ATE300531T1 - Isonipecotamide zur behandlung von integrin vermittelten störungen - Google Patents
Isonipecotamide zur behandlung von integrin vermittelten störungenInfo
- Publication number
- ATE300531T1 ATE300531T1 AT00966823T AT00966823T ATE300531T1 AT E300531 T1 ATE300531 T1 AT E300531T1 AT 00966823 T AT00966823 T AT 00966823T AT 00966823 T AT00966823 T AT 00966823T AT E300531 T1 ATE300531 T1 AT E300531T1
- Authority
- AT
- Austria
- Prior art keywords
- isonipecotamide
- integrin
- treatment
- mediated disorders
- mediated
- Prior art date
Links
- DPBWFNDFMCCGGJ-UHFFFAOYSA-N 4-Piperidine carboxamide Chemical compound NC(=O)C1CCNCC1 DPBWFNDFMCCGGJ-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15661799P | 1999-09-29 | 1999-09-29 | |
| US66713400A | 2000-09-21 | 2000-09-21 | |
| PCT/US2000/026163 WO2001023376A1 (en) | 1999-09-29 | 2000-09-22 | Isonipecotamides for the treatment of integrin-mediated disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE300531T1 true ATE300531T1 (de) | 2005-08-15 |
Family
ID=26853350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00966823T ATE300531T1 (de) | 1999-09-29 | 2000-09-22 | Isonipecotamide zur behandlung von integrin vermittelten störungen |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7718673B2 (de) |
| EP (1) | EP1133489B9 (de) |
| CN (1) | CN1352641A (de) |
| AR (1) | AR034098A1 (de) |
| AT (1) | ATE300531T1 (de) |
| AU (1) | AU7711000A (de) |
| BR (1) | BR0007183A (de) |
| CA (1) | CA2352957A1 (de) |
| CZ (1) | CZ20011872A3 (de) |
| DE (2) | DE60021521D1 (de) |
| ES (1) | ES2244474T3 (de) |
| HU (1) | HUP0200439A2 (de) |
| NO (1) | NO20012612L (de) |
| NZ (1) | NZ511997A (de) |
| PL (1) | PL347976A1 (de) |
| RU (1) | RU2001114518A (de) |
| WO (1) | WO2001023376A1 (de) |
| YU (1) | YU22802A (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE196759T1 (de) | 1990-11-19 | 2000-10-15 | Monsanto Co | Inhibitoren retroviraler proteasen |
| EP1539744A4 (de) | 2002-07-11 | 2007-06-06 | Vicuron Pharm Inc | N-hydroxyamidderivate mit antibakterieller wirkung |
| US20040224986A1 (en) | 2002-08-16 | 2004-11-11 | Bart De Corte | Piperidinyl targeting compounds that selectively bind integrins |
| AU2005229015C1 (en) * | 2004-04-02 | 2013-01-17 | The Regents Of The University Of California | Methods and compositions for treating and preventing disease associated with alphaVbeta5 integrin |
| AU2009246572A1 (en) * | 2008-05-16 | 2009-11-19 | Allergan, Inc. | Selective subtype alpha 2 adrenergic agents and methods for use thereof |
| EP2456460A4 (de) | 2009-07-24 | 2013-02-20 | Univ California | Verfahren und zusammensetzungen zur behandlung und prävention von mit avb5-integrin assoziierten krankheiten |
| MX2019008171A (es) * | 2017-01-09 | 2020-02-05 | Ardelyx Inc | Inhibidores del antiporte mediado por nhe. |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2830555A1 (de) | 1978-07-12 | 1980-03-06 | Bayer Ag | Chinazolinonyl-verbindungen |
