ATE303369T1 - Glucocorticoid rezeptor modulatoren - Google Patents
Glucocorticoid rezeptor modulatorenInfo
- Publication number
- ATE303369T1 ATE303369T1 AT01308789T AT01308789T ATE303369T1 AT E303369 T1 ATE303369 T1 AT E303369T1 AT 01308789 T AT01308789 T AT 01308789T AT 01308789 T AT01308789 T AT 01308789T AT E303369 T1 ATE303369 T1 AT E303369T1
- Authority
- AT
- Austria
- Prior art keywords
- glucocorticoid receptor
- compounds
- present
- receptor modulators
- provides
- Prior art date
Links
- 229940117965 Glucocorticoid receptor modulator Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 2
- JFUAWXPBHXKZGA-IBGZPJMESA-N 4-fluoro-2-[(4r)-5,5,5-trifluoro-4-hydroxy-2-methyl-4-(1h-pyrrolo[2,3-c]pyridin-2-ylmethyl)pentan-2-yl]phenol Chemical compound C([C@@](O)(CC=1NC2=CN=CC=C2C=1)C(F)(F)F)C(C)(C)C1=CC(F)=CC=C1O JFUAWXPBHXKZGA-IBGZPJMESA-N 0.000 abstract 1
- 102000003676 Glucocorticoid Receptors Human genes 0.000 abstract 1
- 108090000079 Glucocorticoid Receptors Proteins 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 108010085012 Steroid Receptors Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940124750 glucocorticoid receptor agonist Drugs 0.000 abstract 1
- 229940126013 glucocorticoid receptor antagonist Drugs 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000004031 partial agonist Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 102000005969 steroid hormone receptors Human genes 0.000 abstract 1
- 230000003637 steroidlike Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24430200P | 2000-10-30 | 2000-10-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE303369T1 true ATE303369T1 (de) | 2005-09-15 |
Family
ID=22922191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01308789T ATE303369T1 (de) | 2000-10-30 | 2001-10-16 | Glucocorticoid rezeptor modulatoren |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6852719B2 (de) |
| EP (1) | EP1201660B1 (de) |
| JP (1) | JP2002193955A (de) |
| AT (1) | ATE303369T1 (de) |
| BR (1) | BR0104834A (de) |
| CA (1) | CA2360313C (de) |
| DE (1) | DE60113032T2 (de) |
| ES (1) | ES2246292T3 (de) |
| MX (1) | MXPA01011108A (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL180679A0 (en) * | 2000-10-27 | 2009-02-11 | Pfizer Prod Inc | Process for the preparation of non-steroidal glucocorticoid receptor modulators |
| WO2004009017A2 (en) * | 2002-07-18 | 2004-01-29 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor and method |
| AU2003299311A1 (en) * | 2002-12-18 | 2004-07-09 | University Of Zurich | Treatment of neuro-psychiatric disorders |
| US7625921B2 (en) * | 2004-01-16 | 2009-12-01 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
| JP4958774B2 (ja) * | 2004-07-02 | 2012-06-20 | コーセプト セラピューティクス， インコーポレイテッド | 改変されたピリミジン糖質コルチコイドレセプター調節因子 |
| US20060154981A1 (en) * | 2005-01-12 | 2006-07-13 | Alcon, Inc. | Method of reducing intraocular pressure and treating glaucoma |
| CA2594943A1 (en) * | 2005-01-19 | 2006-07-27 | Merck & Co., Inc. | Aminomethyl beta-secretase inhibitors for the treatment of alzheimer's disease |
| AU2006206654A1 (en) * | 2005-01-19 | 2006-07-27 | Merck & Co., Inc. | Tertiary carbinamines having substituted heterocycles, which are active as inhibitors of beta-secretase, for the treatment of Alzheimer's disease |
| EP1944290B1 (de) * | 2005-09-14 | 2013-12-04 | Santen Pharmaceutical Co., Ltd. | Neues 1,2-dihydrochinolinderivat mit glucocorticoidrezeptorbindender aktivität |
| SI1995242T1 (sl) | 2006-03-14 | 2013-01-31 | Santen Pharmaceutical Co., Ltd. | Nov derivat 1,2,3,4-tetrahidrokinoksalina z aktivnostjo vezanja glukokortikoidnega receptorja |
| PL2085387T3 (pl) | 2006-11-14 | 2013-09-30 | Ayumi Pharmaceutical Corp | Nowe pochodne 1,2-dihydrochinoliny zawierające jako podstawniki fenylochalkogeno-podstawioną niższą grupę alkilową oraz wprowadzoną przez ester grupę fenylową |
| TWI410422B (zh) | 2007-01-15 | 2013-10-01 | Mitsubishi Tanabe Pharma Corp | 縮合四氫喹啉衍生物及其醫藥用途 |
| WO2008093227A1 (en) * | 2007-02-02 | 2008-08-07 | Pfizer Products Inc. | Tricyclic compounds and their use as glucocorticoid receptor modulators |
| CA2687948A1 (en) | 2007-05-29 | 2008-12-04 | Mamoru Matsuda | Novel 1,2,3,4-tetrahydroquinoxaline derivative which has, as substituent, phenyl group having sulfonic acid ester structure or sulfonic acid amide structure introduced therein andhas glucocorticoid receptor-binding activity |
| KR20110010634A (ko) | 2008-05-12 | 2011-02-01 | 산텐 세이야꾸 가부시키가이샤 | 치환 옥시기를 가지는 2,2,4-트리메틸-6-페닐-1,2-디하이드로퀴놀린 유도체를 포함하는 글루코코르티코이드 수용체 작용제 |
| ES2527137T3 (es) | 2008-07-28 | 2015-01-21 | Pfizer Inc. | Compuestos de fenantrenona, composiciones y procedimientos |
| EA018420B1 (ru) | 2008-09-12 | 2013-07-30 | Сантен Фармасьютикал Ко., Лтд. | Агонист глюкокортикоидного рецептора, содержащий новые производные 1,2,3,4-тетрагидрохиноксалина с фенильной группой, имеющей структуру эфира сульфоновой кислоты, введенной в нее в качестве заместителя |
| GB2477256B (en) | 2008-11-07 | 2013-12-25 | Univ Sheffield | Determination of predisposition towards subclinical Cushing's syndrome or incidentaloma |
| CN103298343A (zh) * | 2011-01-07 | 2013-09-11 | 科赛普特治疗公司 | 类固醇和糖皮质激素受体拮抗剂组合疗法 |
| KR101925955B1 (ko) | 2011-03-18 | 2018-12-06 | 코어셉트 쎄라퓨틱스, 잉크. | 피리미딘 사이클로헥실 글루코코르티코이드 수용체 조절제 |
| TW201422590A (zh) * | 2012-09-07 | 2014-06-16 | Abbvie Inc | 雜環核激素受體調節劑 |
| EP2935284A4 (de) | 2012-12-21 | 2016-04-27 | Abbvie Inc | Heterocyclische nuklearhormonrezeptormodulatoren |
| EP3342768A4 (de) | 2015-08-25 | 2019-01-23 | Santen Pharmaceutical Co., Ltd. | [ 4-(1, 3, 3-trimethyl-2-oxo-3, 4-dihydro-1 h-chinoxalin-7-yl) phenoxy ] ethyloxyverbindung oder salz davon |
| EP3768324B1 (de) | 2018-03-22 | 2025-11-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Verfahren zur modulierung der aktivität innater lymphoider zellen, antikörper-arzneimittelkonjugate und verwendungen in der therapie |
| ES2987563T3 (es) | 2018-06-04 | 2024-11-15 | Corcept Therapeutics Inc | Moduladores del receptor de glucocorticoides ciclohexenilo pirimidina |
| US11903945B2 (en) | 2019-12-11 | 2024-02-20 | Corcept Therapeutics Incorporated | Methods of treating antipsychotic-induced weight gain with miricorilant |
| MX2022013804A (es) | 2020-05-06 | 2022-11-30 | Corcept Therapeutics Inc | Polimorfos de moduladores de los receptores de pirimidin-ciclohexil-glucocorticoides. |
| WO2021226258A1 (en) | 2020-05-06 | 2021-11-11 | Corcept Therapeutics Incorporated | Formulations of pyrimidine cyclohexyl glucocorticoid receptor modulators |
| IL303881A (en) | 2020-12-21 | 2023-08-01 | Corcept Therapeutics Inc | Method of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators |
| US12616698B2 (en) | 2021-05-05 | 2026-05-05 | Corcept Therapeutics Incorporated | Methods for reducing liver fat and for treating fatty liver disorders |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3683091A (en) | 1967-11-13 | 1972-08-08 | Wataru Nagata | Certain phenanthrene compounds for treatment of acne |
| JPS50111098A (de) | 1974-02-18 | 1975-09-01 | ||
| FR2576025B1 (fr) | 1985-01-14 | 1987-01-23 | Roussel Uclaf | Nouveaux steroides substitues en position 10, leur procede et les intermediaires de preparation, leur application comme medicaments, les compositions pharmaceutiques les contenant |
| JPH06263688A (ja) | 1991-09-04 | 1994-09-20 | Otsuka Pharmaceut Factory Inc | フェナンスレン誘導体 |
| KR950703941A (ko) | 1993-10-13 | 1995-11-17 | 오오쓰까 아끼히꼬 | 일산화질소 합성 억제제(nitrogen monoxide synthesis inhibitor) |
| ATE156836T1 (de) | 1994-05-19 | 1997-08-15 | Akzo Nobel Nv | 11,21-bisphenyl-19-nor-pregnan derivate |
| JPH0952899A (ja) | 1994-09-30 | 1997-02-25 | Tsumura & Co | ロイコトリエン拮抗剤 |
| US5696130A (en) | 1994-12-22 | 1997-12-09 | Ligand Pharmaceuticals Incorporated | Tricyclic steroid receptor modulator compounds and methods |
| US5767113A (en) | 1995-05-10 | 1998-06-16 | The Salk Institute For Biological Studies | Compounds useful for concurrently activating glucocorticoid-induced response and reducing multidrug resistance |
| FR2757400B1 (fr) | 1996-12-19 | 1999-12-17 | Hoechst Marion Roussel Inc | Application des composes antiglucocorticoides dans le traitement des psychoses ou des comportements addictifs |
| US5929058A (en) | 1996-12-24 | 1999-07-27 | Zymogenetics, Inc. | Treatment agents and methods for treating type II diabetes and symptoms of type II diabetes |
| IL122740A (en) * | 1997-01-15 | 2003-09-17 | Akzo Nobel Nv | 16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them |
| EP0903146A1 (de) | 1997-09-23 | 1999-03-24 | Applied Research Systems ARS Holdings N.V. | 21-Hydroy-6,19-oxidoprogesterone (21-0H-60P) als ANitoglucocortikoid |
| ZA9811898B (en) | 1997-12-29 | 2000-06-28 | Ortho Mcneil Pharm Inc | Anti-Inflammatory Compounds. |
| SK284689B6 (sk) | 1998-02-13 | 2005-09-08 | Abbott Laboratories | Benzopyrano[3,4-f]chinolínová zlúčenina a liečivo s jej obsahom |
| US6380207B2 (en) | 1998-02-13 | 2002-04-30 | Abbott Laboratories | Glucocortiocoid-selective antiinflammatory agents |
| IL139865A0 (en) | 1998-06-08 | 2002-02-10 | Karobio Ab | A liver selective glucocorticoid antagonist and pharmaceutical compositions containing the same |
| DE69920717T2 (de) | 1998-07-30 | 2005-10-06 | Abbott Laboratories, Abbott Park | Glucocorticoid selektive wirkstoffe |
| GB9816935D0 (en) | 1998-08-05 | 1998-09-30 | Karobio Ab | Novel glucocortoid and thyroid receptor ligands for the treatment of metabolic disorders |
| HK1042889B (zh) * | 1999-04-30 | 2006-12-29 | 辉瑞产品公司 | 糖皮质激素受体调制剂 |
-
2001
- 2001-10-16 ES ES01308789T patent/ES2246292T3/es not_active Expired - Lifetime
- 2001-10-16 AT AT01308789T patent/ATE303369T1/de not_active IP Right Cessation
- 2001-10-16 EP EP01308789A patent/EP1201660B1/de not_active Expired - Lifetime
- 2001-10-16 DE DE60113032T patent/DE60113032T2/de not_active Expired - Fee Related
- 2001-10-26 US US10/012,274 patent/US6852719B2/en not_active Expired - Fee Related
- 2001-10-26 CA CA002360313A patent/CA2360313C/en not_active Expired - Fee Related
- 2001-10-29 BR BR0104834-1A patent/BR0104834A/pt not_active IP Right Cessation
- 2001-10-29 JP JP2001330283A patent/JP2002193955A/ja active Pending
- 2001-10-30 MX MXPA01011108A patent/MXPA01011108A/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| US20040014741A1 (en) | 2004-01-22 |
| CA2360313A1 (en) | 2002-04-30 |
| BR0104834A (pt) | 2002-08-20 |
| EP1201660A1 (de) | 2002-05-02 |
| US6852719B2 (en) | 2005-02-08 |
| DE60113032T2 (de) | 2006-07-06 |
| ES2246292T3 (es) | 2006-02-16 |
| DE60113032D1 (de) | 2005-10-06 |
| MXPA01011108A (es) | 2002-06-04 |
| JP2002193955A (ja) | 2002-07-10 |
| CA2360313C (en) | 2006-12-05 |
| EP1201660B1 (de) | 2005-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |