ATE303396T1 - Verfahren zur herstellung von n6-substituierten aminopurin ribofuranose nucleosiden - Google Patents
Verfahren zur herstellung von n6-substituierten aminopurin ribofuranose nucleosidenInfo
- Publication number
- ATE303396T1 ATE303396T1 AT02718299T AT02718299T ATE303396T1 AT E303396 T1 ATE303396 T1 AT E303396T1 AT 02718299 T AT02718299 T AT 02718299T AT 02718299 T AT02718299 T AT 02718299T AT E303396 T1 ATE303396 T1 AT E303396T1
- Authority
- AT
- Austria
- Prior art keywords
- producing
- nucleosides
- substituted aminopurine
- substituted
- compounds
- Prior art date
Links
- 239000002777 nucleoside Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 title 1
- 150000005018 aminopurines Chemical class 0.000 title 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108010060263 Adenosine A1 Receptor Proteins 0.000 abstract 1
- 102000030814 Adenosine A1 receptor Human genes 0.000 abstract 1
- 108050000203 Adenosine receptors Proteins 0.000 abstract 1
- 102000009346 Adenosine receptors Human genes 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 229910000019 calcium carbonate Inorganic materials 0.000 abstract 1
- 235000010216 calcium carbonate Nutrition 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- -1 ribofuranose nucleoside Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0106867.5A GB0106867D0 (en) | 2001-03-20 | 2001-03-20 | Process |
| PCT/GB2002/001344 WO2002074781A1 (en) | 2001-03-20 | 2002-03-19 | Process for preparing n6-substituted aminopurine ribofuranose nucleosides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE303396T1 true ATE303396T1 (de) | 2005-09-15 |
Family
ID=9911093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02718299T ATE303396T1 (de) | 2001-03-20 | 2002-03-19 | Verfahren zur herstellung von n6-substituierten aminopurin ribofuranose nucleosiden |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7297787B2 (de) |
| EP (1) | EP1370569B1 (de) |
| JP (1) | JP2004534003A (de) |
| AT (1) | ATE303396T1 (de) |
| DE (1) | DE60205875T2 (de) |
| ES (1) | ES2243707T3 (de) |
| GB (1) | GB0106867D0 (de) |
| WO (1) | WO2002074781A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0115178D0 (en) * | 2001-06-20 | 2001-08-15 | Glaxo Group Ltd | Compounds |
| US20050222178A1 (en) * | 2002-06-17 | 2005-10-06 | Mark Shipton | Process |
| WO2004055032A1 (en) * | 2002-12-18 | 2004-07-01 | Glaxo Group Limited | Adenosine derivative in polymorph v form |
| WO2004055033A1 (en) * | 2002-12-18 | 2004-07-01 | Glaxo Group Limited | Adenosine derivative in polymorph iv form |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8729994D0 (en) * | 1987-12-23 | 1988-02-03 | Glaxo Group Ltd | Chemical compounds |
| GB9610031D0 (en) | 1996-05-14 | 1996-07-17 | Glaxo Group Ltd | Chemical compounds |
| AU3255097A (en) | 1996-07-05 | 1998-02-02 | Novo Nordisk A/S | Novel (n)-alkoxyadenine derivatives acting as cytokine inhibitors |
| UA51716C2 (uk) * | 1996-07-08 | 2002-12-16 | Авентіс Фармасьютікалз Продактс Інк. | Сполуки, що мають гіпотензивну, кардіопротекторну, анти-ішемічну та антиліполітичну властивості, фармацевтична композиція та способи лікування |
| AU4377397A (en) | 1996-10-14 | 1998-05-11 | Novo Nordisk A/S | Novel therapeutically active adenosine derivatives |
| GB9723566D0 (en) * | 1997-11-08 | 1998-01-07 | Glaxo Group Ltd | Chemical compounds |
| GB9723589D0 (en) | 1997-11-08 | 1998-01-07 | Glaxo Group Ltd | Chemical compounds |
| GB9723590D0 (en) * | 1997-11-08 | 1998-01-07 | Glaxo Group Ltd | Chemical compounds |
| GB9813554D0 (en) * | 1998-06-23 | 1998-08-19 | Glaxo Group Ltd | Chemical compounds |
| CZ9901996A3 (cs) * | 1999-06-04 | 2001-01-17 | Ústav organické chemie a biochemie AV ČR | Nové 6-fenylpurinové 9-ß-D-ribonukleosidy s antineoplastickým účinkem, jejich použití k přípravě farmaceutických preparátů a farmaceutické přípravky, které je obsahují |
-
2001
- 2001-03-20 GB GBGB0106867.5A patent/GB0106867D0/en not_active Ceased
-
2002
- 2002-03-19 AT AT02718299T patent/ATE303396T1/de not_active IP Right Cessation
- 2002-03-19 EP EP02718299A patent/EP1370569B1/de not_active Expired - Lifetime
- 2002-03-19 WO PCT/GB2002/001344 patent/WO2002074781A1/en not_active Ceased
- 2002-03-19 DE DE60205875T patent/DE60205875T2/de not_active Expired - Lifetime
- 2002-03-19 JP JP2002573790A patent/JP2004534003A/ja active Pending
- 2002-03-19 ES ES02718299T patent/ES2243707T3/es not_active Expired - Lifetime
- 2002-03-19 US US10/471,682 patent/US7297787B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7297787B2 (en) | 2007-11-20 |
| JP2004534003A (ja) | 2004-11-11 |
| WO2002074781A1 (en) | 2002-09-26 |
| GB0106867D0 (en) | 2001-05-09 |
| EP1370569A1 (de) | 2003-12-17 |
| EP1370569B1 (de) | 2005-08-31 |
| US20050176949A1 (en) | 2005-08-11 |
| DE60205875T2 (de) | 2006-05-04 |
| DE60205875D1 (de) | 2005-10-06 |
| ES2243707T3 (es) | 2005-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |