ATE299701T1 - Antibakteriell wirksame hydroxamsäure-derivate - Google Patents

Antibakteriell wirksame hydroxamsäure-derivate

Info

Publication number: ATE299701T1
Authority: AT; Austria
Prior art keywords: group; acid derivatives; represents hydrogen; hydroxamic acid; alkyl
Prior art date: 1999-01-29

Application number

AT00901231T

Other languages

English (en)

Inventor

Michael George Hunter

Raymond Paul Beckett

Martin John Clements

Mark Whittaker

Original Assignee

Vernalis Oxford Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-29

Filing date

2000-01-27

Publication date

2005-08-15

2000-01-27 Application filed by Vernalis Oxford Ltd filed Critical Vernalis Oxford Ltd

2005-08-15 Application granted granted Critical

2005-08-15 Publication of ATE299701T1 publication Critical patent/ATE299701T1/de

Links

NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title 1
239000002253 acid Substances 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
208000035143 Bacterial infection Diseases 0.000 abstract 1
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
125000004450 alkenylene group Chemical group 0.000 abstract 1
150000001370 alpha-amino acid derivatives Chemical class 0.000 abstract 1
235000008206 alpha-amino acids Nutrition 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
208000022362 bacterial infectious disease Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000000524 functional group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
-1 hydroxy, amino, methyl Chemical group 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
150000007970 thio esters Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Indole Compounds (AREA)

AT00901231T 1999-01-29 2000-01-27 Antibakteriell wirksame hydroxamsäure-derivate ATE299701T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9901863.2A GB9901863D0 (en)	1999-01-29	1999-01-29	Antibacterial agents
PCT/GB2000/000233 WO2000044373A1 (en)	1999-01-29	2000-01-27	Antibacterial hydroxamic acid derivatives

Publications (1)

Publication Number	Publication Date
ATE299701T1 true ATE299701T1 (de)	2005-08-15

Family

ID=10846641

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00901231T ATE299701T1 (de)	1999-01-29	2000-01-27	Antibakteriell wirksame hydroxamsäure-derivate

Country Status (8)

Country	Link
US (1)	US6545051B1 (de)
EP (1)	EP1146867B1 (de)
JP (1)	JP2002535362A (de)
AT (1)	ATE299701T1 (de)
AU (1)	AU2118900A (de)
DE (1)	DE60021347T2 (de)
GB (1)	GB9901863D0 (de)
WO (1)	WO2000044373A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1169031A1 (de) *	1999-04-09	2002-01-09	British Biotech Pharmaceuticals Limited	Antimikrobielles mittel
GB0208579D0 (en) *	2002-04-13	2002-05-22	British Biotech Pharm	Antibacterial agents
KR101076018B1 (ko)	2003-01-08	2011-10-21	유니버시티 오브 워싱톤	항균제
KR100648133B1 (ko) *	2005-04-25	2006-11-23	일동제약주식회사	펩티드 데포르밀라제 저해제로서 신규의 히드록사믹 산유도체 및 그 제조방법
TWI519508B (zh)	2007-06-12	2016-02-01	Achaogen Inc	抗菌劑
EP2847168A1 (de)	2012-05-10	2015-03-18	Achaogen, Inc.	Antibakterielle wirkstoffe
AU2017420730B2 (en) *	2017-06-29	2023-12-14	Kimberly-Clark Worldwide, Inc.	Antimicrobial composition including a dihydroxamic acid and methods of inhibiting microbial growth utilizing the same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8921326D0 (en) *	1989-09-21	1989-11-08	Beecham Group Plc	Novel treatment
JPH03157372A (ja) *	1989-11-13	1991-07-05	Yamanouchi Pharmaceut Co Ltd	Ｙｌ―０１８６９ｐ物質及びその製造法
AU671724B2 (en) *	1993-03-16	1996-09-05	British Biotech Pharmaceuticals Limited	Hydroxamic acid derivatives as metalloproteinase inhibitors
GB9320660D0 (en) *	1993-10-07	1993-11-24	British Bio Technology	Inhibition of cytokine production
GB9401129D0 (en) *	1994-01-21	1994-03-16	British Bio Technology	Hydroxamic acid derivatives as metalloproteinase inhibitors
GB9613547D0 (en) *	1996-06-27	1996-08-28	Pharmacia Spa	Matrix metalloproteinase inhibitors
IL128337A0 (en) *	1996-09-10	2000-01-31	British Biotech Pharm	Cytostatic hydroxamic acid derivatives
GB9803005D0 (en) *	1998-02-12	1998-04-08	British Biotech Pharm	Anti-inflammatory agents
GB9804777D0 (en) *	1998-03-07	1998-04-29	British Biotech Pharm	Anti-inflammatory agents
GB2349149A (en) *	1998-03-12	2000-10-25	British Biotech Pharm	Cytostatic agents

1999
- 1999-01-29 GB GBGB9901863.2A patent/GB9901863D0/en not_active Ceased
2000
- 2000-01-27 US US09/889,801 patent/US6545051B1/en not_active Expired - Fee Related
- 2000-01-27 DE DE60021347T patent/DE60021347T2/de not_active Expired - Fee Related
- 2000-01-27 AT AT00901231T patent/ATE299701T1/de not_active IP Right Cessation
- 2000-01-27 WO PCT/GB2000/000233 patent/WO2000044373A1/en not_active Ceased
- 2000-01-27 EP EP00901231A patent/EP1146867B1/de not_active Expired - Lifetime
- 2000-01-27 JP JP2000595676A patent/JP2002535362A/ja active Pending
- 2000-01-27 AU AU21189/00A patent/AU2118900A/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1146867A1 (de)	2001-10-24
EP1146867B1 (de)	2005-07-20
GB9901863D0 (en)	1999-03-17
US6545051B1 (en)	2003-04-08
DE60021347T2 (de)	2006-05-24
JP2002535362A (ja)	2002-10-22
DE60021347D1 (de)	2005-08-25
WO2000044373A1 (en)	2000-08-03
AU2118900A (en)	2000-08-18

Similar Documents

Publication	Publication Date	Title
NZ505675A (en)	2002-11-26	N-alkylamide substituted hydroxamic acid derivatives are used as antibacterial agents
NO20020623L (no)	2002-04-09	Farmasöytiske forbindelser
DK0554543T3 (da)	1996-03-18	1,2,4-triaminobenzenderivater og fremgangsmåde til deres fremstilling
DK0992501T3 (da)	2002-10-28	Pyridoncarboxylsyre derivater som antibakterielle midler
CA2216129A1 (en)	1996-09-26	Lactam-containing hydroxamic acids
ATE357230T1 (de)	2007-04-15	Neue prodrugs für antimicrobielle amidine
BR9910443A (pt)	2001-01-02	Aperfeiçoamento da atividade de agentes antibacterianos de oxazolidinona usando-se derivados de arginina
NZ507560A (en)	2003-06-30	Hydroxamic acid derivatives as antibacterials
DE60021347D1 (de)	2005-08-25	Antibakteriell wirksame hydroxamsäure-derivate
DK0699439T3 (da)	1999-12-27	Behandling af sygdomme forårsaget af talgkirtellidelser med acyl-CoA-cholesterolacyltransferaseinhibitorer
BR0006299A (pt)	2001-09-25	Derivados da 4-oxo-2-ureìdo-1,4,5,6-tetra-hidro-pirimidina
ES2051652A6 (es)	1994-06-16	Procedimiento para la preparacion de compuestos inhibidores de fosfolipasa a2
KR900701756A (ko)	1990-12-04	축합된 피라졸 3-옥소-프로판니트릴 유도체 및 이의 제조방법
EA200400523A1 (ru)	2004-08-26	Производные [[2-(амино-3,4-диоксо-1-циклобутен-1-ил)амино]алкил] кислоты, применяемые для лечения боли
DE69912639D1 (de)	2003-12-11	N-formyl hydroxylamin derivate als antibakterielle mittel
MX15635A (es)	1993-12-01	Amidas de acidos ciclometilen-1,2-dicarboxilicos y el procedimiento para su preparacion.
FI913565A0 (fi)	1991-07-25	Substituerade fenylacetylenfoereningar, laekemedel innehaollande dem samt ett foerfarande foer framstaellning av dessa foereningar och laekemedel.
ATE263183T1 (de)	2004-04-15	A-500359-derivate
MXPA04011879A (es)	2005-09-12	Agente transformante de bacterias.
BR9911965A (pt)	2001-05-29	Composto, derivado de éster, éter ou n-alquilcarbamoìla farmaceuticamente aceitáveis, composição farmacêutica, uso de um composto, processo para o tratamento ou prevenção de uma infecção bacteriana, streptomices griseus, derivado de amida, processo para preparar um composto, e, cepa de streptomyces griseus
WO2002050081A3 (en)	2002-10-17	Antimicrobial agents
PT1175429E (pt)	2003-11-28	Derivados halo de 9-desoxo-9a-aza-9a-homoeritromicina a
BR0015153A (pt)	2002-07-16	Derivados de higromicina
ATE298565T1 (de)	2005-07-15	N-formyl hydroxylamine derivate als inhibitoren der bakteriellen polypeptid deformylase zur behandlung von mikrobiellen infektionen
MX9302870A (es)	1994-02-28	Derivados de octahidronaftalenoxima para inhibicion de biosintesis de colesterol, su preparacion y uso.

Legal Events

Date	Code	Title	Description
2006-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties