ATE332910T1 - Verfahren zur herstellung von 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofura osyl)-9h-purin-6-amin - Google Patents

Verfahren zur herstellung von 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofura osyl)-9h-purin-6-amin

Info

Publication number: ATE332910T1
Authority: AT; Austria
Prior art keywords: deoxy; fluoro; chloro; beta; amine
Prior art date: 2000-02-18

Application number

AT01910961T

Other languages

English (en)

Inventor

John A Montgomery

Anita T Fowler

John A Secrist Iii

Original Assignee

Southern Res Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-18

Filing date

2001-02-16

Publication date

2006-08-15

2001-02-16 Application filed by Southern Res Inst filed Critical Southern Res Inst

2006-08-15 Application granted granted Critical

2006-08-15 Publication of ATE332910T1 publication Critical patent/ATE332910T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 4
KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 2
229910021529 ammonia Inorganic materials 0.000 abstract 2
WDDPHFBMKLOVOX-AYQXTPAHSA-N clofarabine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F WDDPHFBMKLOVOX-AYQXTPAHSA-N 0.000 abstract 2
-1 2-chloro-6-substituted purine Chemical class 0.000 abstract 1
150000004703 alkoxides Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
239000000376 reactant Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT01910961T 2000-02-18 2001-02-16 Verfahren zur herstellung von 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofura osyl)-9h-purin-6-amin ATE332910T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US18342200P	2000-02-18	2000-02-18

Publications (1)

Publication Number	Publication Date
ATE332910T1 true ATE332910T1 (de)	2006-08-15

Family

ID=22672724

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01910961T ATE332910T1 (de)	2000-02-18	2001-02-16	Verfahren zur herstellung von 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofura osyl)-9h-purin-6-amin

Country Status (15)

Country	Link
US (2)	US6949640B2 (de)
EP (1)	EP1261350B1 (de)
JP (2)	JP4555536B2 (de)
KR (1)	KR100695717B1 (de)
AT (1)	ATE332910T1 (de)
AU (2)	AU3851601A (de)
CA (1)	CA2400470C (de)
CY (1)	CY1105636T1 (de)
DE (1)	DE60121425T2 (de)
DK (1)	DK1261350T3 (de)
ES (1)	ES2267725T3 (de)
MX (1)	MXPA02008075A (de)
NZ (1)	NZ520852A (de)
PT (1)	PT1261350E (de)
WO (1)	WO2001060383A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU3851601A (en) *	2000-02-18	2001-08-27	Southern Res Inst	Methods for synthesizing 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h- purin-6-amine
US7528247B2 (en) *	2001-08-02	2009-05-05	Genzyme Corporation	Process for preparing purine nucleosides
WO2003011877A2 (en)	2001-08-02	2003-02-13	Ilex Oncology Inc.	Process for preparing purine nucleosides
US6884880B2 (en) *	2002-08-21	2005-04-26	Ash Stevens, Inc.	Process for the preparation of 9-β-anomeric nucleoside analogs
CA2653247C (en) *	2005-06-14	2012-12-18	Brigham Young University	Methods for selective n-9 glycosylation of purines
EP2070938A1 (de)	2007-12-13	2009-06-17	Heidelberg Pharma AG	Clofarabin-Dietherphospholipid-Derivate
CN101497640B (zh) *	2008-01-30	2011-09-14	江苏正大天晴药业股份有限公司	一种氯法拉滨的晶型
CN102311472B (zh) *	2010-07-09	2014-09-03	神隆(昆山)生化科技有限公司	2-氯-9-(2’-脱氧-2’-氟-β-D-阿拉伯呋喃糖基)-腺嘌呤的制备
CN102060899B (zh) *	2010-12-27	2012-07-25	江苏奥赛康药业股份有限公司	一种奈拉滨N-9位α型异构体、其制备方法及其应用
WO2015118558A2 (en) *	2014-02-04	2015-08-13	Msn Laboratories Private Limited	Process for the preparation of clofarabine
EP2937420A1 (de)	2014-04-23	2015-10-28	Synbias Pharma AG	Verfahren zur Synthese von Clofarabin
WO2018085307A1 (en) *	2016-11-03	2018-05-11	Wu Laurence I	Prodrugs of clofarabine

Family Cites Families (21)

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US3903073A (en) *	1973-12-26	1975-09-02	Abbott Lab	2-Substituted adenosine-5{40 {0 carboxylates
US4625020A (en) *	1983-11-18	1986-11-25	Bristol-Myers Company	Nucleoside process
US4751221A (en) *	1985-10-18	1988-06-14	Sloan-Kettering Institute For Cancer Research	2-fluoro-arabinofuranosyl purine nucleosides
US5310732A (en) *	1986-02-03	1994-05-10	The Scripps Research Institute	2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis
EP0267878A1 (de) *	1986-11-14	1988-05-18	Ciba-Geigy Ag	N9-Cyclopentylsubstituierte Adeninderivate
GB8712745D0 (en) *	1987-05-30	1987-07-01	Wellcome Found	Antiviral compounds
EP0314011A3 (de)	1987-10-30	1990-04-11	F. Hoffmann-La Roche Ag	Purinderivate
KR0138996B1 (ko)	1988-03-16	1998-04-30	레이몬드 에이치. 칸	치환된 아데닌 유도체 및 이를 함유하는 약제학적 조성물
JPH0217199A (ja) *	1988-07-05	1990-01-22	Japan Tobacco Inc	２’−デオキシ−β−アデノシンの製造方法
US5384310A (en) *	1989-05-23	1995-01-24	Southern Research Institute	2'-fluoro-2-haloarabinoadinosines and their pharmaceutical compositions
HU906976D0 (en) *	1989-11-13	1991-05-28	Bristol Myers Squibb Co	Process for producing 2', 3'-didesoxy-2'-fluoarabinonucleoside analogues
US5110919A (en) *	1989-12-04	1992-05-05	Ash Stevens, Inc.	Process for the preparation of 2-amino-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine and novel intermediates
CS276072B6 (en) *	1990-08-06	1992-03-18	Ustav Organicke Chemie A Bioch	(2R)-2-/DI(2-PROPYL)PHOSPHONYLMETHOXY/-3-p-TOLUENESULFONYLOXY -1- TRIMETHYLACETOXYPROPANE AND PROCESS FOR PREPARING THEREOF
US5180824A (en)	1990-11-29	1993-01-19	Berlex Biosciences Inc.	6-azido-2-fluoropurine, useful in the synthesis of nucleosides
US5332814A (en) *	1991-11-12	1994-07-26	Ciba-Geigy Corporation	Process for the preparation of carbacyclic nucleosides, and intermediates
UA41261C2 (uk) *	1992-06-22	2001-09-17	Елі Ліллі Енд Компані	Спосіб одержання збагачених бета-аномером нуклеозидів
NO932286L (no) *	1992-06-22	1993-12-23	Lilly Co Eli	Stereoselektiv anion-glykosyleringsprosess
US5821357A (en) *	1992-06-22	1998-10-13	Eli Lilly And Company	Stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoropurine and triazole nucleosides
US5401838A (en)	1992-06-22	1995-03-28	Eli Lilly And Company	Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5753789A (en) *	1996-07-26	1998-05-19	Yale University	Oligonucleotides containing L-nucleosides
AU3851601A (en) *	2000-02-18	2001-08-27	Southern Res Inst	Methods for synthesizing 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h- purin-6-amine

2001
- 2001-02-16 AU AU3851601A patent/AU3851601A/xx active Pending
- 2001-02-16 MX MXPA02008075A patent/MXPA02008075A/es active IP Right Grant
- 2001-02-16 ES ES01910961T patent/ES2267725T3/es not_active Expired - Lifetime
- 2001-02-16 KR KR1020027010781A patent/KR100695717B1/ko not_active Expired - Fee Related
- 2001-02-16 DE DE60121425T patent/DE60121425T2/de not_active Expired - Lifetime
- 2001-02-16 AT AT01910961T patent/ATE332910T1/de active
- 2001-02-16 WO PCT/US2001/005320 patent/WO2001060383A1/en not_active Ceased
- 2001-02-16 AU AU2001238516A patent/AU2001238516B2/en not_active Expired
- 2001-02-16 EP EP01910961A patent/EP1261350B1/de not_active Expired - Lifetime
- 2001-02-16 CA CA002400470A patent/CA2400470C/en not_active Expired - Lifetime
- 2001-02-16 US US09/889,287 patent/US6949640B2/en not_active Expired - Lifetime
- 2001-02-16 NZ NZ520852A patent/NZ520852A/en not_active IP Right Cessation
- 2001-02-16 PT PT01910961T patent/PT1261350E/pt unknown
- 2001-02-16 DK DK01910961T patent/DK1261350T3/da active
- 2001-02-16 JP JP2001559479A patent/JP4555536B2/ja not_active Expired - Fee Related
2005
- 2005-08-16 US US11/204,176 patent/US7470784B2/en not_active Expired - Lifetime
2006
- 2006-09-28 CY CY20061101407T patent/CY1105636T1/el unknown
2009
- 2009-12-21 JP JP2009289620A patent/JP2010070560A/ja active Pending

Also Published As

Publication number	Publication date
AU3851601A (en)	2001-08-27
JP2010070560A (ja)	2010-04-02
DE60121425T2 (de)	2007-02-01
JP2003522798A (ja)	2003-07-29
US20050288500A1 (en)	2005-12-29
JP4555536B2 (ja)	2010-10-06
AU2001238516B2 (en)	2005-08-04
EP1261350A1 (de)	2002-12-04
DK1261350T3 (da)	2006-11-13
PT1261350E (pt)	2006-11-30
DE60121425D1 (de)	2006-08-24
CY1105636T1 (el)	2010-12-22
US7470784B2 (en)	2008-12-30
CA2400470A1 (en)	2001-08-23
US20030023078A1 (en)	2003-01-30
EP1261350B1 (de)	2006-07-12
NZ520852A (en)	2004-03-26
EP1261350A4 (de)	2003-04-16
KR100695717B1 (ko)	2007-03-15
ES2267725T3 (es)	2007-03-16
MXPA02008075A (es)	2005-06-06
CA2400470C (en)	2008-11-18
KR20030032920A (ko)	2003-04-26
WO2001060383A1 (en)	2001-08-23
US6949640B2 (en)	2005-09-27

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2007-05-15

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