ATE309980T1 - Zubereitungen zur verwendung als therapeutische und nachweismittel - Google Patents

Zubereitungen zur verwendung als therapeutische und nachweismittel

Info

Publication number
ATE309980T1
ATE309980T1 AT97949046T AT97949046T ATE309980T1 AT E309980 T1 ATE309980 T1 AT E309980T1 AT 97949046 T AT97949046 T AT 97949046T AT 97949046 T AT97949046 T AT 97949046T AT E309980 T1 ATE309980 T1 AT E309980T1
Authority
AT
Austria
Prior art keywords
thrag
tyrx
therapeutic
preparations
drugs
Prior art date
Application number
AT97949046T
Other languages
English (en)
Inventor
Patrick Anthony Riley
Andrew Photiou
Tariq Hussain Khan
Helen Mary Isted Osborn
Original Assignee
Patrick Anthony Riley
Andrew Photiou
Tariq Hussain Khan
Helen Mary Isted Osborn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Patrick Anthony Riley, Andrew Photiou, Tariq Hussain Khan, Helen Mary Isted Osborn filed Critical Patrick Anthony Riley
Application granted granted Critical
Publication of ATE309980T1 publication Critical patent/ATE309980T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02—Monothiocarbamic acids; Derivatives thereof
    • C07C333/04—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT97949046T 1996-12-13 1997-12-12 Zubereitungen zur verwendung als therapeutische und nachweismittel ATE309980T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9625895.9A GB9625895D0 (en) 1996-12-13 1996-12-13 Novel compound useful as therapeutic agents and assay reagents
PCT/GB1997/003433 WO1998025886A1 (en) 1996-12-13 1997-12-12 Novel compounds useful as therapeutic agents and assay reagents

Publications (1)

Publication Number Publication Date
ATE309980T1 true ATE309980T1 (de) 2005-12-15

Family

ID=10804381

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97949046T ATE309980T1 (de) 1996-12-13 1997-12-12 Zubereitungen zur verwendung als therapeutische und nachweismittel

Country Status (7)

Country Link
US (1) US6573284B1 (de)
EP (1) EP0944583B1 (de)
AT (1) ATE309980T1 (de)
AU (1) AU748957B2 (de)
DE (1) DE69734670T2 (de)
GB (1) GB9625895D0 (de)
WO (1) WO1998025886A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040014652A1 (en) * 2000-06-01 2004-01-22 Andre Trouet Tumor activated prodrug compounds and methods of making and using the same
EP1303481A1 (de) * 2000-07-26 2003-04-23 Patrick Anthony Riley Phenylethylamin-derivate und ihre anwendung in der behandlung von melanomen
JP3950046B2 (ja) * 2000-09-21 2007-07-25 ファイザー・プロダクツ・インク レゾルシノール誘導体
AU2004222439B2 (en) * 2003-03-20 2008-08-21 Nanocarrier Kabushiki Kaisha Micellar preparation containing sparingly water-soluble anticancer agent and novel block copolymer
HRP20130459T1 (en) 2004-01-22 2013-06-30 University Of Miami Topical co-enzyme q10 formulations and methods of use
CN101023119B (zh) * 2004-09-22 2010-05-05 日本化药株式会社 新型嵌段共聚物,胶束制剂以及含胶束制剂为活性组分的抗癌剂
CA2652656A1 (en) * 2006-05-18 2007-11-29 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of podophyllotoxins
CA2664852A1 (en) * 2006-10-03 2008-04-10 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of resorcinol derivatives
US8454945B2 (en) 2007-03-22 2013-06-04 Berg Pharma Llc Topical formulations having enhanced bioavailability
US8703878B2 (en) * 2007-09-28 2014-04-22 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of steroids
KR101589582B1 (ko) * 2008-03-18 2016-01-28 니폰 가야꾸 가부시끼가이샤 생리활성물질의 고분자량 결합체
JP6058263B2 (ja) 2008-04-11 2017-01-11 バーグ リミテッド ライアビリティ カンパニー 癌細胞においてアポトーシスを誘導する方法および使用
JP5366940B2 (ja) * 2008-05-08 2013-12-11 日本化薬株式会社 葉酸若しくは葉酸誘導体の高分子結合体
CN102481269B (zh) 2009-05-11 2015-10-07 博格有限责任公司 包含辅酶q10的药物组合物及其制备方法
JP5544357B2 (ja) 2009-05-15 2014-07-09 日本化薬株式会社 水酸基を有する生理活性物質の高分子結合体
BR112012022916B1 (pt) * 2010-03-12 2021-11-09 Berg Llc Formulações intravenosas de coenzima q10 (coq10), bem como método de preparação e uso da mesma
JP5856069B2 (ja) 2010-11-17 2016-02-09 日本化薬株式会社 新規なシチジン系代謝拮抗剤の高分子誘導体
JP6092844B2 (ja) 2011-04-04 2017-03-08 バーグ エルエルシー 中枢神経系腫瘍の治療方法
US20140239525A1 (en) 2011-06-17 2014-08-28 Board Of Regents, University Of Texas System Inhalable pharmaceutical compositions
JP5711378B2 (ja) 2011-09-11 2015-04-30 日本化薬株式会社 ブロック共重合体の製造方法
BR112015025424A2 (pt) 2013-04-08 2017-07-18 Berg Llc tratamento de câncer usando terapias de combinação de coenzima q10
MX381399B (es) 2013-09-04 2025-03-12 Berg Llc Formulaciones de coenzima q10 y métodos de uso.
JP2017515800A (ja) 2014-04-08 2017-06-15 ザ・メソジスト・ホスピタル iNOS阻害組成物および乳がん治療薬としてのその使用
WO2017087576A1 (en) 2015-11-16 2017-05-26 Berg Llc Methods of treatment of temozolomide-resistant glioma using coenzyme q10
WO2022026381A1 (en) 2020-07-27 2022-02-03 Board Of Regents, The University Of Texas System Contrast agents for detection of enzyme activities based on melanin synthesis

