DK1023308T3 - Inhibitorer af nukleosidmetabolisme - Google Patents

Inhibitorer af nukleosidmetabolisme

Info

Publication number: DK1023308T3
Authority: DK; Denmark
Prior art keywords: sub; compounds; halogen; chosen; hydroxy
Prior art date: 1997-10-14

Application number

DK98953516T

Other languages

English (en)

Inventor

Vern L Schramm

Richard Hubert Furneaux

Peter Charles Tyler

Original Assignee

Einstein Coll Med

Ind Res Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-14

Filing date

1998-10-14

Publication date

2006-01-23

1998-10-14 Application filed by Einstein Coll Med, Ind Res Ltd filed Critical Einstein Coll Med

2006-01-23 Application granted granted Critical

2006-01-23 Publication of DK1023308T3 publication Critical patent/DK1023308T3/da

Links

239000003112 inhibitor Substances 0.000 title 1
230000004060 metabolic process Effects 0.000 title 1
239000002777 nucleoside Substances 0.000 title 1
150000003833 nucleoside derivatives Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 6
229910052736 halogen Inorganic materials 0.000 abstract 5
150000002367 halogens Chemical class 0.000 abstract 5
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
150000002148 esters Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
239000000651 prodrug Substances 0.000 abstract 2
229940002612 prodrug Drugs 0.000 abstract 2
125000000547 substituted alkyl group Chemical group 0.000 abstract 2
125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Tropical Medicine & Parasitology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Transplantation (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)

DK98953516T 1997-10-14 1998-10-14 Inhibitorer af nukleosidmetabolisme DK1023308T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/949,388 US5985848A (en)	1997-10-14	1997-10-14	Inhibitors of nucleoside metabolism

Publications (1)

Publication Number	Publication Date
DK1023308T3 true DK1023308T3 (da)	2006-01-23

Family

ID=25489007

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98953516T DK1023308T3 (da)	1997-10-14	1998-10-14	Inhibitorer af nukleosidmetabolisme

Country Status (13)

Country	Link
US (7)	US5985848A (da)
EP (1)	EP1023308B1 (da)
JP (1)	JP4451983B2 (da)
KR (1)	KR100637479B1 (da)
CN (2)	CN1220695C (da)
AT (1)	ATE304019T1 (da)
AU (1)	AU749098B2 (da)
CA (1)	CA2305760C (da)
DE (1)	DE69831499T2 (da)
DK (1)	DK1023308T3 (da)
ES (1)	ES2249844T3 (da)
PT (1)	PT1023308E (da)
WO (1)	WO1999019338A1 (da)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5985848A (en) *	1997-10-14	1999-11-16	Albert Einstein College Of Medicine Of Yeshiva University	Inhibitors of nucleoside metabolism
FR2790915B1 (fr) *	1999-03-19	2001-06-01	Commissariat Energie Atomique	Procede de criblage et de selection d'antiparasitaires apicomplexes et/ou d'herbicides et ses applications
CA2696826C (en) *	1999-04-08	2013-01-08	Industrial Research Limited	Process for preparing inhibitors of nucleoside metabolism
US6656915B1 (en)	1999-09-15	2003-12-02	Biocryst Pharmaceuticals, Inc.	Inhibiting T-cell proliferation
US6387923B2 (en) *	2000-03-22	2002-05-14	Biocryst Pharmacueticals, Inc.	Imminoribitol PNP inhibitors, preparation thereof and use thereof
AU2001284564A1 (en) *	2000-08-29	2002-03-13	Albert Einstein College Of Medicine Of Yeshiva University	Nucleoside metabolism inhibitors
US20040076809A1 (en) *	2001-09-13	2004-04-22	Spears Ward R.	Composite flywheel rim having commingled layers with macroscopically uniform patterns of fiber arrangement and methods for manufacturing same
US6660719B2 (en) *	2001-12-17	2003-12-09	Biocryst Pharmaceuticals Inc.	Inhibiting T-Cell proliferation
US7098334B2 (en) *	2002-03-25	2006-08-29	Industrial Research Limited	4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
ATE478872T1 (de) *	2002-03-28	2010-09-15	Ustav Ex Botan Av Cr V V I I O	Pyrazoloä4,3-düpyrimidine, verfahren zu ihrer herstellung und therapeutische anwendung
US20050250728A1 (en) *	2002-05-23	2005-11-10	Shanta Bantia	Enhancing the efficacy of reverse transcriptase and dna polymerase inhibitors (nucleoside analogs) using pnp inhibitors and/or 2'-deoxyguanosine and/or prodrug thereof
ES2363766T3 (es) *	2002-08-21	2011-08-16	Albert Einstein College Of Medicine Of Yeshiva University	Inhibidores de nucleosidasas y fosforilasas de nucleosidos.
NZ523970A (en) *	2003-02-04	2005-02-25	Ind Res Ltd	Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
WO2004081196A2 (en) *	2003-03-11	2004-09-23	Qlt Usa Inc.	Formulations for cell- schedule dependent anticancer agents
US6972331B2 (en) *	2003-04-23	2005-12-06	Biocryst Pharmaceuticals, Inc.	Carboxy pyrrole, process of preparing and use as precursor
WO2005019218A1 (ja) *	2003-08-26	2005-03-03	Teijin Pharma Limited	ピロロピリミジンチオン誘導体
US7557113B2 (en)	2003-08-26	2009-07-07	Teijin Pharma Limited	Substituted pyrrolo[3,2-d]pyrimidine derivatives
US8017634B2 (en)	2003-12-29	2011-09-13	President And Fellows Of Harvard College	Compositions for treating obesity and insulin resistance disorders
NZ533360A (en) *	2004-06-04	2007-02-23	Ind Res Ltd	Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
CA2596142A1 (en) *	2005-02-04	2006-08-10	Uti Limited Partnership	Adenosine analogs useful as anti-bacterial and anti-protozoan agents
CA2615549A1 (en) *	2005-07-27	2007-02-08	Albert Einstein College Of Medicine Of Yeshiva University	Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases
NZ544187A (en) *	2005-12-15	2008-07-31	Ind Res Ltd	Deazapurine analogs of 1'-aza-l-nucleosides
WO2007097643A1 (en) *	2006-02-22	2007-08-30	Industrial Research Limited	Analogues of coformycin and their use for treating protozoan parasite infections
EP1991231A4 (en) *	2006-02-24	2010-01-06	Ind Res Ltd	METHOD FOR THE TREATMENT OF DISEASES WITH NUCLEOSIDE PHOSPHORUSLASES AND NUCLEOSIDASES INHIBITORS
US8916571B2 (en) *	2006-02-24	2014-12-23	Albert Einstein College Of Medicine Of Yeshiva University	Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase
CN101094080B (zh) *	2006-06-22	2012-06-20	华为技术有限公司	一种即按即通系统中的计费方法
AU2007293773B2 (en)	2006-09-07	2013-01-31	Albert Einstein College Of Medicine, Inc.	Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
CN101528749B (zh)	2006-09-07	2013-07-31	工业研究有限公司	核苷磷酸化酶和水解酶的无环胺抑制剂
ES2385759T3 (es) *	2006-12-22	2012-07-31	Industrial Research Limited	Análogos azetidina de inhibidores de nucleosidasa y fosforilasa
BRPI0910850B1 (pt)	2008-04-21	2022-06-14	Otonomy, Inc.	Composição intratimpânica compreendendo fator neurotrófico de crescimento derivado do cérebro (bdnf) para o tratamento ou prevenção da perda auditiva
US11969501B2 (en)	2008-04-21	2024-04-30	Dompé Farmaceutici S.P.A.	Auris formulations for treating otic diseases and conditions
US8784870B2 (en)	2008-07-21	2014-07-22	Otonomy, Inc.	Controlled release compositions for modulating free-radical induced damage and methods of use thereof
UA103195C2 (uk)	2008-08-11	2013-09-25	Глаксосмитклайн Ллк	Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
US20110190265A1 (en) *	2008-09-22	2011-08-04	Schramm Vern L	Methods and compositions for treating bacterial infections by inhibiting quorum sensing
US9493465B2 (en)	2009-07-17	2016-11-15	Victoria Link Limited	3-hydroxypyrrolidine inhibitors of 5′-methylthioadenosine phosphorylase and nucleosidase
MX348759B (es)	2010-10-15	2017-06-28	Biocryst Pharm Inc	Metodos y composiciones para inhibicion de polimerasa.
WO2012074912A1 (en) *	2010-11-29	2012-06-07	Albert Einstein College Of Medicine Of Yeshiva University	Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
DK2670404T3 (da)	2011-02-02	2018-11-19	Univ Princeton	Sirtuinmodulatorer som virusproduktionsmodulatorer
AU2012289042A1 (en)	2011-07-22	2014-03-13	Glaxosmithkline Llc	Composition
WO2013149258A2 (en)	2012-03-30	2013-10-03	Charles Drew University of Medicine and Science	Compositions and methods for treating or preventing metabolic syndrome disorders
AR090699A1 (es)	2012-04-18	2014-12-03	Biocryst Pharm Inc	Compuestos inhibidores de la actividad de la arn polimerasa viral
JP6063571B2 (ja)	2012-08-07	2017-01-18	アルバートアインシュタインカレッジオブメディシン，インコーポレイティド	ヘリコバクター・ピロリ感染の治療
MX359671B (es)	2012-08-24	2018-10-05	Glaxosmithkline Llc Star	Compuestos de pirazolopiridina.
WO2014081643A1 (en) *	2012-11-20	2014-05-30	Glaxosmithkline Llc	Novel compounds
CA2890201A1 (en) *	2012-11-20	2014-05-30	Glaxosmithkline Llc	Novel compounds
PL2922549T3 (pl)	2012-11-20	2017-11-30	Glaxosmithkline Llc	Nowe związki
ES2499965B2 (es) *	2013-03-27	2015-03-31	Universidad De Alicante	Procedimiento de síntesis de compuestos homólogos de azanucleósidos
US9452217B2 (en)	2013-06-22	2016-09-27	Nitor Therapeutics	Methods for potentiating immune response for the treatment of infectious diseases and cancer
HK1232071A1 (zh)	2014-02-12	2018-01-05	Albert Einstein College Of Medicine, Inc.	使用mtan抑制剂治疗h.pylori感染
CA2973152A1 (en) *	2015-01-07	2016-07-14	Euro-Celtique S.A.	Process for manufacture of forodesine
WO2017155886A1 (en)	2016-03-06	2017-09-14	Biocryst Pharmaceuticals, Inc.	Methods and compositions for treatment of zika virus infection
KR20190024983A (ko)	2016-06-29	2019-03-08	오토노미, 인코포레이티드	트리글리세라이드 귀 제제 및 이의 용도
US20220054494A1 (en)	2019-03-13	2022-02-24	University Of Pittsburgh - Of The Commonwealth System Of Higher Education	Methods for treating bladder and urethra dysfunction and disease
WO2023022216A1 (ja)	2021-08-20	2023-02-23	塩野義製薬株式会社	ウイルス増殖抑制作用を有するヌクレオシド誘導体及びそれらのプロドラッグ
GB202218782D0 (en)	2022-12-13	2023-01-25	Mehrling Thomas	Purine nucleoside phosphorylase inhibitor for metabolic syndrome

