ATE548366T1 - Verfahren zur herstellung von dioxolan nukleosidanalogavorstufen - Google Patents
Verfahren zur herstellung von dioxolan nukleosidanalogavorstufenInfo
- Publication number
- ATE548366T1 ATE548366T1 AT03731646T AT03731646T ATE548366T1 AT E548366 T1 ATE548366 T1 AT E548366T1 AT 03731646 T AT03731646 T AT 03731646T AT 03731646 T AT03731646 T AT 03731646T AT E548366 T1 ATE548366 T1 AT E548366T1
- Authority
- AT
- Austria
- Prior art keywords
- formula
- producing
- dioxolane
- analogo
- precursors
- Prior art date
Links
- YNWUIBSEOAWSHW-HIQWKFPQSA-N 5-[(e)-2-bromoethenyl]-1-[(2s,4s)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]pyrimidine-2,4-dione Chemical compound O1[C@@H](CO)OC[C@H]1N1C(=O)NC(=O)C(\C=C\Br)=C1 YNWUIBSEOAWSHW-HIQWKFPQSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002243 precursor Substances 0.000 title 1
- -1 dioxolane compound Chemical class 0.000 abstract 2
- WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical compound C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- IGFXRKMLLMBKSA-UHFFFAOYSA-N purine Chemical compound N1=C[N]C2=NC=NC2=C1 IGFXRKMLLMBKSA-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35096802P | 2002-01-25 | 2002-01-25 | |
| PCT/CA2003/000085 WO2003062229A1 (en) | 2002-01-25 | 2003-01-23 | Process for producing dioxolane nucleoside analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE548366T1 true ATE548366T1 (de) | 2012-03-15 |
Family
ID=27613448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03731646T ATE548366T1 (de) | 2002-01-25 | 2003-01-23 | Verfahren zur herstellung von dioxolan nukleosidanalogavorstufen |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20050085638A1 (de) |
| EP (1) | EP1467990B1 (de) |
| JP (1) | JP4441265B2 (de) |
| AT (1) | ATE548366T1 (de) |
| AU (1) | AU2003236757B2 (de) |
| CA (1) | CA2473736C (de) |
| WO (1) | WO2003062229A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003240970B2 (en) * | 2002-05-31 | 2008-05-15 | Vidacare LLC | Apparatus and method to access bone marrow |
| WO2005074654A2 (en) | 2004-02-03 | 2005-08-18 | Emory University | Methods to manufacture 1,3-dioxolane nucleosides |
| BRPI0813036A2 (pt) * | 2007-07-30 | 2017-10-24 | Rfs Pharma Llc | processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina. |
| CN105503838B (zh) * | 2015-08-26 | 2017-05-31 | 广西慧宝源医药科技有限公司 | 曲沙他滨的合成及其晶型 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6350753B1 (en) * | 1988-04-11 | 2002-02-26 | Biochem Pharma Inc. | 2-Substituted-4-substituted-1,3-dioxolanes and use thereof |
| US5276151A (en) | 1990-02-01 | 1994-01-04 | Emory University | Method of synthesis of 1,3-dioxolane nucleosides |
| ZA923640B (en) | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
| GB9525606D0 (en) | 1995-12-14 | 1996-02-14 | Iaf Biochem Int | Method and compositions for the synthesis of dioxolane nucleosides with - configuration |
| ES2318179T3 (es) * | 2002-11-18 | 2009-05-01 | Shire Canada Inc. | Procedimiento estereoselectivo para la produccion de analogos de nucleosidos de dioxolano. |
| WO2005074654A2 (en) * | 2004-02-03 | 2005-08-18 | Emory University | Methods to manufacture 1,3-dioxolane nucleosides |
-
2003
- 2003-01-23 AT AT03731646T patent/ATE548366T1/de active
- 2003-01-23 EP EP03731646A patent/EP1467990B1/de not_active Expired - Lifetime
- 2003-01-23 US US10/502,440 patent/US20050085638A1/en not_active Abandoned
- 2003-01-23 AU AU2003236757A patent/AU2003236757B2/en not_active Expired
- 2003-01-23 CA CA2473736A patent/CA2473736C/en not_active Expired - Lifetime
- 2003-01-23 JP JP2003562107A patent/JP4441265B2/ja not_active Expired - Lifetime
- 2003-01-23 WO PCT/CA2003/000085 patent/WO2003062229A1/en not_active Ceased
-
2007
- 2007-03-05 US US11/713,724 patent/US7442813B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003062229A1 (en) | 2003-07-31 |
| US20050085638A1 (en) | 2005-04-21 |
| US7442813B2 (en) | 2008-10-28 |
| CA2473736C (en) | 2011-10-11 |
| AU2003236757B2 (en) | 2009-12-03 |
| JP4441265B2 (ja) | 2010-03-31 |
| EP1467990B1 (de) | 2012-03-07 |
| CA2473736A1 (en) | 2003-07-31 |
| JP2005521660A (ja) | 2005-07-21 |
| EP1467990A1 (de) | 2004-10-20 |
| US20070197784A1 (en) | 2007-08-23 |
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