ATE423122T1 - Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri) - Google Patents
Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri)Info
- Publication number
- ATE423122T1 ATE423122T1 AT04743692T AT04743692T ATE423122T1 AT E423122 T1 ATE423122 T1 AT E423122T1 AT 04743692 T AT04743692 T AT 04743692T AT 04743692 T AT04743692 T AT 04743692T AT E423122 T1 ATE423122 T1 AT E423122T1
- Authority
- AT
- Austria
- Prior art keywords
- glutamatracemase
- muri
- inhibitors
- condensed heterocycles
- heterocycles
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49561503P | 2003-08-15 | 2003-08-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE423122T1 true ATE423122T1 (de) | 2009-03-15 |
Family
ID=34193331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04743692T ATE423122T1 (de) | 2003-08-15 | 2004-08-12 | Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri) |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7371757B2 (de) |
| EP (1) | EP1664052B1 (de) |
| JP (1) | JP2007502307A (de) |
| AT (1) | ATE423122T1 (de) |
| DE (1) | DE602004019548D1 (de) |
| WO (1) | WO2005016929A1 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE423122T1 (de) | 2003-08-15 | 2009-03-15 | Astrazeneca Ab | Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri) |
| JP5216912B2 (ja) | 2008-04-29 | 2013-06-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ１受容体拮抗薬としてのインダゾール化合物 |
| JP5411927B2 (ja) | 2008-05-06 | 2014-02-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ１アンタゴニストとしてのピラゾール化合物 |
| PE20110854A1 (es) | 2008-09-26 | 2011-12-23 | Boehringer Ingelheim Int | DERIVADOS DE 1-FENIL-1H-PIRAZOLO[3,4-c]PIRIDINA-4-CARBONILAMINA COMO ANTAGONISTAS DE LOS RECEPTORES CCR1 |
| TW201020258A (en) * | 2008-10-14 | 2010-06-01 | Astrazeneca Ab | Chemical compounds 542 |
| US9040528B2 (en) | 2008-10-14 | 2015-05-26 | Astrazeneca Ab | Chemical compounds 542 |
| AP2012006204A0 (en) | 2009-10-21 | 2012-04-30 | Boehringer Ingelheim Int | Indazole and pyrazolopyridine compounds as CCR1 receptor antagonists. |
| JP5542214B2 (ja) | 2009-10-27 | 2014-07-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ１受容体アンタゴニストとしての複素環化合物 |
| IN2012DN05081A (de) * | 2009-12-08 | 2015-10-09 | Boehringer Ingelheim Int | |
| US8871786B2 (en) | 2010-04-30 | 2014-10-28 | Boehringer Ingelheim International Gmbh | Azaindazole amide compounds as CCR1 receptor antagonists |
| US8546442B2 (en) | 2010-12-23 | 2013-10-01 | Boehringer Ingelheim International Gmbh | Pyrazolopiperidine compounds as CCR1 receptor antagonists |
| CN107007597A (zh) | 2012-05-31 | 2017-08-04 | 菲尼克斯药品股份公司 | 作为孤儿核受体RORγ调节物的经甲酰胺或磺酰胺取代的噻唑及相关衍生物的制药用途 |
| JO3215B1 (ar) | 2012-08-09 | 2018-03-08 | Phenex Pharmaceuticals Ag | حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy |
| US8889671B2 (en) | 2013-01-23 | 2014-11-18 | Astrazeneca Ab | Compounds and methods for treating bacterial infections |
| WO2014160405A1 (en) * | 2013-03-13 | 2014-10-02 | University Of Iowa Research Foundation | Compounds, compositions comprising same, and methods related thereto |
| SG11201609404SA (en) | 2014-05-29 | 2016-12-29 | Entasis Therapeutics Ltd | Fused, spirocyclic heteroaromatic compounds for the treatment of bacterial infections |
| MA42145B1 (fr) | 2015-05-20 | 2020-05-29 | Amgen Inc | Triazoles agonistes du récepteur apj |
| DK3386500T3 (da) | 2015-12-09 | 2022-12-12 | Univ Illinois | Benzothiophen-baserede selektive østrogenreceptor ned-regulatorer |
| EP3452466B1 (de) | 2016-05-03 | 2020-08-12 | Amgen Inc. | Heterocyclische triazolverbindungen als agonisten des apj-rezeptors |
| WO2018081168A2 (en) | 2016-10-24 | 2018-05-03 | The Board Of Trustees Of The University Of Illinois | Benzothiophene-based selective mixed estrogen receptor downregulators |
| US10906890B2 (en) | 2016-11-16 | 2021-02-02 | Amgen Inc. | Triazole phenyl compounds as agonists of the APJ receptor |
| EP3541803B1 (de) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Triazolpyridylverbindungen als agonisten des apj-rezeptors |
| EP3541802B1 (de) | 2016-11-16 | 2025-01-01 | Amgen Inc. | Alkylsubstituierte triazolverbindungen als agonisten des apj-rezeptors |
| WO2018093577A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Cycloalkyl substituted triazole compounds as agonists of the apj receptor |
| EP3541792B1 (de) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Triazol-furan-verbindungen als agonisten des apj-rezeptors |
| US11046680B1 (en) | 2016-11-16 | 2021-06-29 | Amgen Inc. | Heteroaryl-substituted triazoles as APJ receptor agonists |
| JP7229162B2 (ja) | 2017-01-06 | 2023-02-27 | ジー１ セラピューティクス， インコーポレイテッド | 癌の治療に対する併用療法 |
| KR20190117582A (ko) | 2017-02-10 | 2019-10-16 | 쥐원 쎄라퓨틱스, 인크. | 벤조티오펜 에스트로겐 수용체 조정제 |
| WO2019089335A1 (en) | 2017-11-03 | 2019-05-09 | Amgen Inc. | Fused triazole agonists of the apj receptor |
| EP3788037A1 (de) | 2018-05-01 | 2021-03-10 | Amgen Inc. | Substituierte pyrimidinone als agonisten des apj-rezeptors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0102315D0 (sv) * | 2001-06-28 | 2001-06-28 | Astrazeneca Ab | Compounds |
| ATE423122T1 (de) | 2003-08-15 | 2009-03-15 | Astrazeneca Ab | Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri) |
-
2004
- 2004-08-12 AT AT04743692T patent/ATE423122T1/de not_active IP Right Cessation
- 2004-08-12 EP EP04743692A patent/EP1664052B1/de not_active Expired - Lifetime
- 2004-08-12 WO PCT/GB2004/003464 patent/WO2005016929A1/en not_active Ceased
- 2004-08-12 DE DE602004019548T patent/DE602004019548D1/de not_active Expired - Fee Related
- 2004-08-12 US US10/567,797 patent/US7371757B2/en not_active Expired - Fee Related
- 2004-08-12 JP JP2006523672A patent/JP2007502307A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US7371757B2 (en) | 2008-05-13 |
| EP1664052A1 (de) | 2006-06-07 |
| DE602004019548D1 (de) | 2009-04-02 |
| US20060252781A1 (en) | 2006-11-09 |
| WO2005016929A1 (en) | 2005-02-24 |
| EP1664052B1 (de) | 2009-02-18 |
| JP2007502307A (ja) | 2007-02-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |