MA26625A1 - Conjugue de proteine hedgehog a activite accrue, procede pour sa production, et son utilisation therapeutique - Google Patents

Conjugue de proteine hedgehog a activite accrue, procede pour sa production, et son utilisation therapeutique

Info

Publication number
MA26625A1
MA26625A1 MA25560A MA25560A MA26625A1 MA 26625 A1 MA26625 A1 MA 26625A1 MA 25560 A MA25560 A MA 25560A MA 25560 A MA25560 A MA 25560A MA 26625 A1 MA26625 A1 MA 26625A1
Authority
MA
Morocco
Prior art keywords
production
hedgehog protein
therapeutic use
increased activity
protein conjugate
Prior art date
Application number
MA25560A
Other languages
English (en)
Inventor
Esswein Angelika
Lang Kurt
Seytter Tilmann
Rueger Petra
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP98107911A external-priority patent/EP0953575A1/fr
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of MA26625A1 publication Critical patent/MA26625A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
MA25560A 1998-04-30 1999-04-29 Conjugue de proteine hedgehog a activite accrue, procede pour sa production, et son utilisation therapeutique MA26625A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98107911A EP0953575A1 (fr) 1998-04-30 1998-04-30 Conjugué de proteine hedgehog active, procédé pour sa production et utilisation
EP98116733 1998-09-03

Publications (1)

Publication Number Publication Date
MA26625A1 true MA26625A1 (fr) 2004-12-20

Family

ID=26149214

Family Applications (1)

Application Number Title Priority Date Filing Date
MA25560A MA26625A1 (fr) 1998-04-30 1999-04-29 Conjugue de proteine hedgehog a activite accrue, procede pour sa production, et son utilisation therapeutique

Country Status (18)

Country Link
US (4) US6468978B1 (fr)
EP (2) EP0953576B1 (fr)
JP (1) JP3433136B2 (fr)
KR (1) KR19990083621A (fr)
CN (1) CN1233616A (fr)
AT (1) ATE308563T1 (fr)
AU (1) AU719797B2 (fr)
CA (1) CA2269221A1 (fr)
CY (1) CY1105683T1 (fr)
DE (1) DE69928040T2 (fr)
DK (1) DK0953576T3 (fr)
ES (1) ES2252886T3 (fr)
HU (1) HUP9901411A2 (fr)
IL (1) IL129620A (fr)
MA (1) MA26625A1 (fr)
NO (1) NO992090L (fr)
NZ (1) NZ335385A (fr)
SG (1) SG80028A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1034269A1 (fr) * 1997-11-28 2000-09-13 Roche Diagnostics GmbH Mutant actif de proteine du herisson, son procede de preparation et son utilisation a des fins pharmaceutiques
US6897297B1 (en) * 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
DE69928040T2 (de) * 1998-04-30 2006-07-27 Curis, Inc., Cambridge Aktives Hedgehog-Protein-Konjugat, Verfahren zur Herstellung und Verwendung
ES2253851T3 (es) * 1998-08-07 2006-06-01 Curis, Inc. Composicion farmaceutica estable de proteinas hedgehog y uso de la misma.
TW570805B (en) * 1998-09-01 2004-01-11 Hoffmann La Roche Water-soluble pharmaceutical composition in an ionic complex
WO2000035948A1 (fr) * 1998-12-03 2000-06-22 Biogen, Inc. Procedes et compositions servant a traiter des troubles entrainant une excitotoxicite
EP1025861A1 (fr) * 1999-02-04 2000-08-09 Roche Diagnostics GmbH Compositions pharmaceutiques des Proteines Hedgehog rendues hydrophobes, et leur utilisation
AU782493B2 (en) * 1999-06-01 2005-08-04 Curis, Inc. Polymer conjugates of hedgehog proteins and uses
US7052514B2 (en) * 2000-04-28 2006-05-30 Curis, Inc. Methods and reagents for tissue engineering of cartilage in vitro
US7573637B2 (en) * 2004-08-03 2009-08-11 Seiko Epson Corporation Intrinsic polarizer and method of manufacturing an intrinsic polarizer
US8669418B2 (en) * 2005-12-22 2014-03-11 Vib Vzw Means and methods for mediating protein interference
WO2009108868A2 (fr) * 2008-02-27 2009-09-03 Radiomedix Inc. Dérivés hedgehog radiomarqués utilisés en imagerie et en thérapie
US20100172889A1 (en) * 2008-12-05 2010-07-08 Catchmark Jeffrey M Degradable biomolecule compositions
WO2011047047A2 (fr) * 2009-10-13 2011-04-21 The Penn State Research Foundation Composites contenant des polypeptides attachés à des polysaccharides et des molécules
TW201542231A (zh) * 2011-06-06 2015-11-16 Kineta One Llc 以ｓｈｋ為主之醫藥組合物及其製備方法及用途
EP3024887B1 (fr) 2013-07-26 2023-11-22 The Penn State Research Foundation Procédé pour préparation des compositions et revêtements polymères
US20180360973A1 (en) * 2015-12-02 2018-12-20 Hanmi Pharm. Co., Ltd. Protein conjugate using a fatty acid derivative and method for preparation thereof
CN113167782B (zh) * 2018-10-30 2025-07-11 私募蛋白质体操作有限公司 用于样品质量评估的方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5364839A (en) * 1990-06-18 1994-11-15 Genetics Institute, Inc. Osteoinductive pharmaceutical formulations
WO1992009697A1 (fr) * 1990-11-30 1992-06-11 Celtrix Laboratories, Inc. UTILISATION EN OSTEOPATHIE D'UNE PROTEINE MORPHOGENETIQUE D'ORIGINE OSSEUSE ASSOCIEE DE MANIERE SYNERGIQUE AVEC DU BETA DE FACTEUR DE CROISSANCE DE TRANSFORMATION (β-FCT).
US5789543A (en) * 1993-12-30 1998-08-04 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins and uses related thereto
NZ278765A (en) * 1993-12-30 1998-05-27 Harvard College Vertebrate proteins involved in spatial arrangements of differentiated tissues called hedgehog proteins, their production and use
US6281332B1 (en) * 1994-12-02 2001-08-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides
US5700774A (en) * 1996-03-26 1997-12-23 Genetics Institute, Inc. Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
GB9614871D0 (en) 1996-07-15 1996-09-04 Smithkline Beecham Plc Compounds
EP0966478A4 (fr) * 1996-10-07 2002-08-21 Univ Johns Hopkins Med Nouveaux polypeptides derives d'une proteine herisson
EP1034269A1 (fr) * 1997-11-28 2000-09-13 Roche Diagnostics GmbH Mutant actif de proteine du herisson, son procede de preparation et son utilisation a des fins pharmaceutiques
EA003739B1 (ru) * 1997-12-03 2003-08-28 Байоджен, Инк. Гидрофобно-модифицированные белки, способы их получения и их применение
US6897297B1 (en) * 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
DE69928040T2 (de) * 1998-04-30 2006-07-27 Curis, Inc., Cambridge Aktives Hedgehog-Protein-Konjugat, Verfahren zur Herstellung und Verwendung
ES2253851T3 (es) * 1998-08-07 2006-06-01 Curis, Inc. Composicion farmaceutica estable de proteinas hedgehog y uso de la misma.
US7052514B2 (en) * 2000-04-28 2006-05-30 Curis, Inc. Methods and reagents for tissue engineering of cartilage in vitro

Also Published As

Publication number Publication date
NO992090D0 (no) 1999-04-29
DK0953576T3 (da) 2006-03-20
US20070191274A1 (en) 2007-08-16
US7153836B2 (en) 2006-12-26
US6468978B1 (en) 2002-10-22
KR19990083621A (ko) 1999-11-25
JP2000053699A (ja) 2000-02-22
IL129620A0 (en) 2000-02-29
NO992090L (no) 1999-11-01
CN1233616A (zh) 1999-11-03
HUP9901411A2 (hu) 1999-12-28
EP0953576A1 (fr) 1999-11-03
US6818623B2 (en) 2004-11-16
AU2500999A (en) 1999-11-11
DE69928040T2 (de) 2006-07-27
AU719797B2 (en) 2000-05-18
IL129620A (en) 2009-06-15
EP1557427A3 (fr) 2005-10-19
CY1105683T1 (el) 2010-12-22
NZ335385A (en) 2000-09-29
DE69928040D1 (de) 2005-12-08
US20030139574A1 (en) 2003-07-24
SG80028A1 (en) 2001-04-17
ATE308563T1 (de) 2005-11-15
HU9901411D0 (en) 1999-07-28
EP1557427A2 (fr) 2005-07-27
ES2252886T3 (es) 2006-05-16
US20050148510A1 (en) 2005-07-07
CA2269221A1 (fr) 1999-10-30
JP3433136B2 (ja) 2003-08-04
EP0953576B1 (fr) 2005-11-02

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