ATE305305T1 - Verwendung einer kombination von nicotinsäuren oder deren derivaten und riboflavin zur herstellung eines arzneimittels zur behandlung von primären kopfschmerzen - Google Patents
Verwendung einer kombination von nicotinsäuren oder deren derivaten und riboflavin zur herstellung eines arzneimittels zur behandlung von primären kopfschmerzenInfo
- Publication number
- ATE305305T1 ATE305305T1 AT01954332T AT01954332T ATE305305T1 AT E305305 T1 ATE305305 T1 AT E305305T1 AT 01954332 T AT01954332 T AT 01954332T AT 01954332 T AT01954332 T AT 01954332T AT E305305 T1 ATE305305 T1 AT E305305T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- migraine
- riboflavin
- combination
- derivatives
- Prior art date
Links
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 title abstract 4
- 206010019233 Headaches Diseases 0.000 title abstract 3
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002477 riboflavin Drugs 0.000 title abstract 2
- 235000019192 riboflavin Nutrition 0.000 title abstract 2
- 239000002151 riboflavin Substances 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 150000002814 niacins Chemical class 0.000 title 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 abstract 4
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 abstract 3
- KRQUFUKTQHISJB-YYADALCUSA-N 2-[(E)-N-[2-(4-chlorophenoxy)propoxy]-C-propylcarbonimidoyl]-3-hydroxy-5-(thian-3-yl)cyclohex-2-en-1-one Chemical compound CCC\C(=N/OCC(C)OC1=CC=C(Cl)C=C1)C1=C(O)CC(CC1=O)C1CCCSC1 KRQUFUKTQHISJB-YYADALCUSA-N 0.000 abstract 2
- 206010003791 Aura Diseases 0.000 abstract 2
- 208000019695 Migraine disease Diseases 0.000 abstract 2
- 208000000060 Migraine with aura Diseases 0.000 abstract 2
- 208000018912 cluster headache syndrome Diseases 0.000 abstract 2
- 206010015037 epilepsy Diseases 0.000 abstract 2
- 231100000869 headache Toxicity 0.000 abstract 2
- 206010027599 migraine Diseases 0.000 abstract 2
- 235000005152 nicotinamide Nutrition 0.000 abstract 2
- 239000011570 nicotinamide Substances 0.000 abstract 2
- 229960003966 nicotinamide Drugs 0.000 abstract 2
- 235000001968 nicotinic acid Nutrition 0.000 abstract 2
- 239000011664 nicotinic acid Substances 0.000 abstract 2
- 229960003512 nicotinic acid Drugs 0.000 abstract 2
- 208000006561 Cluster Headache Diseases 0.000 abstract 1
- 208000032106 Complicated migraine Diseases 0.000 abstract 1
- 229930003270 Vitamin B Natural products 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 206010052787 migraine without aura Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 235000013343 vitamin Nutrition 0.000 abstract 1
- 239000011782 vitamin Substances 0.000 abstract 1
- 229940088594 vitamin Drugs 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 abstract 1
- 235000019156 vitamin B Nutrition 0.000 abstract 1
- 239000011720 vitamin B Substances 0.000 abstract 1
- 239000011708 vitamin B3 Substances 0.000 abstract 1
- 235000019160 vitamin B3 Nutrition 0.000 abstract 1
- -1 vitamin compounds Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- External Artificial Organs (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2000RM000448A IT1320776B1 (it) | 2000-08-07 | 2000-08-07 | Composizione farmaceutica a base di un'associazione vitaminica per laterapia delle cefalee primarie |
| PCT/IT2001/000388 WO2002011731A2 (en) | 2000-08-07 | 2001-07-20 | Use of the combination of nicotinic acid or derivatives with riboflavin in the manufacture of a medicament for the treatment of primary headaches |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE305305T1 true ATE305305T1 (de) | 2005-10-15 |
Family
ID=11454879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01954332T ATE305305T1 (de) | 2000-08-07 | 2001-07-20 | Verwendung einer kombination von nicotinsäuren oder deren derivaten und riboflavin zur herstellung eines arzneimittels zur behandlung von primären kopfschmerzen |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7456291B2 (de) |
| EP (1) | EP1318815B1 (de) |
| JP (1) | JP2004505919A (de) |
| KR (1) | KR100816140B1 (de) |
| CN (1) | CN100408038C (de) |
| AT (1) | ATE305305T1 (de) |
| AU (2) | AU2001276672B2 (de) |
| CA (1) | CA2417758C (de) |
| DE (1) | DE60113704T2 (de) |
| ES (1) | ES2248362T3 (de) |
| IT (1) | IT1320776B1 (de) |
| RU (1) | RU2274448C2 (de) |
| WO (1) | WO2002011731A2 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8940326B2 (en) | 2007-03-19 | 2015-01-27 | Vita Sciences Llc | Transdermal patch and method for delivery of vitamin B12 |
| JP2014503592A (ja) * | 2011-01-26 | 2014-02-13 | ニコ ワールドワイド,インコーポレイテッド | 片頭痛の療法 |
| JP7499027B2 (ja) * | 2019-12-27 | 2024-06-13 | 小林製薬株式会社 | 内服用医薬組成物 |
| CA3175608A1 (en) * | 2020-04-22 | 2021-10-28 | Linzy O. Scott, Iii | Treatment of conditions associated with thyroid hormone |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2480517A (en) * | 1946-03-02 | 1949-08-30 | Merck & Co Inc | Fused riboflavin-amide |
| DE1670342A1 (de) * | 1966-04-23 | 1970-10-29 | Albert Ag Chem Werke | Verfahren zur Herstellung eines neuen nikotinsauren Salzes |
| SU1168262A1 (ru) * | 1981-02-13 | 1985-07-23 | Белорусский Научно-Исследовательский Институт Неврологии,Нейрохирургии И Физиотерапии | Способ лечени мигрени |
| AU587863B2 (en) * | 1985-10-07 | 1989-08-31 | Basf Aktiengesellschaft | Vitamin-containing granules and production thereof |
| US4973467A (en) * | 1989-10-13 | 1990-11-27 | Natrol, Inc. | Dietary supplement for adults |
| US5246943A (en) * | 1992-05-19 | 1993-09-21 | Warner-Lambert Company | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties |
| US5571441A (en) * | 1994-11-01 | 1996-11-05 | The Procter & Gamble Company | Nutrient supplement compositions providing physiologic feedback |
| GB9601398D0 (en) * | 1996-01-24 | 1996-03-27 | Piper Edwina M | Composition |
| US6017946A (en) * | 1997-10-08 | 2000-01-25 | Posner; Robert | Serotonin containing formulation for oral administration and method of use |
| US6068999A (en) | 1998-06-25 | 2000-05-30 | Hendrix; Curt | Dietary supplement for supporting cerebrovascular tone and treating migraine headaches |
| IT1306141B1 (it) * | 1999-05-17 | 2001-05-30 | Giampiero Valletta | Composizione per il trattamento del prurito uremico e di forme diprurito non riconducibili a lesioni organiche. |
| RU2149001C1 (ru) * | 1999-09-09 | 2000-05-20 | Открытое акционерное общество "Химикофармацевтический комбинат "Акрихин" | Ноотропное лекарственное средство и способ его получения |
-
2000
- 2000-08-07 IT IT2000RM000448A patent/IT1320776B1/it active
-
2001
- 2001-07-20 CA CA002417758A patent/CA2417758C/en not_active Expired - Lifetime
- 2001-07-20 ES ES01954332T patent/ES2248362T3/es not_active Expired - Lifetime
- 2001-07-20 CN CNB018138233A patent/CN100408038C/zh not_active Expired - Lifetime
- 2001-07-20 WO PCT/IT2001/000388 patent/WO2002011731A2/en not_active Ceased
- 2001-07-20 DE DE60113704T patent/DE60113704T2/de not_active Expired - Lifetime
- 2001-07-20 RU RU2003106417/15A patent/RU2274448C2/ru active
- 2001-07-20 KR KR1020037001585A patent/KR100816140B1/ko not_active Expired - Fee Related
- 2001-07-20 AT AT01954332T patent/ATE305305T1/de active
- 2001-07-20 EP EP01954332A patent/EP1318815B1/de not_active Expired - Lifetime
- 2001-07-20 AU AU2001276672A patent/AU2001276672B2/en not_active Ceased
- 2001-07-20 US US10/343,853 patent/US7456291B2/en not_active Expired - Lifetime
- 2001-07-20 AU AU7667201A patent/AU7667201A/xx active Pending
- 2001-07-20 JP JP2002517067A patent/JP2004505919A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20030022352A (ko) | 2003-03-15 |
| KR100816140B1 (ko) | 2008-03-21 |
| CN100408038C (zh) | 2008-08-06 |
| IT1320776B1 (it) | 2003-12-10 |
| AU7667201A (en) | 2002-02-18 |
| US7456291B2 (en) | 2008-11-25 |
| RU2274448C2 (ru) | 2006-04-20 |
| DE60113704D1 (de) | 2006-02-09 |
| CN1635893A (zh) | 2005-07-06 |
| US20030181459A1 (en) | 2003-09-25 |
| ES2248362T3 (es) | 2006-03-16 |
| WO2002011731A2 (en) | 2002-02-14 |
| WO2002011731A3 (en) | 2002-08-15 |
| CA2417758C (en) | 2009-09-08 |
| CA2417758A1 (en) | 2002-02-14 |
| EP1318815B1 (de) | 2005-09-28 |
| ITRM20000448A1 (it) | 2002-02-07 |
| ITRM20000448A0 (it) | 2000-08-07 |
| AU2001276672B2 (en) | 2006-06-01 |
| JP2004505919A (ja) | 2004-02-26 |
| DE60113704T2 (de) | 2006-07-06 |
| EP1318815A2 (de) | 2003-06-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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