NO963225L - Multivariant IL-3 hematopoiese-fusjonsprotein - Google Patents

Multivariant IL-3 hematopoiese-fusjonsprotein

Info

Publication number
NO963225L
NO963225L NO963225A NO963225A NO963225L NO 963225 L NO963225 L NO 963225L NO 963225 A NO963225 A NO 963225A NO 963225 A NO963225 A NO 963225A NO 963225 L NO963225 L NO 963225L
Authority
NO
Norway
Prior art keywords
fusion protein
amino acids
given
hematopoiesic
multivariate
Prior art date
Application number
NO963225A
Other languages
English (en)
Norwegian (no)
Other versions
NO963225D0 (no
Inventor
Christopher S Bauer
Mark Allen Abrams
Sara Ruth Braford-Goldberg
Marie Helena Caparon
Alan Michael Easton
Barbara Kure Klein
John Patrick Mckearn
Peter O Olins
Kumnan Paik
John Warren Thomas
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of NO963225D0 publication Critical patent/NO963225D0/no
Publication of NO963225L publication Critical patent/NO963225L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
NO963225A 1994-02-04 1996-08-01 Multivariant IL-3 hematopoiese-fusjonsprotein NO963225L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/192,325 US6057133A (en) 1992-11-24 1994-02-04 Multivariant human IL-3 fusion proteins and their recombinant production
PCT/US1995/001185 WO1995021254A1 (en) 1994-02-04 1995-02-02 Multivariant il-3 hematopoiesis fusion protein

Publications (2)

Publication Number Publication Date
NO963225D0 NO963225D0 (no) 1996-08-01
NO963225L true NO963225L (no) 1996-09-25

Family

ID=22709185

Family Applications (1)

Application Number Title Priority Date Filing Date
NO963225A NO963225L (no) 1994-02-04 1996-08-01 Multivariant IL-3 hematopoiese-fusjonsprotein

Country Status (17)

Country Link
US (3) US6057133A (de)
EP (2) EP1482044A3 (de)
JP (1) JPH10502801A (de)
KR (1) KR100370264B1 (de)
CN (1) CN1227604A (de)
AT (1) ATE302275T1 (de)
BR (1) BR9506733A (de)
CA (1) CA2182484A1 (de)
CZ (1) CZ289904B6 (de)
DE (1) DE69534381T2 (de)
FI (1) FI963072L (de)
MX (1) MX9603205A (de)
NO (1) NO963225L (de)
NZ (2) NZ330060A (de)
PL (1) PL315791A1 (de)
RO (1) RO118016B1 (de)
WO (1) WO1995021254A1 (de)

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WO1996023888A1 (en) * 1995-02-03 1996-08-08 G.D. Searle & Co. NOVEL c-MPL LIGANDS
PL184424B1 (pl) * 1995-10-05 2002-10-31 Searle & Co Agoniści krwiotwórczych receptorów wieloczynnościowych
US6066318A (en) * 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
CA2234045A1 (en) * 1995-10-05 1997-04-10 G.D. Searle & Co. Interleuken-3 (il-3) receptor agonists
WO1997023639A1 (en) * 1995-12-22 1997-07-03 Toray Industries, Inc. Process for producing biologically active fused proteins
WO1998017810A2 (en) * 1996-10-25 1998-04-30 G.D. Searle & Co. Multi-functional chimeric hematopoietic receptor agonists
US6967092B1 (en) 1996-10-25 2005-11-22 Mc Kearn John P Multi-functional chimeric hematopoietic receptor agonists
DE19900743A1 (de) * 1999-01-12 2000-07-13 Aventis Pharma Gmbh Neue komplexbildende Proteine
WO2001025277A1 (en) * 1999-10-07 2001-04-12 Maxygen Aps Single-chain antagonist polypeptides
US6646110B2 (en) * 2000-01-10 2003-11-11 Maxygen Holdings Ltd. G-CSF polypeptides and conjugates
US6831158B2 (en) * 2000-01-10 2004-12-14 Maxygen Holdings Ltd. G-CSF conjugates
WO2001076639A2 (en) * 2000-04-06 2001-10-18 Pharmacia Corporation Chemically-modified myelopoietin conjugates
JP2004508412A (ja) 2000-09-11 2004-03-18 セラプロ　テクノロジーズ　インコーポレーティッド 抗新生物薬および免疫刺激薬としてのチオニン
WO2003006501A2 (en) * 2001-07-11 2003-01-23 Maxygen Holdings, Ltd. G-csf conjugates
PT1567641E (pt) 2001-08-24 2012-08-21 Uvic Industry Partnerships Inc Proaerolisina contendo sequência de activação de proteases e métodos de uso para o tratamento do cancro da próstata
US7208594B2 (en) * 2002-06-29 2007-04-24 Aquanova Ag Isoflavone concentrates as well as methods for their production
US8227411B2 (en) * 2002-08-20 2012-07-24 BioSurface Engineering Technologies, Incle FGF growth factor analogs
US7598224B2 (en) 2002-08-20 2009-10-06 Biosurface Engineering Technologies, Inc. Dual chain synthetic heparin-binding growth factor analogs
US7166574B2 (en) 2002-08-20 2007-01-23 Biosurface Engineering Technologies, Inc. Synthetic heparin-binding growth factor analogs
US7414028B1 (en) 2004-02-04 2008-08-19 Biosurface Engineering Technologies, Inc. Growth factor analogs
US7528105B1 (en) 2004-02-10 2009-05-05 Biosurface Engineering Technologies Heterodimeric chain synthetic heparin-binding growth factor analogs
US20080227696A1 (en) * 2005-02-22 2008-09-18 Biosurface Engineering Technologies, Inc. Single branch heparin-binding growth factor analogs
US7671012B2 (en) 2004-02-10 2010-03-02 Biosurface Engineering Technologies, Inc. Formulations and methods for delivery of growth factor analogs
US20060024347A1 (en) * 2004-02-10 2006-02-02 Biosurface Engineering Technologies, Inc. Bioactive peptide coatings
EP1725576B1 (de) * 2004-02-20 2010-09-22 Biosurface Engineering Technologies, Inc. Positiver modulator des knochenmorphogenetisches protein-2 (bmp-2)
CN1993460A (zh) * 2004-07-12 2007-07-04 索林集团意大利有限公司 用于培养人细胞的装置和方法
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
RU2007149238A (ru) 2005-06-01 2009-07-20 Максиджен Холдингз Лтд. (Ky) Пегилированные полипептиды гксф и способы их получения
CA2630559A1 (en) 2005-11-21 2007-05-24 Protox Therapeutics Incorporated Modified pore-forming protein toxins and use thereof
US7820172B1 (en) 2006-06-01 2010-10-26 Biosurface Engineering Technologies, Inc. Laminin-derived multi-domain peptides
EP2046350A4 (de) * 2006-06-22 2011-09-14 Biosurface Eng Tech Inc Zusammensetzungen und verfahren zur freisetzung eines bmp-2-amplifikators/coaktivators für verstärkte osteogenese
CN101139399B (zh) * 2007-08-13 2011-01-26 重庆医科大学附属第二医院 重组靶向杀伤白血病细胞的融合蛋白及其制备方法和用途
US8815229B2 (en) 2009-10-12 2014-08-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Granulysin in immunotherapy
EP2542574B1 (de) 2010-03-04 2017-08-09 Pfenex Inc. Verfahren zur herstellung eines löslichen und rekombinanten interferonproteins ohne denaturierung
US8455218B2 (en) 2010-04-01 2013-06-04 Pfenex, Inc. Methods for G-CSF production in a Pseudomonas host cell
WO2013043196A1 (en) * 2011-09-23 2013-03-28 Bluebird Bio, Inc. Improved gene therapy methods
AU2018347796B2 (en) 2017-10-10 2025-07-24 Medicenna Therapeutics, Inc. IL-4-fusion formulations for treatment of central nervous system (CNS) tumors
CN112513276B (zh) 2018-07-30 2024-03-15 张晋宇 蛋白质异二聚体及其用途

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JPH04500508A (ja) * 1988-07-20 1992-01-30 イミュネックス・コーポレーション 非グリコシル化　ヒト　インターロイキン―３　組成物
US5218092A (en) * 1988-09-29 1993-06-08 Kyowa Hakko Kogyo Co., Ltd. Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
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ATE154638T1 (de) * 1989-08-14 1997-07-15 Gist Brocades Nv Mutanten von interleukin-3
US5108910A (en) * 1989-08-22 1992-04-28 Immunex Corporation DNA sequences encoding fusion proteins comprising GM-CSF and IL-3
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Also Published As

Publication number Publication date
CN1227604A (zh) 1999-09-01
EP1482044A3 (de) 2005-05-18
RO118016B1 (ro) 2002-12-30
FI963072A7 (fi) 1996-08-02
CZ229896A3 (en) 1996-12-11
WO1995021254A1 (en) 1995-08-10
US6057133A (en) 2000-05-02
EP0742826A1 (de) 1996-11-20
DE69534381T2 (de) 2006-11-23
FI963072A0 (fi) 1996-08-02
NZ281421A (en) 1998-05-27
AU1835695A (en) 1995-08-21
CZ289904B6 (cs) 2002-04-17
ATE302275T1 (de) 2005-09-15
MX9603205A (es) 1997-03-29
CA2182484A1 (en) 1995-08-10
NO963225D0 (no) 1996-08-01
EP0742826B1 (de) 2005-08-17
NZ330060A (en) 1999-11-29
FI963072L (fi) 1996-08-02
US6030812A (en) 2000-02-29
DE69534381D1 (de) 2005-09-22
US6022535A (en) 2000-02-08
EP1482044A2 (de) 2004-12-01
BR9506733A (pt) 1997-09-23
KR100370264B1 (ko) 2003-05-09
KR970700766A (ko) 1997-02-12
PL315791A1 (en) 1996-12-09
AU697433B2 (en) 1998-10-08
JPH10502801A (ja) 1998-03-17

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