ATE303817T1 - Verwendung von osteoprotegerin zur vorbeugung und behandlung cardiovaskulärer erkrankungen - Google Patents

Verwendung von osteoprotegerin zur vorbeugung und behandlung cardiovaskulärer erkrankungen

Info

Publication number
ATE303817T1
ATE303817T1 AT99918766T AT99918766T ATE303817T1 AT E303817 T1 ATE303817 T1 AT E303817T1 AT 99918766 T AT99918766 T AT 99918766T AT 99918766 T AT99918766 T AT 99918766T AT E303817 T1 ATE303817 T1 AT E303817T1
Authority
AT
Austria
Prior art keywords
osteoprotegerin
cardiovascular diseases
preventing
treating cardiovascular
opg
Prior art date
Application number
AT99918766T
Other languages
English (en)
Inventor
Scott Simonet
Ildiko Sarosi
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of ATE303817T1 publication Critical patent/ATE303817T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT99918766T 1998-04-23 1999-04-21 Verwendung von osteoprotegerin zur vorbeugung und behandlung cardiovaskulärer erkrankungen ATE303817T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/064,832 US6790823B1 (en) 1998-04-23 1998-04-23 Compositions and methods for the prevention and treatment of cardiovascular diseases
PCT/US1999/008793 WO1999053942A1 (en) 1998-04-23 1999-04-21 Compositions comprising osteoprotegerin for the prevention and treatment of cardiovascular diseases

Publications (1)

Publication Number Publication Date
ATE303817T1 true ATE303817T1 (de) 2005-09-15

Family

ID=22058524

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99918766T ATE303817T1 (de) 1998-04-23 1999-04-21 Verwendung von osteoprotegerin zur vorbeugung und behandlung cardiovaskulärer erkrankungen

Country Status (11)

Country Link
US (1) US6790823B1 (de)
EP (1) EP1073456B1 (de)
JP (1) JP4776774B2 (de)
AT (1) ATE303817T1 (de)
AU (1) AU757806B2 (de)
CA (1) CA2325360C (de)
DE (1) DE69927147T2 (de)
DK (1) DK1073456T3 (de)
ES (1) ES2248998T3 (de)
SI (1) SI1073456T1 (de)
WO (1) WO1999053942A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL117175A (en) 1995-02-20 2005-11-20 Sankyo Co Osteoclastogenesis inhibitory factor protein
DE69740107D1 (de) 1996-12-23 2011-03-10 Immunex Corp Rezeptor aktivator von nf-kappa b, rezeptor is mitglied der tnf rezeptor superfamilie
ES2263204T5 (es) 1997-04-15 2013-10-14 Daiichi Sankyo Company, Limited Nueva proteína y proceso para producir la misma
US6316408B1 (en) 1997-04-16 2001-11-13 Amgen Inc. Methods of use for osetoprotegerin binding protein receptors
ES2284203T5 (es) 1997-04-16 2016-03-11 Amgen Inc. Proteínas de unión a osteoprotegerina y sus receptores
JP4380067B2 (ja) * 1998-04-23 2009-12-09 味の素株式会社 抗血栓活性物質及びグリコカリシンの検出法
AU762574B2 (en) 1998-05-14 2003-06-26 Immunex Corporation Method of inhibiting osteoclast activity
EP1377610A2 (de) * 2001-04-03 2004-01-07 Société des Produits Nestlé S.A. Osteoprotegerin in milch
US7198798B2 (en) * 2001-05-10 2007-04-03 University Of Washington Methods and devices for promoting endothelial morphogenesis
US7064189B2 (en) 2001-05-25 2006-06-20 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to trail receptors
US8649843B2 (en) * 2001-11-24 2014-02-11 Ben A. Arnold Automated calcium scoring of the aorta
US7718776B2 (en) 2002-04-05 2010-05-18 Amgen Inc. Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors
US7585840B2 (en) 2002-04-10 2009-09-08 Merck Serono S.A. Use of osteoprotegerin for the treatment and/or prevention of fibrotic disease
EP1515743A2 (de) * 2002-04-10 2005-03-23 Applied Research Systems ARS Holding N.V. Verwendung von osteoprotegerin zur vorbeugung gegen und behandlung von fibrose/sklerose
US7612153B2 (en) 2004-10-25 2009-11-03 Intezyne Technologies, Inc. Heterobifunctional poly(ethylene glycol) and uses thereof
US7601796B2 (en) 2005-01-04 2009-10-13 Intezyne Technologies, Inc. Synthesis of hybrid block copolymers and uses thereof
US7561727B2 (en) * 2005-06-02 2009-07-14 Nordic Bioscience Imaging A/S Method of deriving a quantitative measure of a degree of calcification of an aorta
US7463758B2 (en) * 2005-06-02 2008-12-09 Nordio Bioscience A/S Method of deriving a quantitative measure of a degree of calcification of an aorta
EP2433644A1 (de) 2010-09-22 2012-03-28 IMBA-Institut für Molekulare Biotechnologie GmbH Brustkrebstherapeutika
FR2970870A1 (fr) * 2011-01-31 2012-08-03 Centre Nat Rech Scient Modulation de la proliferation des cellules epitheliales de l'unite epidermo-pilo-sebacee via rank

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
JP2877509B2 (ja) 1989-05-19 1999-03-31 アムジエン・インコーポレーテツド メタロプロテイナーゼ阻害剤
US5580722A (en) * 1989-07-18 1996-12-03 Oncogene Science, Inc. Methods of determining chemicals that modulate transcriptionally expression of genes associated with cardiovascular disease
US6369027B1 (en) 1995-12-22 2002-04-09 Amgen Inc. Osteoprotegerin

Also Published As

Publication number Publication date
WO1999053942A1 (en) 1999-10-28
US6790823B1 (en) 2004-09-14
DK1073456T3 (da) 2005-10-24
CA2325360C (en) 2008-11-04
AU3660599A (en) 1999-11-08
JP4776774B2 (ja) 2011-09-21
DE69927147D1 (de) 2005-10-13
WO1999053942A8 (en) 1999-12-02
CA2325360A1 (en) 1999-10-28
AU757806B2 (en) 2003-03-06
JP2002512199A (ja) 2002-04-23
ES2248998T3 (es) 2006-03-16
SI1073456T1 (sl) 2005-12-31
DE69927147T2 (de) 2006-01-26
EP1073456A1 (de) 2001-02-07
EP1073456B1 (de) 2005-09-07

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