UA65522C2 - Inner cellular isoform of interleukin-1 receptor antagonist - Google Patents

Inner cellular isoform of interleukin-1 receptor antagonist Download PDF

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Publication number
UA65522C2
UA65522C2 UA97052129A UA97052129A UA65522C2 UA 65522 C2 UA65522 C2 UA 65522C2 UA 97052129 A UA97052129 A UA 97052129A UA 97052129 A UA97052129 A UA 97052129A UA 65522 C2 UA65522 C2 UA 65522C2
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UA
Ukraine
Prior art keywords
sequence
polypeptide
isi
cells
antagonist
Prior art date
Application number
UA97052129A
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English (en)
Ukrainian (uk)
Original Assignee
Applied Research Systems
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Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of UA65522C2 publication Critical patent/UA65522C2/uk

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)
UA97052129A 1994-10-13 1995-12-10 Inner cellular isoform of interleukin-1 receptor antagonist UA65522C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI942097A IT1270662B (it) 1994-10-13 1994-10-13 Antagonista della interleuchina-1
PCT/EP1995/004023 WO1996012022A1 (en) 1994-10-13 1995-10-12 Intracellular isoform of the interleukin-1 receptor antagonist

Publications (1)

Publication Number Publication Date
UA65522C2 true UA65522C2 (en) 2004-04-15

Family

ID=11369705

Family Applications (1)

Application Number Title Priority Date Filing Date
UA97052129A UA65522C2 (en) 1994-10-13 1995-12-10 Inner cellular isoform of interleukin-1 receptor antagonist

Country Status (18)

Country Link
US (1) US5739282A (de)
EP (1) EP0786002B1 (de)
JP (1) JPH10509306A (de)
KR (1) KR100237936B1 (de)
CN (2) CN100363053C (de)
AT (1) ATE303439T1 (de)
BR (1) BR9509317A (de)
CA (1) CA2202470C (de)
DE (1) DE69534419T2 (de)
EE (1) EE03697B1 (de)
ES (1) ES2243942T3 (de)
IT (1) IT1270662B (de)
MX (1) MX9702616A (de)
NO (1) NO320494B1 (de)
PT (1) PT786002E (de)
RU (1) RU2193064C2 (de)
UA (1) UA65522C2 (de)
WO (1) WO1996012022A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5075222A (en) * 1988-05-27 1991-12-24 Synergen, Inc. Interleukin-1 inhibitors
US5872095A (en) * 1990-05-01 1999-02-16 Chiron Corporation IL-1 receptor antagonists medicaments
US6380162B1 (en) * 1996-10-31 2002-04-30 Applied Research Systems Ars Holding N.V. Ice inhibiting peptides
ES2312179T3 (es) * 1996-12-06 2009-02-16 Amgen Inc. Terapia combinada que utiliza un inhibidor del il-1 para el tratamiento de enfermedades mediadas por el il-1.
US6294170B1 (en) 1997-08-08 2001-09-25 Amgen Inc. Composition and method for treating inflammatory diseases
IL126562A0 (en) * 1998-10-14 1999-08-17 Interpharm Lab Ltd Expression and secretion of icil-1 receptor antagonist type ii
US20020077276A1 (en) * 1999-04-27 2002-06-20 Fredeking Terry M. Compositions and methods for treating hemorrhagic virus infections and other disorders
US7166712B2 (en) * 2000-07-12 2007-01-23 Philadelphia, Health And Education Corporation Mammalian MDM2 binding proteins and uses thereof
PL3718564T3 (pl) * 2003-12-23 2024-03-18 Genentech, Inc. Nowe przeciwciała anty-IL 13 i ich zastosowania
ES2706848T3 (es) 2004-07-06 2019-04-01 Zymogenetics Inc Composición farmacéutica que comprende FGF18 y antagonista de IL-1 y método de uso
RU2326947C2 (ru) * 2004-11-23 2008-06-20 Общество с ограниченной ответственностью "ЦИТОКИН" Способ получения рекомбинантного антагониста рецептора интерлейкина-1 человека "арил"
BRPI0706788A2 (pt) * 2006-01-31 2011-04-05 Novartis Ag anticorpos antagonistas il-17
CN101918018B (zh) 2007-11-14 2012-12-05 再生医药有限公司 使用白介素-1受体拮抗剂作为骨髓保护剂的方法
CN101690801B (zh) 2009-10-26 2012-08-01 上海交通大学 白细胞介素-1受体拮抗剂的用途及其药物组合物
ES2600616T3 (es) 2011-03-14 2017-02-10 Phlogo Aps Antagonistas del receptor de la interleucina-1
US9156897B2 (en) 2012-06-08 2015-10-13 Alkermes, Inc. Fusion polypeptides comprising an active protein linked to a mucin-domain polypeptide
WO2015191783A2 (en) 2014-06-10 2015-12-17 Abbvie Inc. Biomarkers for inflammatory disease and methods of using same
EA202191354A1 (ru) * 2018-11-15 2021-08-11 Янссен Байотек, Инк. Способы и композиции для прогнозирования ответа на терапию воспалительного заболевания кишечника

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0148009B1 (ko) * 1988-05-27 1998-08-01 그래고리 비. 아보트 인터루킨-1 억제제
EP0502956B1 (de) * 1989-11-29 1997-04-23 Amgen Boulder Inc. Herstellung eines rekombinanten menschlichen interleukin-1-hemmers
AU649245B2 (en) * 1990-04-02 1994-05-19 Amgen, Inc. Methods for treating interleukin-1 mediated diseases
WO1991017184A1 (en) * 1990-04-27 1991-11-14 The Upjohn Company Modified interleukin-1 inhibitors
AU655766B2 (en) * 1990-05-01 1995-01-12 Chiron Corporation Interleukin-1 antagonist and uses thereof

Also Published As

Publication number Publication date
DE69534419D1 (de) 2005-10-06
CA2202470C (en) 2008-09-16
DE69534419T2 (de) 2006-06-14
EP0786002B1 (de) 2005-08-31
IT1270662B (it) 1997-05-07
NO320494B1 (no) 2005-12-12
CA2202470A1 (en) 1996-04-25
NO971624L (no) 1997-05-30
BR9509317A (pt) 1997-10-14
CN100363053C (zh) 2008-01-23
ATE303439T1 (de) 2005-09-15
WO1996012022A1 (en) 1996-04-25
KR970706391A (ko) 1997-11-03
NO971624D0 (no) 1997-04-09
RU2193064C2 (ru) 2002-11-20
EP0786002A1 (de) 1997-07-30
CN1679919A (zh) 2005-10-12
ES2243942T3 (es) 2005-12-01
KR100237936B1 (ko) 2000-01-15
JPH10509306A (ja) 1998-09-14
AU701471B2 (en) 1999-01-28
CN1224707C (zh) 2005-10-26
EE9700090A (et) 1997-10-15
MX9702616A (es) 1998-04-30
EE03697B1 (et) 2002-04-15
ITMI942097A0 (it) 1994-10-13
AU3841795A (en) 1996-05-06
ITMI942097A1 (it) 1996-04-13
CN1161058A (zh) 1997-10-01
US5739282A (en) 1998-04-14
HK1002659A1 (en) 1998-09-11
PT786002E (pt) 2005-11-30
HK1081124A1 (zh) 2006-05-12

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