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1543630A1 (de) * 1966-12-23 1969-07-31 Bayer Ag Verfahren zur Herstellung von tert. Butyloxycarbonylderivaten von Aminosaeuren
CH547799A (de) 1970-10-30 1974-04-11 Hoffmann La Roche Verfahren zur herstellung von indolinderivaten.
US3801624A (en) * 1970-12-09 1974-04-02 Aldrich Chem Co Inc Di-substituted beta-phenethylcarbamic acid esters
IT1048122B (it) * 1973-05-23 1980-11-20 Simes Carbammati di ergoline
DE2448257A1 (de) * 1974-10-10 1976-04-22 Troponwerke Dinklage & Co Cumarinabkoemmlinge, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4115539A (en) 1976-05-17 1978-09-19 Union Carbide Corporation Analytical or clinical derivatives, tagged derivatives and methods of analysis using such derivatives
US4812590A (en) * 1987-06-25 1989-03-14 Merck & Co., Inc. Carbamates of 4-hydroxyanisole as prodrugs for chemotherapy of melanoma
IL102645A (en) 1992-07-26 1998-02-22 Yeda Res & Dev Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them
FR2699532B1 (fr) * 1992-12-18 1995-02-24 Oreal Nouveaux composés indolines, compositions tinctoriales à base de ces composés et procédé de teinture des fibres kératiniques.
JPH0782280A (ja) * 1993-06-30 1995-03-28 Kanebo Ltd 新規なプロドラッグおよびその製造方法
EP0731106B1 (de) * 1993-10-01 2004-11-17 Teikoku Hormone Mfg. Co., Ltd. Dolastatin-derivate
GB9320660D0 (en) * 1993-10-07 1993-11-24 British Bio Technology Inhibition of cytokine production
CA2155448A1 (en) * 1994-08-11 1996-02-12 Katerina Leftheris Inhibitors of farnesyl protein transferase

Also Published As

Publication number Publication date
US6573284B1 (en) 2003-06-03
EP0944583A1 (de) 1999-09-29
GB9625895D0 (en) 1997-01-29
AU7846998A (en) 1998-07-03
AU748957B2 (en) 2002-06-13
DE69734670D1 (de) 2005-12-22
DE69734670T2 (de) 2006-06-29
WO1998025886A1 (en) 1998-06-18
EP0944583B1 (de) 2005-11-16

Similar Documents

Publication Publication Date Title
DE69734670D1 (de) Zubereitungen zur verwendung als therapeutische und nachweismittel
TR200201225T2 (tr) Heteosiklik ikameli pirazolonlar.
ES2133807T3 (es) Compuestos de peptidilo y su uso terapeutico como inhibidores de metaloproteasas.
BR1101081A (pt) Composto e composição farmacêutica
YU40701A (sh) Piperidini kao modulatori ccr5
DE69329240D1 (de) 17-ether und thioether von 4-aza-steroiden
DK0741694T3 (da) Phenyleddikesyrederivater, fremgangsmåder og mellemprodukter til deres fremstilling og midler indeholdende disse
DE60041973D1 (de) Substituierte piperidin-verbindungen als modulatoren der chemokine receptor aktivität
DE69729877D1 (de) Mycophenol bisphosponatverbindungen
DK0966465T3 (da) Inhibitorer af IMPDH-enzymer
AP1697A (en) Azabicycloalkanes as CCR5 modulators.
TR199901578T2 (xx) Klaritromisin form 0 kristali
TR200001012T2 (tr) Yeni ariloksi-alkil-dialkilaminler.
PT1206473E (pt) Pirrolocarbazoles e isoindolonas fundidos isomericos
EP1334719A3 (de) Pentafluorobenzensulfonamide und Analoge
TR200101412T2 (tr) Yeni bileşikler.
DE69842133D1 (de) Zusammensetzungen und Kits zur Erhöhung der Abgabe von therapeutischen Mitteln an Zellen
DE60101372D1 (de) Pyrimidinverbindungen und ihre verwendung als modulatoren der chemokin-rezeptor-aktivität
TR200202310T2 (tr) Östrojen agonist/antagonist metabolitleri
SE9904129D0 (sv) Novel compounds
ES2145021T3 (es) Derivados de 1-bifenil-piridona, su preparacion y su uso como antagonistas de la angiotensina ii.
ATE323495T1 (de) Steroid-3-o-sulfamat-derivate als estronsulfatase-hemmer
ATE451107T1 (de) 3-o-sulfamatsteroidderivate als hemmer von estronsulfatase
PT736009E (pt) N-oxidos de 4-arilpiperazinas e 4-arilpiperidinas como farmacos antipsicoticos
DE60022879D1 (de) Reporterverbindungen und verfahren zur auffindung von hochspezifische proteaseaktivität

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties