ATE30268T1 - Verfahren und vorrichtung zur partikelzaehlung in einem begrenzten volumen. - Google Patents

Verfahren und vorrichtung zur partikelzaehlung in einem begrenzten volumen.

Info

Publication number
ATE30268T1
ATE30268T1 AT83304019T AT83304019T ATE30268T1 AT E30268 T1 ATE30268 T1 AT E30268T1 AT 83304019 T AT83304019 T AT 83304019T AT 83304019 T AT83304019 T AT 83304019T AT E30268 T1 ATE30268 T1 AT E30268T1
Authority
AT
Austria
Prior art keywords
dispersion
particle
fluorescence
excitation light
limited volume
Prior art date
Application number
AT83304019T
Other languages
English (en)
Inventor
Jonathan Briggs
Original Assignee
Syva Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syva Co filed Critical Syva Co
Application granted granted Critical
Publication of ATE30268T1 publication Critical patent/ATE30268T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G01N2015/0222—Investigating a scatter or diffraction pattern from dynamic light scattering, e.g. photon correlation spectroscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/08—Optical fibres; light guides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
AT83304019T 1982-07-12 1983-07-11 Verfahren und vorrichtung zur partikelzaehlung in einem begrenzten volumen. ATE30268T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/397,285 US4564598A (en) 1982-07-12 1982-07-12 Limited volume method for particle counting
EP83304019A EP0099266B1 (de) 1982-07-12 1983-07-11 Verfahren und Vorrichtung zur Partikelzählung in einem begrenzten Volumen

Publications (1)

Publication Number Publication Date
ATE30268T1 true ATE30268T1 (de) 1987-10-15

Family

ID=23570573

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83304019T ATE30268T1 (de) 1982-07-12 1983-07-11 Verfahren und vorrichtung zur partikelzaehlung in einem begrenzten volumen.

Country Status (7)

Country Link
US (1) US4564598A (de)
EP (1) EP0099266B1 (de)
JP (1) JPH068821B2 (de)
AT (1) ATE30268T1 (de)
AU (1) AU573176B2 (de)
CA (1) CA1215182A (de)
DE (1) DE3374079D1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4739171A (en) * 1982-07-12 1988-04-19 Syntex (U.S.A.) Inc. Limited volume method and apparatus for particle counting
US4584277A (en) * 1983-04-05 1986-04-22 Syntex (U.S.A.) Inc. Fluorescent multiparameter particle analysis
DE3319526C2 (de) * 1983-05-28 1994-10-20 Max Planck Gesellschaft Anordnung mit einem physikalischen Sensor
US4560881A (en) * 1984-03-13 1985-12-24 Syntex (U.S.A.) Inc. Method and apparatus for enhanced detection of electromagnetic signals
US5026905A (en) * 1984-08-28 1991-06-25 Syntex (U.S.A.) Inc. Fluorescent dyes
US4748129A (en) * 1984-08-28 1988-05-31 Snytex (U.S.A.) Inc. Assay method employing fluorescent cell incorporative dye
US5145774A (en) * 1984-08-28 1992-09-08 Syntex (U.S.A.) Inc. Fluorescent dyes
US4676640A (en) * 1984-09-12 1987-06-30 Syntex (U.S.A.) Inc. Fluctuation analysis for enhanced particle detection
AT383684B (de) * 1984-09-17 1987-08-10 Avl Verbrennungskraft Messtech Anordnung zur fluoreszenzoptischen messung von stoffkonzentrationen in einer probe
JPS61128169A (ja) * 1984-11-27 1986-06-16 Mitsubishi Chem Ind Ltd 免疫分析法
CA1304006C (en) 1985-12-20 1992-06-23 Edwin F. Ullman Particle separation method
US5019350A (en) * 1986-02-13 1991-05-28 Pfizer Hospital Products, Inc. Fluorescent polymers
JPH0799354B2 (ja) * 1986-03-26 1995-10-25 株式会社日立製作所 異物検出方法および装置
GB8621426D0 (en) * 1986-09-05 1986-10-15 Health Lab Service Board Particle analysis
US4894547A (en) * 1987-09-28 1990-01-16 Yale University Optical method and apparatus for detecting and measuring aging, photoaging, dermal disease and pigmentation in skin
US5013150A (en) * 1988-04-01 1991-05-07 Syntex (U.S.A.) Inc. Method for detection of fluorescence or light scatter
US4934811A (en) * 1988-04-01 1990-06-19 Syntex (U.S.A.) Inc. Apparatus and method for detection of fluorescence or light scatter
US5278048A (en) * 1988-10-21 1994-01-11 Molecular Devices Corporation Methods for detecting the effect of cell affecting agents on living cells
JP2993982B2 (ja) * 1988-10-21 1999-12-27 モレキユラー デヴアイシズ コーポレイシヨン 生細胞に対する細胞作用剤の効果を検出するための方法及び装置
FR2638848B1 (fr) * 1988-11-04 1993-01-22 Chemunex Sa Procede de detection et/ou de dosage dans un milieu liquide ou semi-liquide d'au moins une substance organique, biologique ou medicamenteuse soluble, par une methode d'agglutination
US5026159A (en) * 1989-05-19 1991-06-25 Acrogen, Inc. Area-modulated luminescence (AML)
US5204884A (en) * 1991-03-18 1993-04-20 University Of Rochester System for high-speed measurement and sorting of particles
US5199576A (en) * 1991-04-05 1993-04-06 University Of Rochester System for flexibly sorting particles
US5304492A (en) * 1991-11-26 1994-04-19 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Spectrophotometer for chemical analyses of fluids
US5391272A (en) * 1992-03-06 1995-02-21 Andcare, Inc. Electrochemical immunoassay methods
US5396075A (en) * 1993-07-27 1995-03-07 The United States Of America As Represented By The United States Department Of Energy Method for in situ characterization of a medium of dispersed matter in a continuous phase
DE4429239A1 (de) * 1994-08-18 1996-02-22 Basf Ag Verfahren zur Fluoreszenz-Korrelations-Spektroskopie und Vorrichtung zu dessen Durchführung
WO2000052451A1 (en) * 1999-03-03 2000-09-08 Evotec Analytical Systems Gmbh Homogeneous fluorescence assay
EP1033567A1 (de) * 1999-03-03 2000-09-06 Evotec Analytical Systems GmbH In homogener Phase durchgeführter Fluoreszenz-Assay
CA2309528C (en) * 1999-06-08 2007-10-09 Ortho-Clinical Diagnostics, Inc. Simultaneous determination of forward and reverse abo blood group
EP1239284A1 (de) * 2001-03-08 2002-09-11 The Technology Partnership Public Limited Company Nicht-trennender Testverfahren und System mit opaken Partikeln
US7232687B2 (en) * 2004-04-07 2007-06-19 Beckman Coulter, Inc. Multiple sorter monitor and control subsystem for flow cytometer
EP1607737A1 (de) * 2004-06-17 2005-12-21 Patrick Hunziker Gerät und Methode zur Detektion und Messung von Nukleinsäuresträngen in Lösung
EP4027130B1 (de) 2007-02-01 2022-11-02 Sysmex Corporation Probenanalysator
WO2008144383A1 (en) * 2007-05-16 2008-11-27 Buckman Laboratories International, Inc. Methods to detect organic contaminants in pulp and fiber
DE102008029700A1 (de) * 2008-06-24 2010-01-14 Palas Gmbh Partikel- Und Lasermesstechnik Verfahren zum Bestimmen des Eindringens von Prüfpartikeln in einen Messbereich
US10161924B2 (en) * 2014-03-24 2018-12-25 National Technology & Engineering Solutions Of Sandia, Llc Sensor system that uses embedded optical fibers

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1506017A (en) * 1974-03-04 1978-04-05 Int Diagnostic Tech Fluorometric system and method for the detection of biologically derived substances
US4199559A (en) * 1974-08-12 1980-04-22 Syva Company Fluorescence quenching with immunological pairs in immunoassays
GB1596521A (en) * 1977-10-20 1981-08-26 Int Diagnostic Tech Apparatus for fluorometric assay
CA1111762A (en) * 1977-12-28 1981-11-03 David S. Frank Fluorescent rare earth chelate in polymeric latex particles
DE2842343A1 (de) * 1978-09-28 1980-04-10 Siemens Ag Fluoreszenz-messanordnung
US4256834A (en) * 1979-04-09 1981-03-17 Syva Company Fluorescent scavenger particle immunoassay
US4419583A (en) * 1980-05-31 1983-12-06 Noeller Hans Guenter Polarization fluoroimmunoassay with pulsed light source
US4421860A (en) * 1980-10-07 1983-12-20 The Regents Of The University Of California Homogeneous fluoroimmunoassay involving autocorrelation processing of optically sensed signals
EP0059032A1 (de) * 1981-02-03 1982-09-01 Virgil B. Elings Farbstoff-Konzentrationsmessung im Blutstrom

Also Published As

Publication number Publication date
DE3374079D1 (en) 1987-11-19
EP0099266A2 (de) 1984-01-25
EP0099266B1 (de) 1987-10-14
JPH068821B2 (ja) 1994-02-02
EP0099266A3 (en) 1984-12-12
US4564598A (en) 1986-01-14
AU573176B2 (en) 1988-06-02
AU1672483A (en) 1984-01-19
JPS5981559A (ja) 1984-05-11
CA1215182A (en) 1986-12-09

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee