ATE357230T1 - Neue prodrugs für antimicrobielle amidine - Google Patents
Neue prodrugs für antimicrobielle amidineInfo
- Publication number
- ATE357230T1 ATE357230T1 AT00950293T AT00950293T ATE357230T1 AT E357230 T1 ATE357230 T1 AT E357230T1 AT 00950293 T AT00950293 T AT 00950293T AT 00950293 T AT00950293 T AT 00950293T AT E357230 T1 ATE357230 T1 AT E357230T1
- Authority
- AT
- Austria
- Prior art keywords
- amidine
- antimicrobial
- new prodrugs
- prodrugs
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14282699P | 1999-07-08 | 1999-07-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE357230T1 true ATE357230T1 (de) | 2007-04-15 |
Family
ID=22501448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00950293T ATE357230T1 (de) | 1999-07-08 | 2000-07-06 | Neue prodrugs für antimicrobielle amidine |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6486200B1 (de) |
| EP (1) | EP1242059B1 (de) |
| JP (1) | JP2003504329A (de) |
| AT (1) | ATE357230T1 (de) |
| AU (1) | AU779923B2 (de) |
| CA (1) | CA2377902A1 (de) |
| DE (1) | DE60034063T2 (de) |
| ES (1) | ES2282127T3 (de) |
| WO (1) | WO2001003685A2 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4368582B2 (ja) * | 2001-01-13 | 2009-11-18 | ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 牛ウイルス性下痢ウイルス(bvdv)感染およびc型肝炎ウイルス(hcv)感染を処置するのに有用な化合物、方法、および組成物 |
| EP1837024A3 (de) * | 2001-01-13 | 2007-11-14 | University Of North Carolina At Chapel Hill | Verbindungen, Verfahren und Zusammensetzung zur Behandlung von Boviner Virusdiarrhoe-Virus (BVDV)-Infektion und Hepatitis-C-Virus (HCV)-Infektion |
| US7163955B2 (en) | 2001-01-13 | 2007-01-16 | The University Of North Carolina At Chapel Hill | Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection |
| US7232924B2 (en) | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
| US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US6951880B2 (en) | 2002-05-16 | 2005-10-04 | Genelabs Technologies, Inc. | Aryl and heteroaryl compounds as antibacterial and antifungal agents |
| AU2003295923B2 (en) * | 2002-11-27 | 2007-10-25 | Georgia State University Research Foundation, Inc. | Dicationic 2,5-diarylfuran aza-analogs as anti-protozoan agents |
| WO2005009377A2 (en) * | 2003-07-23 | 2005-02-03 | University Of Kentucky Research Foundation | Novel oral bioavailable prodrugs |
| US7262223B2 (en) | 2004-01-23 | 2007-08-28 | Neurochem (International) Limited | Amidine derivatives for treating amyloidosis |
| US7382516B2 (en) * | 2004-06-18 | 2008-06-03 | Angstrom, Inc. | Discretely controlled micromirror with multi-level positions |
| JP2008500965A (ja) * | 2004-03-17 | 2008-01-17 | エムペックス・ファーマシューティカルズ・インコーポレーテッド | 細菌の排出ポンプ阻害剤の使用および投与 |
| US7994225B2 (en) * | 2004-03-17 | 2011-08-09 | Rempex Pharmaceuticals, Inc. | Bacterial efflux pump inhibitors for the treatment of ophthalmic and otic infections |
| US7160946B2 (en) * | 2004-04-01 | 2007-01-09 | National Starch And Chemical Investment Holding Corporation | Method to improve high temperature cohesive strength with adhesive having multi-phase system |
| CN101351204B (zh) * | 2005-12-29 | 2011-01-12 | 富山化学工业株式会社 | 芳脒衍生物及其盐、以及含有它们的抗真菌药 |
| GB0619325D0 (en) * | 2006-09-30 | 2006-11-08 | Univ Strathclyde | New compounds |
| DE102007013855A1 (de) | 2007-03-20 | 2008-09-25 | Merck Patent Gmbh | Substituierte Tetrahydrochinoline |
| WO2009043902A1 (en) * | 2007-10-05 | 2009-04-09 | Universite De Mons Hainaut | Bisbenzimidazoles as antimalarial agents |
| WO2009151627A2 (en) * | 2008-06-12 | 2009-12-17 | The Charles Stark Draper Laboratory, Inc. | Endosome-disrupting compostions and conjugates |
| DE102009004204A1 (de) * | 2009-01-09 | 2010-07-15 | Christian-Albrechts-Universität Zu Kiel | Verfahren zur verbesserten Bioaktivierung von Arzneistoffen |
| EP2690832B1 (de) * | 2011-03-25 | 2019-11-13 | Nec Corporation | Kommunikationsvorrichtung, kommunikationssystem und kommunikationsverfahren |
| CN111646971B (zh) * | 2020-07-22 | 2022-05-31 | 河南省三生药业有限公司 | 一种合成4-(羟甲基)-5-甲基-[1,3]二氧杂环戊烯-2-酮的方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR76941B (de) * | 1980-11-07 | 1984-09-04 | Sumitomo Chemical Co | |
| YU45662B (sh) * | 1983-09-20 | 1992-07-20 | Berol Nobel (Suisse) S.A. | Postupak za dobijanje fenmedifama ili dezmedifama |
| US4595683A (en) * | 1984-04-27 | 1986-06-17 | William H. Rorer, Inc. | 3- and 5-[bicyclic ether or bicyclic alkylene thioether]alkylene amino thiatriazines, and their pharmaceutical uses |
| GB8714873D0 (en) * | 1987-06-25 | 1987-07-29 | Bp Chemicals Additives | Additives |
| US5260473A (en) * | 1991-04-29 | 1993-11-09 | Monsanto Company | Preparation of urethane and carbonate products |
| GB9206989D0 (en) * | 1992-03-31 | 1992-05-13 | Glaxo Group Ltd | Chemical compounds |
| US5521189A (en) | 1994-05-06 | 1996-05-28 | The University Of Nc At Ch | Methods of treating pneumocystis carinii pneumonia |
| US5668166A (en) * | 1995-06-07 | 1997-09-16 | Georgia State University Research Foundation, Inc. | Methods of inhibiting pneumocystis carinii pneumonia and compounds useful therefor |
| US5723495A (en) * | 1995-11-16 | 1998-03-03 | The University Of North Carolina At Chapel Hill | Benzamidoxime prodrugs as antipneumocystic agents |
| TWI238827B (en) * | 1995-12-21 | 2005-09-01 | Astrazeneca Ab | Prodrugs of thrombin inhibitors |
-
2000
- 2000-07-06 ES ES00950293T patent/ES2282127T3/es not_active Expired - Lifetime
- 2000-07-06 WO PCT/US2000/018499 patent/WO2001003685A2/en not_active Ceased
- 2000-07-06 AU AU63416/00A patent/AU779923B2/en not_active Ceased
- 2000-07-06 DE DE60034063T patent/DE60034063T2/de not_active Expired - Fee Related
- 2000-07-06 AT AT00950293T patent/ATE357230T1/de not_active IP Right Cessation
- 2000-07-06 EP EP00950293A patent/EP1242059B1/de not_active Expired - Lifetime
- 2000-07-06 CA CA002377902A patent/CA2377902A1/en not_active Abandoned
- 2000-07-06 JP JP2001508966A patent/JP2003504329A/ja not_active Withdrawn
- 2000-07-07 US US09/612,138 patent/US6486200B1/en not_active Expired - Fee Related
-
2001
- 2001-07-31 US US09/918,787 patent/US6503940B2/en not_active Expired - Fee Related
-
2002
- 2002-07-30 US US10/208,947 patent/US6649652B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6486200B1 (en) | 2002-11-26 |
| CA2377902A1 (en) | 2001-01-18 |
| JP2003504329A (ja) | 2003-02-04 |
| AU6341600A (en) | 2001-01-30 |
| US20020019437A1 (en) | 2002-02-14 |
| ES2282127T3 (es) | 2007-10-16 |
| DE60034063T2 (de) | 2007-07-26 |
| AU779923B2 (en) | 2005-02-17 |
| EP1242059A2 (de) | 2002-09-25 |
| EP1242059B1 (de) | 2007-03-21 |
| DE60034063D1 (de) | 2007-05-03 |
| WO2001003685A3 (en) | 2002-07-11 |
| WO2001003685A2 (en) | 2001-01-18 |
| US20030092755A1 (en) | 2003-05-15 |
| US6503940B2 (en) | 2003-01-07 |
| US6649652B2 (en) | 2003-11-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |