ATE309991T1 - Cyclin abhängige kinase(cdk)4 hemmer und deren verwendung zur behandlung von krebs - Google Patents
Cyclin abhängige kinase(cdk)4 hemmer und deren verwendung zur behandlung von krebsInfo
- Publication number
- ATE309991T1 ATE309991T1 AT98922070T AT98922070T ATE309991T1 AT E309991 T1 ATE309991 T1 AT E309991T1 AT 98922070 T AT98922070 T AT 98922070T AT 98922070 T AT98922070 T AT 98922070T AT E309991 T1 ATE309991 T1 AT E309991T1
- Authority
- AT
- Austria
- Prior art keywords
- cancer
- cdk
- inhibitors
- treatment
- dependent kinase
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 102000003903 Cyclin-dependent kinases Human genes 0.000 title 1
- 108090000266 Cyclin-dependent kinases Proteins 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 abstract 2
- 102100036252 Cyclin-dependent kinase 4 Human genes 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 102000003910 Cyclin D Human genes 0.000 abstract 1
- 108090000259 Cyclin D Proteins 0.000 abstract 1
- 108010024986 Cyclin-Dependent Kinase 2 Proteins 0.000 abstract 1
- 102100032857 Cyclin-dependent kinase 1 Human genes 0.000 abstract 1
- 102100036239 Cyclin-dependent kinase 2 Human genes 0.000 abstract 1
- 101000868333 Homo sapiens Cyclin-dependent kinase 1 Proteins 0.000 abstract 1
- 101000909198 Homo sapiens DNA polymerase delta catalytic subunit Proteins 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- FZEYVTFCMJSGMP-UHFFFAOYSA-N acridone Chemical class C1=CC=C2C(=O)C3=CC=CC=C3NC2=C1 FZEYVTFCMJSGMP-UHFFFAOYSA-N 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 150000007658 benzothiadiazines Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 231100001274 therapeutic index Toxicity 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
- C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
- C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
- C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4425697P | 1997-04-28 | 1997-04-28 | |
| PCT/US1998/008602 WO1998049146A2 (en) | 1997-04-28 | 1998-04-28 | Cyclin dependent kinase (cdk)4 inhibitors and their use for treating cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE309991T1 true ATE309991T1 (de) | 2005-12-15 |
Family
ID=21931359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98922070T ATE309991T1 (de) | 1997-04-28 | 1998-04-28 | Cyclin abhängige kinase(cdk)4 hemmer und deren verwendung zur behandlung von krebs |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6630464B1 (de) |
| EP (1) | EP0977738B1 (de) |
| JP (1) | JP2002506427A (de) |
| AT (1) | ATE309991T1 (de) |
| AU (1) | AU736979B2 (de) |
| CA (1) | CA2288154A1 (de) |
| DE (1) | DE69832374D1 (de) |
| WO (1) | WO1998049146A2 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100423899B1 (ko) * | 2000-05-10 | 2004-03-24 | 주식회사 엘지생명과학 | 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸 |
| MXPA03005870A (es) * | 2001-02-14 | 2005-02-14 | Warner Lambert Co | Inhibirores de benzotiadiazina de metaloproteinasas de la matriz. |
| DE60325579D1 (de) * | 2002-03-25 | 2009-02-12 | Theryte Ltd | Krebsbehandlung |
| WO2011159726A2 (en) | 2010-06-14 | 2011-12-22 | The Scripps Research Institute | Reprogramming of cells to a new fate |
| US20150353542A1 (en) | 2013-01-14 | 2015-12-10 | Amgen Inc. | Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture |
| AU2014253932B2 (en) | 2013-04-16 | 2020-04-30 | Memorial Sloan-Kettering Cancer Center | Companion diagnostic for CDK4 inhibitors |
| US11921116B2 (en) | 2016-03-09 | 2024-03-05 | Memorial Sloan Kettering Cancer Center | Enigma and CDH18 as companion diagnostics for CDK4 inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3090783A (en) * | 1962-06-12 | 1963-05-21 | Olin Mathieson | Dihydrobenzothiadiazines |
| DE3331459A1 (de) * | 1982-08-31 | 1984-03-01 | Martin Dr.med. 6900 Heidelberg Berger | Zubereitung zur tumorbehandlung mit einem gehalt an diazoxid und dessen verwendung |
| FR2676737A1 (fr) * | 1991-05-23 | 1992-11-27 | Groupe Enseignement Rech Chim | Dimeres 9-thioacridinoniques pontes par une chaine heteroatomique incluant un noyau biphenyle. |
| US6242443B1 (en) * | 1996-06-21 | 2001-06-05 | Novo Nordisk Ais | 1,2,4-benzothiadiazine derivatives, their preparation and use |
-
1998
- 1998-04-28 WO PCT/US1998/008602 patent/WO1998049146A2/en not_active Ceased
- 1998-04-28 JP JP54731998A patent/JP2002506427A/ja not_active Abandoned
- 1998-04-28 DE DE69832374T patent/DE69832374D1/de not_active Expired - Lifetime
- 1998-04-28 AU AU74698/98A patent/AU736979B2/en not_active Ceased
- 1998-04-28 EP EP98922070A patent/EP0977738B1/de not_active Expired - Lifetime
- 1998-04-28 AT AT98922070T patent/ATE309991T1/de not_active IP Right Cessation
- 1998-04-28 US US09/403,659 patent/US6630464B1/en not_active Expired - Lifetime
- 1998-04-28 CA CA002288154A patent/CA2288154A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2288154A1 (en) | 1998-11-05 |
| WO1998049146A3 (en) | 1999-08-12 |
| AU736979B2 (en) | 2001-08-09 |
| EP0977738A2 (de) | 2000-02-09 |
| US6630464B1 (en) | 2003-10-07 |
| AU7469898A (en) | 1998-11-24 |
| EP0977738B1 (de) | 2005-11-16 |
| WO1998049146A2 (en) | 1998-11-05 |
| JP2002506427A (ja) | 2002-02-26 |
| DE69832374D1 (de) | 2005-12-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |