ATE308499T1 - Verfahren zur herstellung von anthracyclinederivaten - Google Patents
Verfahren zur herstellung von anthracyclinederivatenInfo
- Publication number
- ATE308499T1 ATE308499T1 AT01943338T AT01943338T ATE308499T1 AT E308499 T1 ATE308499 T1 AT E308499T1 AT 01943338 T AT01943338 T AT 01943338T AT 01943338 T AT01943338 T AT 01943338T AT E308499 T1 ATE308499 T1 AT E308499T1
- Authority
- AT
- Austria
- Prior art keywords
- anthracycline derivatives
- producing anthracycline
- producing
- derivatives
- demethoxydaunomycinone
- Prior art date
Links
- 229940045799 anthracyclines and related substance Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- PXKSREQRHMKAHR-UFBFGSQYSA-N (8s,10s)-1-acetyl-6,8,10,11-tetrahydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione Chemical compound C1[C@H](O)C[C@H](O)C2=C1C(O)=C1C(=O)C(C=CC=C3C(=O)C)=C3C(=O)C1=C2O PXKSREQRHMKAHR-UFBFGSQYSA-N 0.000 abstract 1
- ZUFQFGSMHXKORU-UHFFFAOYSA-N 9-acetyl-6,7,9,11-tetrahydroxy-8,10-dihydro-7h-tetracene-5,12-dione Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C(O)=C1C(O)CC(C(=O)C)(O)CC1=C2O ZUFQFGSMHXKORU-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/30—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reactions not involving the formation of esterified sulfo groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2000MI001122A IT1318532B1 (it) | 2000-05-19 | 2000-05-19 | Procedimento di sintesi di derivati antraciclinici. |
| PCT/EP2001/005304 WO2001087814A2 (en) | 2000-05-19 | 2001-05-10 | A process for the preparation of anthracycline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE308499T1 true ATE308499T1 (de) | 2005-11-15 |
Family
ID=11445091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01943338T ATE308499T1 (de) | 2000-05-19 | 2001-05-10 | Verfahren zur herstellung von anthracyclinederivaten |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6844455B2 (de) |
| EP (1) | EP1282590B1 (de) |
| AT (1) | ATE308499T1 (de) |
| AU (1) | AU2001265939A1 (de) |
| DE (1) | DE60114608T2 (de) |
| IT (1) | IT1318532B1 (de) |
| WO (1) | WO2001087814A2 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7053191B2 (en) | 2003-05-21 | 2006-05-30 | Solux Corporation | Method of preparing 4-R-substituted 4-demethoxydaunorubicin |
| FR2871156B1 (fr) * | 2004-06-04 | 2006-08-25 | Archemis Sa | Procede de preparation de derives de la rhodomycinone |
| MX2007002284A (es) * | 2004-08-23 | 2009-02-12 | Sicor Inc | Síntesis de idarubicina aglicona. |
| US8357785B2 (en) | 2008-01-08 | 2013-01-22 | Solux Corporation | Method of aralkylation of 4′-hydroxyl group of anthracylins |
| WO2010125466A1 (en) * | 2009-04-28 | 2010-11-04 | Tbd-Biodiscovery | Methods for the synthesis of amrubicin |
| US8846882B2 (en) | 2011-04-29 | 2014-09-30 | Synbias Pharma Ag | Method of producing 4-demethoxydaunorubicin |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8804429D0 (en) * | 1988-02-25 | 1988-03-23 | Erba Carlo Spa | New 4-demethyl-4-0-(fluorobenzensulfonyl)anthracycline glycosides |
| GB8808475D0 (en) * | 1988-04-11 | 1988-05-11 | Erba Carlo Spa | Process for preparing 4-demethoxydauno-mycinone |
-
2000
- 2000-05-19 IT IT2000MI001122A patent/IT1318532B1/it active
-
2001
- 2001-05-10 AT AT01943338T patent/ATE308499T1/de not_active IP Right Cessation
- 2001-05-10 US US10/276,823 patent/US6844455B2/en not_active Expired - Fee Related
- 2001-05-10 DE DE60114608T patent/DE60114608T2/de not_active Expired - Fee Related
- 2001-05-10 WO PCT/EP2001/005304 patent/WO2001087814A2/en not_active Ceased
- 2001-05-10 EP EP01943338A patent/EP1282590B1/de not_active Expired - Lifetime
- 2001-05-10 AU AU2001265939A patent/AU2001265939A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US6844455B2 (en) | 2005-01-18 |
| EP1282590A2 (de) | 2003-02-12 |
| EP1282590B1 (de) | 2005-11-02 |
| DE60114608T2 (de) | 2006-06-01 |
| IT1318532B1 (it) | 2003-08-27 |
| ITMI20001122A1 (it) | 2001-11-19 |
| US20040044189A1 (en) | 2004-03-04 |
| AU2001265939A1 (en) | 2001-11-26 |
| ITMI20001122A0 (it) | 2000-05-19 |
| DE60114608D1 (de) | 2005-12-08 |
| WO2001087814A2 (en) | 2001-11-22 |
| WO2001087814A3 (en) | 2002-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |