1 (en)	2011-06-06	2012-12-13	Chevron Phillips Chemical Company Lp	Use of metallocene compounds for cancer treatment
US11332480B2 (en)	2017-04-27	2022-05-17	Pharma Mar, S.A.	Antitumoral compounds

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4950649A (en)	1980-09-12	1990-08-21	University Of Illinois	Didemnins and nordidemnins
DE3161556D1 (en)	1980-09-12	1984-01-05	Univ Illinois	Novel antibiotics, derivatives thereof, processes for their extraction, and compositions containing them
US4493796A (en)	1980-09-12	1985-01-15	Board Of Trustees, Univ. Of Ill.	Didemnins A, B, C, and derivatives thereof, as antiviral agents
IT1153974B (it)	1982-09-23	1987-01-21	Erba Farmitalia	Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento
US4948791A (en)	1989-04-10	1990-08-14	The Board Of Trustees Of The University Of Illinois	Novel Cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum
GB8922026D0 (en)	1989-09-29	1989-11-15	Pharma Mar Sa	Novel anti-viral and cytotoxic agent
DE4120327A1 (de)	1991-06-20	1992-12-24	Basf Ag	Neue peptide, ihre herstellung und verwendung
US5462726A (en)	1993-12-17	1995-10-31	Bristol-Myers Squibb Company	Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A2 receptor antagonist and pharmaceutical compositions containing such solvents
US5861439A (en)	1994-11-14	1999-01-19	Alza Corporation	Method for enhanced electrotransport agent delivery
ES2102322B1 (es)	1995-07-13	1998-03-01	Pharma Mar Sa	Procedimiento de preparacion de didemnina a.
JP4172726B2 (ja)	1996-05-22	2008-10-29	ルイトポルド・ファーマシューティカルズ・インコーポレーテッド	シス―ドコサヘキサエン酸とドセタキセルとの共有複合体を含有する製剤
US6156724A (en)	1996-06-07	2000-12-05	Rinehart; Kenneth L.	Uses of didemnins as immunomodulating agents
ATE208323T1 (de)	1996-07-03	2001-11-15	Paxton C G Ltd	Behälter
JP2001503746A (ja)	1996-10-24	2001-03-21	ザ・ボード・オブ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・イリノイ	ジデムニン類似体の半合成法
ES2202644T3 (es)	1996-10-24	2004-04-01	The Board Of Trustees Of The University Of Illinois	Sintesis total del analogo hip amino de la didemnin a.
US6034058A (en)	1997-04-15	2000-03-07	Rinehart; Kenneth L.	Semi-synthetic alanyl dilemnin analogs
EP0981352B8 (de)	1997-05-07	2009-06-17	Pharma Mar, S.A.	Verwendung von Aplidine zur Behandlung von kardiovaskulären Erkrankungen
GB9803448D0 (en)	1998-02-18	1998-04-15	Pharma Mar Sa	Pharmaceutical formulation
PT1100589E (pt)	1998-07-30	2005-05-31	Sigma Tau Ind Farmaceuti	Utilizacao de propionil-l-carnitina e acetil-l-carnitina na preparacao de medicamentos com actividade anticancerigena
US20010021380A1 (en)	1999-04-19	2001-09-13	Pluenneke John D.	Soluble tumor necrosis factor receptor treatment of medical disorders
CA2373643A1 (en)	1999-05-25	2000-11-30	Point Therapeutics, Inc.	Anti-tumor comprising boroproline compounds
US6890904B1 (en)	1999-05-25	2005-05-10	Point Therapeutics, Inc.	Anti-tumor agents
KR100518986B1 (ko)	1999-11-15	2005-10-06	파르마 마르, 에스.에이.	아플리딘을 사용하여 암을 치료하는 방법
US6509315B1 (en)	2000-04-07	2003-01-21	The Trustees Of The University Of Pennsylvania	Didemnin analogs and fragments and methods of making and using them
IL152111A0 (en)	2000-04-07	2003-07-31	Univ Pennsylvania	Tamandarin and didemnin analogs and methods of making and using them
UA76718C2 (uk)	2000-06-30	2006-09-15	Фарма Мар, С.А.	Протипухлинні похідні аплідину
CA2423462A1 (en)	2000-10-05	2002-04-11	Immunex Corporation	Nectin polypeptides, polynucleotides, methods of making and use thereof
AU2001294024C1 (en)	2000-10-12	2006-11-23	Pharma Mar, S.A.	Treatment of cancers by aplidine in conjunction with a myoprotector
AU2002224417A1 (en)	2000-10-18	2002-04-29	Immunex Corporation	Methods for treating il-18 mediated disorders
ES2315404T3 (es)	2001-10-19	2009-04-01	Pharma Mar, S.A.	Uso de aplidina para el tratamiento de cancer de pancreas.
RU2341283C2 (ru)	2003-03-12	2008-12-20	Фарма Мар, С.А.	Усовершенствованное лечение опухолей

2001
- 2001-10-12 HK HK03106440.0A patent/HK1054191A1/zh unknown
- 2001-10-12 PL PL01361179A patent/PL361179A1/xx not_active Application Discontinuation
- 2001-10-12 NZ NZ525196A patent/NZ525196A/en unknown
- 2001-10-12 KR KR10-2003-7005081A patent/KR20030038812A/ko not_active Withdrawn
- 2001-10-12 CN CNA018204740A patent/CN1479622A/zh active Pending
- 2001-10-12 RU RU2003113210/14A patent/RU2003113210A/ru not_active Application Discontinuation
- 2001-10-12 US US10/398,835 patent/US7507766B2/en not_active Expired - Fee Related
- 2001-10-12 BR BR0114604-1A patent/BR0114604A/pt not_active IP Right Cessation
- 2001-10-12 IL IL15527301A patent/IL155273A0/xx unknown
- 2001-10-12 ES ES01974510T patent/ES2243555T3/es not_active Expired - Lifetime
- 2001-10-12 AT AT01974510T patent/ATE299028T1/de not_active IP Right Cessation
- 2001-10-12 CZ CZ2003993A patent/CZ2003993A3/cs unknown
2003
- 2003-04-11 NO NO20031673A patent/NO20031673L/no not_active Application Discontinuation
2009
- 2009-11-06 JP JP2009255266A patent/JP2010031043A/ja active Pending

Also Published As

Publication number	Publication date
NZ525196A (en)	2004-09-24
CN1479622A (zh)	2004-03-03
NO20031673D0 (no)	2003-04-11
BR0114604A (pt)	2003-10-14
RU2003113210A (ru)	2004-11-27
ATE299028T1 (de)	2005-07-15
US7507766B2 (en)	2009-03-24
ES2243555T3 (es)	2005-12-01
PL361179A1 (en)	2004-09-20
KR20030038812A (ko)	2003-05-16
CZ2003993A3 (cs)	2004-02-18
NO20031673L (no)	2003-06-12
HK1054191A1 (zh)	2003-11-21
US20040010043A1 (en)	2004-01-15
JP2010031043A (ja)	2010-02-12

Publication	Publication Date	Title
HUP0200503A3 (en)	2005-06-28	N-cyanomethyl amides as protease inhibitors and pharmaceutical compositions containing them
EP1478406A4 (de)	2006-01-11	Zusammensetzungen zur abgabe von therapeutika und anderen materialien und verfahren zu ihrer herstellung und verwendung
MY129406A (en)	2007-03-30	Taste masked liquid pharmaceutical compositions
MY129356A (en)	2007-03-30	Electrospun pharmaceutical compositions
AU7326801A (en)	2002-01-30	Compositions containing therapeutically active components having enhanced solubility
DK1157037T3 (da)	2003-11-24	GCSF-konjugater
AP1450A (en)	2005-07-25	Solid oral dosage form comprising a combination of metformin and glibenclamide.
MY134190A (en)	2007-11-30	Compositions and methods for stimulating gastrointestinal motility.
IL153297A0 (en)	2003-07-06	Compounds and compositions for delivering active agents
ID27503A (id)	2001-04-12	Tts yang mengandung antioksidan
BG66093B1 (bg)	2011-04-29	Състави с контролирано освобождаване, съдържащи нимесулид
HUP0302922A3 (en)	2007-02-28	Imidazolo-5-yl-2-anilino-pyrimidines as agents for the inhibition of the cell proliferation and pharmaceutical compositions containing them
HUP0304084A3 (en)	2010-10-28	Dipeptide derivatives having an terminal 2-thioacyl group as vasopeptidase inhibitors and pharmaceutical compositions containing them
WO2002051424A8 (en)	2002-08-01	Drugs against articular failure
HUP0104934A3 (en)	2002-05-28	Peptide analogues of pacap, pharmaceutical compositions comprising thereof and their use
PL370292A1 (en)	2005-05-16	Formulations for oral administration of active compounds
HUP0301240A3 (en)	2004-03-29	Pyridazine compounds effective as beta-2-adrenoreceptor agonists as well as pde4-inhibitors and pharmaceutical compositions containing them
ZA98214B (en)	1999-08-11	Treatment of multiple sclerosis through ingestion or inhalation of copolymer-1.
NZ503308A (en)	2001-02-23	Alpha-ketoamide multicatalytic protease inhibitors
IL160523A0 (en)	2004-07-25	PHARMACEUTICAL COMPOSITION COMPRISING GABAPENTIN OR AN ANALOGUE THEREOF AND AN alpha-AMINOAMIDE AND ITS ANALGESIC USE
HUP0400494A3 (en)	2004-08-30	Polyamine analogues as cytotoxic agents and pharmaceutical compositions containing them
HUP0303636A3 (en)	2006-02-28	Dihydronaphthalenederivative compounds and pharmaceutical compositions containing them as active ingredient
PL361179A1 (en)	2004-09-20	Treatment of cancers
WO2002030441A3 (en)	2002-08-01	Treatment of cancers by aplidine in conjunction with a myoprotector
WO2002026324A3 (en)	2002-07-04	Tocol-based compositions containing amiodarone