| GB8829296D0 (en) | 1988-12-15 | 1989-01-25 | Ici Plc | Anti-tumour compounds |
| JPH04334357A (ja) * | 1991-05-02 | 1992-11-20 | Fujirebio Inc | 酵素阻害作用を有するアシル誘導体 |
| US5352667A (en) | 1991-11-22 | 1994-10-04 | Ofer Lider | Non-peptidic surrogates of the Arg-Gly-Asp sequence and pharmaceutical compositions comprising them |
| DE4208051A1 (de) * | 1992-03-13 | 1993-09-16 | Bayer Ag | Substituierte phenylessigsaeureamide |
| JPH08504194A (ja) | 1992-12-01 | 1996-05-07 | メルク エンド カンパニー インコーポレーテッド | フィブリノーゲンレセプターアンタゴニスト |
| US6268380B1 (en) | 1993-02-19 | 2001-07-31 | G. D. Searle & Co. | Urea derivatives useful as platelet aggregation inhibitors |
| DE4309867A1 (de) | 1993-03-26 | 1994-09-29 | Cassella Ag | Neue Harnstoffderivate, ihre Herstellung und Verwendung |
| GB9313268D0 (en) | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Chemical compounds |
| DE69429328T2 (de) | 1993-09-22 | 2002-06-13 | Fujisawa Pharmaceutical Co., Ltd. | N-(3-piperidinylcarbonyl)-b-alanin derivate als paf-antagonisten |
| JPH10501222A (ja) | 1994-05-27 | 1998-02-03 | メルク エンド カンパニー インコーポレーテッド | 破骨細胞仲介骨吸収を抑制するための化合物 |
| EP0799202A1 (de) * | 1994-12-23 | 1997-10-08 | Dr. Karl Thomae GmbH | Piperazinderivate, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| US5700801A (en) * | 1994-12-23 | 1997-12-23 | Karl Thomae, Gmbh | Piperazine derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them |
| US5602155A (en) | 1995-01-17 | 1997-02-11 | G. D. Searle & Co. | Platelet aggregation inhibitors |
| ATE308981T1 (de) | 1995-08-14 | 2005-11-15 | Scripps Research Inst | Verfahren und mittel zur hemmung der durch alpha v beta 5 vermittelten angiogenese |
| IL123164A (en) | 1995-08-30 | 2001-03-19 | Searle & Co | Meta-guanidine urea thiourea or azacyclic amino benzoic acid derivatives and pharmaceutical compositions containing them |
| US6100423A (en) | 1995-08-30 | 2000-08-08 | G. D. Searle & Co. | Amino benzenepropanoic acid compounds and derivatives thereof |
| JPH11513382A (ja) | 1995-10-20 | 1999-11-16 | ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング | ５員複素環化合物、これらの化合物を含む医薬品、それらの使用及びそれらの調製方法 |
| DE19548709A1 (de) | 1995-12-23 | 1997-07-03 | Merck Patent Gmbh | Tyrosinderivate |
| DE69710319T2 (de) | 1996-03-29 | 2002-08-14 | G.D. SEARLE & CO., CHICAGO | Para-substituierte phenylpropansäure derivate als integrin-antagonisten |
| ES2243996T3 (es) | 1996-05-01 | 2005-12-01 | Ortho-Mcneil Pharmaceutical, Inc. | Derivados carboxamida de pirrolidina, piperidina y hexahidroazepina utilizados en el tratamiento de trastornos de trombosis. |
| DE19642591A1 (de) | 1996-10-15 | 1998-04-16 | Basf Ag | Neue Piperidin-Ketocarbonsäure-Derivate, deren Herstellung und Anwendung |
| JP3841898B2 (ja) * | 1996-11-21 | 2006-11-08 | 三菱電機株式会社 | 深部線量測定装置 |
| WO1998025892A1 (en) | 1996-12-09 | 1998-06-18 | Eli Lilly And Company | Integrin antagonists |
| AR011913A1 (es) | 1997-03-06 | 2000-09-13 | Yamano Masaki | Derivados de 4,4-difluoro-2,3,4,5-tetrahidro-1h-1-benzoazepina y composiciones farmaceuticas de los mismos. |
| CN1280574A (zh) | 1997-10-27 | 2001-01-17 | 雷迪研究基金会 | 新的杂环化合物及其在医药中的应用、它们的制备方法和含有它们的药物组合物 |
| US6066651A (en) | 1997-10-29 | 2000-05-23 | Ortho-Mcneil Pharmaceutical, Inc. | Orally-active nipecotamide glycolamide esters for the treatment of thrombosis disorders |
| AU1415099A (en) | 1997-11-18 | 1999-06-07 | Merck & Co., Inc. | 4-substituted-4-piperidine carboxamide derivatives |
| JP2003504301A (ja) | 1998-04-01 | 2003-02-04 | ブリストル−マイヤーズ スクイブ ファーマ カンパニー | インテグリンアンタゴニスト |
| JP4142253B2 (ja) | 1998-05-11 | 2008-09-03 | ノボ ノルディスク アクティーゼルスカブ | 成長ホルモン放出特性を有する化合物 |
| TW591026B (en) * | 1998-06-23 | 2004-06-11 | Upjohn Co | Inhibitors of alpha4beta1 mediated cell adhesion |
| US6388054B1 (en) | 1998-08-20 | 2002-05-14 | John M. Stewart | Anti-cancer compounds |
| WO2000033836A1 (en) | 1998-12-04 | 2000-06-15 | Ontogen Corporation | 5-membered heterocycles for the treatment of human diseases involving modulators of selectins |
| AU6523200A (en) | 1999-08-06 | 2001-03-05 | Smithkline Beecham Corporation | Vitronectin receptor antagonists useful for the treatment of strokes |
| JP2003506562A (ja) | 1999-08-10 | 2003-02-18 | ザ、プロクター、エンド、ギャンブル、カンパニー | 洗浄水溶性低密度フィラー粒子を含有する非水性液体洗剤 |
-
2000
- 2000-09-22 CZ CZ20011872A patent/CZ20011872A3/cs unknown
- 2000-09-22 ES ES00966823T patent/ES2244474T3/es not_active Expired - Lifetime
- 2000-09-22 DE DE60021521A patent/DE60021521D1/de not_active Expired - Fee Related
- 2000-09-22 DE DE60021521T patent/DE60021521T4/de not_active Expired - Lifetime
- 2000-09-22 NZ NZ511997A patent/NZ511997A/xx unknown
- 2000-09-22 PL PL00347976A patent/PL347976A1/xx not_active Application Discontinuation
- 2000-09-22 EP EP00966823A patent/EP1133489B9/de not_active Expired - Lifetime
- 2000-09-22 CA CA002352957A patent/CA2352957A1/en not_active Abandoned
- 2000-09-22 BR BR0007183-8A patent/BR0007183A/pt not_active IP Right Cessation
- 2000-09-22 WO PCT/US2000/026163 patent/WO2001023376A1/en not_active Ceased
- 2000-09-22 AT AT00966823T patent/ATE300531T1/de not_active IP Right Cessation
- 2000-09-22 RU RU2001114518/04A patent/RU2001114518A/ru not_active Application Discontinuation
- 2000-09-22 HU HU0200439A patent/HUP0200439A2/hu unknown
- 2000-09-22 CN CN00803033A patent/CN1352641A/zh active Pending
- 2000-09-22 AU AU77110/00A patent/AU7711000A/en not_active Abandoned
- 2000-09-28 AR ARP000105121A patent/AR034098A1/es unknown
- 2000-09-29 YU YU22802A patent/YU22802A/sh unknown
-
2001
- 2001-05-28 NO NO20012612A patent/NO20012612L/no not_active Application Discontinuation
-
2003
- 2003-01-16 US US10/345,808 patent/US7718673B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PL347976A1 (en) | 2002-05-06 |
| CN1352641A (zh) | 2002-06-05 |
| EP1133489A1 (de) | 2001-09-19 |
| WO2001023376A1 (en) | 2001-04-05 |
| EP1133489B1 (de) | 2005-07-27 |
| US20030181440A1 (en) | 2003-09-25 |
| US7718673B2 (en) | 2010-05-18 |
| CA2352957A1 (en) | 2001-04-05 |
| AU7711000A (en) | 2001-04-30 |
| BR0007183A (pt) | 2002-02-05 |
| HUP0200439A2 (en) | 2002-06-29 |
| YU22802A (sh) | 2005-06-10 |
| DE60021521T4 (de) | 2006-09-21 |
| DE60021521D1 (de) | 2005-09-01 |
| NO20012612L (no) | 2001-07-17 |
| NO20012612D0 (no) | 2001-05-28 |
| RU2001114518A (ru) | 2003-04-20 |
| ES2244474T3 (es) | 2005-12-16 |
| EP1133489B9 (de) | 2006-05-03 |
| CZ20011872A3 (cs) | 2002-03-13 |
| DE60021521T2 (de) | 2006-06-08 |
| NZ511997A (en) | 2004-12-24 |
| AR034098A1 (es) | 2004-02-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60019556D1 (de) | 2-amino-benzoxazinonderivate zur behandlung von fettleibigkeit | |
| DE60019555D1 (de) | 2-oxy-benzoxazinonderivate zur behandlung von fettleibigkeit | |
| DE60028358D1 (de) | Hmg1 antagonisten zur behandlung von entzündungen | |
| DE60023873D1 (de) | Mittel zur behandlung von erkrankungen der speiseröhre | |
| DE60023128D1 (de) | Pyrazolecarboxamide zur behandlung von fettleibigkeit und anderen erkrankungen | |
| DE50009504D1 (de) | Verwendung von retigabin zur behandlung von neuropathischen schmerzen | |
| ATE275145T1 (de) | Chinazolinderivate zur behandlung von tumoren | |
| ATE394103T1 (de) | Verwendung von rosuvastatin (zd-4522) zur behandlung von heterozygoter familiärer hypercholesterolämie | |
| DE60019158D1 (de) | Neue oxabispidin-verbindungen zur behandlung von herzarrhythmien | |
| DE60136477D1 (de) | Retinoide zur behandlung von emphysem | |
| DE50014041D1 (de) | Verwendung von epinastin zur behandlung von allergischer rhinitis/konjunktivitis | |
| DE69925865D1 (de) | 4-(aminomethyl)-piperidinbenzamide zur behandlung von gastrointestinalen störungen | |
| DE60030554T8 (de) | Verwendungen von et743 zur behandlung von krebs | |
| ATE279386T1 (de) | Retinoide zur behandlung von emphysem | |
| EP1117431A4 (de) | Behandlung von acidose | |
| DE60027429D1 (de) | Dihydrobenzodiazepinen und deren verwendung zur behandlung von dyslipidämien | |
| DE50105735D1 (de) | Chlorzoxazon zur behandlung von psoriasis | |
| DE60104791D1 (de) | Cyclobutendion-Derivate zur Behandlung von Artherosclerose | |
| DE60021252D1 (de) | Antikonvulsiva zur behandlung von autismus | |
| DE60001255D1 (de) | Zusammensetzung zur Behandlung von Polyesterfaser | |
| ATE253578T1 (de) | Oxazinochinolone zur behandlung von viralen infektionen | |
| ATE300531T1 (de) | Isonipecotamide zur behandlung von integrin vermittelten störungen | |
| DE60117122D1 (de) | Verwendung von mirtazapin zur behandlung von schlafstörungen | |
| ATE230741T1 (de) | 3-tetrahydropyridin-4-yl-indole zur behandlung von psychotischen störungen | |
| ATE251167T1 (de) | Oxazinocarbazole zur behandlung von cns- erkrankungen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |