ATE308563T1 - Aktives hedgehog-protein-konjugat, verfahren zur herstellung und verwendung - Google Patents

Aktives hedgehog-protein-konjugat, verfahren zur herstellung und verwendung

Info

Publication number: ATE308563T1
Authority: AT; Austria
Prior art keywords: preparation; hydrophobic; protein conjugate; hedgehog; amino acids
Prior art date: 1998-04-30

Application number

AT99108032T

Other languages

English (en)

Inventor

Angelika Esswein

Kurt Lang

Petra Rueger

Tilmann Seytter

Original Assignee

Curis Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-30

Filing date

1999-04-23

Publication date

2005-11-15

1998-04-30 Priority claimed from EP98107911A external-priority patent/EP0953575A1/de

1999-04-23 Application filed by Curis Inc filed Critical Curis Inc

2005-11-15 Application granted granted Critical

2005-11-15 Publication of ATE308563T1 publication Critical patent/ATE308563T1/de

Links

102000003693 Hedgehog Proteins Human genes 0.000 title abstract 2
108090000031 Hedgehog Proteins Proteins 0.000 title abstract 2
230000002209 hydrophobic effect Effects 0.000 abstract 3
150000001413 amino acids Chemical class 0.000 abstract 2
241000289669 Erinaceus europaeus Species 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
239000003102 growth factor Substances 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
229920006395 saturated elastomer Chemical group 0.000 abstract 1
229930195734 saturated hydrocarbon Chemical group 0.000 abstract 1
-1 thio compound Chemical class 0.000 abstract 1
229930195735 unsaturated hydrocarbon Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Toxicology (AREA)
Neurology (AREA)
Physical Education & Sports Medicine (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Dermatology (AREA)
Biomedical Technology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurosurgery (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT99108032T 1998-04-30 1999-04-23 Aktives hedgehog-protein-konjugat, verfahren zur herstellung und verwendung ATE308563T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98107911A EP0953575A1 (de)	1998-04-30	1998-04-30	Aktives Hedgehog-Protein-Konjugat, Verfahren zur Herstellung und Verwendung
EP98116733		1998-09-03

Publications (1)

Publication Number	Publication Date
ATE308563T1 true ATE308563T1 (de)	2005-11-15

Family

ID=26149214

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99108032T ATE308563T1 (de)	1998-04-30	1999-04-23	Aktives hedgehog-protein-konjugat, verfahren zur herstellung und verwendung

Country Status (18)

Country	Link
US (4)	US6468978B1 (de)
EP (2)	EP1557427A3 (de)
JP (1)	JP3433136B2 (de)
KR (1)	KR19990083621A (de)
CN (1)	CN1233616A (de)
AT (1)	ATE308563T1 (de)
AU (1)	AU719797B2 (de)
CA (1)	CA2269221A1 (de)
CY (1)	CY1105683T1 (de)
DE (1)	DE69928040T2 (de)
DK (1)	DK0953576T3 (de)
ES (1)	ES2252886T3 (de)
HU (1)	HUP9901411A2 (de)
IL (1)	IL129620A (de)
MA (1)	MA26625A1 (de)
NO (1)	NO992090L (de)
NZ (1)	NZ335385A (de)
SG (1)	SG80028A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1999028454A1 (en) *	1997-11-28	1999-06-10	Roche Diagnostics Gmbh	An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes
US6897297B1 (en) *	1997-12-03	2005-05-24	Curis, Inc.	Hydrophobically-modified protein compositions and methods
ES2252886T3 (es) *	1998-04-30	2006-05-16	Curis, Inc.	Conjugado de proteinas de erizo activo, proceso para su produccion y uso.
ES2253851T3 (es)	1998-08-07	2006-06-01	Curis, Inc.	Composicion farmaceutica estable de proteinas hedgehog y uso de la misma.
TW570805B (en) *	1998-09-01	2004-01-11	Hoffmann La Roche	Water-soluble pharmaceutical composition in an ionic complex
EP1135411B1 (de) *	1998-12-03	2006-05-17	Curis, Inc.	Verfahren unfd zusammensetzungen zur behandlung von krankheiten bei denen exitotoxizität beteiligt ist
EP1025861A1 (de) *	1999-02-04	2000-08-09	Roche Diagnostics GmbH	Pharmazeutische Zusammensetzung von hydrophob modifizierten Hedgehog-Proteinen und deren Verwendung
AU782493B2 (en) *	1999-06-01	2005-08-04	Curis, Inc.	Polymer conjugates of hedgehog proteins and uses
WO2001082994A1 (en) *	2000-04-28	2001-11-08	Curis, Inc.	Methods and reagents for tissue engineering of cartilage in vitro
US7573637B2 (en) *	2004-08-03	2009-08-11	Seiko Epson Corporation	Intrinsic polarizer and method of manufacturing an intrinsic polarizer
US8669418B2 (en) *	2005-12-22	2014-03-11	Vib Vzw	Means and methods for mediating protein interference
US20100316566A1 (en) *	2008-02-27	2010-12-16	Radiomedix Inc.	Radiolabeled hedgehog derivatives for imaging and therapy
WO2010065908A2 (en) *	2008-12-05	2010-06-10	Catchmark Jeffrey M	Degradable biomolecule compositions
US20110086236A1 (en) *	2009-10-13	2011-04-14	The Penn State Research Foundation	Composites containing polypeptides attached to polysaccharides and molecules
SG195302A1 (en) *	2011-06-06	2013-12-30	Kineta One Llc	Shk-based pharmaceutical compositions and methods of manufacturing and using the same
US10202517B2 (en)	2013-07-26	2019-02-12	The Penn State Research Foundation	Polymer compositions and coatings
EP3384935A4 (de) *	2015-12-02	2019-08-21	Hanmi Pharm. Co., Ltd.	Proteinkomplex mit fettsäurederivat und herstellungsverfahren dafür
CA3116768A1 (en) *	2018-10-30	2020-05-07	Somalogic, Inc.	Methods for sample quality assessment

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5364839A (en) *	1990-06-18	1994-11-15	Genetics Institute, Inc.	Osteoinductive pharmaceutical formulations
WO1992009697A1 (en) *	1990-11-30	1992-06-11	Celtrix Laboratories, Inc.	USE OF A BONE MORPHOGENETIC PROTEIN IN SYNERGISTIC COMBINATION WITH TGF-β FOR BONE REPAIR
US5789543A (en) *	1993-12-30	1998-08-04	President And Fellows Of Harvard College	Vertebrate embryonic pattern-inducing proteins and uses related thereto
EP0741783B1 (de) *	1993-12-30	2009-03-18	President And Fellows Of Harvard College	"hedgehog-like" proteine von wirbeltieren, die embryonale strukturen induzieren
US6281332B1 (en) *	1994-12-02	2001-08-28	The Johns Hopkins University School Of Medicine	Hedgehog-derived polypeptides
US5700774A (en) *	1996-03-26	1997-12-23	Genetics Institute, Inc.	Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
GB9614871D0 (en)	1996-07-15	1996-09-04	Smithkline Beecham Plc	Compounds
CA2267106A1 (en) *	1996-10-07	1998-07-16	The Johns Hopkins University School Of Medicine	Novel hedgehog-derived polypeptides
WO1999028454A1 (en) *	1997-11-28	1999-06-10	Roche Diagnostics Gmbh	An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes
US6897297B1 (en) *	1997-12-03	2005-05-24	Curis, Inc.	Hydrophobically-modified protein compositions and methods
PT1036092E (pt) *	1997-12-03	2005-09-30	Biogen Inc	Compos~icoes e metodos de proteinas hidrofobicamente modificadas
ES2252886T3 (es) *	1998-04-30	2006-05-16	Curis, Inc.	Conjugado de proteinas de erizo activo, proceso para su produccion y uso.
ES2253851T3 (es) *	1998-08-07	2006-06-01	Curis, Inc.	Composicion farmaceutica estable de proteinas hedgehog y uso de la misma.
WO2001082994A1 (en) *	2000-04-28	2001-11-08	Curis, Inc.	Methods and reagents for tissue engineering of cartilage in vitro

