ATE309995T1 - Substituierte (aminoiminomethyl oder aminomethyl) dihydrobenzofurane und benozopyrane - Google Patents
Substituierte (aminoiminomethyl oder aminomethyl) dihydrobenzofurane und benozopyraneInfo
- Publication number
- ATE309995T1 ATE309995T1 AT00968181T AT00968181T ATE309995T1 AT E309995 T1 ATE309995 T1 AT E309995T1 AT 00968181 T AT00968181 T AT 00968181T AT 00968181 T AT00968181 T AT 00968181T AT E309995 T1 ATE309995 T1 AT E309995T1
- Authority
- AT
- Austria
- Prior art keywords
- factor
- aminoiminomethyl
- aminomethyl
- substituted
- compounds
- Prior art date
Links
- -1 AMINOIMINOMETHYL Chemical class 0.000 title abstract 4
- 108010074860 Factor Xa Proteins 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 108010029144 Factor IIa Proteins 0.000 abstract 2
- 108090000190 Thrombin Proteins 0.000 abstract 2
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 abstract 2
- 150000001562 benzopyrans Chemical class 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 229960004072 thrombin Drugs 0.000 abstract 2
- 230000001668 ameliorated effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
- Saccharide Compounds (AREA)
- Fats And Perfumes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15076799P | 1999-08-26 | 1999-08-26 | |
| GBGB9924155.6A GB9924155D0 (en) | 1999-10-12 | 1999-10-12 | Chemical compounds |
| PCT/IB2000/001562 WO2001014358A2 (en) | 1999-08-26 | 2000-08-12 | Substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benozopyrans |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE309995T1 true ATE309995T1 (de) | 2005-12-15 |
Family
ID=26316000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00968181T ATE309995T1 (de) | 1999-08-26 | 2000-08-12 | Substituierte (aminoiminomethyl oder aminomethyl) dihydrobenzofurane und benozopyrane |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6599918B2 (de) |
| EP (1) | EP1222182B1 (de) |
| AT (1) | ATE309995T1 (de) |
| AU (1) | AU7812900A (de) |
| CA (1) | CA2383257C (de) |
| DE (1) | DE60024120T2 (de) |
| ES (1) | ES2250196T3 (de) |
| IL (1) | IL148084A0 (de) |
| MX (1) | MXPA02001735A (de) |
| WO (1) | WO2001014358A2 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2456985A1 (en) * | 2001-08-15 | 2003-02-27 | Icos Corporation | 2h-phthalazin-1-ones and methods for use thereof |
| CA2461381A1 (en) * | 2001-10-04 | 2003-04-10 | Wyeth | Chroman derivatives as 5-hydroxytryptamine-6 ligands |
| JP4561698B2 (ja) * | 2002-02-19 | 2010-10-13 | 小野薬品工業株式会社 | 縮合ピリダジン誘導体化合物およびその化合物を有効成分として含有する薬剤 |
| AU2003218824A1 (en) * | 2002-04-10 | 2003-10-20 | Dongbu Hannong Chemical Co., Ltd | Benzopyran derivatives substituted with secondary amines including tetrazole, method for the preparation thereof and pharmaceutical compositions containing them |
| US7593482B2 (en) | 2004-09-30 | 2009-09-22 | St-Ericsson Sa | Wireless communication system with hardware-based frequency burst detection |
| EP2336107B1 (de) * | 2004-09-30 | 2015-09-23 | Takeda Pharmaceutical Company Limited | Protonenpumpenhemmer |
| EP2327692B9 (de) | 2005-08-30 | 2014-06-04 | Takeda Pharmaceutical Company Limited | 1-Heterocyclylsulfonyl, 2-Aminomethyl, 5-(Hetero-)Aryl substituierte 1-H-Pyrrolderivate als Magensäuresekretionsinhibitoren |
| CL2007001873A1 (es) | 2006-06-27 | 2008-01-04 | Takeda Pharmaceutical | Acido((3s))-6-((¨2,6-dimetil-4-(3-(metilsulfonil)-propoxi)bifenil-3-il)metoxi-2,3-dihidro-1-benzofuran-3-il)acetico o una sal del mismo |
| US8933105B2 (en) * | 2007-02-28 | 2015-01-13 | Takeda Pharmaceutical Company Limited | Pyrrole compounds |
| PE20110300A1 (es) * | 2008-08-27 | 2011-06-16 | Takeda Pharmaceutical | Compuestos de pirrol como inhibidores de la bomba de protones |
| CN103626747B (zh) * | 2013-10-22 | 2015-04-08 | 湖南大学 | N-(2,3-二氢苯并呋喃-5-基)苯并吡喃-4-酰胺及其制备方法与应用 |
| WO2016104630A1 (ja) * | 2014-12-26 | 2016-06-30 | 武田薬品工業株式会社 | 縮合複素環化合物 |
| EP3247332A1 (de) * | 2015-01-20 | 2017-11-29 | Incarda Therapeutics, Inc. | Einheitsaerosoldosen für antikoagulation |
| CN113214199B (zh) * | 2021-04-28 | 2023-03-10 | 江西师范大学 | 一种苯并呋喃-3-氧代羧酸酯类化合物的合成方法 |
| CN114057720B (zh) * | 2021-12-13 | 2024-02-23 | 陶金辉 | 一种靶向p2x7r的小分子抑制剂及其在治疗结肠癌中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0350163A3 (de) * | 1988-06-09 | 1990-11-22 | Beecham Group Plc | Renin inhibierende Peptide |
| ZA928276B (en) * | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
| JP3202994B2 (ja) * | 1996-05-31 | 2001-08-27 | シー・アンド・シー・リサーチ・ラボラトリーズ | 選却的トロンビン抑制剤として有用な芳香族アミジン誘導体 |
| JP2002514162A (ja) * | 1996-07-08 | 2002-05-14 | デュポン ファーマシューティカルズ カンパニー | Ｘａ因子阻害薬およびトロンビン阻害薬としてのアミジノインドール類、アミジノアゾール類、およびそれらの類似体 |
| US5886191A (en) * | 1997-08-18 | 1999-03-23 | Dupont Pharmaceuticals Company | Amidinoindoles, amidinoazoles, and analogs thereof |
-
2000
- 2000-08-12 AT AT00968181T patent/ATE309995T1/de not_active IP Right Cessation
- 2000-08-12 ES ES00968181T patent/ES2250196T3/es not_active Expired - Lifetime
- 2000-08-12 WO PCT/IB2000/001562 patent/WO2001014358A2/en not_active Ceased
- 2000-08-12 CA CA2383257A patent/CA2383257C/en not_active Expired - Fee Related
- 2000-08-12 DE DE60024120T patent/DE60024120T2/de not_active Expired - Lifetime
- 2000-08-12 IL IL14808400A patent/IL148084A0/xx unknown
- 2000-08-12 MX MXPA02001735A patent/MXPA02001735A/es active IP Right Grant
- 2000-08-12 EP EP00968181A patent/EP1222182B1/de not_active Expired - Lifetime
- 2000-08-12 AU AU78129/00A patent/AU7812900A/en not_active Abandoned
-
2002
- 2002-02-22 US US10/081,113 patent/US6599918B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1222182A2 (de) | 2002-07-17 |
| MXPA02001735A (es) | 2002-08-06 |
| US20020193410A1 (en) | 2002-12-19 |
| DE60024120T2 (de) | 2006-07-27 |
| AU7812900A (en) | 2001-03-19 |
| WO2001014358A2 (en) | 2001-03-01 |
| US6599918B2 (en) | 2003-07-29 |
| EP1222182B1 (de) | 2005-11-16 |
| DE60024120D1 (de) | 2005-12-22 |
| WO2001014358A3 (en) | 2001-05-17 |
| CA2383257C (en) | 2010-09-28 |
| IL148084A0 (en) | 2002-09-12 |
| CA2383257A1 (en) | 2001-03-01 |
| ES2250196T3 (es) | 2006-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |