ATE299506T1 - Verfahren zur herstellung von pyrazolo(1,5- b)pyridazin-derivaten - Google Patents

Verfahren zur herstellung von pyrazolo(1,5- b)pyridazin-derivaten

Info

Publication number: ATE299506T1
Authority: AT; Austria
Prior art keywords: 6alkyl; 6alkoxy; nsc1; fluorine atoms; substituted
Prior art date: 1999-12-22

Application number

AT00990004T

Other languages

English (en)

Inventor

Neil Mathews

Richard A Ward

Andrew J Whitehead

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-22

Filing date

2000-12-20

Publication date

2005-07-15

2000-12-20 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2005-07-15 Application granted granted Critical

2005-07-15 Publication of ATE299506T1 publication Critical patent/ATE299506T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
CXHVEWNQMCXEGM-UHFFFAOYSA-N pyrazolo[1,5-b]pyridazine Chemical class C1=CC=NN2N=CC=C21 CXHVEWNQMCXEGM-UHFFFAOYSA-N 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 5
125000001153 fluoro group Chemical group F* 0.000 abstract 4
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical group 0.000 abstract 2
-1 C1-6alkylsulphonyl Chemical group 0.000 abstract 1
125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Pharmacology & Pharmacy (AREA)
Rheumatology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Cephalosporin Compounds (AREA)

AT00990004T 1999-12-22 2000-12-20 Verfahren zur herstellung von pyrazolo(1,5- b)pyridazin-derivaten ATE299506T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9930358.8A GB9930358D0 (en)	1999-12-22	1999-12-22	Process for the preparation of chemical compounds
PCT/EP2000/013001 WO2001046194A2 (en)	1999-12-22	2000-12-20	Process for the preparation of pyrazolo[1,5-b]pyridazine derivatives

Publications (1)

Publication Number	Publication Date
ATE299506T1 true ATE299506T1 (de)	2005-07-15

Family

ID=10866856

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00990004T ATE299506T1 (de)	1999-12-22	2000-12-20	Verfahren zur herstellung von pyrazolo(1,5- b)pyridazin-derivaten

Country Status (22)

Country	Link
US (1)	US6803463B2 (de)
EP (1)	EP1242424B1 (de)
JP (1)	JP2003518121A (de)
KR (1)	KR20020062362A (de)
CN (1)	CN1197864C (de)
AT (1)	ATE299506T1 (de)
AU (1)	AU776777B2 (de)
BR (1)	BR0016549A (de)
CA (1)	CA2395569A1 (de)
CZ (1)	CZ20022178A3 (de)
DE (1)	DE60021286T2 (de)
ES (1)	ES2243343T3 (de)
GB (1)	GB9930358D0 (de)
HK (1)	HK1047586B (de)
HU (1)	HUP0203407A3 (de)
IL (1)	IL150274A0 (de)
MX (1)	MXPA02006132A (de)
NO (1)	NO323412B1 (de)
NZ (1)	NZ519691A (de)
PL (1)	PL356141A1 (de)
WO (1)	WO2001046194A2 (de)
ZA (1)	ZA200204911B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0021494D0 (en) *	2000-09-01	2000-10-18	Glaxo Group Ltd	Chemical comkpounds
GB0112802D0 (en) *	2001-05-25	2001-07-18	Glaxo Group Ltd	Pyrimidine derivatives
GB0112810D0 (en) *	2001-05-25	2001-07-18	Glaxo Group Ltd	Pyrimidine derivatives
AU2003258630A1 (en)	2002-08-19	2004-03-11	Glaxo Group Limited	Pyrimidine derivatives as selective cox-2 inhibitors
GB0221443D0 (en)	2002-09-16	2002-10-23	Glaxo Group Ltd	Pyridine derivates
GB0227443D0 (en) *	2002-11-25	2002-12-31	Glaxo Group Ltd	Pyrimidine derivatives
GB0229808D0 (en) *	2002-12-20	2003-01-29	Glaxo Group Ltd	Novel compositions
US7145762B2 (en) *	2003-02-11	2006-12-05	Taser International, Inc.	Systems and methods for immobilizing using plural energy stores
GB0319037D0 (en) *	2003-08-13	2003-09-17	Glaxo Group Ltd	7-Azaindole Derivatives
DE102006040754B3 (de) *	2006-08-31	2008-03-27	Knorr-Bremse Systeme für Nutzfahrzeuge GmbH	Scheibenbremse, insbesondere für ein Nutzfahrzeug

Family Cites Families (20)

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Publication number	Priority date	Publication date	Assignee	Title
JPS58134094A (ja)	1982-02-02	1983-08-10	Mitsubishi Paper Mills Ltd	３―ホルミル―ピラゾロ〔１，５―ｂ〕ピリダジン類
US5002941A (en)	1985-12-12	1991-03-26	Smithkline Beecham Corporation	Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
US4925849A (en)	1987-06-15	1990-05-15	Fujisawa Pharmaceutical Company, Ltd.	Pharmaceutically useful pyrazolopyridines
US5155114A (en)	1989-01-23	1992-10-13	Fujisawa Pharmaceutical Company, Ltd.	Method of treatment using pyrazolopyridine compound
GB8901423D0 (en)	1989-01-23	1989-03-15	Fujisawa Pharmaceutical Co	Pyrazolopyridine compound and processes for preparation thereof
WO1991000092A1 (en)	1989-06-13	1991-01-10	Smithkline Beecham Corporation	Inhibition of interleukin-1 and tumor necrosis factor production by monocytes and/or macrophages
AU622330B2 (en)	1989-06-23	1992-04-02	Takeda Chemical Industries Ltd.	Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
AU8205991A (en)	1990-06-12	1992-01-07	Smithkline Beecham Corporation	Inhibition of 5-lipoxygenase and cyclooxygenase pathway mediated diseases
GB9015764D0 (en)	1990-07-18	1990-09-05	Fujisawa Pharmaceutical Co	Pyrazolopyridine compound and processes for preparation thereof
US5300478A (en)	1993-01-28	1994-04-05	Zeneca Limited	Substituted fused pyrazolo compounds
US5474995A (en)	1993-06-24	1995-12-12	Merck Frosst Canada, Inc.	Phenyl heterocycles as cox-2 inhibitors
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KR19980703559A (ko) *	1995-04-04	1998-11-05	그레이엄브레레톤	이미다조［1,2-ａ］피리딘 유도체
US5700816A (en)	1995-06-12	1997-12-23	Isakson; Peter C.	Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor
CA2224563A1 (en)	1995-06-12	1996-12-27	G.D. Searle & Co.	Combination of a cyclooxygenase-2 inhibitor and a leukotriene b4 receptor antagonist for the treatment of inflammations
WO1996041626A1 (en)	1995-06-12	1996-12-27	G.D. Searle & Co.	Compositions comprising a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor
ES2203985T3 (es)	1997-09-05	2004-04-16	Glaxo Group Limited	Derivados de 2,3-diaril-pirazolo(1,5)piridazina, su preparacion y su uso como inhibidores de la ciclooxigenasa 2(cox-2)`.
ATE261444T1 (de) *	1999-02-27	2004-03-15	Glaxo Group Ltd	Pyrazolopyridine
GB9919778D0 (en)	1999-08-21	1999-10-27	Zeneca Ltd	Chemical compounds

1999
- 1999-12-22 GB GBGB9930358.8A patent/GB9930358D0/en not_active Ceased
2000
- 2000-12-20 AT AT00990004T patent/ATE299506T1/de not_active IP Right Cessation
- 2000-12-20 PL PL00356141A patent/PL356141A1/xx not_active Application Discontinuation
- 2000-12-20 CZ CZ20022178A patent/CZ20022178A3/cs unknown
- 2000-12-20 CN CNB008176582A patent/CN1197864C/zh not_active Expired - Fee Related
- 2000-12-20 WO PCT/EP2000/013001 patent/WO2001046194A2/en not_active Ceased
- 2000-12-20 KR KR1020027007988A patent/KR20020062362A/ko not_active Ceased
- 2000-12-20 US US10/168,002 patent/US6803463B2/en not_active Expired - Fee Related
- 2000-12-20 AU AU26751/01A patent/AU776777B2/en not_active Ceased
- 2000-12-20 ES ES00990004T patent/ES2243343T3/es not_active Expired - Lifetime
- 2000-12-20 NZ NZ519691A patent/NZ519691A/en unknown
- 2000-12-20 HU HU0203407A patent/HUP0203407A3/hu unknown
- 2000-12-20 CA CA002395569A patent/CA2395569A1/en not_active Abandoned
- 2000-12-20 HK HK02108757.4A patent/HK1047586B/en not_active IP Right Cessation
- 2000-12-20 JP JP2001547104A patent/JP2003518121A/ja active Pending
- 2000-12-20 BR BR0016549-2A patent/BR0016549A/pt not_active IP Right Cessation
- 2000-12-20 DE DE60021286T patent/DE60021286T2/de not_active Expired - Fee Related
- 2000-12-20 IL IL15027400A patent/IL150274A0/xx unknown
- 2000-12-20 MX MXPA02006132A patent/MXPA02006132A/es active IP Right Grant
- 2000-12-20 EP EP00990004A patent/EP1242424B1/de not_active Expired - Lifetime
2002
- 2002-06-19 ZA ZA200204911A patent/ZA200204911B/en unknown
- 2002-06-21 NO NO20023041A patent/NO323412B1/no unknown

Also Published As

Publication number	Publication date
HUP0203407A3 (en)	2004-12-28
US6803463B2 (en)	2004-10-12
EP1242424B1 (de)	2005-07-13
AU776777B2 (en)	2004-09-23
EP1242424A2 (de)	2002-09-25
CN1413215A (zh)	2003-04-23
NZ519691A (en)	2004-06-25
HK1047586B (en)	2005-12-16
HK1047586A1 (en)	2003-02-28
ZA200204911B (en)	2004-02-13
MXPA02006132A (es)	2002-12-05
CN1197864C (zh)	2005-04-20
AU2675101A (en)	2001-07-03
NO20023041L (no)	2002-08-16
BR0016549A (pt)	2002-09-17
NO323412B1 (no)	2007-04-30
CZ20022178A3 (cs)	2003-02-12
CA2395569A1 (en)	2001-06-28
US20030078267A1 (en)	2003-04-24
DE60021286D1 (de)	2005-08-18
ES2243343T3 (es)	2005-12-01
IL150274A0 (en)	2002-12-01
GB9930358D0 (en)	2000-02-09
NO20023041D0 (no)	2002-06-21
WO2001046194A3 (en)	2002-05-30
WO2001046194A2 (en)	2001-06-28
DE60021286T2 (de)	2005-12-29
HUP0203407A2 (hu)	2003-01-28
JP2003518121A (ja)	2003-06-03
KR20020062362A (ko)	2002-07-25
PL356141A1 (en)	2004-06-14

Legal Events

Date	Code	Title	Description
2006-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
TW369526B (en)	1999-09-11	Diazabicyclic neurokinin antagonists
WO2003016282A3 (en)	2003-04-24	Substituted 1h-dihydropyrazoles, their preparation and use
UY25344A1 (es)	1999-09-27	Procedimiento para la preparacion de derivados de la tienopirimidina y de la tienopiridina utiles como agentes anticancerigenos
EA200000188A1 (ru)	2000-10-30	Производные 2,3-диарил-пиразоло[1,5-b]-пиридазинов, их получение и их применение в качестве ингибиторов циклооксигеназы-2 (цог-2)
ATE349451T1 (de)	2007-01-15	Verfahren zur herstellung von clopidogrel
YU94103A (sh)	2006-03-03	Novi derivati sulfonske kiseline
DE60021286D1 (de)	2005-08-18	Verfahren zur herstellung von pyrazolo[1,5-b]pyridazin-derivaten
CA2244139A1 (en)	1997-08-07	Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
NZ332923A (en)	2000-03-27	Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
FI906408A0 (fi)	1990-12-27	Menetelmä terapeuttisesti käyttökelpoisten 2-aminopyrimidiini-4-karboksamidijohdannaisten valmistamiseksi
AU8728801A (en)	2001-10-15	Method and agents on the basis of 2-mercaptopropionic acid amides for durable hair forming and a method for producing same
DK0628042T3 (da)	2001-11-12	Serotoninerge ergolinderivater
ATE268771T1 (de)	2004-06-15	Verfahren zur herstellung von pyrazolopyridinderivaten
DE3854109D1 (de)	1995-08-10	Verfahren zur herstellung von chinolincarbonsäuren.
AU5125798A (en)	1998-06-29	Novel n-benzenesulphonyl-l-proline derivatives, method for preparing and therapeutic use
ES554827A0 (es)	1988-07-16	Procedimiento para preparar acidos hexenoicos.
ES554830A0 (es)	1988-07-16	Procedimiento para preparar derivados de 1,3-oxatiano
HUP0104045A2 (hu)	2002-05-29	Eljárás 4-[(2',5'-diamino-6'-halogén-pirimidin-4'-il)-amino]-ciklopent-2-enilmetanol-származékok előállítására
PL367073A1 (en)	2005-02-21	Dihydroimidazo [5,1-a]-$g(b)-carboline derivatives, method for preparing same and use thereof as medicine
ATE73767T1 (de)	1992-04-15	Fluorine enthaltende vitamin-d3-derivate und verfahren zu ihrer herstellung.
HUP0201374A2 (hu)	2005-01-28	Új piperidinil-alkil-amino-piridazinon-származékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények, és eljárás a hatóanyag előállítására
HU900728D0 (en)	1990-04-28	Process for preparation of calcium antagonistics
DE3764918D1 (de)	1990-10-18	2,6-piperazin-dion-derivate, ihre verfahren zur herstellung und sie enthaltende pharmazeutische zusammensetzungen.
TW353070B (en)	1999-02-21	Chloropyridylcarbonyl derivatives
ES2055925T3 (es)	1994-09-01	Derivados de la 9-fluor-prostaglandina, procedimiento para su obtencion y su uso farmaceutico.