ATE310532T1 - Kombination von defibrotid und g-csf und ihre verwendung zur aktivierung hämatopoietischer vorläuferzellen - Google Patents

Kombination von defibrotid und g-csf und ihre verwendung zur aktivierung hämatopoietischer vorläuferzellen

Info

Publication number: ATE310532T1
Authority: AT; Austria
Prior art keywords: defibrotide; csf; combination; cells; pronector
Prior art date: 2000-04-18

Application number

AT01931582T

Other languages

English (en)

Inventor

Laura Ferro

Roberto Porta

Massimo Iacobelli

Alessandro Massimo Gianni

Carmelo Carlo Stella

Original Assignee

Gentium Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-18

Filing date

2001-04-10

Publication date

2005-12-15

2001-04-10 Application filed by Gentium Spa filed Critical Gentium Spa

2005-12-15 Application granted granted Critical

2005-12-15 Publication of ATE310532T1 publication Critical patent/ATE310532T1/de

Links

230000003394 haemopoietic effect Effects 0.000 title abstract 3
102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 title abstract 2
108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 title abstract 2
JNWFIPVDEINBAI-UHFFFAOYSA-N [5-hydroxy-4-[4-(1-methylindol-5-yl)-5-oxo-1H-1,2,4-triazol-3-yl]-2-propan-2-ylphenyl] dihydrogen phosphate Chemical compound C1=C(OP(O)(O)=O)C(C(C)C)=CC(C=2N(C(=O)NN=2)C=2C=C3C=CN(C)C3=CC=2)=C1O JNWFIPVDEINBAI-UHFFFAOYSA-N 0.000 title abstract 2
229960004120 defibrotide Drugs 0.000 title abstract 2
230000004913 activation Effects 0.000 title 1
210000000130 stem cell Anatomy 0.000 abstract 2
241000124008 Mammalia Species 0.000 abstract 1
210000005259 peripheral blood Anatomy 0.000 abstract 1
239000011886 peripheral blood Substances 0.000 abstract 1
230000002123 temporal effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Diabetes (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT01931582T 2000-04-18 2001-04-10 Kombination von defibrotid und g-csf und ihre verwendung zur aktivierung hämatopoietischer vorläuferzellen ATE310532T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00830293A EP1147777A1 (de)	2000-04-18	2000-04-18	Kombination von Defibrotid und G-CSF und ihre Verwendung zur Aktivierung der hämatopoiestischen Vorläuferzellen
PCT/EP2001/004105 WO2001078761A2 (en)	2000-04-18	2001-04-10	Mixture of defibrotide and g-csf ant its use for activating haematopoietic progenitors

Publications (1)

Publication Number	Publication Date
ATE310532T1 true ATE310532T1 (de)	2005-12-15

Family

ID=8175292

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT05108424T ATE443524T1 (de)	2000-04-18	2001-04-10	Kombination von defibrotide und g-csf und ihre verwendung zur aktivierung hämatopoietischer vorläuferzellen
AT01931582T ATE310532T1 (de)	2000-04-18	2001-04-10	Kombination von defibrotid und g-csf und ihre verwendung zur aktivierung hämatopoietischer vorläuferzellen

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT05108424T ATE443524T1 (de)	2000-04-18	2001-04-10	Kombination von defibrotide und g-csf und ihre verwendung zur aktivierung hämatopoietischer vorläuferzellen

Country Status (31)

Country	Link
US (1)	US20040131588A1 (de)
EP (3)	EP1147777A1 (de)
JP (1)	JP5205668B2 (de)
KR (1)	KR100849491B1 (de)
CN (1)	CN1183962C (de)
AT (2)	ATE443524T1 (de)
AU (2)	AU2001258322B2 (de)
BG (1)	BG107203A (de)
CA (1)	CA2406179C (de)
CY (1)	CY1104971T1 (de)
CZ (1)	CZ20023426A3 (de)
DE (2)	DE60140015D1 (de)
DK (2)	DK1621207T3 (de)
EE (1)	EE200200596A (de)
ES (2)	ES2252227T3 (de)
HR (1)	HRP20020835A2 (de)
HU (1)	HUP0300560A3 (de)
IL (1)	IL152328A (de)
IS (1)	IS2171B (de)
MX (1)	MXPA02010346A (de)
NO (1)	NO20024988L (de)
NZ (1)	NZ522016A (de)
PL (1)	PL358100A1 (de)
PT (1)	PT1621207E (de)
RO (1)	RO121006B1 (de)
RU (1)	RU2248216C2 (de)
SI (1)	SI21079B (de)
SK (1)	SK14892002A3 (de)
UA (1)	UA73566C2 (de)
WO (1)	WO2001078761A2 (de)
ZA (1)	ZA200208413B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
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US8771663B2 (en)	2000-04-18	2014-07-08	Gentium Spa	Formulation having mobilising activity
PL1660115T3 (pl) *	2003-07-29	2011-11-30	Dompe Spa	Farmaceutyczna kombinacja G-CSF i PLGF użyteczna wobec komórek macierzystych krwi
WO2005017160A2 (en) *	2003-08-13	2005-02-24	Children's Hospital Medical Center	Mobilization of hematopoietic cells
US20050069553A1 (en)	2003-08-13	2005-03-31	Yi Zheng	Chimeric peptides for the regulation of GTPases
EP2103689A1 (de) *	2008-03-19	2009-09-23	Gentium S.p.A.	Synthetische Phosphodiester-Oligonukleotide und deren therapeutische Verwendungen
RU2376985C1 (ru) *	2008-07-17	2009-12-27	Владислав Николаевич Ласкавый	Средство для активации стволовых клеток
ES2694239T3 (es)	2010-11-12	2018-12-19	Gentium S.R.L.	Defibrótido para su uso en profilaxis y/o tratamiento de la enfermedad de Injerto contra huésped (GVHD)
RU2627177C2 (ru)	2012-06-22	2017-08-03	Джентиум С.Р.Л.	Способ определения биологической активности дефибротида, основанный на применении эуглобулина
EP3026122A1 (de)	2014-11-27	2016-06-01	Gentium S.p.A.	Zellenbasiertes Verfahren zur Bestimmung der Wirksamkeit von Defibrotid
CN106567694A (zh) *	2016-11-14	2017-04-19	北京国泰通源技术有限公司	智能控水短节
RU2758487C2 (ru) *	2018-01-12	2021-10-28	Селлмиг Биолабс Инк.	Способы получения цитокапсул и цитокапсулярных трубок
CN114730031B (zh)	2019-11-13	2024-04-12	富士胶片株式会社	装饰膜、成型物及电子器件
CN117072108A (zh) *	2023-06-28	2023-11-17	中国石油天然气集团有限公司	一种旋转防喷控压一体化装置、密封方法及控压方法

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US3899481A (en)	1970-11-03	1975-08-12	Crinos Industria Farmaco	Process for the controlled partial degradation of deoxyribonucleic acid extracted from animal organs
DE2154279A1 (de)	1970-11-03	1972-05-25	Crinos Industria Farmaco	Medikamente für das fibrinolytische System
IT1043823B (it) *	1970-11-03	1980-02-29	Prephar	Procedimento per l estrazione di acidi nucleici da organi animali
IT1206341B (it)	1984-02-16	1989-04-14	Crinos Industria Farmaco	Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio.
US4694134A (en)	1985-05-28	1987-09-15	Ajax Magnethermic Corporation	Apparatus for overheating edges of skelp for the production of compression welded pipe
IT1190313B (it)	1986-04-17	1988-02-16	Crinos Industria Farmaco	Procedimento per l'ottenimento di polidesossiribonucleotidi chimicamente definiti e riproducibili e prodotto farmacologicamente attivo risultante
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IT1223322B (it) *	1987-10-23	1990-09-19	Crinos Industria Farmaco	Metodo per prevenire la formazione di coaguli sanguigni nel circuito extracorporeo di apparecchi di dialisi a composizione utile per esso
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JPH08127539A (ja) *	1994-10-31	1996-05-21	Ajinomoto Co Inc	ヒトｉｌ−１１を含有する末梢血幹細胞増加剤
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EP0937461B1 (de) *	1996-07-10	2005-07-06	Meiji Dairies Corporation	Verwendung von proteinen aus der mk familie als hämatopoietischer faktor
AU1705599A (en) *	1997-11-26	1999-06-15	Allegheny University Of The Health Sciences	Methods for mobilizing hematopoietic facilitating cells and hematopoietic stem cells into the peripheral blood
US6573372B2 (en) *	1999-01-07	2003-06-03	Heska Corporation	Feline immunoglobulin E molecules and compositions there of

2000
- 2000-04-18 EP EP00830293A patent/EP1147777A1/de not_active Withdrawn
2001
- 2001-04-10 PT PT05108424T patent/PT1621207E/pt unknown
- 2001-04-10 AU AU2001258322A patent/AU2001258322B2/en not_active Ceased
- 2001-04-10 AU AU5832201A patent/AU5832201A/xx active Pending
- 2001-04-10 PL PL01358100A patent/PL358100A1/xx not_active Application Discontinuation
- 2001-04-10 AT AT05108424T patent/ATE443524T1/de active
- 2001-04-10 WO PCT/EP2001/004105 patent/WO2001078761A2/en not_active Ceased
- 2001-04-10 RU RU2002130719/15A patent/RU2248216C2/ru not_active IP Right Cessation
- 2001-04-10 SI SI200120022A patent/SI21079B/sl not_active IP Right Cessation
- 2001-04-10 DK DK05108424.2T patent/DK1621207T3/da active
- 2001-04-10 CZ CZ20023426A patent/CZ20023426A3/cs unknown
- 2001-04-10 JP JP2001576061A patent/JP5205668B2/ja not_active Expired - Fee Related
- 2001-04-10 EP EP01931582A patent/EP1276497B1/de not_active Expired - Lifetime
- 2001-04-10 EE EEP200200596A patent/EE200200596A/xx unknown
- 2001-04-10 RO ROA200201305A patent/RO121006B1/ro unknown
- 2001-04-10 KR KR1020027013967A patent/KR100849491B1/ko not_active Expired - Fee Related
- 2001-04-10 DK DK01931582T patent/DK1276497T3/da active
- 2001-04-10 US US10/432,741 patent/US20040131588A1/en not_active Abandoned
- 2001-04-10 IL IL152328A patent/IL152328A/en active IP Right Grant
- 2001-04-10 SK SK1489-2002A patent/SK14892002A3/sk unknown
- 2001-04-10 EP EP05108424A patent/EP1621207B1/de not_active Expired - Lifetime
- 2001-04-10 NZ NZ522016A patent/NZ522016A/en unknown
- 2001-04-10 CA CA2406179A patent/CA2406179C/en not_active Expired - Fee Related
- 2001-04-10 DE DE60140015T patent/DE60140015D1/de not_active Expired - Lifetime
- 2001-04-10 AT AT01931582T patent/ATE310532T1/de active
- 2001-04-10 CN CNB018082025A patent/CN1183962C/zh not_active Expired - Fee Related
- 2001-04-10 HU HU0300560A patent/HUP0300560A3/hu unknown
- 2001-04-10 MX MXPA02010346A patent/MXPA02010346A/es active IP Right Grant
- 2001-04-10 ES ES01931582T patent/ES2252227T3/es not_active Expired - Lifetime
- 2001-04-10 ES ES05108424T patent/ES2335776T3/es not_active Expired - Lifetime
- 2001-04-10 HR HR20020835A patent/HRP20020835A2/xx not_active Application Discontinuation
- 2001-04-10 DE DE60115222T patent/DE60115222T2/de not_active Expired - Lifetime
- 2001-10-04 UA UA2002119177A patent/UA73566C2/uk unknown
2002
- 2002-10-14 IS IS6581A patent/IS2171B/is unknown
- 2002-10-16 NO NO20024988A patent/NO20024988L/no not_active Application Discontinuation
- 2002-10-17 BG BG107203A patent/BG107203A/bg unknown
- 2002-10-17 ZA ZA200208413A patent/ZA200208413B/en unknown
2006
- 2006-02-08 CY CY20061100179T patent/CY1104971T1/el unknown

Also Published As

Publication number	Publication date
CA2406179A1 (en)	2001-10-25
NZ522016A (en)	2004-10-29
JP2004500437A (ja)	2004-01-08
SK14892002A3 (sk)	2003-06-03
EP1276497B1 (de)	2005-11-23
IS2171B (is)	2006-11-15
EP1147777A1 (de)	2001-10-24
EP1621207B1 (de)	2009-09-23
AU2001258322B2 (en)	2006-03-16
IS6581A (is)	2002-10-14
NO20024988L (no)	2002-12-02
EP1621207A2 (de)	2006-02-01
MXPA02010346A (es)	2004-09-06
DK1621207T3 (da)	2010-02-01
HUP0300560A2 (hu)	2003-06-28
KR100849491B1 (ko)	2008-07-31
PT1621207E (pt)	2009-12-28
SI21079B (sl)	2006-08-31
UA73566C2 (en)	2005-08-15
IL152328A (en)	2009-12-24
WO2001078761A2 (en)	2001-10-25
EP1621207A3 (de)	2006-11-22
RO121006B1 (ro)	2006-11-30
CY1104971T1 (el)	2010-03-03
CN1183962C (zh)	2005-01-12
DE60115222T2 (de)	2006-08-10
SI21079A (sl)	2003-06-30
HUP0300560A3 (en)	2005-07-28
NO20024988D0 (no)	2002-10-16
CZ20023426A3 (cs)	2003-05-14
WO2001078761A3 (en)	2002-01-24
ES2252227T3 (es)	2006-05-16
RU2248216C2 (ru)	2005-03-20
HRP20020835A2 (en)	2005-10-31
PL358100A1 (en)	2004-08-09
ZA200208413B (en)	2003-10-17
US20040131588A1 (en)	2004-07-08
ATE443524T1 (de)	2009-10-15
AU5832201A (en)	2001-10-30
JP5205668B2 (ja)	2013-06-05
DE60115222D1 (de)	2005-12-29
ES2335776T3 (es)	2010-04-05
CA2406179C (en)	2012-03-27
DK1276497T3 (da)	2006-03-27
KR20030010603A (ko)	2003-02-05
EP1276497A2 (de)	2003-01-22
IL152328A0 (en)	2003-05-29
CN1434719A (zh)	2003-08-06
DE60140015D1 (de)	2009-11-05
BG107203A (bg)	2003-05-30
RU2002130719A (ru)	2004-03-27
EE200200596A (et)	2004-04-15

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2006-07-15

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Publication	Publication Date	Title
ATE443524T1 (de)	2009-10-15	Kombination von defibrotide und g-csf und ihre verwendung zur aktivierung hämatopoietischer vorläuferzellen
AU2001269688A1 (en)	2002-01-14	Combination containing an antifolate and methylmalonic acid lowering agent
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