IS2274B - Aðferð til að búa til kamptóþesín afleiður - Google Patents

Aðferð til að búa til kamptóþesín afleiður

Info

Publication number: IS2274B
Authority: IS; Iceland
Prior art keywords: pct; date; camptothecin derivatives; sec; formula
Prior art date: 1995-11-02

Application number

IS4730A

Other languages

English (en)

Other versions

IS4730A (is

Inventor

Gerard Fang Francis

Xie Shiping

Original Assignee

Osi Pharmaceuticals, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-02

Filing date

1998-04-29

Publication date

2007-09-15

1998-04-29 Application filed by Osi Pharmaceuticals, Inc. filed Critical Osi Pharmaceuticals, Inc.

1998-04-29 Publication of IS4730A publication Critical patent/IS4730A/is

2007-09-15 Publication of IS2274B publication Critical patent/IS2274B/is

Links

VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 3
KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 abstract 1
229940127093 camptothecin Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IS4730A 1995-11-02 1998-04-29 Aðferð til að búa til kamptóþesín afleiður IS2274B (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US613895P	1995-11-02	1995-11-02
PCT/US1996/017574 WO1997016454A1 (en)	1995-11-02	1996-11-01	Method for preparing camptothecin derivatives

Publications (2)

Publication Number	Publication Date
IS4730A IS4730A (is)	1998-04-29
IS2274B true IS2274B (is)	2007-09-15

Family

ID=21719492

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS4730A IS2274B (is)	1995-11-02	1998-04-29	Aðferð til að búa til kamptóþesín afleiður

Country Status (17)

Country	Link
US (2)	US6143891A (is)
EP (1)	EP0876373B1 (is)
JP (1)	JP3499246B2 (is)
AT (1)	ATE301659T1 (is)
AU (1)	AU717315B2 (is)
CA (1)	CA2236420A1 (is)
CZ (1)	CZ133898A3 (is)
DE (1)	DE69635057T2 (is)
EA (1)	EA001400B1 (is)
ES (1)	ES2247606T3 (is)
HU (1)	HUP9802407A3 (is)
IL (1)	IL124287A (is)
IS (1)	IS2274B (is)
NO (1)	NO324308B1 (is)
NZ (1)	NZ322318A (is)
PL (1)	PL186540B1 (is)
WO (1)	WO1997016454A1 (is)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5491237A (en) *	1994-05-03	1996-02-13	Glaxo Wellcome Inc.	Intermediates in pharmaceutical camptothecin preparation
US6716982B2 (en)	1995-11-02	2004-04-06	Osi Pharmaceuticals, Inc.	Method for preparing camptothecin derivatives
US6559309B2 (en)	1996-11-01	2003-05-06	Osi Pharmaceuticals, Inc.	Preparation of a camptothecin derivative by intramolecular cyclisation
US6288072B1 (en) *	1999-12-29	2001-09-11	Monroe E. Wall	Camptothecin β-alanine esters with topoisomerase I inhibition
AR035684A1 (es)	2001-02-21	2004-06-23	Yakult Honsha Kk	Procedimiento para preparar 2'-amino-5'-hidroxipropiofenona, uso de la misma para la preparacion de analogos de camptotecina, procedimiento para prepararlos, compuestos intermediarios, procedimiento para preparar una cetona triciclica utilizada en la sintesis de analogos de camptotecina
AU2003207369A1 (en) *	2002-02-18	2003-09-04	Dr. Reddy's Laboratories Limited	A process for the preparation of 10-hydroxy-9-n,n-dimethylaminomethyl-5-(2'-fluoroethoxy)-20(s)-camptothecin hydrochloride
US6593334B1 (en)	2002-05-02	2003-07-15	The University Of North Carolina At Chapel Hill	Camptothecin-taxoid conjugates as antimitotic and antitumor agents
US7067666B2 (en) *	2003-06-27	2006-06-27	Research Triangle Institute	7-substituted camptothecin and camptothecin analogs and methods for producing the same
US20070207149A1 (en)	2004-04-27	2007-09-06	Wellstat Biologics Corporation	Cancer treatment using viruses and camptothecins
US7767200B2 (en)	2005-07-14	2010-08-03	Wellstat Biologics Corporation	Cancer treatment using viruses, fluoropyrimidines and camptothecins
CN103288842B (zh) *	2012-02-24	2016-01-13	中国人民解放军第二军医大学	氟取代e环喜树碱类似物及其作为药物的用途
AU2016326747A1 (en)	2015-09-25	2018-03-01	Zy Therapeutics Inc.	Drug formulation based on particulates comprising polysaccharide-vitamin conjugate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE913790A1 (en) *	1990-10-31	1992-05-22	Smithkline Beecham Corp	SUBSTITUTED INDOLIZINO [1,2-b]QUINOLINONES
WO1993016698A1 (en) *	1992-02-21	1993-09-02	Smithkline Beecham Corporation	SUBSTITUTED FURO[3',4':6,7]INDOLIZINO[1,2-b]QUINOLINONES

1996
- 1996-11-01 JP JP51758897A patent/JP3499246B2/ja not_active Expired - Fee Related
- 1996-11-01 CZ CZ981338A patent/CZ133898A3/cs unknown
- 1996-11-01 NZ NZ322318A patent/NZ322318A/xx unknown
- 1996-11-01 IL IL12428796A patent/IL124287A/en not_active IP Right Cessation
- 1996-11-01 EA EA199800354A patent/EA001400B1/ru not_active IP Right Cessation
- 1996-11-01 US US09/068,185 patent/US6143891A/en not_active Expired - Fee Related
- 1996-11-01 DE DE69635057T patent/DE69635057T2/de not_active Expired - Fee Related
- 1996-11-01 CA CA002236420A patent/CA2236420A1/en not_active Abandoned
- 1996-11-01 ES ES96938728T patent/ES2247606T3/es not_active Expired - Lifetime
- 1996-11-01 PL PL96326869A patent/PL186540B1/pl not_active IP Right Cessation
- 1996-11-01 HU HU9802407A patent/HUP9802407A3/hu unknown
- 1996-11-01 AT AT96938728T patent/ATE301659T1/de not_active IP Right Cessation
- 1996-11-01 AU AU76038/96A patent/AU717315B2/en not_active Ceased
- 1996-11-01 EP EP96938728A patent/EP0876373B1/en not_active Expired - Lifetime
- 1996-11-01 WO PCT/US1996/017574 patent/WO1997016454A1/en not_active Ceased
1998
- 1998-04-29 IS IS4730A patent/IS2274B/is unknown
- 1998-04-30 NO NO19981970A patent/NO324308B1/no unknown
2000
- 2000-08-15 US US09/638,945 patent/US6284891B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IL124287A (en)	2004-06-01
AU717315B2 (en)	2000-03-23
ATE301659T1 (de)	2005-08-15
NZ322318A (en)	2000-01-28
DE69635057D1 (de)	2005-09-15
PL326869A1 (en)	1998-10-26
EA199800354A1 (ru)	1999-02-25
JP3499246B2 (ja)	2004-02-23
IS4730A (is)	1998-04-29
US6143891A (en)	2000-11-07
EP0876373A1 (en)	1998-11-11
EP0876373B1 (en)	2005-08-10
CZ133898A3 (cs)	1998-08-12
JPH11515028A (ja)	1999-12-21
DE69635057T2 (de)	2006-06-01
ES2247606T3 (es)	2006-03-01
PL186540B1 (pl)	2004-01-30
US6284891B1 (en)	2001-09-04
HUP9802407A1 (hu)	1999-04-28
CA2236420A1 (en)	1997-05-09
NO981970D0 (no)	1998-04-30
NO981970L (no)	1998-06-30
EA001400B1 (ru)	2001-02-26
NO324308B1 (no)	2007-09-24
AU7603896A (en)	1997-05-22
HUP9802407A3 (en)	2000-01-28
WO1997016454A1 (en)	1997-05-09

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