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4711955A (en) *	1981-04-17	1987-12-08	Yale University	Modified nucleotides and methods of preparing and using same
DK0942000T3 (da) *	1989-10-24	2004-11-01	Isis Pharmaceuticals Inc	2'-modificerede oligonukleotider
US5506351A (en) *	1992-07-23	1996-04-09	Isis Pharmaceuticals	Process for the preparation of 2'-O-alkyl guanosine and related compounds
US5223618A (en) *	1990-08-13	1993-06-29	Isis Pharmaceuticals, Inc.	4'-desmethyl nucleoside analog compounds
AU1739097A (en)	1996-02-23	1997-09-10	Albert Einstein College Of Medicine Of Yeshiva University	Enzyme detection/assay method and substrates
US5985848A (en) *	1997-10-14	1999-11-16	Albert Einstein College Of Medicine Of Yeshiva University	Inhibitors of nucleoside metabolism
US7022677B1 (en) *	1999-02-18	2006-04-04	Kaken Pharmaceutical Co., Ltd.	Amide derivatives as growth hormone secretagogues
CA2696826C (en)	1999-04-08	2013-01-08	Industrial Research Limited	Process for preparing inhibitors of nucleoside metabolism
US6448799B1 (en) *	1999-09-30	2002-09-10	Hitachi Electronics Engineering Co., Ltd.	Timing adjustment method and apparatus for semiconductor IC tester
AU2001284564A1 (en)	2000-08-29	2002-03-13	Albert Einstein College Of Medicine Of Yeshiva University	Nucleoside metabolism inhibitors
US6458799B1 (en)	2000-08-31	2002-10-01	Biocryst Pharmaceuticals, Inc.	Deazaguanine analog, preparation thereof and use thereof
US7098334B2 (en)	2002-03-25	2006-08-29	Industrial Research Limited	4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
ES2363766T3 (es)	2002-08-21	2011-08-16	Albert Einstein College Of Medicine Of Yeshiva University	Inhibidores de nucleosidasas y fosforilasas de nucleosidos.
NZ523970A (en)	2003-02-04	2005-02-25	Ind Res Ltd	Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
NZ533360A (en)	2004-06-04	2007-02-23	Ind Res Ltd	Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
JP2008508287A (ja)	2004-07-27	2008-03-21	バイオクリスト・フアーマシユーテイカルズ・インコーポレイテツド	５’−メチルチオアデノシンホスホリラーゼ及び５’メチルチオアデノシン／ｓ−アデノシルホモシステインヌクレオシダーゼの阻害剤
NZ540160A (en)	2005-05-20	2008-03-28	Einstein Coll Med	Inhibitors of nucleoside phosphorylases
NZ544187A (en)	2005-12-15	2008-07-31	Ind Res Ltd	Deazapurine analogs of 1'-aza-l-nucleosides
US8916571B2 (en)	2006-02-24	2014-12-23	Albert Einstein College Of Medicine Of Yeshiva University	Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase
EP1991231A4 (en)	2006-02-24	2010-01-06	Ind Res Ltd	METHOD FOR THE TREATMENT OF DISEASES WITH NUCLEOSIDE PHOSPHORUSLASES AND NUCLEOSIDASES INHIBITORS

1997
- 1997-10-14 US US08/949,388 patent/US5985848A/en not_active Expired - Lifetime
1998
- 1998-10-14 WO PCT/US1998/021717 patent/WO1999019338A1/en not_active Ceased
- 1998-10-14 DE DE69831499T patent/DE69831499T2/de not_active Expired - Lifetime
- 1998-10-14 AU AU10866/99A patent/AU749098B2/en not_active Expired
- 1998-10-14 ES ES98953516T patent/ES2249844T3/es not_active Expired - Lifetime
- 1998-10-14 DK DK98953516T patent/DK1023308T3/da active
- 1998-10-14 US US09/172,321 patent/US6066722A/en not_active Expired - Lifetime
- 1998-10-14 CN CNB988114895A patent/CN1220695C/zh not_active Expired - Lifetime
- 1998-10-14 JP JP2000515909A patent/JP4451983B2/ja not_active Expired - Lifetime
- 1998-10-14 AT AT98953516T patent/ATE304019T1/de active
- 1998-10-14 EP EP98953516A patent/EP1023308B1/en not_active Expired - Lifetime
- 1998-10-14 CA CA002305760A patent/CA2305760C/en not_active Expired - Lifetime
- 1998-10-14 CN CNB2005100920669A patent/CN100393722C/zh not_active Expired - Lifetime
- 1998-10-14 PT PT98953516T patent/PT1023308E/pt unknown
- 1998-10-14 KR KR1020007003944A patent/KR100637479B1/ko not_active Expired - Lifetime
2000
- 2000-02-03 US US09/496,741 patent/US6228847B1/en not_active Expired - Lifetime
2001
- 2001-03-28 US US09/820,276 patent/US6492347B2/en not_active Expired - Lifetime
2002
- 2002-10-10 US US10/268,652 patent/US6803455B2/en not_active Expired - Lifetime
2004
- 2004-09-02 US US10/932,841 patent/US7211653B2/en not_active Expired - Fee Related
2007
- 2007-03-26 US US11/728,730 patent/US7390890B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5985848A (en)	1999-11-16
EP1023308B1 (en)	2005-09-07
AU749098B2 (en)	2002-06-20
HK1089159A1 (zh)	2006-11-24
CA2305760C (en)	2008-06-03
WO1999019338A1 (en)	1999-04-22
CN1757646A (zh)	2006-04-12
US20050026936A1 (en)	2005-02-03
AU1086699A (en)	1999-05-03
PT1023308E (pt)	2005-11-30
CN100393722C (zh)	2008-06-11
US6228847B1 (en)	2001-05-08
CN1279686A (zh)	2001-01-10
DE69831499T2 (de)	2006-06-14
US6803455B2 (en)	2004-10-12
US7390890B2 (en)	2008-06-24
KR100637479B1 (ko)	2006-10-20
CA2305760A1 (en)	1999-04-22
US20070197561A1 (en)	2007-08-23
EP1023308A4 (en)	2002-05-29
CN1220695C (zh)	2005-09-28
DE69831499D1 (de)	2005-10-13
US20030096830A1 (en)	2003-05-22
EP1023308A1 (en)	2000-08-02
US6066722A (en)	2000-05-23
JP2001519437A (ja)	2001-10-23
US20020061898A1 (en)	2002-05-23
JP4451983B2 (ja)	2010-04-14
KR20010031082A (ko)	2001-04-16
ES2249844T3 (es)	2006-04-01
US7211653B2 (en)	2007-05-01
US6492347B2 (en)	2002-12-10
ATE304019T1 (de)	2005-09-15

Publication	Publication Date	Title
ATE304019T1 (de)	2005-09-15	Inhibitoren des nukleosid-metabolismus
EP2308845A3 (en)	2011-08-10	Caspase inhibitors and uses thereof
TR199800924T2 (xx)	1998-08-21	Quinoline t�revleri.
WO2001009103A3 (en)	2001-05-31	Imidazole antiproliferative agents
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ATE250623T1 (de)	2003-10-15	4'-c-ethynyl-purin-nukleoside
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ES2175624T3 (es)	2002-11-16	Derivados de pirazolo(4,3-d)pirimidina y composiciones farmaceuticas que los contienen.
IL108602A0 (en)	1994-05-30	N-alkyl-2-substituted atp analogues, their preparation and pharmaceutical compositions containing them
CA2085345A1 (en)	1991-12-16	Pyrimidine nucleoside derivatives
NZ227436A (en)	1992-10-28	Cell proliferation inhibiting composition comprising a substituted styrene derivative
DK0918776T3 (da)	2004-07-12	Totalsyntese af antitumor acylfulvener
AU5551594A (en)	1994-06-08	Substituted amino alkyl compounds
TW360652B (en)	1999-06-11	Acryloyl substituted disstamycin derivatives, process for preparing them, and pharmaceutical composition comprising them
MY118004A (en)	2004-08-30	Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
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