ATE30033T1 - Verfahren zur herstellung von retro-inverso polypeptiden in fester phase. - Google Patents

Verfahren zur herstellung von retro-inverso polypeptiden in fester phase.

Info

Publication number
ATE30033T1
ATE30033T1 AT83200889T AT83200889T ATE30033T1 AT E30033 T1 ATE30033 T1 AT E30033T1 AT 83200889 T AT83200889 T AT 83200889T AT 83200889 T AT83200889 T AT 83200889T AT E30033 T1 ATE30033 T1 AT E30033T1
Authority
AT
Austria
Prior art keywords
retro
inverso
production
bis
solid phase
Prior art date
Application number
AT83200889T
Other languages
English (en)
Inventor
Antonello Pessi
Massimo Pinori
Antonio Silvio Verdini
Giuseppe Claudio Viscomi
Original Assignee
Enichem Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enichem Spa filed Critical Enichem Spa
Application granted granted Critical
Publication of ATE30033T1 publication Critical patent/ATE30033T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT83200889T 1982-06-24 1983-06-17 Verfahren zur herstellung von retro-inverso polypeptiden in fester phase. ATE30033T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT22046/82A IT1190891B (it) 1982-06-24 1982-06-24 Metodo per la sintesi in fase solida di polipeptidi retroinvertiti
EP83200889A EP0097994B1 (de) 1982-06-24 1983-06-17 Verfahren zur Herstellung von retro-inverso Polypeptiden in fester Phase

Publications (1)

Publication Number Publication Date
ATE30033T1 true ATE30033T1 (de) 1987-10-15

Family

ID=11190672

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83200889T ATE30033T1 (de) 1982-06-24 1983-06-17 Verfahren zur herstellung von retro-inverso polypeptiden in fester phase.

Country Status (4)

Country Link
EP (1) EP0097994B1 (de)
AT (1) ATE30033T1 (de)
DE (1) DE3373908D1 (de)
IT (1) IT1190891B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI843837A7 (fi) * 1983-02-07 1984-09-28 Ab Haessle Entsyymi-inhibiittorit.
IT1164225B (it) * 1983-05-13 1987-04-08 Anic Spa Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione
IT1164240B (it) * 1983-05-25 1987-04-08 Anic Spa Decapeptide parzialmente retro-invertito inibitore specifico della renina con elevata resistenza alla idrolisi enzimatica
IT1164239B (it) * 1983-05-25 1987-04-08 Anic Spa Un retro-inverso analogo del decapeptide (5-14)dell'angiotensinogeno equino inibitore specifico della renina con elevata resistenza all'idrolisi enzimatica
US4668476A (en) * 1984-03-23 1987-05-26 Applied Biosystems, Inc. Automated polypeptide synthesis apparatus
IT1178789B (it) * 1984-12-21 1987-09-16 Assorenti Peptidi retro-invertiti analoghi del potenziatore della bradichinina bpp 5a
IT1178786B (it) * 1984-12-21 1987-09-16 Assorenti Analoghi retro-inverso parzialmente modificati della neurotensina
IT1184317B (it) * 1985-02-05 1987-10-28 Eniricerche Spa Retro-inverso analoghi del peptide potenziatore della bradichina bpp5a
IT1190389B (it) * 1985-09-19 1988-02-16 Eniricerche Spa Esapeptidi ad attivita' ipotensiva
IT1188206B (it) * 1985-11-28 1988-01-07 Eniricerche Spa Procedimento per la sintesi in fase solida di peptidi in cui almeno un legame ammidico e' retroinvertito
GB2187461A (en) * 1986-02-03 1987-09-09 Medical Res Council Monitoring method for the synthesis of a linear of amino acid residues
EP0253190B1 (de) * 1986-07-16 1992-12-30 ENIRICERCHE S.p.A. Teilweise retro-invertierte Analoge des Tuftsin, Methode zu ihrer Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten
IT1196500B (it) * 1986-07-16 1988-11-16 Eniricerche Spa Derivati dell'acido malonico e metodi per la loro sintesi
HUT71860A (en) 1992-08-27 1996-02-28 Deakin Res Ltd Retro-, inverso-, and retro-inverso synthetic peptide analogues
FR2717081B1 (fr) * 1994-03-14 1996-06-21 Centre Nat Rech Scient Rétropeptides, anticorps dirigés contre ces derniers, et leurs utilisations pour la vaccination et le diagnostic in vitro.
US6916904B2 (en) 2002-04-24 2005-07-12 Zolaris Biosciences, Llc Inhibition of immune complex formation
AU2005221187B2 (en) 2004-03-10 2011-09-01 Trinity Therapeutics, Inc. Method for inhibiting immune complex formation in a subjetc
WO2008124768A1 (en) 2007-04-09 2008-10-16 The General Hospital Corporation Hemojuvelin fusion proteins and uses thereof
TWI573806B (zh) 2008-04-17 2017-03-11 巴克斯歐塔公司 生物活性胜肽
MX2011000647A (es) 2008-07-18 2011-09-29 Trinity Therapeutics Inc Metodos para el tratamiento de infecciones por fiebre de dengue mediadas por el sistema inmunitario e intensificacion dependiente de anticuerpos de infecciones por fiebre de dengue, incluyendo fiebre hemorragica de dengue y sindrome de choque de deng
WO2012135081A2 (en) 2011-03-25 2012-10-04 Children's Medical Center Corporation Lin28-mediated control of let-7 biogenesis
US9486507B2 (en) 2011-06-10 2016-11-08 Biogen Ma Inc. Pro-coagulant compounds and methods of use thereof
CA3077804C (en) 2012-01-09 2023-07-25 Serpin Pharma, Llc Peptides and methods of using same
CN104619727B (zh) 2012-06-25 2019-04-05 布里格姆及妇女医院股份有限公司 靶向治疗
PL2968470T3 (pl) 2013-03-12 2021-05-31 The General Hospital Corporation Zmodyfikowane białka stanowiące substancję hamującą rozwój przewodów müllera (mis) i ich zastosowania do leczenia chorób
EP3065769A4 (de) 2013-11-08 2017-05-31 Biogen MA Inc. Prokoagulatorische fusionsverbindung
EP3194446B1 (de) 2014-09-18 2022-10-26 Cedars-Sinai Medical Center Zusammensetzungen und verfahren zur behandlung von fibrose
US12551526B2 (en) 2015-04-22 2026-02-17 Cedars-Sinai Medical Center Enterically delivered bitter oligopeptides for the treatment for type 2 diabetes
WO2017040287A1 (en) 2015-08-28 2017-03-09 Serpin Pharma, Llc Methods for treatment of diseases
WO2017075451A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
WO2017075478A2 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by use of immune cell gene signatures
WO2017075465A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
WO2018049025A2 (en) 2016-09-07 2018-03-15 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses
US12280088B2 (en) 2018-09-10 2025-04-22 Board Of Regents, The University Of Texas System Dry powder formulation of caveolin-1 peptides and methods of use thereof
EP3849580A4 (de) 2018-09-10 2022-06-15 Lung Therapeutics, Inc. Modifizierte peptidfragmente von cav-1-protein und deren verwendung zur behandlung von fibrose
US20220160814A1 (en) 2019-03-11 2022-05-26 Lung Therapeutics, Inc. Compositions and methods for protecting type 2 alveolar epithelial cells (aec2)
EP4507787A1 (de) 2022-04-13 2025-02-19 Paradigm Immunotherapeutics, Inc. Verfahren zur prävention oder behandlung von infektionen durch respiratorische viren mit sars-cov-2

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3862114A (en) * 1971-11-22 1975-01-21 Ici Australia Ltd Analogs of substance p

Also Published As

Publication number Publication date
DE3373908D1 (en) 1987-11-05
IT8222046A0 (it) 1982-06-24
IT1190891B (it) 1988-02-24
EP0097994B1 (de) 1987-09-30
EP0097994A2 (de) 1984-01-11
EP0097994A3 (en) 1985-11-27

Similar Documents

Publication Publication Date Title
ATE30033T1 (de) Verfahren zur herstellung von retro-inverso polypeptiden in fester phase.
Büllesbach et al. Total synthesis of human relaxin and human relaxin derivatives by solid-phase peptide synthesis and site-directed chain combination
Croft The amino acid sequence of γ-crystallin (fraction II) from calf lens
Sanger Chemistry of insulin: determination of the structure of insulin opens the way to greater understanding of life processes
US3929758A (en) Cyclization of cysteine-containing peptides
Kang et al. Amino acid sequence of cyanogen bromide peptides from the amino-terminal region of chick skin collagen
DeLange et al. Calf and Pea Histone IV: I. Amino acid compositions and the identical cooh-terminal 19-residue sequence
Han et al. The covalent structure of beef heart myoglobin
DE69129865D1 (de) Osteogene peptide
Katsoyannis Synthesis of Insulin: Availability of A and B chains readily leads to the synthesis of this protein.
ATE123063T1 (de) Peptide zur diagnose von htlv-iii-antikörpern, deren herstellung und verwendung.
DE3486154D1 (de) Cardiodilatin, ein neues peptidhormon und verfahren zu seiner herstellung.
Wuu et al. Amino acid sequence of porcine neurophysin-I
Dixon et al. The isolation and structure of α-melanocyte-stimulating hormone from horse pituitaries
HAN et al. The covalent structure of sheep‐heart myoglobin
BR112014026077B1 (pt) Método de síntese em fase sólida de uma cadeia b de insulina protegida, parcialmente protegida ou desprotegida ou um derivado da cadeia b de insulina, e método para preparação de um peptídeo da cadeia b de insulina
SU1423000A3 (ru) Способ получени пептидов
ES2044928T3 (es) Enzima alfa-amidante en terminal c y procedimiento para la produccion y el uso del mismo.
Peeters et al. Structural studies on rat prostatic binding protein: The primary structure of component C1 from subunit F
Poulsen et al. Partial amino acid sequence of the large subunit of ribulosebisphosphate carboxylase from barley
Davison et al. Identification of the sites in opsin modified by photoactivated azido [125I] iodobenzene
KATSOYANNIS Synthetic insulins
CN117466968A (zh) 一种多对二硫键多肽的合成方法
Timpl et al. Cyanogen bromide cleavage of bovine fibrinogen. Identification of a dimeric N-terminal peptide and two other disulfide containing fragments
D'Alessio et al. Ribonuclease BS-1: sequence of two cyanogen bromide peptides

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee