ATE155788T1 - Verfahren zur herstellung von rufloxacin und salze davon - Google Patents
Verfahren zur herstellung von rufloxacin und salze davonInfo
- Publication number
- ATE155788T1 ATE155788T1 AT94931550T AT94931550T ATE155788T1 AT E155788 T1 ATE155788 T1 AT E155788T1 AT 94931550 T AT94931550 T AT 94931550T AT 94931550 T AT94931550 T AT 94931550T AT E155788 T1 ATE155788 T1 AT E155788T1
- Authority
- AT
- Austria
- Prior art keywords
- rufloxacin
- salts
- pct
- formula
- producing
- Prior art date
Links
- 229960004062 rufloxacin Drugs 0.000 title abstract 3
- NJCJBUHJQLFDSW-UHFFFAOYSA-N Rufloxacin Chemical compound C1CN(C)CCN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN3CCSC1=C32 NJCJBUHJQLFDSW-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- IDOOHFNLEQZVKF-UHFFFAOYSA-N 2-quinolin-2-ylethanethiol Chemical compound C1=CC=CC2=NC(CCS)=CC=C21 IDOOHFNLEQZVKF-UHFFFAOYSA-N 0.000 abstract 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- -1 rufloxacin ester Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI932286A IT1270836B (it) | 1993-10-27 | 1993-10-27 | Procedimento per la preparazione di rufloxacina e suoi sali |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE155788T1 true ATE155788T1 (de) | 1997-08-15 |
Family
ID=11367102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94931550T ATE155788T1 (de) | 1993-10-27 | 1994-10-26 | Verfahren zur herstellung von rufloxacin und salze davon |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5731433A (de) |
| EP (1) | EP0725785B1 (de) |
| JP (1) | JPH09504283A (de) |
| AT (1) | ATE155788T1 (de) |
| DE (1) | DE69404476T2 (de) |
| DK (1) | DK0725785T3 (de) |
| ES (1) | ES2105780T3 (de) |
| IT (1) | IT1270836B (de) |
| WO (1) | WO1995011907A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2467321A1 (en) * | 2004-05-14 | 2005-11-14 | Paul J. Santerre | Polymeric coupling agents and pharmaceutically-active polymers made therefrom |
| EP3740494A4 (de) | 2018-02-02 | 2021-11-03 | Ripple Therapeutics Corporation | Glasformulierungen mit steroid-dimeren und verwendungen davon |
| WO2020154815A1 (en) | 2019-02-01 | 2020-08-06 | Ripple Therapeutics Corporation | Crystalline forms of dexamethasone dimers and uses thereof |
| US12509469B2 (en) | 2019-08-07 | 2025-12-30 | Ripple Therapeutics Corporation | Compositions and methods for the treatment of pain and dependence disorders |
| CA3176134A1 (en) | 2020-05-01 | 2021-11-04 | Ripple Therapeutics Corporation | Heterodimer compositions and methods for the treatment of ocular disorders |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3517709A1 (de) * | 1985-01-05 | 1986-07-10 | Bayer Ag | Basische zubereitungen von chinoloncarbonsaeuren |
| JPH0228178A (ja) * | 1988-04-23 | 1990-01-30 | Toyama Chem Co Ltd | 新規なピリドンカルボン酸誘導体およびその塩並びにそれらの製造法 |
| IT1248011B (it) * | 1991-06-07 | 1995-01-05 | Mediolanum Farmaceutici Spa | Procedimento per la preparazione dell'acido 9-fluoro-10- (4-metil-1-piperazinil)-7-oxo-2,3-diidro-7h-pirido (1,2,3-de) (1,4)benzotiadin-6-carbossilico cloridrato. |
-
1993
- 1993-10-27 IT ITMI932286A patent/IT1270836B/it active IP Right Grant
-
1994
- 1994-10-26 JP JP7512408A patent/JPH09504283A/ja active Pending
- 1994-10-26 EP EP94931550A patent/EP0725785B1/de not_active Expired - Lifetime
- 1994-10-26 AT AT94931550T patent/ATE155788T1/de not_active IP Right Cessation
- 1994-10-26 ES ES94931550T patent/ES2105780T3/es not_active Expired - Lifetime
- 1994-10-26 DK DK94931550.1T patent/DK0725785T3/da active
- 1994-10-26 DE DE69404476T patent/DE69404476T2/de not_active Expired - Fee Related
- 1994-10-26 WO PCT/EP1994/003512 patent/WO1995011907A1/en not_active Ceased
- 1994-10-26 US US08/632,426 patent/US5731433A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0725785A1 (de) | 1996-08-14 |
| ITMI932286A1 (it) | 1995-04-27 |
| WO1995011907A1 (en) | 1995-05-04 |
| DE69404476T2 (de) | 1997-12-04 |
| US5731433A (en) | 1998-03-24 |
| DE69404476D1 (de) | 1997-09-04 |
| DK0725785T3 (da) | 1998-02-23 |
| JPH09504283A (ja) | 1997-04-28 |
| ES2105780T3 (es) | 1997-10-16 |
| EP0725785B1 (de) | 1997-07-23 |
| ITMI932286A0 (it) | 1993-10-27 |
| IT1270836B (it) | 1997-05-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEFA | Change of the company name | ||
| REN | Ceased due to non-payment of the annual fee |