ATE451107T1 - 3-o-sulfamatsteroidderivate als hemmer von estronsulfatase - Google Patents

3-o-sulfamatsteroidderivate als hemmer von estronsulfatase

Info

Publication number: ATE451107T1
Authority: AT; Austria
Prior art keywords: estron; sulfatase; inhibitors; steroid derivatives; sulfamate
Prior art date: 1997-12-04

Application number

AT98957034T

Other languages

English (en)

Inventor

Michael Reed

Barry Potter

Original Assignee

Sterix Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-04

Filing date

1998-12-03

Publication date

2009-12-15

1998-12-03 Application filed by Sterix Ltd filed Critical Sterix Ltd

2009-12-15 Application granted granted Critical

2009-12-15 Publication of ATE451107T1 publication Critical patent/ATE451107T1/de

Links

DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 title abstract 3
229960003399 estrone Drugs 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title abstract 2
229920013685 Estron Polymers 0.000 title 1
102000005262 Sulfatase Human genes 0.000 title 1
108060007951 sulfatase Proteins 0.000 title 1
-1 sulphamate compound Chemical class 0.000 abstract 3
DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000003544 oxime group Chemical group 0.000 abstract 1
IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical group NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Enzymes And Modification Thereof (AREA)

AT98957034T 1997-12-04 1998-12-03 3-o-sulfamatsteroidderivate als hemmer von estronsulfatase ATE451107T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB9725749A GB2331987B (en)	1997-12-04	1997-12-04	Polycyclic sulphamate inhibitors of oestrone sulphatase
PCT/GB1998/003620 WO1999027936A1 (en)	1997-12-04	1998-12-03	Steroid 3-o-sulphamate derivatives as inhibitors of oestrone sulphatase

Publications (1)

Publication Number	Publication Date
ATE451107T1 true ATE451107T1 (de)	2009-12-15

Family

ID=10823155

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98957034T ATE451107T1 (de)	1997-12-04	1998-12-03	3-o-sulfamatsteroidderivate als hemmer von estronsulfatase

Country Status (9)

Country	Link
US (1)	US6670353B2 (de)
EP (1)	EP1051178B1 (de)
JP (1)	JP2001524525A (de)
AT (1)	ATE451107T1 (de)
AU (1)	AU1345899A (de)
DE (1)	DE69841374D1 (de)
ES (1)	ES2337427T3 (de)
GB (1)	GB2331987B (de)
WO (1)	WO1999027936A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20040127473A1 (en) *	1996-12-05	2004-07-01	Reed Michael John	Compound
GB2331987B (en)	1997-12-04	2002-11-27	Imperial College	Polycyclic sulphamate inhibitors of oestrone sulphatase
US7078395B1 (en)	1999-06-16	2006-07-18	Sterix Limited	Methods for treating or preventing cancer by preventing, inhibiting or arresting cell cycling
NZ515061A (en) *	1999-04-30	2004-04-30	Sterix Ltd	Use of a cyclic compound in cell cycling
GB9913536D0 (en) *	1999-06-10	1999-08-11	Sterix Ltd	Use
WO2001044268A1 (en) *	1999-12-13	2001-06-21	Sterix Limited	Halogenated sulphamate-, phosphonate-, thiophosphonate-, sulphonate- and sulphonamide- compounds as inhibitors of steroid sulphatase
US7335650B2 (en)	2000-01-14	2008-02-26	Sterix Limited	Composition
AU2001248849A1 (en)	2000-04-24	2001-11-07	Kyowa Hakko Kogyo Co. Ltd.	Estra-1,3,5(10)-triene derivatives
GB0025788D0 (en) *	2000-10-20	2000-12-06	Sterix Ltd	Use
GB0306717D0 (en) *	2003-03-24	2003-04-30	Sterix Ltd	Compound
GB0306718D0 (en) *	2003-03-24	2003-04-30	Sterix Ltd	Compound
EA011123B1 (ru) *	2003-03-24	2008-12-30	Стерикс Лимитед	Производные эстрогена в качестве ингибиторов стероидной сульфатазы
GB0511190D0 (en) *	2005-06-01	2005-07-06	Sterix Ltd	Use
GB0624105D0 (en) *	2006-12-01	2007-01-10	Sterix Ltd	Use
EP2149371A1 (de) *	2008-07-28	2010-02-03	PregLem S.A.	Verwendung von Steroid-Sulfatase-Hemmern zur Behandlung von Frühgeburtsleiden

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1398026A (en) *	1972-11-10	1975-06-18	Jenapharm Veb	Steroid esters
DE3046719C2 (de) *	1980-12-11	1983-02-17	Klinge Pharma GmbH, 8000 München	1,1,2-Triphenyl-but-1-en-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel
US5273993A (en) *	1989-06-12	1993-12-28	A. H. Robins Company, Incorporated	Compounds having one or more aminosulfonyloxy radicals useful as pharmaceuticals
GB9625334D0 (en) *	1996-12-05	1997-01-22	Imperial College	Compound
US6011024A (en) *	1991-08-28	2000-01-04	Imperial College Of Science Technology & Medicine	Steroid sulphatase inhibitors
GB9118478D0 (en) *	1991-08-29	1991-10-16	Imperial College	Steroid sulphatase inhibitors
GB9118465D0 (en) *	1991-08-29	1991-10-16	Imperial College	Steroid sulphatase inhibitors
US5556847A (en) *	1994-10-27	1996-09-17	Duquesne University Of The Holy Ghost	Methods of effecting memory enhancement mediated by steroid sulfatase inhibitors
US5571933A (en) *	1994-11-17	1996-11-05	Duquesne University Of The Holy Ghost	Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
US5567831A (en) *	1995-08-16	1996-10-22	Duguesne University Of The Holy Ghost	Non-steroidal sulfatase inhibitor compounds and their method of use
ES2233998T3 (es) *	1996-03-05	2005-06-16	Sterix Limited	Compuestos que comprenden un grupo sulfamato.
US5763492A (en)	1996-10-01	1998-06-09	Duguesne University Of The Holy Ghost	Methods for effecting memory enhancement mediated by non-steroidal sulfatase inhibitors
GB2331987B (en)	1997-12-04	2002-11-27	Imperial College	Polycyclic sulphamate inhibitors of oestrone sulphatase
US6248780B1 (en)	1998-10-01	2001-06-19	Duquesne University Of The Holy Ghost	Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same

1997
- 1997-12-04 GB GB9725749A patent/GB2331987B/en not_active Expired - Fee Related
1998
- 1998-12-03 AU AU13458/99A patent/AU1345899A/en not_active Abandoned
- 1998-12-03 DE DE69841374T patent/DE69841374D1/de not_active Expired - Lifetime
- 1998-12-03 EP EP98957034A patent/EP1051178B1/de not_active Expired - Lifetime
- 1998-12-03 JP JP2000522921A patent/JP2001524525A/ja active Pending
- 1998-12-03 ES ES98957034T patent/ES2337427T3/es not_active Expired - Lifetime
- 1998-12-03 AT AT98957034T patent/ATE451107T1/de not_active IP Right Cessation
- 1998-12-03 WO PCT/GB1998/003620 patent/WO1999027936A1/en not_active Ceased
2000
- 2000-05-17 US US09/572,237 patent/US6670353B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1051178B1 (de)	2009-12-09
WO1999027936A1 (en)	1999-06-10
US20020198396A1 (en)	2002-12-26
GB2331987A9 (en)	1900-01-01
AU1345899A (en)	1999-06-16
GB9725749D0 (en)	1998-02-04
ES2337427T3 (es)	2010-04-23
GB2331987B (en)	2002-11-27
JP2001524525A (ja)	2001-12-04
US6670353B2 (en)	2003-12-30
GB2331987A (en)	1999-06-09
DE69841374D1 (de)	2010-01-21
EP1051178A1 (de)	2000-11-15

Legal Events

Date	Code	Title	Description
2010-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE451107T1 (de)	2009-12-15	3-o-sulfamatsteroidderivate als hemmer von estronsulfatase
DE69733061D1 (de)	2005-05-25	Nicht-steroidale polyzyklische sulfamat-derivate, deren herstellung und deren verwendung als östron sulfatase inhibitoren
BR9206434A (pt)	1994-09-27	Inibidores de esteróide sulfatase
ATE195530T1 (de)	2000-09-15	17-ether und thioether von 4-aza-steroiden
ATE323495T1 (de)	2006-05-15	Steroid-3-o-sulfamat-derivate als estronsulfatase-hemmer
ES2085876T3 (es)	1996-06-16	Derivado de bifenilmetano, su utilizacion y composiciones farmacologicas que contienen el mismo.
BR9807638A (pt)	2000-03-21	Compostos antiinflamatórios
DE69739051D1 (de)	2008-11-27	Östrogen-Sulfamate als Sulfataseinhibitoren
EA199800484A1 (ru)	1999-02-25	Лактоновые производные 17.бета.-карбокси, карботио и амид андростанов
ES2059779T3 (es)	1994-11-16	Compuestos anti-androgenos.
ES2149448T3 (es)	2000-11-01	Agentes terapeuticos y analiticos.
ATE145213T1 (de)	1996-11-15	Kardioaktive steroide
FI932446A0 (fi)	1993-05-28	2b,19-metylaminobrosteroider som aromatasinhibitorer
NO934063L (no)	1993-11-09	Fremgangsmaate for aa redusere det elektriske forbruket til mikroprosessorbaserte anordninger samt anordning for utfoerelse av fremgangsmaaten
ATE124417T1 (de)	1995-07-15	2,19-methylenoxy- und 2,19-methylenthiogebrückte steroide und ihre verwendung als inhibitoren von aromatase und 19-hydroxylase.
ATE124952T1 (de)	1995-07-15	Haloethyl substituierte enzymhemmende steroiden.