ATE305055T1 - Enzyminhibitoren, die sich von silanol ableiten - Google Patents

Enzyminhibitoren, die sich von silanol ableiten

Info

Publication number
ATE305055T1
ATE305055T1 AT97934103T AT97934103T ATE305055T1 AT E305055 T1 ATE305055 T1 AT E305055T1 AT 97934103 T AT97934103 T AT 97934103T AT 97934103 T AT97934103 T AT 97934103T AT E305055 T1 ATE305055 T1 AT E305055T1
Authority
AT
Austria
Prior art keywords
heteroatoms
carbons
sup
enzymin
hibitors
Prior art date
Application number
AT97934103T
Other languages
English (en)
Inventor
Scott Mcn Sieburth
Alfred M Mutahi
Chien-An Chen
Original Assignee
Univ New York State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York State Res Found filed Critical Univ New York State Res Found
Application granted granted Critical
Publication of ATE305055T1 publication Critical patent/ATE305055T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0834—Compounds having one or more O-Si linkage
    • C07F7/0836—Compounds with one or more Si-OH or Si-O-metal linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0834—Compounds having one or more O-Si linkage
    • C07F7/0838—Compounds with one or more Si-O-Si sequences
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/21—Cyclic compounds having at least one ring containing silicon, but no carbon in the ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AT97934103T 1996-07-12 1997-07-11 Enzyminhibitoren, die sich von silanol ableiten ATE305055T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/680,330 US5760019A (en) 1996-07-12 1996-07-12 Silanol enzyme inhibitors
PCT/US1997/012041 WO1998002578A1 (en) 1996-07-12 1997-07-11 Silanol enzyme inhibitors

Publications (1)

Publication Number Publication Date
ATE305055T1 true ATE305055T1 (de) 2005-10-15

Family

ID=24730659

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97934103T ATE305055T1 (de) 1996-07-12 1997-07-11 Enzyminhibitoren, die sich von silanol ableiten

Country Status (8)

Country Link
US (4) US5760019A (de)
EP (1) EP1019533B1 (de)
JP (1) JP2000515513A (de)
AT (1) ATE305055T1 (de)
AU (1) AU717621B2 (de)
CA (1) CA2258685A1 (de)
DE (1) DE69734250T2 (de)
WO (1) WO1998002578A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760019A (en) * 1996-07-12 1998-06-02 The Research Foundation Of State University Of New York Silanol enzyme inhibitors
EP0922455A1 (de) * 1997-05-14 1999-06-16 Nissui Pharmaceutical Co., Ltd. Hiv-1-protease-hemmer, verfahren zu dessen herstellung und medizinische zusammensetzungen
US6093829A (en) * 1997-08-14 2000-07-25 Mona Industries, Inc. Silicone monomers and oligomers having a carboxyl functional group thereon
US6762271B2 (en) * 2001-11-02 2004-07-13 Bausch & Lomb Incorporated High refractive index aromatic-based silyl monomers
DE102008002183A1 (de) * 2008-06-03 2009-12-10 Evonik Degussa Gmbh Verfahren zur Aufarbeitung salzhaltiger Rückstände aus der Herstellung von aminofunktionellen Organosilanen
DE102008002181A1 (de) * 2008-06-03 2009-12-10 Evonik Degussa Gmbh Verfahren zur wässrigen Aufarbeitung eines Ammoniumhalogenide und/oder organische Aminhydrohalogenide enthaltenden aminofunktionellen Organosilans
US8987493B2 (en) 2010-05-20 2015-03-24 Temple University—Of the Commonwealth System of Higher Education Process for synthesis of silane dipeptide analogs
MX2014005976A (es) * 2011-11-21 2014-08-27 Bayer Ip Gmbh Derivados de n-[(silil trisustituido)metil]-carboxamida fungicidas.

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3860709A (en) * 1971-09-29 1975-01-14 Dow Corning Method of inhibiting the growth of bacteria and fungi using organosilicon amines
JPS5583713A (en) * 1978-12-19 1980-06-24 Shin Etsu Chem Co Ltd Anti-tumor agent composed mainly of organo-silicon compound
US4420475A (en) * 1979-09-10 1983-12-13 Sandoz, Inc. Silicon-bearing amides
US5142056A (en) 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
CA1204720A (en) * 1982-09-30 1986-05-20 Hajimu Kitahara Packing materials for chromatographic use and a method for analysis of an enantiomer mixture using the same
ES2053582T3 (es) * 1986-08-13 1994-08-01 Ciba Geigy Ag Procedimiento para la obtencion de derivados del acido 5-amino-4-hidroxivalerianico.
FR2610522B1 (fr) * 1987-02-06 1989-08-18 Gueyne Jean Produit therapeutique a base de derives organiques du silicium
FR2611496B1 (fr) * 1987-03-04 1992-07-03 Gueyne Jean Organo-silicies cosmetiques
FR2619113B2 (fr) * 1987-05-26 1991-06-28 Exsymol Sa Nouveaux produits de condensation de silanols, leurs preparation et application
DE3830825A1 (de) * 1987-09-15 1989-03-23 Sandoz Ag Hydrophile reninhemmer, ihre herstellung und verwendung
US5215968A (en) * 1988-12-10 1993-06-01 Hoechst Aktiengesellschaft Dipeptide derivatives having an enzyme inhibitory action
FR2645442A1 (fr) * 1989-04-07 1990-10-12 Gueyne Jean Produit therapeutique a base de compose organique du silicium et de polyamine polycarboxylee, particulierement utile pour le traitement de l'atherome
DE4004898A1 (de) * 1990-02-16 1991-08-22 Merck Patent Gmbh Peptid-analoga
GB9123251D0 (en) * 1991-11-01 1991-12-18 Croda Int Plc Protein-silicone copolymers
FR2684002A1 (fr) * 1991-11-26 1993-05-28 Duffaut Norbert Traitement du sida au moyen de compositions aqueuses dont la base incontournable a ce jour est constituee, avant potentialisation, de derives organosilicies.
US5486598A (en) * 1994-05-20 1996-01-23 University Of Florida Silica mediated synthesis of peptides
US5760019A (en) * 1996-07-12 1998-06-02 The Research Foundation Of State University Of New York Silanol enzyme inhibitors
US6887677B1 (en) * 1999-07-12 2005-05-03 Trustees Of Dartmouth College Compounds and methods for identifying compounds which inhibit a new class of aspartyl proteases
US6951731B2 (en) * 2001-06-08 2005-10-04 Wisconsin Alumni Research Foundation Method for evaluating inhibition of aspartic proteases

Also Published As

Publication number Publication date
AU717621B2 (en) 2000-03-30
JP2000515513A (ja) 2000-11-21
US20030096793A1 (en) 2003-05-22
EP1019533B1 (de) 2005-09-21
WO1998002578A1 (en) 1998-01-22
US20050171059A1 (en) 2005-08-04
US6441212B1 (en) 2002-08-27
CA2258685A1 (en) 1998-01-22
DE69734250T2 (de) 2006-06-29
DE69734250D1 (de) 2006-02-02
EP1019533A4 (de) 2001-07-25
EP1019533A1 (de) 2000-07-19
US6960678B2 (en) 2005-11-01
US7087776B2 (en) 2006-08-08
US5760019A (en) 1998-06-02
AU3724097A (en) 1998-02-09

Similar Documents

Publication Publication Date Title
DK0804200T3 (da) Anvendelse af noribogain-derivater til behandling af kemisk afhængighed hos pattedyr
ATE280190T1 (de) Feuchtigkeitshärtbare zusammensetzungen, die silanendgruppen enthalten
IS6257A (is) Frumuviðloðunartálmar
DK0682033T3 (da) Hydrolyserbare og polymeriserbare silaner
ATE136882T1 (de) Carbamidsäureester-derivate, mittel und herstellungsverfahren
DE3675408D1 (de) Phenylcarbamate.
DE3578789D1 (de) Physostigminderivate mit acetylcholinesterase-inhibitoreigenschaften, und das entsprechende herstellungsverfahren.
DE69734250D1 (de) Enzyminhibitoren, die sich von silanol ableiten
TR200000309T2 (tr) Sıvı temizlik bileşimleri.
DE60239170D1 (de) Bicyclische Verbindungen
ES2055384T3 (es) Compuestos dioxafosforinanos y composiciones poliolefinicas estabilizadas con ellos.
TR199800190T1 (xx) Enantiyo-se�ici epoksidasyon kataliz�rleri olarak kullan�labilen dinaftazepinyum tuzlar�.
GB0021633D0 (en) Surfactant
EA200200665A1 (ru) Новые соединения бензолсульфонамида, способ их получения и фармацевтические композиции, их содержащие
TR199802517T2 (xx) Dibenzo-Oksazepin ve-Dioksepin, Bunlar�n Anti-T�m�r Maddeleri Olarak Kullan�mlar�.
ATE241976T1 (de) N,n'-bis (sulfonyl) hydrazine die als antineoplastische mittel nützlich sind
DK138388A (da) Isoquinolinderivater
TR199900768T2 (xx) Hidroksimik ve hidrazonik gruplu fungisidler.
ATE88856T1 (de) Quaternierte stickstoffhaltige verbindungen.
MY147944A (en) Substituted 1,2,4-trioxanes as antimalarial agents and a process of producing the substituted 1,2,4-trioxanes
DK0882075T3 (da) Brændstof- og smøremiddeladditiver
IL78625A (en) 3(2h)-furanone 4-(1-alkoxy)methoxy derivatives and their preparation
UA12823C2 (uk) 1, 4-біс(4-ізоціанатофенокси)тетрафторбензол як мономер для отримання поліуретанів, що мають підвищену гідролітичну та термічну стійкість
DE69019573D1 (de) Luciferinderivate.
TH32338A (th) สารประกอบไซเลนอินทรีย์

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties