ATE305463T1 - Omega-zykloalkyl 17-heteroaryl prostaglandin-e2- analoga als ep2-rezeptoragonisten - Google Patents
Omega-zykloalkyl 17-heteroaryl prostaglandin-e2- analoga als ep2-rezeptoragonistenInfo
- Publication number
- ATE305463T1 ATE305463T1 AT02791192T AT02791192T ATE305463T1 AT E305463 T1 ATE305463 T1 AT E305463T1 AT 02791192 T AT02791192 T AT 02791192T AT 02791192 T AT02791192 T AT 02791192T AT E305463 T1 ATE305463 T1 AT E305463T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- carbon atoms
- bond
- heteroaryl
- radical
- Prior art date
Links
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 title 1
- 229960002986 dinoprostone Drugs 0.000 title 1
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 title 1
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4018—Esters of cycloaliphatic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33883801P | 2001-11-05 | 2001-11-05 | |
| PCT/US2002/034301 WO2003040126A1 (en) | 2001-11-05 | 2002-10-25 | φ-CYCLOALKYL 17-HETEROARYL PROSTAGLANDIN E2 ANALOGS AS EP2-RECEPTOR AGONISTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE305463T1 true ATE305463T1 (de) | 2005-10-15 |
Family
ID=23326368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02791192T ATE305463T1 (de) | 2001-11-05 | 2002-10-25 | Omega-zykloalkyl 17-heteroaryl prostaglandin-e2- analoga als ep2-rezeptoragonisten |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US6710072B2 (de) |
| EP (1) | EP1442033B1 (de) |
| KR (1) | KR20050039733A (de) |
| CN (1) | CN1617868A (de) |
| AT (1) | ATE305463T1 (de) |
| BR (1) | BR0213911A (de) |
| CA (1) | CA2466517A1 (de) |
| DE (1) | DE60206408T2 (de) |
| ES (1) | ES2246419T3 (de) |
| MX (1) | MXPA04004164A (de) |
| NZ (1) | NZ532519A (de) |
| WO (1) | WO2003040126A1 (de) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7855226B2 (en) * | 2003-02-11 | 2010-12-21 | Allergan, Inc. | Treatment of inflammatory bowel disease |
| US6875787B2 (en) * | 2003-02-11 | 2005-04-05 | Allergan, Inc. | 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure |
| GB0329620D0 (en) * | 2003-12-22 | 2004-01-28 | Pharmagene Lab Ltd | EP2 receptor agonists |
| WO2005080367A1 (en) | 2004-02-12 | 2005-09-01 | Pharmagene Laboratories Limited | Ep2 receptor agonists |
| EP1812017A2 (de) * | 2004-10-21 | 2007-08-01 | Duke University | Ophthalmologische arzneimittel |
| US7091231B2 (en) * | 2004-12-10 | 2006-08-15 | Allergan, Inc. | 12-Aryl prostaglandin analogs |
| BRPI0605926A2 (pt) | 2005-01-14 | 2009-05-26 | Allergan Inc | ciclopentanos substituìdos ou ciclopentanonas como agentes terapêuticos |
| EP1856042B1 (de) * | 2005-03-10 | 2012-06-27 | Allergan, Inc. | Substituierte gammalactame als therapeutika |
| US7674786B2 (en) * | 2005-05-06 | 2010-03-09 | Allergan, Inc. | Therapeutic β-lactams |
| ATE515263T1 (de) * | 2005-05-06 | 2011-07-15 | Allergan Inc | Substituierte beta-lactame und deren verwendung in der medizin |
| WO2007005176A1 (en) * | 2005-06-29 | 2007-01-11 | Allergan, Inc. | Pyrrolidinones for the treatment of glaucoma and ocular hypertension |
| CA2618486A1 (en) | 2005-08-09 | 2007-02-15 | Asterand Uk Limited | Ep2 receptor agonists |
| US7585895B2 (en) * | 2005-12-06 | 2009-09-08 | Allergan, Inc. | Therapeutic substituted cyclopentanes |
| US7427685B2 (en) | 2005-12-06 | 2008-09-23 | Allergan, Inc. | Therapeutic substituted cyclopentanes |
| US7592364B2 (en) * | 2006-02-28 | 2009-09-22 | Allergan, Inc. | Substituted gamma lactams as therapeutic agents |
| EP1996546B1 (de) * | 2006-03-20 | 2014-11-26 | Allergan, Inc. | Substituierte gamma-lactame als prostaglandin-ep4-agonisten |
| US20070254920A1 (en) * | 2006-04-26 | 2007-11-01 | Aerie Pharmaceuticals, Inc. | Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use |
| US20090016981A1 (en) | 2006-05-03 | 2009-01-15 | Allergan, Inc. | Therapeutic compounds |
| US7439372B2 (en) | 2006-05-03 | 2008-10-21 | Allergan, Inc. | Therapeutic compounds |
| ATE502914T1 (de) * | 2006-08-09 | 2011-04-15 | Allergan Inc | Therapeutische amide und entsprechende verbindungen |
| US7985767B2 (en) * | 2006-09-06 | 2011-07-26 | Allergan, Inc. | Therapeutic amides |
| EP1903037A1 (de) * | 2006-09-07 | 2008-03-26 | Bayer Schering Pharma Aktiengesellschaft | 1-(Het)aryl-3-[hetaryl-piperidin-4-yl]-thioharnstoffe als Modulatoren des EP2-Rezeptors |
| US8193373B2 (en) | 2006-12-11 | 2012-06-05 | Allergan, Inc. | Therapeutic compounds |
| EP2097689A1 (de) * | 2006-12-28 | 2009-09-09 | LG Electronics Inc. | Eisherstellungssystem und verfahren zur eisherstellung eines kühlschrankes |
| CA2675981A1 (en) * | 2007-01-22 | 2008-07-31 | Allergan, Inc. | Thiophene derivatives useful as ocular hypotensive agents |
| CA2675632A1 (en) * | 2007-01-22 | 2008-07-31 | Allergan, Inc. | Substituted arylcyclopentenes as therapeutic agents |
| CA2676291C (en) * | 2007-01-31 | 2017-11-28 | Allergan, Inc. | Substituted gamma lactams as therapeutic agents |
| EP2220057A4 (de) | 2007-11-14 | 2011-10-12 | Cayman Chem Co | Prostaglandin-e1- und e2-analoga zur behandlung verschiedener medizinischer leiden |
| US8063033B2 (en) * | 2008-01-18 | 2011-11-22 | Allergan, Inc. | Therapeutic beta-lactams |
| US7956051B2 (en) * | 2008-01-24 | 2011-06-07 | Allergan, Inc. | Therapeutic amides and related compounds |
| US8633310B2 (en) * | 2008-02-19 | 2014-01-21 | Allergan, Inc. | Therapeutic substituted lactams |
| WO2009111322A1 (en) * | 2008-03-04 | 2009-09-11 | Allergan, Inc. | Substituted cyclopentanes having prostaglandin activity |
| US8202855B2 (en) | 2008-03-04 | 2012-06-19 | Allergan, Inc | Substituted beta-lactams |
| US7964596B2 (en) * | 2008-03-07 | 2011-06-21 | Allergan, Inc. | Therapeutic compounds |
| US20090233921A1 (en) * | 2008-03-11 | 2009-09-17 | Allergan, Inc. | Therapeutic cyclopentane derivatives |
| US7960379B2 (en) * | 2008-03-14 | 2011-06-14 | Allergan, Inc. | Therapeutic compounds |
| US7705001B2 (en) * | 2008-03-18 | 2010-04-27 | Allergan, Inc | Therapeutic substituted gamma lactams |
| US8198318B2 (en) * | 2008-03-18 | 2012-06-12 | Allergen, Inc. | Therapeutic amides |
| US7960378B2 (en) * | 2008-03-18 | 2011-06-14 | Allergan, Inc. | Therapeutic compounds |
| US7732443B2 (en) * | 2008-03-18 | 2010-06-08 | Yariv Donde | Therapeutic substituted cyclopentanes |
| US7956055B2 (en) * | 2008-03-25 | 2011-06-07 | Allergan, Inc. | Substituted gamma lactams as therapeutic agents |
| BRPI0911543A2 (pt) * | 2008-04-24 | 2015-10-13 | Allergan Inc | arilciclopentenos substituídos como agentes terapêuticos |
| US7737140B2 (en) * | 2008-04-24 | 2010-06-15 | Allergan, Inc. | Therapeutic compounds |
| UA103616C2 (ru) | 2008-04-24 | 2013-11-11 | Аллерган, Инк. | Замещенные гамма-лактамы как терапевтические агенты |
| CA2731279A1 (en) * | 2008-04-24 | 2009-10-29 | Allergan, Inc. | Therapeutic compounds |
| JP2011518834A (ja) | 2008-04-24 | 2011-06-30 | アラーガン インコーポレイテッド | 治療剤としての置換ガンマラクタム |
| US7964634B2 (en) * | 2008-04-24 | 2011-06-21 | Allergan, Inc. | Therapeutic compounds |
| BRPI0910741A2 (pt) * | 2008-04-24 | 2015-09-29 | Allergan Inc | arilciclopentenos substituídos como agonistas de prostaglantina ep2 |
| WO2009132087A1 (en) | 2008-04-24 | 2009-10-29 | Allergan, Inc. | Thiophene derivatives useful as ocular hypotensive agents |
| CA2728229A1 (en) * | 2008-05-09 | 2009-11-12 | Allergan, Inc. | Therapeutic substituted thiazolidinones, oxazolidinones, and related compounds |
| EP2303836A1 (de) * | 2008-05-09 | 2011-04-06 | Allergan, Inc. | Therapeutische cyclopentanderivate |
| US7713967B2 (en) | 2008-05-09 | 2010-05-11 | Allergan, Inc. | Therapeutic substituted hydantoins, and related compounds |
| WO2009137412A1 (en) * | 2008-05-09 | 2009-11-12 | Allergan, Inc. | Therapeutic compounds |
| JP2011519937A (ja) * | 2008-05-09 | 2011-07-14 | アラーガン インコーポレイテッド | 治療用ｎ‐アリールまたはｎ‐ヘテロアリールピラゾリジンおよびピラゾリジノン誘導体 |
| US7981887B2 (en) * | 2008-05-09 | 2011-07-19 | Allergan, Inc. | Therapeutic compounds |
| CA2724972A1 (en) * | 2008-05-09 | 2009-11-12 | Allergan, Inc. | Therapeutic compounds |
| EP2291346A2 (de) * | 2008-05-15 | 2011-03-09 | Allergan, Inc. | Therapeutische substituierte cyclopentane |
| EP2285775B1 (de) * | 2008-05-20 | 2017-03-22 | Allergan, Inc. | Zur Behandlung von unter anderem erhöhtem Augeninnendruck oder Alopezie geeignete Lactame |
| CA2724605A1 (en) | 2008-05-27 | 2009-12-03 | Allergan, Inc. | Prostaglandin prodrugs as hypotensive agents |
| US7985765B2 (en) * | 2008-08-20 | 2011-07-26 | Allergan, Inc. | Therapeutic substituted pyrroles |
| US20110293549A1 (en) | 2009-02-03 | 2011-12-01 | Athena Cosmetics, Inc. | Composition, method and kit for enhancing hair |
| CN105592851A (zh) | 2013-09-30 | 2016-05-18 | 帕西昂Api服务公司 | 利用复分解反应的前列腺素和前列腺素中间体的新合成途径 |
| US10105488B2 (en) | 2013-12-12 | 2018-10-23 | Medtronic Minimed, Inc. | Predictive infusion device operations and related methods and systems |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5034413A (en) * | 1989-07-27 | 1991-07-23 | Allergan, Inc. | Intraocular pressure reducing 9,11-diacyl prostaglandins |
| US5028624A (en) * | 1989-07-27 | 1991-07-02 | Allergan, Inc. | Intraocular pressure reducing 9,15-diacyl prostaglandins |
| US4994274A (en) * | 1989-07-27 | 1991-02-19 | Allergan, Inc. | Intraocular pressure reducing 11,15-diacyl prostaglandins and method of using |
| CA2021316C (en) * | 1989-07-27 | 2000-10-24 | Ming Fai Chan | Intraocular pressure reducing 11-acyl prostaglandins |
| CA2221110C (en) * | 1995-05-18 | 2009-08-04 | Allergan | Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents for the treatment of ocular hypertension |
| JP2001139544A (ja) * | 1999-11-12 | 2001-05-22 | Taisho Pharmaceut Co Ltd | プロスタグランジン誘導体 |
| KR20030019628A (ko) * | 2000-07-31 | 2003-03-06 | 오노 야꾸힝 고교 가부시키가이샤 | 프로스타글란딘 유도체를 유효 성분으로 하는 발기부전치료제 |
| US6248783B1 (en) * | 2000-09-20 | 2001-06-19 | Allergan Sales, Inc. | Cyclopentane 1-hydroxy alkyl or alkenyl-2-one or 2-hydroxy derivatives as therapeutic agents |
| US6376533B1 (en) * | 2000-10-20 | 2002-04-23 | Allergan Sales, Inc. | Omega-cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists |
-
2002
- 2002-10-25 NZ NZ532519A patent/NZ532519A/en unknown
- 2002-10-25 CN CNA02826178XA patent/CN1617868A/zh active Pending
- 2002-10-25 AT AT02791192T patent/ATE305463T1/de not_active IP Right Cessation
- 2002-10-25 MX MXPA04004164A patent/MXPA04004164A/es active IP Right Grant
- 2002-10-25 BR BR0213911-1A patent/BR0213911A/pt not_active IP Right Cessation
- 2002-10-25 DE DE60206408T patent/DE60206408T2/de not_active Expired - Fee Related
- 2002-10-25 WO PCT/US2002/034301 patent/WO2003040126A1/en not_active Ceased
- 2002-10-25 KR KR1020047006769A patent/KR20050039733A/ko not_active Withdrawn
- 2002-10-25 CA CA002466517A patent/CA2466517A1/en not_active Abandoned
- 2002-10-25 ES ES02791192T patent/ES2246419T3/es not_active Expired - Lifetime
- 2002-10-25 EP EP02791192A patent/EP1442033B1/de not_active Expired - Lifetime
- 2002-10-29 US US10/283,629 patent/US6710072B2/en not_active Expired - Fee Related
-
2003
- 2003-11-04 US US10/701,977 patent/US7022726B2/en not_active Expired - Lifetime
-
2004
- 2004-10-26 US US10/974,268 patent/US7223746B2/en not_active Expired - Lifetime
-
2007
- 2007-06-06 US US11/696,995 patent/US7514462B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE60206408D1 (de) | 2006-02-09 |
| HK1066801A1 (en) | 2005-04-01 |
| US7223746B2 (en) | 2007-05-29 |
| DE60206408T2 (de) | 2006-06-22 |
| MXPA04004164A (es) | 2004-09-06 |
| US20070219262A1 (en) | 2007-09-20 |
| EP1442033B1 (de) | 2005-09-28 |
| CA2466517A1 (en) | 2003-05-15 |
| US20040106580A1 (en) | 2004-06-03 |
| US7022726B2 (en) | 2006-04-04 |
| NZ532519A (en) | 2006-11-30 |
| US7514462B2 (en) | 2009-04-07 |
| ES2246419T3 (es) | 2006-02-16 |
| US20030130239A1 (en) | 2003-07-10 |
| US6710072B2 (en) | 2004-03-23 |
| CN1617868A (zh) | 2005-05-18 |
| KR20050039733A (ko) | 2005-04-29 |
| WO2003040126A1 (en) | 2003-05-15 |
| EP1442033A1 (de) | 2004-08-04 |
| US20050113338A1 (en) | 2005-05-26 |
| BR0213911A (pt) | 2004-09-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE305463T1 (de) | Omega-zykloalkyl 17-heteroaryl prostaglandin-e2- analoga als ep2-rezeptoragonisten | |
| DK0783486T3 (da) | Hidtil ukendte prostaglandinsynthaseinhibitorer | |
| MX9203165A (es) | Derivados de succinimida y composicion farmaceutica que los contiene . | |
| YU48390B (sh) | Novi derivati 2-anilinopirimidina, postupak za njihovo dobijanje i sredstva za uništavanje štetočina, koja sadrže ove derivate | |
| EP1468990A4 (de) | Piperazinderivat | |
| HRP20090162T1 (en) | Quinolinone-carboxamide compounds as 5-ht4 receptor agonists | |
| HRP20021023B1 (en) | Sulfonyl-pyrrolidine derivatives useful for the treatment of neurological disorders | |
| CA2221110A1 (en) | Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents for the treatment of ocular hypertension | |
| YU47481B (sh) | Derivati beta-laktama i postupak za njihovo dobijanje | |
| TR200400857T4 (tr) | Yeni galantamın türevleri ve analogları | |
| DE69121408D1 (de) | Pgf 1-alkohole und deren verwendung als augendrucksenkende mittel | |
| DK1390036T3 (da) | Prostansyrederivater som midler til nedsættelse af intraokulært tryk | |
| ATE285410T1 (de) | Naphthyridinderivate oder salze davon | |
| EA200400641A1 (ru) | Производные 4-фенил-1-пиперазинила, -пиперидинила и -тетрагидропиридила и содержащая их фармацевтическая композиция | |
| FR2847899B1 (fr) | Derives d'indole-3-carboxamide, leur preparation et leur application en therapeutique | |
| NO20022977L (no) | Substituerte homopiperidinylbenzimidazolanaloger som fundiske relaksanter | |
| DE502004002035D1 (de) | Acetale, ihre verwendung als riechstoffe und verfahren zu ihrer herstellung | |
| AR002749A1 (es) | Derivados de estiril bencimidazol y composicion farmaceutica que los comprende. | |
| MEP12408A (en) | Acyloxypyrrolidine derivatives and use thereof as ligands of v1b or both v1b and v1a receptors | |
| AR002204A1 (es) | Compuestos piridiniminil-1,2-bencisoxazoles y bencisotiazoles utiles como agentes para aliviar la disfuncion de la memoria, compuestos intermediarios,procedimientos de preparacion, composiciones que hacen uso de dichos compuestos e intermediarios. | |
| DK1097154T3 (da) | Substituerede benzimidazoler, fremstilling og anvendelse deraf som midler til bekæmpelse af parasitiske protozoer | |
| ATE215083T1 (de) | Bicyclische carboxamide als 5-ht1a rezeptoren liganden | |
| DE69011714D1 (de) | Kalziumantagonisten. | |
| PL453256A1 (pl) | Związki porfirynowo-cukrowe typu A4 oraz sposób ich wytwarzania | |
| US4269995A (en) | 19,20-Didehydro-13,14-dihydro-PG2 compounds |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |