MA26625A1 - Conjugue de proteine hedgehog a activite accrue, procede pour sa production, et son utilisation therapeutique - Google Patents

Conjugue de proteine hedgehog a activite accrue, procede pour sa production, et son utilisation therapeutique

Info

Publication number
MA26625A1
MA26625A1 MA25560A MA25560A MA26625A1 MA 26625 A1 MA26625 A1 MA 26625A1 MA 25560 A MA25560 A MA 25560A MA 25560 A MA25560 A MA 25560A MA 26625 A1 MA26625 A1 MA 26625A1
Authority
MA
Morocco
Prior art keywords
production
hedgehog protein
therapeutic use
increased activity
protein conjugate
Prior art date
Application number
MA25560A
Other languages
English (en)
Inventor
Esswein Angelika
Lang Kurt
Seytter Tilmann
Rueger Petra
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP98107911A external-priority patent/EP0953575A1/fr
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of MA26625A1 publication Critical patent/MA26625A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
MA25560A 1998-04-30 1999-04-29 Conjugue de proteine hedgehog a activite accrue, procede pour sa production, et son utilisation therapeutique MA26625A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98107911A EP0953575A1 (fr) 1998-04-30 1998-04-30 Conjugué de proteine hedgehog active, procédé pour sa production et utilisation
EP98116733 1998-09-03

Publications (1)

Publication Number Publication Date
MA26625A1 true MA26625A1 (fr) 2004-12-20

Family

ID=26149214

Family Applications (1)

Application Number Title Priority Date Filing Date
MA25560A MA26625A1 (fr) 1998-04-30 1999-04-29 Conjugue de proteine hedgehog a activite accrue, procede pour sa production, et son utilisation therapeutique

Country Status (18)

Country Link
US (4) US6468978B1 (fr)
EP (2) EP1557427A3 (fr)
JP (1) JP3433136B2 (fr)
KR (1) KR19990083621A (fr)
CN (1) CN1233616A (fr)
AT (1) ATE308563T1 (fr)
AU (1) AU719797B2 (fr)
CA (1) CA2269221A1 (fr)
CY (1) CY1105683T1 (fr)
DE (1) DE69928040T2 (fr)
DK (1) DK0953576T3 (fr)
ES (1) ES2252886T3 (fr)
HU (1) HUP9901411A2 (fr)
IL (1) IL129620A (fr)
MA (1) MA26625A1 (fr)
NO (1) NO992090L (fr)
NZ (1) NZ335385A (fr)
SG (1) SG80028A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001525341A (ja) * 1997-11-28 2001-12-11 ロッシュ ディアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング 活性ヘッジホッグタンパク質変異体、その調製方法及び医薬への適用
US6897297B1 (en) * 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
EP1557427A3 (fr) * 1998-04-30 2005-10-19 Curis, Inc. Conjugué de protein "hedgehog"
US6207718B1 (en) 1998-08-07 2001-03-27 Ontogeny, Inc. Pharmaceutical compositions containing hedgehog protein
TW570805B (en) * 1998-09-01 2004-01-11 Hoffmann La Roche Water-soluble pharmaceutical composition in an ionic complex
ATE326480T1 (de) * 1998-12-03 2006-06-15 Curis Inc Verfahren unfd zusammensetzungen zur behandlung von krankheiten bei denen exitotoxizität beteiligt ist
EP1025861A1 (fr) * 1999-02-04 2000-08-09 Roche Diagnostics GmbH Compositions pharmaceutiques des Proteines Hedgehog rendues hydrophobes, et leur utilisation
JP2003502292A (ja) * 1999-06-01 2003-01-21 バイオジェン インコーポレイテッド ヘッジホッグタンパク質のポリマー結合体及び利用
WO2001082994A1 (fr) * 2000-04-28 2001-11-08 Curis, Inc. Methodes et reactifs d'elaboration de cartilages in vitro
US7573637B2 (en) * 2004-08-03 2009-08-11 Seiko Epson Corporation Intrinsic polarizer and method of manufacturing an intrinsic polarizer
US8669418B2 (en) * 2005-12-22 2014-03-11 Vib Vzw Means and methods for mediating protein interference
US20100316566A1 (en) * 2008-02-27 2010-12-16 Radiomedix Inc. Radiolabeled hedgehog derivatives for imaging and therapy
WO2010065908A2 (fr) * 2008-12-05 2010-06-10 Catchmark Jeffrey M Compositions de biomolécule dégradables
WO2011047047A2 (fr) * 2009-10-13 2011-04-21 The Penn State Research Foundation Composites contenant des polypeptides attachés à des polysaccharides et des molécules
AU2012268441B2 (en) * 2011-06-06 2016-05-12 Kineta One, Llc ShK-based pharmaceutical compositions and methods of manufacturing and using the same
EP3024887B1 (fr) 2013-07-26 2023-11-22 The Penn State Research Foundation Procédé pour préparation des compositions et revêtements polymères
JP6989503B2 (ja) * 2015-12-02 2022-01-05 ハンミ ファーマシューティカル カンパニー リミテッド 脂肪酸誘導体を用いたタンパク質結合体及びその製造方法
KR102806666B1 (ko) * 2018-10-30 2025-05-12 소마로직 오퍼레이팅 컴퍼니, 인코포레이티드 샘플 품질 평가 방법

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5364839A (en) * 1990-06-18 1994-11-15 Genetics Institute, Inc. Osteoinductive pharmaceutical formulations
EP0513334A4 (en) * 1990-11-30 1993-08-04 Celtrix Laboratories, Inc. Use of a bone morphogenetic protein in synergistic combination with tgf--g(b) for bone repair
US5789543A (en) * 1993-12-30 1998-08-04 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins and uses related thereto
AU704178B2 (en) * 1993-12-30 1999-04-15 Imperial Cancer Research Technology Ltd Vertebrate embryonic pattern-inducing hedgehog-like proteins
US6281332B1 (en) * 1994-12-02 2001-08-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides
US5700774A (en) * 1996-03-26 1997-12-23 Genetics Institute, Inc. Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
GB9614871D0 (en) 1996-07-15 1996-09-04 Smithkline Beecham Plc Compounds
AU728541B2 (en) * 1996-10-07 2001-01-11 Johns Hopkins University School Of Medicine, The Novel hedgehog-derived polypeptides
JP2001525341A (ja) * 1997-11-28 2001-12-11 ロッシュ ディアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング 活性ヘッジホッグタンパク質変異体、その調製方法及び医薬への適用
MXPA00005494A (es) * 1997-12-03 2003-05-19 Curis Inc Composiciones de proteina hidrofobicamente modificada y metodos.
US6897297B1 (en) * 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
EP1557427A3 (fr) * 1998-04-30 2005-10-19 Curis, Inc. Conjugué de protein "hedgehog"
US6207718B1 (en) * 1998-08-07 2001-03-27 Ontogeny, Inc. Pharmaceutical compositions containing hedgehog protein
WO2001082994A1 (fr) * 2000-04-28 2001-11-08 Curis, Inc. Methodes et reactifs d'elaboration de cartilages in vitro

Also Published As

Publication number Publication date
CY1105683T1 (el) 2010-12-22
SG80028A1 (en) 2001-04-17
US20070191274A1 (en) 2007-08-16
HUP9901411A2 (hu) 1999-12-28
AU2500999A (en) 1999-11-11
US20030139574A1 (en) 2003-07-24
US6468978B1 (en) 2002-10-22
CA2269221A1 (fr) 1999-10-30
US20050148510A1 (en) 2005-07-07
NO992090D0 (no) 1999-04-29
US7153836B2 (en) 2006-12-26
AU719797B2 (en) 2000-05-18
HU9901411D0 (en) 1999-07-28
NZ335385A (en) 2000-09-29
ATE308563T1 (de) 2005-11-15
EP1557427A2 (fr) 2005-07-27
NO992090L (no) 1999-11-01
IL129620A (en) 2009-06-15
DE69928040T2 (de) 2006-07-27
DK0953576T3 (da) 2006-03-20
JP2000053699A (ja) 2000-02-22
CN1233616A (zh) 1999-11-03
IL129620A0 (en) 2000-02-29
EP0953576A1 (fr) 1999-11-03
US6818623B2 (en) 2004-11-16
ES2252886T3 (es) 2006-05-16
DE69928040D1 (de) 2005-12-08
KR19990083621A (ko) 1999-11-25
EP1557427A3 (fr) 2005-10-19
JP3433136B2 (ja) 2003-08-04
EP0953576B1 (fr) 2005-11-02

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