1999
- 1999-04-23 ES ES99108032T patent/ES2252886T3/es not_active Expired - Lifetime
- 1999-04-23 DK DK99108032T patent/DK0953576T3/da active
- 1999-04-23 EP EP05009341A patent/EP1557427A3/de not_active Withdrawn
- 1999-04-23 DE DE69928040T patent/DE69928040T2/de not_active Expired - Fee Related
- 1999-04-23 EP EP99108032A patent/EP0953576B1/de not_active Expired - Lifetime
- 1999-04-23 AT AT99108032T patent/ATE308563T1/de not_active IP Right Cessation
- 1999-04-26 NZ NZ335385A patent/NZ335385A/xx unknown
- 1999-04-27 IL IL129620A patent/IL129620A/en not_active IP Right Cessation
- 1999-04-28 US US09/301,199 patent/US6468978B1/en not_active Expired - Fee Related
- 1999-04-28 SG SG9902117A patent/SG80028A1/en unknown
- 1999-04-28 HU HU9901411A patent/HUP9901411A2/hu unknown
- 1999-04-29 MA MA25560A patent/MA26625A1/fr unknown
- 1999-04-29 CN CN99106302A patent/CN1233616A/zh active Pending
- 1999-04-29 NO NO992090A patent/NO992090L/no not_active Application Discontinuation
- 1999-04-29 AU AU25009/99A patent/AU719797B2/en not_active Ceased
- 1999-04-29 KR KR1019990015503A patent/KR19990083621A/ko not_active Abandoned
- 1999-04-29 CA CA002269221A patent/CA2269221A1/en not_active Abandoned
- 1999-04-30 JP JP12500599A patent/JP3433136B2/ja not_active Expired - Fee Related
2002
- 2002-10-21 US US10/278,060 patent/US6818623B2/en not_active Expired - Fee Related
2004
- 2004-10-08 US US10/961,982 patent/US7153836B2/en not_active Expired - Fee Related
2006
- 2006-02-01 CY CY20061100133T patent/CY1105683T1/el unknown
- 2006-12-22 US US11/645,014 patent/US20070191274A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US6468978B1 (en)	2002-10-22
IL129620A0 (en)	2000-02-29
US20050148510A1 (en)	2005-07-07
SG80028A1 (en)	2001-04-17
DE69928040D1 (de)	2005-12-08
HUP9901411A2 (hu)	1999-12-28
AU2500999A (en)	1999-11-11
IL129620A (en)	2009-06-15
MA26625A1 (fr)	2004-12-20
EP0953576A1 (de)	1999-11-03
EP1557427A3 (de)	2005-10-19
CN1233616A (zh)	1999-11-03
DK0953576T3 (da)	2006-03-20
CA2269221A1 (en)	1999-10-30
EP0953576B1 (de)	2005-11-02
CY1105683T1 (el)	2010-12-22
US20030139574A1 (en)	2003-07-24
HU9901411D0 (en)	1999-07-28
US6818623B2 (en)	2004-11-16
NO992090D0 (no)	1999-04-29
US20070191274A1 (en)	2007-08-16
JP2000053699A (ja)	2000-02-22
JP3433136B2 (ja)	2003-08-04
EP1557427A2 (de)	2005-07-27
DE69928040T2 (de)	2006-07-27
NO992090L (no)	1999-11-01
NZ335385A (en)	2000-09-29
US7153836B2 (en)	2006-12-26
ES2252886T3 (es)	2006-05-16
AU719797B2 (en)	2000-05-18
KR19990083621A (ko)	1999-11-25

Legal Events

Date

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Title

Description

2006-06-15

UEP

Publication of translation of european patent specification

Ref document number: 0953576

Country of ref document: EP

2010-01-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE308563T1 (de)	2005-11-15	Aktives hedgehog-protein-konjugat, verfahren zur herstellung und verwendung
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