ATE302275T1 - Hämatopoietisches fusionsprotein multivariantes il-3 enthaltend - Google Patents

Hämatopoietisches fusionsprotein multivariantes il-3 enthaltend

Info

Publication number
ATE302275T1
ATE302275T1 AT95910141T AT95910141T ATE302275T1 AT E302275 T1 ATE302275 T1 AT E302275T1 AT 95910141 T AT95910141 T AT 95910141T AT 95910141 T AT95910141 T AT 95910141T AT E302275 T1 ATE302275 T1 AT E302275T1
Authority
AT
Austria
Prior art keywords
fusion protein
amino acids
given
multivariant
terminus
Prior art date
Application number
AT95910141T
Other languages
English (en)
Inventor
Christopher S Bauer
Mark Allen Abrams
Sarah Ruth Braford-Goldberg
Marie Helena Caparon
Alan Michael Easton
Barbara Kure Klein
Kearn John Patrick Mc
Peter O Olins
Kumnan Paik
John Warren Thomas
Original Assignee
Searle Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle Llc filed Critical Searle Llc
Application granted granted Critical
Publication of ATE302275T1 publication Critical patent/ATE302275T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
AT95910141T 1994-02-04 1995-02-02 Hämatopoietisches fusionsprotein multivariantes il-3 enthaltend ATE302275T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/192,325 US6057133A (en) 1992-11-24 1994-02-04 Multivariant human IL-3 fusion proteins and their recombinant production
PCT/US1995/001185 WO1995021254A1 (en) 1994-02-04 1995-02-02 Multivariant il-3 hematopoiesis fusion protein

Publications (1)

Publication Number Publication Date
ATE302275T1 true ATE302275T1 (de) 2005-09-15

Family

ID=22709185

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95910141T ATE302275T1 (de) 1994-02-04 1995-02-02 Hämatopoietisches fusionsprotein multivariantes il-3 enthaltend

Country Status (17)

Country Link
US (3) US6057133A (de)
EP (2) EP1482044A3 (de)
JP (1) JPH10502801A (de)
KR (1) KR100370264B1 (de)
CN (1) CN1227604A (de)
AT (1) ATE302275T1 (de)
BR (1) BR9506733A (de)
CA (1) CA2182484A1 (de)
CZ (1) CZ289904B6 (de)
DE (1) DE69534381T2 (de)
FI (1) FI963072L (de)
MX (1) MX9603205A (de)
NO (1) NO963225L (de)
NZ (2) NZ330060A (de)
PL (1) PL315791A1 (de)
RO (1) RO118016B1 (de)
WO (1) WO1995021254A1 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5581476A (en) 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
WO1996023888A1 (en) * 1995-02-03 1996-08-08 G.D. Searle & Co. NOVEL c-MPL LIGANDS
PL184424B1 (pl) * 1995-10-05 2002-10-31 Searle & Co Agoniści krwiotwórczych receptorów wieloczynnościowych
US6066318A (en) * 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
CA2234045A1 (en) * 1995-10-05 1997-04-10 G.D. Searle & Co. Interleuken-3 (il-3) receptor agonists
WO1997023639A1 (en) * 1995-12-22 1997-07-03 Toray Industries, Inc. Process for producing biologically active fused proteins
WO1998017810A2 (en) * 1996-10-25 1998-04-30 G.D. Searle & Co. Multi-functional chimeric hematopoietic receptor agonists
US6967092B1 (en) 1996-10-25 2005-11-22 Mc Kearn John P Multi-functional chimeric hematopoietic receptor agonists
DE19900743A1 (de) * 1999-01-12 2000-07-13 Aventis Pharma Gmbh Neue komplexbildende Proteine
WO2001025277A1 (en) * 1999-10-07 2001-04-12 Maxygen Aps Single-chain antagonist polypeptides
US6646110B2 (en) * 2000-01-10 2003-11-11 Maxygen Holdings Ltd. G-CSF polypeptides and conjugates
US6831158B2 (en) * 2000-01-10 2004-12-14 Maxygen Holdings Ltd. G-CSF conjugates
WO2001076639A2 (en) * 2000-04-06 2001-10-18 Pharmacia Corporation Chemically-modified myelopoietin conjugates
JP2004508412A (ja) 2000-09-11 2004-03-18 セラプロ　テクノロジーズ　インコーポレーティッド 抗新生物薬および免疫刺激薬としてのチオニン
WO2003006501A2 (en) * 2001-07-11 2003-01-23 Maxygen Holdings, Ltd. G-csf conjugates
PT1567641E (pt) 2001-08-24 2012-08-21 Uvic Industry Partnerships Inc Proaerolisina contendo sequência de activação de proteases e métodos de uso para o tratamento do cancro da próstata
US7208594B2 (en) * 2002-06-29 2007-04-24 Aquanova Ag Isoflavone concentrates as well as methods for their production
US8227411B2 (en) * 2002-08-20 2012-07-24 BioSurface Engineering Technologies, Incle FGF growth factor analogs
US7598224B2 (en) 2002-08-20 2009-10-06 Biosurface Engineering Technologies, Inc. Dual chain synthetic heparin-binding growth factor analogs
US7166574B2 (en) 2002-08-20 2007-01-23 Biosurface Engineering Technologies, Inc. Synthetic heparin-binding growth factor analogs
US7414028B1 (en) 2004-02-04 2008-08-19 Biosurface Engineering Technologies, Inc. Growth factor analogs
US7528105B1 (en) 2004-02-10 2009-05-05 Biosurface Engineering Technologies Heterodimeric chain synthetic heparin-binding growth factor analogs
US20080227696A1 (en) * 2005-02-22 2008-09-18 Biosurface Engineering Technologies, Inc. Single branch heparin-binding growth factor analogs
US7671012B2 (en) 2004-02-10 2010-03-02 Biosurface Engineering Technologies, Inc. Formulations and methods for delivery of growth factor analogs
US20060024347A1 (en) * 2004-02-10 2006-02-02 Biosurface Engineering Technologies, Inc. Bioactive peptide coatings
EP1725576B1 (de) * 2004-02-20 2010-09-22 Biosurface Engineering Technologies, Inc. Positiver modulator des knochenmorphogenetisches protein-2 (bmp-2)
CN1993460A (zh) * 2004-07-12 2007-07-04 索林集团意大利有限公司 用于培养人细胞的装置和方法
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
RU2007149238A (ru) 2005-06-01 2009-07-20 Максиджен Холдингз Лтд. (Ky) Пегилированные полипептиды гксф и способы их получения
CA2630559A1 (en) 2005-11-21 2007-05-24 Protox Therapeutics Incorporated Modified pore-forming protein toxins and use thereof
US7820172B1 (en) 2006-06-01 2010-10-26 Biosurface Engineering Technologies, Inc. Laminin-derived multi-domain peptides
EP2046350A4 (de) * 2006-06-22 2011-09-14 Biosurface Eng Tech Inc Zusammensetzungen und verfahren zur freisetzung eines bmp-2-amplifikators/coaktivators für verstärkte osteogenese
CN101139399B (zh) * 2007-08-13 2011-01-26 重庆医科大学附属第二医院 重组靶向杀伤白血病细胞的融合蛋白及其制备方法和用途
US8815229B2 (en) 2009-10-12 2014-08-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Granulysin in immunotherapy
EP2542574B1 (de) 2010-03-04 2017-08-09 Pfenex Inc. Verfahren zur herstellung eines löslichen und rekombinanten interferonproteins ohne denaturierung
US8455218B2 (en) 2010-04-01 2013-06-04 Pfenex, Inc. Methods for G-CSF production in a Pseudomonas host cell
WO2013043196A1 (en) * 2011-09-23 2013-03-28 Bluebird Bio, Inc. Improved gene therapy methods
AU2018347796B2 (en) 2017-10-10 2025-07-24 Medicenna Therapeutics, Inc. IL-4-fusion formulations for treatment of central nervous system (CNS) tumors
CN112513276B (zh) 2018-07-30 2024-03-15 张晋宇 蛋白质异二聚体及其用途

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993007171A1 (en) * 1991-10-07 1993-04-15 Medvet Science Pty. Ltd. Human il-3 variants
US4438032A (en) * 1981-01-30 1984-03-20 The Regents Of The University Of California Unique T-lymphocyte line and products derived therefrom
DE3588199T2 (de) * 1984-07-06 1999-04-08 Novartis Ag, Basel Lymphokin-Herstellung und -Reinigung
AU588819B2 (en) * 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene
JPS63500636A (ja) * 1985-08-23 1988-03-10 麒麟麦酒株式会社 多分化能性顆粒球コロニー刺激因子をコードするｄｎａ
US4810643A (en) * 1985-08-23 1989-03-07 Kirin- Amgen Inc. Production of pluripotent granulocyte colony-stimulating factor
US4877729A (en) * 1986-07-14 1989-10-31 Genetics Institute, Inc. Recombinant DNA encoding novel family of primate hematopoietic growth factors
US4959455A (en) * 1986-07-14 1990-09-25 Genetics Institute, Inc. Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
US5032395A (en) * 1986-07-14 1991-07-16 Genetics Institute, Inc. Method of inducing leukocytosis with a combination of IL-3 and GM-CSF
EP0790307A1 (de) * 1986-12-16 1997-08-20 Gist-Brocades B.V. Molekulare Klonierung und Expression von menschlichem IL-3
WO1988005469A1 (en) * 1987-01-20 1988-07-28 Immunex Corporation Human interleukin-3 proteins
JPH04500508A (ja) * 1988-07-20 1992-01-30 イミュネックス・コーポレーション 非グリコシル化　ヒト　インターロイキン―３　組成物
US5218092A (en) * 1988-09-29 1993-06-08 Kyowa Hakko Kogyo Co., Ltd. Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US5516512A (en) * 1989-08-14 1996-05-14 Gist-Brocades, N.V. N- and C-terminal truncation and deletion mutants of human interleukin-3
ATE154638T1 (de) * 1989-08-14 1997-07-15 Gist Brocades Nv Mutanten von interleukin-3
US5108910A (en) * 1989-08-22 1992-04-28 Immunex Corporation DNA sequences encoding fusion proteins comprising GM-CSF and IL-3
DK0489116T3 (da) * 1989-08-22 1994-05-02 Immunex Corp Fusionsproteiner omfattende GM-CSF og IL-3
US5073627A (en) * 1989-08-22 1991-12-17 Immunex Corporation Fusion proteins comprising GM-CSF and IL-3
DE3939703C2 (de) * 1989-12-01 1998-07-02 Boehringer Ingelheim Kg Verbesserte transdermale Applikation von pharmakologisch aktiven Verbindungen
JPH0463595A (ja) * 1990-04-03 1992-02-28 Kirin Brewery Co Ltd ヒトインターロイキン３誘導体
AU651152B2 (en) * 1990-08-29 1994-07-14 Genetics Institute, Llc Multidomain hematopoiesis stimulators
WO1992006116A1 (en) * 1990-09-28 1992-04-16 Ortho Pharmaceutical Corporation Hybrid growth factors
DE4030850A1 (de) * 1990-09-29 1992-04-02 Henkel Kgaa Bleichmittelzubereitung
US5199942A (en) * 1991-06-07 1993-04-06 Immunex Corporation Method for improving autologous transplantation
US5376367A (en) * 1991-11-22 1994-12-27 Immunex Corporation Fusion proteins comprising MGF and IL-3
CA2150116A1 (en) * 1992-11-24 1994-06-09 S. Christopher Bauer Interleukin-3 (il-3) multiple mutation polypeptides
US5501962A (en) * 1993-06-21 1996-03-26 G. D. Searle & Co. Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same

Also Published As

Publication number Publication date
CN1227604A (zh) 1999-09-01
EP1482044A3 (de) 2005-05-18
RO118016B1 (ro) 2002-12-30
FI963072A7 (fi) 1996-08-02
CZ229896A3 (en) 1996-12-11
WO1995021254A1 (en) 1995-08-10
US6057133A (en) 2000-05-02
EP0742826A1 (de) 1996-11-20
DE69534381T2 (de) 2006-11-23
NO963225L (no) 1996-09-25
FI963072A0 (fi) 1996-08-02
NZ281421A (en) 1998-05-27
AU1835695A (en) 1995-08-21
CZ289904B6 (cs) 2002-04-17
MX9603205A (es) 1997-03-29
CA2182484A1 (en) 1995-08-10
NO963225D0 (no) 1996-08-01
EP0742826B1 (de) 2005-08-17
NZ330060A (en) 1999-11-29
FI963072L (fi) 1996-08-02
US6030812A (en) 2000-02-29
DE69534381D1 (de) 2005-09-22
US6022535A (en) 2000-02-08
EP1482044A2 (de) 2004-12-01
BR9506733A (pt) 1997-09-23
KR100370264B1 (ko) 2003-05-09
KR970700766A (ko) 1997-02-12
PL315791A1 (en) 1996-12-09
AU697433B2 (en) 1998-10-08
JPH10502801A (ja) 1998-03-17

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