IT1164239B - Un retro-inverso analogo del decapeptide (5-14)dell'angiotensinogeno equino inibitore specifico della renina con elevata resistenza all'idrolisi enzimatica - Google Patents

Un retro-inverso analogo del decapeptide (5-14)dell'angiotensinogeno equino inibitore specifico della renina con elevata resistenza all'idrolisi enzimatica

Info

Publication number
IT1164239B
IT1164239B IT21281/83A IT2128183A IT1164239B IT 1164239 B IT1164239 B IT 1164239B IT 21281/83 A IT21281/83 A IT 21281/83A IT 2128183 A IT2128183 A IT 2128183A IT 1164239 B IT1164239 B IT 1164239B
Authority
IT
Italy
Prior art keywords
retro
angiotensinogen
decapeptide
equine
high resistance
Prior art date
Application number
IT21281/83A
Other languages
English (en)
Other versions
IT8321281A1 (it
IT8321281A0 (it
Inventor
Massimo Pinori
Antonio Silvio Verdini
Original Assignee
Anic Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anic Spa filed Critical Anic Spa
Publication of IT8321281A0 publication Critical patent/IT8321281A0/it
Priority to IT21281/83A priority Critical patent/IT1164239B/it
Priority to EP84200710A priority patent/EP0127234B1/en
Priority to AT84200710T priority patent/ATE29890T1/de
Priority to DE8484200710T priority patent/DE3466396D1/de
Priority to US06/612,798 priority patent/US4560505A/en
Priority to CA000454917A priority patent/CA1249699A/en
Priority to AU28553/84A priority patent/AU558572B2/en
Priority to JP59104834A priority patent/JPH0672153B2/ja
Publication of IT8321281A1 publication Critical patent/IT8321281A1/it
Application granted granted Critical
Publication of IT1164239B publication Critical patent/IT1164239B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/32—Modification to prevent enzymatic degradation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
IT21281/83A 1983-05-25 1983-05-25 Un retro-inverso analogo del decapeptide (5-14)dell'angiotensinogeno equino inibitore specifico della renina con elevata resistenza all'idrolisi enzimatica IT1164239B (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IT21281/83A IT1164239B (it) 1983-05-25 1983-05-25 Un retro-inverso analogo del decapeptide (5-14)dell'angiotensinogeno equino inibitore specifico della renina con elevata resistenza all'idrolisi enzimatica
EP84200710A EP0127234B1 (en) 1983-05-25 1984-05-17 A retro-inverso analogue of the (5-14) decapeptide of equine angiotensinogen, as a specific renin inhibitor with high resistance to enzymatic hydrolysis
AT84200710T ATE29890T1 (de) 1983-05-25 1984-05-17 Retroinversoanalog des (5-14)-decapeptids von equin angiotensinogen als spezifischer renininhibitor mit hoher bestaendigkeit gegenueber enzymatischer hydrolyse.
DE8484200710T DE3466396D1 (en) 1983-05-25 1984-05-17 A retro-inverso analogue of the (5-14) decapeptide of equine angiotensinogen, as a specific renin inhibitor with high resistance to enzymatic hydrolysis
US06/612,798 US4560505A (en) 1983-05-25 1984-05-22 Retro-inverso analog of the (5-14) decapeptide of equine angiotensinogen, as a specific renin inhibitor with high resistance to enzymatic hydrolysis
CA000454917A CA1249699A (en) 1983-05-25 1984-05-23 Retro-inverso analogue of the (5-14) decapeptide of equine angiotensinogen, as a specific renin inhibitor with high resistance to enzymatic hydrolysis
AU28553/84A AU558572B2 (en) 1983-05-25 1984-05-24 Retro-inverso analogue of the (5-14) decapeptide of equine angiotensinogen
JP59104834A JPH0672153B2 (ja) 1983-05-25 1984-05-25 ペプチド

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21281/83A IT1164239B (it) 1983-05-25 1983-05-25 Un retro-inverso analogo del decapeptide (5-14)dell'angiotensinogeno equino inibitore specifico della renina con elevata resistenza all'idrolisi enzimatica

Publications (3)

Publication Number Publication Date
IT8321281A0 IT8321281A0 (it) 1983-05-25
IT8321281A1 IT8321281A1 (it) 1984-11-25
IT1164239B true IT1164239B (it) 1987-04-08

Family

ID=11179480

Family Applications (1)

Application Number Title Priority Date Filing Date
IT21281/83A IT1164239B (it) 1983-05-25 1983-05-25 Un retro-inverso analogo del decapeptide (5-14)dell'angiotensinogeno equino inibitore specifico della renina con elevata resistenza all'idrolisi enzimatica

Country Status (8)

Country Link
US (1) US4560505A (it)
EP (1) EP0127234B1 (it)
JP (1) JPH0672153B2 (it)
AT (1) ATE29890T1 (it)
AU (1) AU558572B2 (it)
CA (1) CA1249699A (it)
DE (1) DE3466396D1 (it)
IT (1) IT1164239B (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1190389B (it) * 1985-09-19 1988-02-16 Eniricerche Spa Esapeptidi ad attivita' ipotensiva
EP0253190B1 (en) * 1986-07-16 1992-12-30 ENIRICERCHE S.p.A. Partially retro-inverted tuftsin analogues, method for the preparation thereof and pharmaceutical compositions containing them
EP0326364B1 (en) * 1988-01-26 1994-06-22 Sankyo Company Limited Renin inhibitory oligopeptides, their preparation and use
US5807979A (en) * 1988-04-08 1998-09-15 The Scripps Research Institute Synthetic, three-dimensionally stabilized polypeptide mimics of HIV
WO1989009783A1 (en) * 1988-04-08 1989-10-19 Scripps Clinic And Research Foundation Polypeptides stabilized by covalent hydrogen bond replacements
DE4004820A1 (de) * 1989-08-05 1991-04-25 Bayer Ag Renininhibitoren, verfahren zur herstellung und ihre verwendung in arzneimitteln
US5242903A (en) * 1989-08-05 1993-09-07 Bayer Aktiengesellschaft Renin inhibitors
US6458357B1 (en) 1997-09-09 2002-10-01 Myelos Corporation Retro-inverso neurotrophic and analgesic peptides
NZ567952A (en) * 2003-03-24 2009-12-24 Sequoia Pharmaceuticals Inc Long acting biologically active conjugates

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4269827A (en) * 1980-06-23 1981-05-26 The Massachusetts General Hospital Process and composition for reducing blood pressure
NO812612L (no) * 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
JPS5759846A (en) * 1980-08-06 1982-04-10 Ferring Pharma Ltd Polypeptide homologue and manufacture of hydroxy or keto homologue of dipeptide
IT1212508B (it) * 1981-12-22 1989-11-22 Anic Spa Analoghi retro - invertiti dei penta - ed esapeptidi c - terminali della sostanza p. utili come vasodilatatori
IT1190891B (it) * 1982-06-24 1988-02-24 Anic Spa Metodo per la sintesi in fase solida di polipeptidi retroinvertiti

Also Published As

Publication number Publication date
US4560505A (en) 1985-12-24
JPH0672153B2 (ja) 1994-09-14
EP0127234A2 (en) 1984-12-05
CA1249699A (en) 1989-01-31
EP0127234B1 (en) 1987-09-23
JPS59231055A (ja) 1984-12-25
IT8321281A1 (it) 1984-11-25
DE3466396D1 (en) 1987-10-29
EP0127234A3 (en) 1985-09-04
AU2855384A (en) 1984-11-29
IT8321281A0 (it) 1983-05-25
AU558572B2 (en) 1987-02-05
ATE29890T1 (de) 1987-10-15

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