ATE309980T1 - Zubereitungen zur verwendung als therapeutische und nachweismittel - Google Patents
Zubereitungen zur verwendung als therapeutische und nachweismittelInfo
- Publication number
- ATE309980T1 ATE309980T1 AT97949046T AT97949046T ATE309980T1 AT E309980 T1 ATE309980 T1 AT E309980T1 AT 97949046 T AT97949046 T AT 97949046T AT 97949046 T AT97949046 T AT 97949046T AT E309980 T1 ATE309980 T1 AT E309980T1
- Authority
- AT
- Austria
- Prior art keywords
- thrag
- tyrx
- therapeutic
- preparations
- drugs
- Prior art date
Links
- 238000001514 detection method Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 239000013543 active substance Substances 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 102000003425 Tyrosinase Human genes 0.000 abstract 1
- 108060008724 Tyrosinase Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 125000001493 tyrosinyl group Chemical class [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C333/02—Monothiocarbamic acids; Derivatives thereof
- C07C333/04—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9625895.9A GB9625895D0 (en) | 1996-12-13 | 1996-12-13 | Novel compound useful as therapeutic agents and assay reagents |
| PCT/GB1997/003433 WO1998025886A1 (en) | 1996-12-13 | 1997-12-12 | Novel compounds useful as therapeutic agents and assay reagents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE309980T1 true ATE309980T1 (de) | 2005-12-15 |
Family
ID=10804381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97949046T ATE309980T1 (de) | 1996-12-13 | 1997-12-12 | Zubereitungen zur verwendung als therapeutische und nachweismittel |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6573284B1 (de) |
| EP (1) | EP0944583B1 (de) |
| AT (1) | ATE309980T1 (de) |
| AU (1) | AU748957B2 (de) |
| DE (1) | DE69734670T2 (de) |
| GB (1) | GB9625895D0 (de) |
| WO (1) | WO1998025886A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040014652A1 (en) * | 2000-06-01 | 2004-01-22 | Andre Trouet | Tumor activated prodrug compounds and methods of making and using the same |
| AU7570201A (en) * | 2000-07-26 | 2002-02-05 | Riley Patrick Anthony | Phenylethylamine derivatives and their use in the treatment of melanoma |
| WO2002024613A2 (en) * | 2000-09-21 | 2002-03-28 | Pfizer Products, Inc. | Resorcinol derivatives |
| AU2004222439B2 (en) * | 2003-03-20 | 2008-08-21 | Nanocarrier Kabushiki Kaisha | Micellar preparation containing sparingly water-soluble anticancer agent and novel block copolymer |
| CA3031283A1 (en) | 2004-01-22 | 2005-08-04 | University Of Miami | Topical co-enzyme q10 formulations and methods of use |
| DK1792927T3 (da) * | 2004-09-22 | 2013-06-10 | Nippon Kayaku Kk | Ny blokcopolymer, micelletilberedning og anticancermiddel indeholdende samme som aktiv ingrediens |
| CN101448875A (zh) * | 2006-05-18 | 2009-06-03 | 日本化药株式会社 | 鬼臼毒素类的高分子量结合体 |
| ES2584840T3 (es) * | 2006-10-03 | 2016-09-29 | Nippon Kayaku Kabushiki Kaisha | Compuesto de un derivado de resorcinol con un polímero |
| MX363435B (es) | 2007-03-22 | 2019-03-22 | Berg Llc | Formulaciones topicas que tienen biodisponibilidad aumentada. |
| JP5349318B2 (ja) | 2007-09-28 | 2013-11-20 | 日本化薬株式会社 | ステロイド類の高分子結合体 |
| JP5687899B2 (ja) * | 2008-03-18 | 2015-03-25 | 日本化薬株式会社 | 生理活性物質の高分子結合体 |
| AU2009233785B2 (en) | 2008-04-11 | 2015-08-20 | Berg Llc | Methods and use of inducing apoptosis in cancer cells |
| US9149540B2 (en) * | 2008-05-08 | 2015-10-06 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of folic acid or folic acid derivative |
| BRPI1010576A2 (pt) | 2009-05-11 | 2016-03-15 | Berg Biosystems Llc | métodos para tratamento de distúrbios oncológicos usando transferidores epimetabólicos, moléculas intracelulares multidimensionais ou influenciadores ambientais. |
| EP2431403B1 (de) | 2009-05-15 | 2016-09-28 | Nipponkayaku Kabushikikaisha | Polymerkonjugat aus einer bioaktiven substanz mit einer hydroxidgruppe |
| PT2544663T (pt) * | 2010-03-12 | 2018-04-05 | Berg Llc | Formulações intravenosas de coenzima q10 (coq10) e métodos de uso da mesma |
| TW201304805A (zh) | 2010-11-17 | 2013-02-01 | Nippon Kayaku Kk | 新穎之胞核苷系代謝拮抗劑之高分子衍生物 |
| EP2694463B8 (de) | 2011-04-04 | 2019-10-09 | Berg LLC | Behandlung von tumoren im zentralnervensystem mit coenzym q10 |
| AU2012271274B2 (en) | 2011-06-17 | 2017-07-27 | Berg Llc | Inhalable pharmaceutical compositions |
| WO2013035641A1 (ja) | 2011-09-11 | 2013-03-14 | 日本化薬株式会社 | ブロック共重合体の製造方法 |
| SG11201508272YA (en) | 2013-04-08 | 2015-11-27 | Berg Llc | Treatment of cancer using coenzyme q10 combination therapies |
| JP6595478B2 (ja) | 2013-09-04 | 2019-10-23 | バーグ エルエルシー | コエンザイムq10の連続注入によるがんの治療方法 |
| WO2015157471A1 (en) | 2014-04-08 | 2015-10-15 | The Methodist Hospital | Inos-inhibitory compositions and their use as breast cancer therapeutics |
| WO2017087576A1 (en) | 2015-11-16 | 2017-05-26 | Berg Llc | Methods of treatment of temozolomide-resistant glioma using coenzyme q10 |
| US12576166B2 (en) | 2020-07-27 | 2026-03-17 | Board Of Regents, The University Of Texas System | Contrast agents for detection of enzyme activities based on melanin synthesis |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1543630A1 (de) * | 1966-12-23 | 1969-07-31 | Bayer Ag | Verfahren zur Herstellung von tert. Butyloxycarbonylderivaten von Aminosaeuren |
| CH547799A (de) * | 1970-10-30 | 1974-04-11 | Hoffmann La Roche | Verfahren zur herstellung von indolinderivaten. |
| US3801624A (en) * | 1970-12-09 | 1974-04-02 | Aldrich Chem Co Inc | Di-substituted beta-phenethylcarbamic acid esters |
| IT1048122B (it) * | 1973-05-23 | 1980-11-20 | Simes | Carbammati di ergoline |
| DE2448257A1 (de) * | 1974-10-10 | 1976-04-22 | Troponwerke Dinklage & Co | Cumarinabkoemmlinge, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| US4115539A (en) * | 1976-05-17 | 1978-09-19 | Union Carbide Corporation | Analytical or clinical derivatives, tagged derivatives and methods of analysis using such derivatives |
| US4812590A (en) * | 1987-06-25 | 1989-03-14 | Merck & Co., Inc. | Carbamates of 4-hydroxyanisole as prodrugs for chemotherapy of melanoma |
| IL102645A (en) | 1992-07-26 | 1998-02-22 | Yeda Res & Dev | Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them |
| FR2699532B1 (fr) * | 1992-12-18 | 1995-02-24 | Oreal | Nouveaux composés indolines, compositions tinctoriales à base de ces composés et procédé de teinture des fibres kératiniques. |
| JPH0782280A (ja) * | 1993-06-30 | 1995-03-28 | Kanebo Ltd | 新規なプロドラッグおよびその製造方法 |
| CA2173150C (en) * | 1993-10-01 | 2004-11-30 | Kyoichi Sakakibara | Novel peptide derivatives |
| GB9320660D0 (en) * | 1993-10-07 | 1993-11-24 | British Bio Technology | Inhibition of cytokine production |
| CA2155448A1 (en) * | 1994-08-11 | 1996-02-12 | Katerina Leftheris | Inhibitors of farnesyl protein transferase |
-
1996
- 1996-12-13 GB GBGB9625895.9A patent/GB9625895D0/en active Pending
-
1997
- 1997-12-12 AT AT97949046T patent/ATE309980T1/de not_active IP Right Cessation
- 1997-12-12 EP EP97949046A patent/EP0944583B1/de not_active Expired - Lifetime
- 1997-12-12 WO PCT/GB1997/003433 patent/WO1998025886A1/en not_active Ceased
- 1997-12-12 US US09/319,866 patent/US6573284B1/en not_active Expired - Fee Related
- 1997-12-12 DE DE69734670T patent/DE69734670T2/de not_active Expired - Fee Related
- 1997-12-12 AU AU78469/98A patent/AU748957B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0944583A1 (de) | 1999-09-29 |
| AU7846998A (en) | 1998-07-03 |
| US6573284B1 (en) | 2003-06-03 |
| DE69734670T2 (de) | 2006-06-29 |
| AU748957B2 (en) | 2002-06-13 |
| WO1998025886A1 (en) | 1998-06-18 |
| GB9625895D0 (en) | 1997-01-29 |
| DE69734670D1 (de) | 2005-12-22 |
| EP0944583B1 (de) | 2005-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |