DK0937074T3 - Benzonaphthyridiner som bronkiale terapeutiske midler - Google Patents

Benzonaphthyridiner som bronkiale terapeutiske midler

Info

Publication number
DK0937074T3
DK0937074T3 DK97950093T DK97950093T DK0937074T3 DK 0937074 T3 DK0937074 T3 DK 0937074T3 DK 97950093 T DK97950093 T DK 97950093T DK 97950093 T DK97950093 T DK 97950093T DK 0937074 T3 DK0937074 T3 DK 0937074T3
Authority
DK
Denmark
Prior art keywords
pct
benzonaphthyridines
bronchial therapeutics
date
sec
Prior art date
Application number
DK97950093T
Other languages
English (en)
Inventor
Beate Gutterer
Armin Hatzelmann
Karl Sanders
Rolf Beume
Dietrich Haefner
Hans-Peter Kley
Karl-Josef Goebel
Dieter Flockerzi
Beate Schmidt
Hermann Amschler
Wolf-Ruediger Ulrich
Thomas Martin
Thomas Baer
Hildegard Boss
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Application granted granted Critical
Publication of DK0937074T3 publication Critical patent/DK0937074T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
DK97950093T 1996-11-11 1997-11-05 Benzonaphthyridiner som bronkiale terapeutiske midler DK0937074T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19646298 1996-11-11
EP96118188 1996-11-13
DE19739056 1997-09-05
PCT/EP1997/006096 WO1998021208A1 (en) 1996-11-11 1997-11-05 Benzonaphthyridines as bronchial therapeutics

Publications (1)

Publication Number Publication Date
DK0937074T3 true DK0937074T3 (da) 2003-06-23

Family

ID=27216810

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97950093T DK0937074T3 (da) 1996-11-11 1997-11-05 Benzonaphthyridiner som bronkiale terapeutiske midler

Country Status (30)

Country Link
US (1) US6008215A (da)
EP (1) EP0937074B1 (da)
JP (1) JP4223075B2 (da)
KR (1) KR100484045B1 (da)
CN (1) CN1090188C (da)
AT (1) ATE234300T1 (da)
AU (1) AU733129B2 (da)
BG (1) BG63695B1 (da)
BR (1) BR9713338B1 (da)
CA (1) CA2270964C (da)
CY (1) CY2476B1 (da)
CZ (1) CZ288752B6 (da)
DE (1) DE69719778T2 (da)
DK (1) DK0937074T3 (da)
EA (1) EA001551B1 (da)
EE (1) EE03829B1 (da)
ES (1) ES2195189T3 (da)
GE (1) GEP20012390B (da)
HU (1) HU226981B1 (da)
ID (1) ID22042A (da)
IL (1) IL129054A (da)
NO (1) NO312764B1 (da)
NZ (1) NZ334976A (da)
PL (1) PL189641B1 (da)
PT (1) PT937074E (da)
RS (1) RS49607B (da)
SI (1) SI0937074T1 (da)
SK (1) SK283269B6 (da)
TR (1) TR199900856T2 (da)
WO (1) WO1998021208A1 (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2330738A1 (en) 1998-05-05 1999-11-11 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel n-oxides of benzonaphthyridines
SI1109810T1 (en) 1998-08-31 2004-12-31 Altana Pharma Ag Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity
IT1303272B1 (it) * 1998-10-29 2000-11-06 Zambon Spa Derivati triciclici inibitori della fosfodiesterasi 4
ATE356810T1 (de) * 1999-01-15 2007-04-15 Altana Pharma Ag Polysubstituted 6-phenylphenanthridines mit pde- iv hemmender wirkung
EE05105B1 (et) * 1999-01-15 2008-12-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Fenlfenantridiinid, nende kasutamine ravimite valmistamiseks ning neid sisaldav ravim
AU2107700A (en) * 1999-01-15 2000-08-01 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridine-n-oxides with pde-iv inhibiting activity
EP1147103B1 (en) 1999-01-15 2005-05-04 ALTANA Pharma AG Phenantrhridine-n-oxides with pde-iv inhibiting activity
PL200923B1 (pl) 1999-08-21 2009-02-27 Nycomed Gmbh Lek zawierający inhibitor PDE w połączeniu z agonistą receptoraß₂ -adrenergicznego oraz zastosowanie połączenia roflumilastu i salmeterolu
NL1017973C2 (nl) * 2000-05-10 2002-11-08 Tristem Trading Cyprus Ltd Inrichting.
US6936622B2 (en) 2001-02-21 2005-08-30 Altana Pharma Ag 6-phenylbenzonaphthyridines
US6479493B1 (en) 2001-08-23 2002-11-12 Cell Pathways, Inc. Methods for treatment of type I diabetes
AU2003263216A1 (en) * 2002-08-17 2004-03-11 Nycomed Gmbh Benzonaphthyridines with PDE 3/4 inhibiting activity
US7470704B2 (en) 2002-09-04 2008-12-30 Nycomed Gmbh Benzonaphthyridines
JP4638736B2 (ja) * 2002-09-04 2011-02-23 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規のベンゾナフチリジン
JP2006522151A (ja) 2003-04-01 2006-09-28 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 不妊症におけるホスホジエステラーゼ阻害剤
PL2589599T4 (pl) 2004-03-03 2015-06-30 Takeda Gmbh Nowe hydroksy-6-heteroarylofenantrydyny i ich zastosowanie jako inhibitorów PDE4
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
MXPA06009892A (es) * 2004-03-10 2007-03-01 Altana Pharma Ag Nuevas hidroxi-6-fenilfenantridinas sustituidas con amido y su uso como inhibidores de la fosfodiesterasa tipo 4 (pde4).
EP1732925A1 (en) * 2004-03-17 2006-12-20 Altana Pharma AG Novel n-(alkoxyalkyl)carbamoyl- substituted 6-phenyl-benzonaphthyridine derivatives and their use as pde3/4 inhibitors
US7589205B2 (en) 2004-09-08 2009-09-15 Nycomed Gmbh 3-thia-10-aza-phenanthrene derivatives
DE602005027866D1 (de) 2004-09-08 2011-06-16 Nycomed Gmbh 3-oxa-10-aza-phenanthrene als pde4- oder pde3/4-inhibitoren
ES2337083T3 (es) 2005-03-02 2010-04-20 Nycomed Gmbh (2r,4ar,10br)-6-(2,6-dimetoxipiridin-3-il)-9-exoti-8-metoxi-1,2,3,4,4a,10b-hexahidrofenantridin-2-ol, sal de hc1.
WO2007045979A1 (en) 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Pharmaceutical compositions of muscarinic receptor antagonists
TW200808695A (en) * 2006-06-08 2008-02-16 Amgen Inc Benzamide derivatives and uses related thereto
DK2061765T3 (da) * 2006-09-01 2015-01-26 Senhwa Biosciences Inc Serin-threonin-proteinkinase- og parp-modulatorer
WO2009132136A1 (en) 2008-04-23 2009-10-29 Rigel Pharmaceuticals, Inc. Carboxamide compounds for the treatment of metabolic disorders
AR079451A1 (es) 2009-12-18 2012-01-25 Nycomed Gmbh Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolina
CN108299429B (zh) * 2018-04-09 2021-10-08 中南大学 一类八氢苯并萘啶化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899494A (en) * 1970-05-13 1975-08-12 Sandoz Ltd Substituted 6-phenyl benzo-naphthyridines
EP0247971A3 (en) * 1986-05-29 1990-01-17 Sandoz Ag Novel pharmaceutical compositions comprising and use of cis-6-(4-acetanilido)-8,9-dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin
MY105344A (en) * 1990-05-16 1994-09-30 Byk Gulden Lomberg Chemische Fabrik New sulphonyl compounds

Also Published As

Publication number Publication date
ATE234300T1 (de) 2003-03-15
AU5317098A (en) 1998-06-03
PL333429A1 (en) 1999-12-06
JP2001503442A (ja) 2001-03-13
ID22042A (id) 1999-08-26
EE9900105A (et) 1999-10-15
BG63695B1 (bg) 2002-09-30
SK62399A3 (en) 1999-10-08
TR199900856T2 (xx) 1999-07-21
KR20000053100A (ko) 2000-08-25
RS49607B (sr) 2007-06-04
HUP0000426A3 (en) 2001-04-28
NO992282L (no) 1999-05-11
HU226981B1 (hu) 2010-04-28
BR9713338B1 (pt) 2009-12-01
ES2195189T3 (es) 2003-12-01
WO1998021208A1 (en) 1998-05-22
SK283269B6 (sk) 2003-04-01
PT937074E (pt) 2003-07-31
CZ167599A3 (cs) 1999-11-17
KR100484045B1 (ko) 2005-04-20
DE69719778D1 (de) 2003-04-17
EA001551B1 (ru) 2001-04-23
SI0937074T1 (en) 2003-08-31
CN1236367A (zh) 1999-11-24
AU733129B2 (en) 2001-05-10
CY2476B1 (en) 2005-05-03
EP0937074B1 (en) 2003-03-12
HUP0000426A2 (hu) 2001-02-28
EE03829B1 (et) 2002-08-15
CA2270964A1 (en) 1998-05-22
IL129054A0 (en) 2000-02-17
DE69719778T2 (de) 2004-02-05
CN1090188C (zh) 2002-09-04
NO992282D0 (no) 1999-05-11
US6008215A (en) 1999-12-28
CZ288752B6 (cs) 2001-08-15
NZ334976A (en) 2000-10-27
CA2270964C (en) 2007-07-31
EP0937074A1 (en) 1999-08-25
EA199900421A1 (ru) 1999-10-28
NO312764B1 (no) 2002-07-01
HK1022151A1 (en) 2000-07-28
GEP20012390B (en) 2001-03-25
BG103310A (en) 2000-05-31
YU19499A (sh) 2001-09-28
BR9713338A (pt) 2000-05-09
JP4223075B2 (ja) 2009-02-12
IL129054A (en) 2002-07-25
PL189641B1 (pl) 2005-09-30

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