DK1401839T3 - Antidepressive (SSSRI) azaheterocyclylmethylderivater af 7,8-dihydro-3H-6,9-dioxa-1,3-diazacyclopenta[a]naphthalen - Google Patents

Antidepressive (SSSRI) azaheterocyclylmethylderivater af 7,8-dihydro-3H-6,9-dioxa-1,3-diazacyclopenta[a]naphthalen

Info

Publication number: DK1401839T3
Authority: DK; Denmark
Prior art keywords: sssri; diazacyclopenta; azaheterocyclyl; dioxa; antidepressant
Prior art date: 2001-04-26

Application number

DK02728968T

Other languages

English (en)

Other versions

DK1401839T5 (da

Inventor

Gary Paul Stack

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-26

Filing date

2002-04-23

Publication date

2005-10-24

2002-04-23 Application filed by Wyeth Corp filed Critical Wyeth Corp

2005-10-24 Application granted granted Critical

2005-10-24 Publication of DK1401839T3 publication Critical patent/DK1401839T3/da

2006-03-13 Publication of DK1401839T5 publication Critical patent/DK1401839T5/da

Links

230000001430 anti-depressive effect Effects 0.000 title 1
239000000935 antidepressant agent Substances 0.000 title 1
229940005513 antidepressants Drugs 0.000 title 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title 1
UFWIBTONFRDIAS-UHFFFAOYSA-N naphthalene-acid Natural products C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 title 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
208000007848 Alcoholism Diseases 0.000 abstract 1
208000022497 Cocaine-Related disease Diseases 0.000 abstract 1
208000020401 Depressive disease Diseases 0.000 abstract 1
206010013654 Drug abuse Diseases 0.000 abstract 1
208000030814 Eating disease Diseases 0.000 abstract 1
208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
208000011688 Generalised anxiety disease Diseases 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
206010033664 Panic attack Diseases 0.000 abstract 1
201000001880 Sexual dysfunction Diseases 0.000 abstract 1
206010041250 Social phobia Diseases 0.000 abstract 1
206010001584 alcohol abuse Diseases 0.000 abstract 1
208000025746 alcohol use disease Diseases 0.000 abstract 1
201000001272 cocaine abuse Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
235000014632 disordered eating Nutrition 0.000 abstract 1
208000029364 generalized anxiety disease Diseases 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
208000019906 panic disease Diseases 0.000 abstract 1
231100000872 sexual dysfunction Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Addiction (AREA)
Obesity (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Gynecology & Obstetrics (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK02728968T 2001-04-26 2002-04-23 Antidepressive (SSSRI) azaheterocyclylmethylderivater af 7,8-dihydro-3H-6,9-dioxa-1,3-diazacyclopenta[a]naphthalen DK1401839T5 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US28657901P	2001-04-26	2001-04-26
PCT/US2002/012993 WO2002088131A1 (en)	2001-04-26	2002-04-23	Antidepressant (sssri) azaheterocyclymethyl derivatives of 7,8-dihydro-3h-t,9-dioxa-1,3-diazacyclopenta[a]naphthalene

Publications (2)

Publication Number	Publication Date
DK1401839T3 true DK1401839T3 (da)	2005-10-24
DK1401839T5 DK1401839T5 (da)	2006-03-13

Family

ID=23099245

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02728968T DK1401839T5 (da)	2001-04-26	2002-04-23	Antidepressive (SSSRI) azaheterocyclylmethylderivater af 7,8-dihydro-3H-6,9-dioxa-1,3-diazacyclopenta[a]naphthalen

Country Status (12)

Country	Link
US (1)	US6573283B2 (da)
EP (1)	EP1401839B9 (da)
JP (1)	JP2004527561A (da)
CN (1)	CN1267434C (da)
AT (1)	ATE304016T1 (da)
BR (1)	BR0209408A (da)
CA (1)	CA2445552A1 (da)
DE (1)	DE60206048T2 (da)
DK (1)	DK1401839T5 (da)
ES (1)	ES2247327T3 (da)
MX (1)	MXPA03009828A (da)
WO (1)	WO2002088131A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6927226B2 (en) *	2001-04-26	2005-08-09	Wyeth	Antidepressant azaheterocyclymethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diazacyclopenta[a]naphthalene
ES2364340T3 (es)	2004-03-30	2011-08-31	Vertex Pharmaceuticals Incorporated	Azaindoles útiles como inhibidores de jak y otras proteína quinasas.
CN101678022A (zh)	2006-12-21	2010-03-24	弗特克斯药品有限公司	可用作蛋白激酶抑制剂的5-氰基-4-(吡咯并[2,3b]吡啶-3-基)嘧啶衍生物
LT3141252T (lt)	2009-06-17	2018-11-12	Vertex Pharmaceuticals Inc.	Gripo virusų replikacijos inhibitoriai
RU2013132681A (ru)	2010-12-16	2015-01-27	Вертекс Фармасьютикалз Инкорпорейтед	Ингибиторы репликации вирусов гриппа
UA118010C2 (uk)	2011-08-01	2018-11-12	Вертекс Фармасьютікалз Інкорпорейтед	Інгібітори реплікації вірусів грипу
JP6618901B2 (ja)	2013-11-13	2019-12-11	バーテックスファーマシューティカルズインコーポレイテッドＶｅｒｔｅｘＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃｏｒｐｏｒａｔｅｄ	インフルエンザウイルスの複製の阻害剤を調製する方法
LT3068776T (lt)	2013-11-13	2019-08-12	Vertex Pharmaceuticals Incorporated	Gripo virusų replikacijos inhibitoriai
EP3294717B1 (en)	2015-05-13	2020-07-29	Vertex Pharmaceuticals Inc.	Methods of preparing inhibitors of influenza viruses replication
EP3294735B8 (en)	2015-05-13	2022-01-05	Vertex Pharmaceuticals Incorporated	Inhibitors of influenza viruses replication
CA3209458A1 (en) *	2021-03-08	2022-09-15	Chunyang JIN	Small molecule antagonists for the relaxin-3/rxfp3 system

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1991013872A1 (en) *	1990-03-15	1991-09-19	The Upjohn Company	Therapeutically useful heterocyclic indole compounds
DE4135474A1 (de)	1991-10-28	1993-04-29	Bayer Ag	2-aminomethyl-chromane
DE4140540A1 (de)	1991-12-09	1993-06-17	Bayer Ag	Neue azaheterocyclylmethyl-chromane
US5741789A (en)	1995-01-17	1998-04-21	Eli Lilly And Company	Compounds having effects on serotonin-related systems
US5756532A (en) *	1995-11-06	1998-05-26	American Home Products Corporation	Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives
GB9526495D0 (en)	1995-12-23	1996-02-28	Knoll Ag	Therapeutic agents
DK0932609T3 (da) *	1996-10-15	2003-09-01	Wyeth Corp	Azaheterocyclomethylderivater af 2,3,8,9-tetrahydro-7H-1,4-dioxino[2,3-e]indol-8-on
US5869490A (en)	1996-10-15	1999-02-09	American Home Products Corporation	Azaheterocyclymethyl derivatives of 2,3,8,9-tetrahydro-7h-1,4-dioxino (2,3-e) indol-8-one
GB9627005D0 (en)	1996-12-27	1997-02-12	Knoll Ag	Therapeutic agents
GB9704948D0 (en)	1997-03-11	1997-04-30	Knoll Ag	Therapeutic agents
US6458802B1 (en) *	2001-03-14	2002-10-01	Wyeth	Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-dioxino [2,3-f]quinoline

2002
- 2002-04-23 ES ES02728968T patent/ES2247327T3/es not_active Expired - Lifetime
- 2002-04-23 US US10/128,762 patent/US6573283B2/en not_active Expired - Fee Related
- 2002-04-23 AT AT02728968T patent/ATE304016T1/de not_active IP Right Cessation
- 2002-04-23 MX MXPA03009828A patent/MXPA03009828A/es active IP Right Grant
- 2002-04-23 DK DK02728968T patent/DK1401839T5/da active
- 2002-04-23 JP JP2002585430A patent/JP2004527561A/ja active Pending
- 2002-04-23 WO PCT/US2002/012993 patent/WO2002088131A1/en not_active Ceased
- 2002-04-23 DE DE60206048T patent/DE60206048T2/de not_active Expired - Fee Related
- 2002-04-23 BR BR0209408-8A patent/BR0209408A/pt not_active IP Right Cessation
- 2002-04-23 CA CA002445552A patent/CA2445552A1/en not_active Abandoned
- 2002-04-23 EP EP02728968A patent/EP1401839B9/en not_active Expired - Lifetime
- 2002-04-23 CN CNB028088174A patent/CN1267434C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2247327T3 (es)	2006-03-01
DE60206048T2 (de)	2006-07-13
CN1267434C (zh)	2006-08-02
EP1401839B1 (en)	2005-09-07
DK1401839T5 (da)	2006-03-13
JP2004527561A (ja)	2004-09-09
DE60206048D1 (de)	2005-10-13
CN1535274A (zh)	2004-10-06
EP1401839B9 (en)	2005-11-30
ATE304016T1 (de)	2005-09-15
EP1401839A1 (en)	2004-03-31
BR0209408A (pt)	2004-07-06
MXPA03009828A (es)	2005-03-07
US20020183351A1 (en)	2002-12-05
WO2002088131A1 (en)	2002-11-07
US6573283B2 (en)	2003-06-03
CA2445552A1 (en)	2002-11-07

Publication	Publication Date	Title
WO2002085896A8 (en)	2002-11-28	Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-benzodioxan
DK1401839T5 (da)	2006-03-13	Antidepressive (SSSRI) azaheterocyclylmethylderivater af 7,8-dihydro-3H-6,9-dioxa-1,3-diazacyclopenta[a]naphthalen
BR122012023120B8 (pt)	2022-01-18	Composto inibidor da recaptação de serotonina
DK1381613T3 (da)	2005-01-24	Antidepressive azaheterocyclylmethylderivater af oxaheterocyclokondenserede 1,4-benzodioxaner
DK1392700T3 (da)	2004-10-25	Antidepressive azaheterocyclylmethylderivater af 7,8-dihydro-1,6,9-trioxa-3-aza-cyclopenta[a]naphthalen
WO2004009017A3 (en)	2004-07-08	Modulators of the glucocorticoid receptor and method
SE0201544D0 (sv)	2002-05-17	Novel compounds and thier use
DE60213576D1 (de)	2006-09-14	ANTIDEPRESSIVE AZAHETEROCYCLYLMETHYL-DERIVATE VON 2,3-DIHYDRO-1,4-DIOXINOi2,3-föCHINOXALIN
EA200200137A1 (ru)	2002-06-27	Лечение невротических нарушений
PT1626720E (pt)	2008-11-10	Derivados de 4-(2-fenilsulfanil-fenil)-piperidina como inibidores da recaptação da serotonina
DK1392697T3 (da)	2005-02-14	Antidepressive azaheterocyclylmethylderivater af 2,3-dihydro-1,4-dioxino[2.3-f]quinolin
AU2002259010A1 (en)	2002-11-11	Antidepressant indoletetrahydropyridine derivatives of 2,3-dihydro-7h-(1,4)dioxino(2,3-e)indole
NO20035673D0 (no)	2003-12-18	Nye heteroarylderivater, deres fremstilling og anvendelse
NO20052308D0 (no)	2005-05-11	Nye benzoksazociner og deres terapeutiske anvendelse.
EE200300424A (et)	2003-12-15	Meetod ftalaani valmistamiseks
CA2451229A1 (en)	2003-01-09	Indole derivatives
TW200643629A (en)	2006-12-16	Positive photosensitive resin composition
NO20065809L (no)	2007-01-15	Fremstilling av nye substituerte haloaren-forbindelser
TH71835A (th)	2005-11-07	สารประกอบใหม่ 2-พิริดินิลเอธิลเบนแซมีด
TH1801004336A (th)	2019-03-08	อนุพันธ์สไพโรไซคลิค 1h-ไพรโรลิดีน-2,4-ไดโอนที่ถูกแทนที่ซิส-อัลคอกซี