ATE323686T1 - Substituierte 2-arylbenzazole und ihre verwendung als antitumorale mittel - Google Patents

Substituierte 2-arylbenzazole und ihre verwendung als antitumorale mittel

Info

Publication number
ATE323686T1
ATE323686T1 AT00954726T AT00954726T ATE323686T1 AT E323686 T1 ATE323686 T1 AT E323686T1 AT 00954726 T AT00954726 T AT 00954726T AT 00954726 T AT00954726 T AT 00954726T AT E323686 T1 ATE323686 T1 AT E323686T1
Authority
AT
Austria
Prior art keywords
substituted
arylbenzazoles
amino acid
substituent
antitumoral agents
Prior art date
Application number
AT00954726T
Other languages
English (en)
Inventor
Malcolm Francis Graham Stevens
Tracey Dawn Poole
Andrew David Westwell
Ian Paul Hutchinson
Mei-Sze Chua
Original Assignee
Cancer Res Ventures Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Res Ventures Ltd filed Critical Cancer Res Ventures Ltd
Application granted granted Critical
Publication of ATE323686T1 publication Critical patent/ATE323686T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT00954726T 1999-08-20 2000-08-21 Substituierte 2-arylbenzazole und ihre verwendung als antitumorale mittel ATE323686T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9919673.5A GB9919673D0 (en) 1999-08-20 1999-08-20 2-Arlybenzazole compounds

Publications (1)

Publication Number Publication Date
ATE323686T1 true ATE323686T1 (de) 2006-05-15

Family

ID=10859458

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00954726T ATE323686T1 (de) 1999-08-20 2000-08-21 Substituierte 2-arylbenzazole und ihre verwendung als antitumorale mittel

Country Status (13)

Country Link
US (1) US6858633B1 (de)
EP (1) EP1204650B1 (de)
JP (1) JP2003507462A (de)
AT (1) ATE323686T1 (de)
AU (1) AU783360B2 (de)
CA (1) CA2382406C (de)
CY (1) CY1105091T1 (de)
DE (1) DE60027435T2 (de)
DK (1) DK1204650T3 (de)
ES (1) ES2263483T3 (de)
GB (1) GB9919673D0 (de)
PT (1) PT1204650E (de)
WO (1) WO2001014354A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2324686C2 (ru) * 2000-08-24 2008-05-20 Юнивесити Оф Питсбэг ПРОИЗВОДНЫЕ ТИОФЛАВИНА, СВЯЗЫВАЮЩИЕ АМИЛОИД, СПОСОБ ОБНАРУЖЕНИЯ in vivo ОТЛОЖЕНИЙ АМИЛОИДА И СПОСОБ РАСПОЗНАВАНИЯ БОЛЕЗНИ АЛЬЦГЕЙМЕРА
US7270800B2 (en) 2000-08-24 2007-09-18 University Of Pittsburgh Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
AU2003212490A1 (en) * 2002-02-13 2003-09-04 Amersham Plc Benzothiazole derivatives for in vivo imaging of amyloid plaques
US20050244718A1 (en) * 2002-07-01 2005-11-03 Eike Poetsch Polymerizable, luminescent compounds and mixtures, luminescent polymer materials and their use
CA2800237C (en) 2002-12-19 2016-05-17 The Scripps Research Institute Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
GB0229686D0 (en) 2002-12-20 2003-01-29 Amersham Plc Solid-phase fluorination of benzothiazoles
CA2438032C (en) * 2003-03-14 2013-05-07 University Of Pittsburgh Benzothiazole derivative compounds, compositions and uses
PT1611115E (pt) * 2003-03-14 2012-12-07 Univ Pittsburgh Compostos derivados de benzotiazole, composições e utilizações
US8236282B2 (en) 2003-08-22 2012-08-07 University of Pittsburgh—of the Commonwealth System of Higher Education Benzothiazole derivative compounds, compositions and uses
WO2005113523A1 (en) 2004-05-20 2005-12-01 Foldrx Pharmaceuticals, Inc. 2-((hetero) aryl)-benzoxazole compounds and derivatives, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
JP5301999B2 (ja) 2005-10-31 2013-09-25 メルク・シャープ・アンド・ドーム・コーポレーション Ｃｅｔｐ阻害薬
EP2808020A1 (de) * 2006-04-21 2014-12-03 The Government Of The United States, As Represented by The Secretary Of Health And Human Services Beta-amyloid-pet-bildgebungsmittel
CA2689523A1 (en) 2007-06-20 2008-12-24 Merck Sharp & Dohme Corp. Cetp inhibitors derived from benzoxazole arylamides
EP2166847B1 (de) 2007-06-20 2014-11-19 Merck Sharp & Dohme Corp. Cetp-hemmer aus benzoxazolarylamiden
WO2008156715A1 (en) 2007-06-20 2008-12-24 Merck & Co., Inc. Cetp inhibitors derived from benzoxazole arylamides
RU2475267C2 (ru) * 2007-08-30 2013-02-20 Джи-И Хелткер Лимитед Радиофармацевтическая композиция
EP2627361B1 (de) * 2010-10-12 2017-09-20 Mayo Foundation For Medical Education And Research Abbildung von meningiomen mit phenylbenzothiazol-, stilben- oder biphenylalkynderivaten
US8592603B2 (en) * 2011-02-22 2013-11-26 Kaohsiung Medical University Synthesis of 2-(4-aminophenyl) benzothiazole derivatives and use thereof
RU2586330C2 (ru) 2011-09-16 2016-06-10 Пфайзер Инк. Твердые формы ингибитора диссоциации транстиретина
WO2014004664A2 (en) 2012-06-27 2014-01-03 Mayo Foundation For Medical Education And Research Treatment of meningiomas using phenylbenzothiazole, stilbene, biphenylalkyne, or pyridine derivatives
US9573881B2 (en) 2012-12-25 2017-02-21 Nippon Soda Co., Ltd. Halogenated aniline and method for producing same
WO2015127548A1 (en) * 2014-02-28 2015-09-03 The Royal Institution For The Advancement Of Learning / Mcgill University Tc-ptp inhibitors as apc activators for immunotherapy
PL3296294T3 (pl) * 2015-05-09 2020-08-24 Jiangsu Atom Bioscience And Pharmaceutical Co., Ltd Związek do leczenia lub zapobiegania nowotworowi piersi
CN111170963B (zh) * 2018-11-12 2023-05-23 江苏新元素医药科技有限公司 4-(苯并硒唑-2-基)芳胺类化合物治疗胃癌的用途
CN111170962B (zh) * 2018-11-12 2023-05-23 江苏新元素医药科技有限公司 4-(苯并硒唑-2-基)芳胺类化合物治疗肠癌的用途
CN111166744B (zh) * 2018-11-12 2024-06-25 诺丁汉大学 4-(苯并噻唑-2-基)芳胺类化合物治疗胃癌的用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU37546A1 (de) * 1958-08-22
US3401048A (en) * 1964-06-22 1968-09-10 Mitsui Kagaku Kogyo Kabushiki 2-styrylazole optical brightener
DE2333378A1 (de) * 1973-06-30 1975-01-23 Basf Ag Neue verbindungen der benzoxazol- und der benzthiazolreihe und farbbildner fuer kopierverfahren
GB9317949D0 (en) 1993-08-28 1993-10-13 Stevens Malcolm F G Benzothiazole compounds
GB9503946D0 (en) * 1995-02-28 1995-04-19 Cancer Res Campaign Tech Benzazole compounds
JPH1160573A (ja) 1997-08-22 1999-03-02 Nippon Kayaku Co Ltd トリアジン誘導体及びテロメラーゼ阻害剤

Also Published As

Publication number Publication date
US6858633B1 (en) 2005-02-22
AU6708500A (en) 2001-03-19
WO2001014354A1 (en) 2001-03-01
CY1105091T1 (el) 2009-11-04
ES2263483T3 (es) 2006-12-16
AU783360B2 (en) 2005-10-20
JP2003507462A (ja) 2003-02-25
DE60027435D1 (de) 2006-05-24
CA2382406C (en) 2009-05-19
DK1204650T3 (da) 2006-08-21
EP1204650B1 (de) 2006-04-19
DE60027435T2 (de) 2007-04-19
PT1204650E (pt) 2006-08-31
CA2382406A1 (en) 2001-03-01
GB9919673D0 (en) 1999-10-20
EP1204650A1 (de) 2002-05-15

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