ATE311187T1 - (2-imidazolin-2-ylamino)quinoxaline zur behandlung von neuralen verletzungen - Google Patents
(2-imidazolin-2-ylamino)quinoxaline zur behandlung von neuralen verletzungenInfo
- Publication number
- ATE311187T1 ATE311187T1 AT00906868T AT00906868T ATE311187T1 AT E311187 T1 ATE311187 T1 AT E311187T1 AT 00906868 T AT00906868 T AT 00906868T AT 00906868 T AT00906868 T AT 00906868T AT E311187 T1 ATE311187 T1 AT E311187T1
- Authority
- AT
- Austria
- Prior art keywords
- quinoxaline
- ylamino
- imidazoline
- treatment
- hydrogen
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/225,036 US6194415B1 (en) | 1995-06-28 | 1999-01-04 | Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury |
| PCT/US2000/000068 WO2000040245A1 (en) | 1999-01-04 | 2000-01-04 | Method of using (2-imidazolin-2-ylamino) quinoxalines in treating neural injury |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE311187T1 true ATE311187T1 (de) | 2005-12-15 |
Family
ID=22843255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00906868T ATE311187T1 (de) | 1999-01-04 | 2000-01-04 | (2-imidazolin-2-ylamino)quinoxaline zur behandlung von neuralen verletzungen |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US6194415B1 (de) |
| EP (1) | EP1146877B1 (de) |
| JP (2) | JP2002534387A (de) |
| CN (1) | CN1205932C (de) |
| AT (1) | ATE311187T1 (de) |
| AU (1) | AU762641B2 (de) |
| BR (1) | BR0007394A (de) |
| CA (1) | CA2357014C (de) |
| DE (1) | DE60024407T2 (de) |
| ES (1) | ES2251968T3 (de) |
| HK (1) | HK1040938B (de) |
| WO (1) | WO2000040245A1 (de) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5856329A (en) * | 1995-06-28 | 1999-01-05 | Allergan | Method of using (2-imidazolin-2-ylamino) quinoxalines in treating ocular neural injury |
| US6294553B1 (en) | 2000-02-15 | 2001-09-25 | Allergan Sales, Inc. | Method for treating ocular pain |
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| US7708711B2 (en) * | 2000-04-14 | 2010-05-04 | Glaukos Corporation | Ocular implant with therapeutic agents and methods thereof |
| US6638239B1 (en) * | 2000-04-14 | 2003-10-28 | Glaukos Corporation | Apparatus and method for treating glaucoma |
| US7867186B2 (en) | 2002-04-08 | 2011-01-11 | Glaukos Corporation | Devices and methods for treatment of ocular disorders |
| US20030082183A1 (en) * | 2000-11-01 | 2003-05-01 | Wheeler Larry A. | Methods and compositions for treatment of ocular neovascularization and neural injury |
| AU2006201701B2 (en) * | 2000-11-01 | 2007-07-12 | Allergan, Inc. | Methods and compositions for treatment of ocular neovascularization and neural injury |
| WO2002058730A2 (en) * | 2000-11-01 | 2002-08-01 | Allergan, Inc. | Compositions for treatment of ocular neovascularization |
| US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
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| US7678065B2 (en) * | 2001-05-02 | 2010-03-16 | Glaukos Corporation | Implant with intraocular pressure sensor for glaucoma treatment |
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| US8529927B2 (en) * | 2004-04-30 | 2013-09-10 | Allergan, Inc. | Alpha-2 agonist polymeric drug delivery systems |
| US8425929B2 (en) * | 2004-04-30 | 2013-04-23 | Allergan, Inc. | Sustained release intraocular implants and methods for preventing retinal dysfunction |
| US20050244463A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
| PT1761266E (pt) | 2004-05-25 | 2013-06-04 | Galderma Pharma Sa | Compostos, formulações, e métodos para tratamento ou prevenção de distúrbios inflamatórios da pele |
| US7931909B2 (en) * | 2005-05-10 | 2011-04-26 | Allergan, Inc. | Ocular therapy using alpha-2 adrenergic receptor compounds having enhanced anterior clearance rates |
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| US7534795B2 (en) * | 2005-10-25 | 2009-05-19 | Allergan, Inc. | Compounds and their use related to compositions for treating disease |
| JP2009514969A (ja) | 2005-11-09 | 2009-04-09 | コンビナトアールエックス インコーポレーティッド | 医学的状態を治療するための方法、組成物、およびキット |
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| US20100203165A1 (en) | 2008-08-01 | 2010-08-12 | Gerald Horn | Compositions and methods for treatment of disorders or conditions of the eye |
| US9095506B2 (en) | 2008-11-17 | 2015-08-04 | Allergan, Inc. | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
| US8034813B2 (en) * | 2008-11-18 | 2011-10-11 | Bausch & Lomb Incorporated | Polymorphs of brimonidine pamoate |
| US12478503B2 (en) | 2009-05-18 | 2025-11-25 | Glaukos Corporation | Implants with controlled drug delivery features and methods of using same |
| US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| WO2010135731A1 (en) * | 2009-05-22 | 2010-11-25 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
| US8299079B2 (en) | 2009-05-22 | 2012-10-30 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
| US8987270B2 (en) | 2009-07-27 | 2015-03-24 | Eye Therapies Llc | Formulations of selective alpha-2 agonists and methods of use thereof |
| DK2498783T3 (en) | 2009-11-09 | 2018-12-10 | Allergan Inc | COMPOSITIONS AND PROCEDURES FOR STIMULATING HAIR GROWTH |
| MX346362B (es) | 2009-11-10 | 2017-03-15 | Allegro Pharmaceuticals Inc * | Composiciones y metodos para inhibir la adhesion celular o dirigir agentes de diagnostico o terapeuticos a sitios de enlace rgd. |
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| EP2329849B1 (de) | 2009-11-18 | 2015-04-29 | Galderma Research & Development | Kombination aus einem Alpha-2-Adrenozeptor-Agonisten und einem nichtsteroidalen entzündungshemmenden Mittel zur Behandlung oder Prävention einer Entzündungskrankheit der Haut |
| US8394800B2 (en) | 2009-11-19 | 2013-03-12 | Galderma Laboratories, L.P. | Method for treating psoriasis |
| US20110152271A1 (en) * | 2009-12-17 | 2011-06-23 | Gerald Horn | Compositions and methods for ophthalmic delivery of nasal decongestants |
| US9522153B2 (en) | 2009-12-22 | 2016-12-20 | Allergan, Inc. | Compositions and methods for lowering intraocular pressure |
| CN106038476B (zh) | 2010-03-26 | 2020-04-17 | 盖尔德马研究及发展公司 | 安全和有效治疗红斑的改进的方法和组合物 |
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| EP2629757A2 (de) | 2010-10-21 | 2013-08-28 | Galderma S.A. | Brimonidin-gelzusammensetzungen und verwendungsverfahren |
| US8053427B1 (en) | 2010-10-21 | 2011-11-08 | Galderma R&D SNC | Brimonidine gel composition |
| US8445526B2 (en) | 2011-02-03 | 2013-05-21 | Glaucoma & Nasal Therapies Llc | Compositions and methods for treatment of glaucoma |
| US11363951B2 (en) | 2011-09-13 | 2022-06-21 | Glaukos Corporation | Intraocular physiological sensor |
| JP2014530847A (ja) | 2011-10-19 | 2014-11-20 | ガルデルマ ソシエテ アノニム | 毛細血管腫の治療方法 |
| EP2768502A2 (de) | 2011-10-19 | 2014-08-27 | Galderma S.A. | Verfahren zur verringerung gesichtsrötung mittels systematischer verwendung von phosphodiesterase-typ 5-hemmern |
| EP2956096A1 (de) | 2013-02-15 | 2015-12-23 | Allergan, Inc. | Implantat mit langzeit-wirkstofffreisetzung |
| US9730638B2 (en) | 2013-03-13 | 2017-08-15 | Glaukos Corporation | Intraocular physiological sensor |
| US8999938B2 (en) | 2013-06-21 | 2015-04-07 | Gnt Llc | Ophthalmic lipophilic drug delivery vehicle formulations |
| CN105658221B (zh) | 2013-09-26 | 2022-05-10 | 高德美国际公司 | 用于治疗萎缩性皮肤瘢痕形成的前列腺素F2α及其类似物 |
| EP3570867A4 (de) * | 2017-01-19 | 2020-12-23 | Allegro Pharmaceuticals, LLC | Therapeutische und neuroprotektive peptide |
| JP2023511370A (ja) | 2020-01-22 | 2023-03-17 | シーロス セラピューティクス, インコーポレイテッド | Nmda拮抗薬の副作用の低減 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4029792A (en) | 1972-02-29 | 1977-06-14 | Pfizer Inc. | (2-Imidazolin-2-ylamino) substituted -quinoxalines and -quinazolines as antihypertensive agents |
| BE795970A (fr) | 1972-02-29 | 1973-08-27 | Pfizer | Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant |
| US5180721A (en) | 1989-05-22 | 1993-01-19 | Allergan, Inc. | Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure |
| US5077292A (en) | 1989-10-12 | 1991-12-31 | Allergan, Inc. | (2-imidazolin-2-ylamino) tetrahydroquinoxalines and methods for using same |
| US5021416A (en) * | 1989-10-31 | 1991-06-04 | Allergan, Inc. | Method for using (2-imidazolin-2-ylamino) quinoxalines to reduce or maintain intraocular pressure |
| US5215991A (en) | 1990-01-26 | 1993-06-01 | Allergan, Inc. | Combination of selective alpha-adrenergic agonists and Na+ /H+ ex |
| BR9408342A (pt) | 1993-12-17 | 1997-08-19 | Procter & Gamble | Compostos de 6-(2-imidazolinilamino) quinoxalina úteis como agonistas de adrenoceptores de alfa-2 |
| WO1996013267A2 (en) | 1994-10-27 | 1996-05-09 | Allergan | Combinations of prostaglandins and brimonidine or derivatives thereof for the treatment of glaucoma |
| US5856329A (en) * | 1995-06-28 | 1999-01-05 | Allergan | Method of using (2-imidazolin-2-ylamino) quinoxalines in treating ocular neural injury |
| WO1998018469A1 (en) * | 1996-10-31 | 1998-05-07 | Nippon Shinyaku Co., Ltd. | Cranial nerve cell protectives |
-
1999
- 1999-01-04 US US09/225,036 patent/US6194415B1/en not_active Expired - Lifetime
-
2000
- 2000-01-04 JP JP2000592002A patent/JP2002534387A/ja active Pending
- 2000-01-04 ES ES00906868T patent/ES2251968T3/es not_active Expired - Lifetime
- 2000-01-04 CN CNB008025266A patent/CN1205932C/zh not_active Expired - Lifetime
- 2000-01-04 AT AT00906868T patent/ATE311187T1/de active
- 2000-01-04 AU AU28460/00A patent/AU762641B2/en not_active Expired
- 2000-01-04 BR BR0007394-6A patent/BR0007394A/pt not_active Application Discontinuation
- 2000-01-04 CA CA002357014A patent/CA2357014C/en not_active Expired - Lifetime
- 2000-01-04 EP EP00906868A patent/EP1146877B1/de not_active Expired - Lifetime
- 2000-01-04 DE DE60024407T patent/DE60024407T2/de not_active Expired - Lifetime
- 2000-01-04 WO PCT/US2000/000068 patent/WO2000040245A1/en not_active Ceased
- 2000-01-04 HK HK02102938.9A patent/HK1040938B/en not_active IP Right Cessation
- 2000-09-06 US US09/655,579 patent/US6248741B1/en not_active Expired - Fee Related
-
2001
- 2001-06-18 US US09/883,753 patent/US20010046998A1/en not_active Abandoned
-
2002
- 2002-02-22 US US10/080,451 patent/US6465464B2/en not_active Expired - Lifetime
- 2002-06-03 US US10/162,088 patent/US20020183328A1/en not_active Abandoned
-
2005
- 2005-12-07 US US11/296,116 patent/US8455492B2/en not_active Expired - Fee Related
-
2007
- 2007-06-27 JP JP2007168778A patent/JP2007291129A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20020111357A1 (en) | 2002-08-15 |
| DE60024407D1 (de) | 2006-01-05 |
| JP2007291129A (ja) | 2007-11-08 |
| CA2357014C (en) | 2009-08-04 |
| US20010046998A1 (en) | 2001-11-29 |
| US20020183328A1 (en) | 2002-12-05 |
| CN1205932C (zh) | 2005-06-15 |
| HK1040938A1 (en) | 2002-06-28 |
| CN1335773A (zh) | 2002-02-13 |
| EP1146877A1 (de) | 2001-10-24 |
| US20060089361A1 (en) | 2006-04-27 |
| US6194415B1 (en) | 2001-02-27 |
| JP2002534387A (ja) | 2002-10-15 |
| HK1040938B (en) | 2006-05-12 |
| DE60024407T2 (de) | 2006-08-10 |
| US6465464B2 (en) | 2002-10-15 |
| WO2000040245A1 (en) | 2000-07-13 |
| ES2251968T3 (es) | 2006-05-16 |
| BR0007394A (pt) | 2001-10-30 |
| AU762641B2 (en) | 2003-07-03 |
| AU2846000A (en) | 2000-07-24 |
| US8455492B2 (en) | 2013-06-04 |
| EP1146877B1 (de) | 2005-11-30 |
| US6248741B1 (en) | 2001-06-19 |
| CA2357014A1 (en) | 2000-07-13 |
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