ATE304019T1 - Inhibitoren des nukleosid-metabolismus - Google Patents

Inhibitoren des nukleosid-metabolismus

Info

Publication number: ATE304019T1
Authority: AT; Austria
Prior art keywords: sub; compounds; halogen; chosen; hydroxy
Prior art date: 1997-10-14

Application number

AT98953516T

Other languages

English (en)

Inventor

Richard Hubert Furneaux

Peter Charles Tyler

Vern L Schramm

Original Assignee

Einstein Coll Med

Ind Res Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-14

Filing date

1998-10-14

Publication date

2005-09-15

1998-10-14 Application filed by Einstein Coll Med, Ind Res Ltd filed Critical Einstein Coll Med

2005-09-15 Application granted granted Critical

2005-09-15 Publication of ATE304019T1 publication Critical patent/ATE304019T1/de

Links

239000003112 inhibitor Substances 0.000 title 1
230000004060 metabolic process Effects 0.000 title 1
239000002777 nucleoside Substances 0.000 title 1
150000003833 nucleoside derivatives Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 6
229910052736 halogen Inorganic materials 0.000 abstract 5
150000002367 halogens Chemical class 0.000 abstract 5
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
150000002148 esters Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
239000000651 prodrug Substances 0.000 abstract 2
229940002612 prodrug Drugs 0.000 abstract 2
125000000547 substituted alkyl group Chemical group 0.000 abstract 2
125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Tropical Medicine & Parasitology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Transplantation (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)

AT98953516T 1997-10-14 1998-10-14 Inhibitoren des nukleosid-metabolismus ATE304019T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/949,388 US5985848A (en)	1997-10-14	1997-10-14	Inhibitors of nucleoside metabolism
PCT/US1998/021717 WO1999019338A1 (en)	1997-10-14	1998-10-14	Inhibitors of nucleoside metabolism

Publications (1)

Publication Number	Publication Date
ATE304019T1 true ATE304019T1 (de)	2005-09-15

Family

ID=25489007

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98953516T ATE304019T1 (de)	1997-10-14	1998-10-14	Inhibitoren des nukleosid-metabolismus

Country Status (13)

Country	Link
US (7)	US5985848A (de)
EP (1)	EP1023308B1 (de)
JP (1)	JP4451983B2 (de)
KR (1)	KR100637479B1 (de)
CN (2)	CN1220695C (de)
AT (1)	ATE304019T1 (de)
AU (1)	AU749098B2 (de)
CA (1)	CA2305760C (de)
DE (1)	DE69831499T2 (de)
DK (1)	DK1023308T3 (de)
ES (1)	ES2249844T3 (de)
PT (1)	PT1023308E (de)
WO (1)	WO1999019338A1 (de)

Families Citing this family (55)

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US5985848A (en) *	1997-10-14	1999-11-16	Albert Einstein College Of Medicine Of Yeshiva University	Inhibitors of nucleoside metabolism
FR2790915B1 (fr) *	1999-03-19	2001-06-01	Commissariat Energie Atomique	Procede de criblage et de selection d'antiparasitaires apicomplexes et/ou d'herbicides et ses applications
PT1165564E (pt) *	1999-04-08	2009-04-16	Einstein Coll Med	Processo para a preparação de inibidores do metabolismo de nucleósidos
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WO2007016291A2 (en) *	2005-07-27	2007-02-08	Albert Einstein College Of Medicine Of Yeshiva University	Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases
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CN101094080B (zh) *	2006-06-22	2012-06-20	华为技术有限公司	一种即按即通系统中的计费方法
US8383636B2 (en) *	2006-09-07	2013-02-26	Industrial Research Limited	Acyclic amine inhibitors of 5-methytioadenosine phosphorylase and nucleosidase
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WO2010033236A2 (en)	2008-09-22	2010-03-25	Albert Einstein College Of Medicine Of Yeshiva University	Methods and compositions for treating bacterial infections by inhibiting quorum sensing
JP5861243B2 (ja)	2009-07-17	2016-02-16	アルバートアインシュタインカレッジオブメディシンオブイエシバユニバーシティ	５’−メチルチオアデノシンホスホリラーゼ及びヌクレオシダーゼの３−ヒドロキシピロリジン阻害剤
LT2898885T (lt)	2010-10-15	2018-02-26	Biocryst Pharmaceuticals, Inc.	Pirolopirimidino dariniai, skirti naudoti virusinių infekcijų gydymui
US9290501B2 (en) *	2010-11-29	2016-03-22	Albert Einstein College Of Medicine, Inc.	Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
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WO2013014052A1 (en)	2011-07-22	2013-01-31	Glaxosmithkline Llc	Composition
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KR20150085081A (ko) *	2012-11-20	2015-07-22	글락소스미스클라인 엘엘씨	신규 화합물
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EP3104707B1 (de)	2014-02-12	2020-07-15	Albert Einstein College of Medicine, Inc.	Behandlung von infektionen mit h. pylori mittels mtan-inhibitoren
JP2018502858A (ja) *	2015-01-07	2018-02-01	ユーロ−セルティックエス．ア．	フォロデシンの製造方法
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1997
- 1997-10-14 US US08/949,388 patent/US5985848A/en not_active Expired - Lifetime
1998
- 1998-10-14 KR KR1020007003944A patent/KR100637479B1/ko not_active Expired - Lifetime
- 1998-10-14 DE DE69831499T patent/DE69831499T2/de not_active Expired - Lifetime
- 1998-10-14 CN CNB988114895A patent/CN1220695C/zh not_active Expired - Lifetime
- 1998-10-14 US US09/172,321 patent/US6066722A/en not_active Expired - Lifetime
- 1998-10-14 AU AU10866/99A patent/AU749098B2/en not_active Expired
- 1998-10-14 AT AT98953516T patent/ATE304019T1/de active
- 1998-10-14 PT PT98953516T patent/PT1023308E/pt unknown
- 1998-10-14 DK DK98953516T patent/DK1023308T3/da active
- 1998-10-14 CA CA002305760A patent/CA2305760C/en not_active Expired - Lifetime
- 1998-10-14 EP EP98953516A patent/EP1023308B1/de not_active Expired - Lifetime
- 1998-10-14 JP JP2000515909A patent/JP4451983B2/ja not_active Expired - Lifetime
- 1998-10-14 CN CNB2005100920669A patent/CN100393722C/zh not_active Expired - Lifetime
- 1998-10-14 WO PCT/US1998/021717 patent/WO1999019338A1/en not_active Ceased
- 1998-10-14 ES ES98953516T patent/ES2249844T3/es not_active Expired - Lifetime
2000
- 2000-02-03 US US09/496,741 patent/US6228847B1/en not_active Expired - Lifetime
2001
- 2001-03-28 US US09/820,276 patent/US6492347B2/en not_active Expired - Lifetime
2002
- 2002-10-10 US US10/268,652 patent/US6803455B2/en not_active Expired - Lifetime
2004
- 2004-09-02 US US10/932,841 patent/US7211653B2/en not_active Expired - Fee Related
2007
- 2007-03-26 US US11/728,730 patent/US7390890B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69831499D1 (de)	2005-10-13
ES2249844T3 (es)	2006-04-01
PT1023308E (pt)	2005-11-30
US20070197561A1 (en)	2007-08-23
WO1999019338A1 (en)	1999-04-22
AU749098B2 (en)	2002-06-20
CA2305760A1 (en)	1999-04-22
DK1023308T3 (da)	2006-01-23
US5985848A (en)	1999-11-16
US7211653B2 (en)	2007-05-01
EP1023308B1 (de)	2005-09-07
EP1023308A4 (de)	2002-05-29
JP4451983B2 (ja)	2010-04-14
JP2001519437A (ja)	2001-10-23
KR100637479B1 (ko)	2006-10-20
US6228847B1 (en)	2001-05-08
HK1089159A1 (zh)	2006-11-24
US20020061898A1 (en)	2002-05-23
US7390890B2 (en)	2008-06-24
KR20010031082A (ko)	2001-04-16
DE69831499T2 (de)	2006-06-14
CN1279686A (zh)	2001-01-10
CN100393722C (zh)	2008-06-11
US20030096830A1 (en)	2003-05-22
CA2305760C (en)	2008-06-03
EP1023308A1 (de)	2000-08-02
AU1086699A (en)	1999-05-03
US6492347B2 (en)	2002-12-10
CN1220695C (zh)	2005-09-28
US6803455B2 (en)	2004-10-12
CN1757646A (zh)	2006-04-12
US6066722A (en)	2000-05-23
US20050026936A1 (en)	2005-02-03

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2006-05-15

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