ATE311437T1 - Verwendung von wachstumsfaktoren und hormonen zur vermehrung menschlicher chondrozyten und knorpelgewebeherstellung - Google Patents

Verwendung von wachstumsfaktoren und hormonen zur vermehrung menschlicher chondrozyten und knorpelgewebeherstellung

Info

Publication number
ATE311437T1
ATE311437T1 AT99951475T AT99951475T ATE311437T1 AT E311437 T1 ATE311437 T1 AT E311437T1 AT 99951475 T AT99951475 T AT 99951475T AT 99951475 T AT99951475 T AT 99951475T AT E311437 T1 ATE311437 T1 AT E311437T1
Authority
AT
Austria
Prior art keywords
cells
tissue
cartilage tissue
hormones
growth factors
Prior art date
Application number
AT99951475T
Other languages
English (en)
Inventor
Lisa E Freed
Ivan Martin
Robert Langer
Gordana Vunjak-Novakovic
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of ATE311437T1 publication Critical patent/ATE311437T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/135—Platelet-derived growth factor [PDGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/33—Insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
AT99951475T 1998-09-18 1999-09-17 Verwendung von wachstumsfaktoren und hormonen zur vermehrung menschlicher chondrozyten und knorpelgewebeherstellung ATE311437T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10104798P 1998-09-18 1998-09-18
US09/397,417 US6582960B1 (en) 1998-09-18 1999-09-17 Use of fibroblast growth factor 2 for expansion of chondrocytes and tissue engineering
PCT/US1999/021369 WO2000017321A2 (en) 1998-09-18 1999-09-17 Use of growth factors and hormones for expansion of mammalian cells and tissue engineering

Publications (1)

Publication Number Publication Date
ATE311437T1 true ATE311437T1 (de) 2005-12-15

Family

ID=22282845

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99951475T ATE311437T1 (de) 1998-09-18 1999-09-17 Verwendung von wachstumsfaktoren und hormonen zur vermehrung menschlicher chondrozyten und knorpelgewebeherstellung

Country Status (8)

Country Link
US (1) US6582960B1 (de)
EP (1) EP1112348B1 (de)
JP (1) JP2004502401A (de)
AT (1) ATE311437T1 (de)
CA (1) CA2344399A1 (de)
DE (1) DE69928678T2 (de)
ES (1) ES2251842T3 (de)
WO (1) WO2000017321A2 (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0896825B1 (de) 1997-08-14 2002-07-17 Sulzer Innotec Ag Zusammensetzung und Vorrichtung zur Reparatur von Knorpelgewebe in vivo bestehend aus Nanokapseln mit osteoinduktiven und/oder chondroinduktiven Faktoren
EP1099443A1 (de) 1999-11-11 2001-05-16 Sulzer Orthopedics Ltd. Transplantations/Implantatsvorrichtung und ihre Herstellungsmethode
US20040087016A1 (en) * 2000-05-12 2004-05-06 University Of Utah Research Foundation Compositions and methods for cell dedifferentiation and tissue regeneration
WO2001088103A2 (en) * 2000-05-12 2001-11-22 University Of Utah Research Foundation Compositions and methods for tissue dedifferentiation and regeneration
EP1160315A1 (de) * 2000-05-29 2001-12-05 Kantonsspital Basel Verwendung von Biochemischen Faktoren zur Gewebetechnologie
BR0307033A (pt) * 2002-01-22 2004-12-07 Pfizer ácidos 3-(imidazolil)-2-aminopropanóicos para o uso como inibidores tafi-a para o tratamento de doenças trombóticas
US7622562B2 (en) 2002-06-26 2009-11-24 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
AU2003275240A1 (en) * 2002-09-24 2004-04-23 Massachusetts Institute Of Technology Methods and compositions for soluble cpg15
AU2003303071B2 (en) 2002-12-16 2009-04-23 Technion Research & Development Foundation Ltd. Methods of preparing feeder cells-free, xeno-free human embryonic stem cells and stem cell cultures prepared using same
ES2405080T3 (es) 2003-02-26 2013-05-30 Zimmer Orthobiologics, Inc. Preparado para la reparación de un tejido cartilaginoso, en particular de defectos de cartílagos articulares
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7488348B2 (en) 2003-05-16 2009-02-10 Musculoskeletal Transplant Foundation Cartilage allograft plug
WO2005032476A2 (en) * 2003-09-30 2005-04-14 Massachusetts Institute Of Technology Methods and compositions for cpg15-2
ES2396689T3 (es) 2003-12-11 2013-02-25 Isto Technologies Inc. Sistema de cartílago particulado
CN101014699B (zh) * 2004-08-24 2010-05-26 富士软件株式会社 去分化型软骨细胞向软骨细胞的再分化用培养基
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
US7273756B2 (en) * 2004-10-01 2007-09-25 Isto Technologies, Inc. Method for chondrocyte expansion with phenotype retention
US8017394B2 (en) * 2004-10-01 2011-09-13 Isto Technologies, Inc. Method for chondrocyte expansion with phenotype retention
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US9981063B2 (en) * 2004-11-24 2018-05-29 Mayo Foundation For Medical Education And Research Biosynthetic composite for osteochondral defect repair
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
JP4044579B2 (ja) 2005-08-02 2008-02-06 株式会社Ｐｇリサーチ 人工軟骨組織
US20070036842A1 (en) * 2005-08-15 2007-02-15 Concordia Manufacturing Llc Non-woven scaffold for tissue engineering
EP1916964A4 (de) 2005-08-26 2015-11-04 Zimmer Inc Implantate und verfahren zur behebung, ersetzung und behandlung von gelenkkrankheiten
JP2009508596A (ja) 2005-09-19 2009-03-05 ヒストジェニックス コーポレイション 細胞支持基材及びその調製方法
EP1764117A1 (de) 2005-09-20 2007-03-21 Zimmer GmbH Implantat zur Wiederherstellung von Knorpeldefekten und Verfahren zu seiner Herstellung
JP4893915B2 (ja) * 2005-11-09 2012-03-07 独立行政法人産業技術総合研究所 移植材料
WO2007095113A2 (en) * 2006-02-10 2007-08-23 Massachusetts Institute Of Technology Cpg15 and cpg15-2 compounds and inhibitors as insulin receptor and insulin-like growth factor receptor agonists and antagonists
KR100816395B1 (ko) * 2006-09-21 2008-03-27 (주)필미아젠 세포 유래 세포외기질막의 제조방법
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
AU2008240191B2 (en) 2007-04-12 2013-09-19 Zimmer, Inc. Compositions and methods for tissue repair
EP2201910B1 (de) * 2007-06-01 2013-04-03 Allergan, Inc. Gerät zur Erzeugung des zugspannungsinduzierten Wachstums von biologischem Gewebe
US20090081276A1 (en) * 2007-08-13 2009-03-26 Eben Alsberg Bioresorbable implant composition
WO2009111069A1 (en) 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
CA2833001C (en) 2010-04-21 2020-06-23 Octane Biotech, Inc. Automated cell culture system
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
WO2014164815A2 (en) 2013-03-12 2014-10-09 Allergan, Inc. Adipose tissue combinations, devices, and uses thereof
US20140350516A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Mechanical syringe accessory
KR20150014369A (ko) * 2013-07-24 2015-02-06 주식회사 엠씨티티바이오 구슬형 연골세포 치료제의 제조방법
US9248384B2 (en) 2013-10-02 2016-02-02 Allergan, Inc. Fat processing system
US10029048B2 (en) 2014-05-13 2018-07-24 Allergan, Inc. High force injection devices
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
BR112017019272A2 (pt) 2015-03-10 2018-05-02 Allergan Pharmaceuticals Holdings Ireland Unlimited Company injetor de múltiplas agulhas
US10596321B2 (en) 2016-04-08 2020-03-24 Allergan, Inc. Aspiration and injection device
US10406252B2 (en) 2017-01-19 2019-09-10 Curium Us Llc Systems and methods for autoclave cart loading and unloading system
US11696929B2 (en) 2017-09-20 2023-07-11 The Regents Of The University Of California Methods and systems for conserving highly expanded cells
EP4175687A4 (de) 2020-07-06 2024-07-24 The Regents of the University of California Schmelz- und meld-ansatz zur reparatur von gewebedefekten

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5512600A (en) 1993-01-15 1996-04-30 Massachusetts Institute Of Technology Preparation of bonded fiber structures for cell implantation
FI953569A7 (fi) * 1993-01-29 1995-09-25 Neurospheres Ltd Neuraalisten kantasolujen geneettinen modifikaatio
US5709854A (en) 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
PT793714E (pt) * 1994-11-16 2002-12-31 Amgen Inc Utilizacao do factor de celulas estaminais e do receptor de interleucina 6 soluvel para a expansao ex vivo de celulas hematopoieticas multipotentes
US5716404A (en) 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
WO1998004681A2 (en) * 1996-07-25 1998-02-05 Genzyme Corporation Chondrocyte media formulations and culture procedures
US5919702A (en) * 1996-10-23 1999-07-06 Advanced Tissue Science, Inc. Production of cartilage tissue using cells isolated from Wharton's jelly
DE69734395T2 (de) * 1996-12-06 2006-07-27 Osiris Therapeutics, Inc. Verbesserte chondrogene differenzierung von menschlichen mesenchym-stammzellen

Also Published As

Publication number Publication date
WO2000017321A3 (en) 2000-07-13
EP1112348B1 (de) 2005-11-30
CA2344399A1 (en) 2000-03-30
DE69928678T2 (de) 2006-07-20
EP1112348A2 (de) 2001-07-04
WO2000017321A2 (en) 2000-03-30
ES2251842T3 (es) 2006-05-01
US6582960B1 (en) 2003-06-24
DE69928678D1 (de) 2006-01-05
JP2004502401A (ja) 2004-01-29
WO2000017321A9 (en) 2001-07-12

Similar Documents

Publication Publication Date Title
ATE311437T1 (de) Verwendung von wachstumsfaktoren und hormonen zur vermehrung menschlicher chondrozyten und knorpelgewebeherstellung
Kaps et al. Human platelet supernatant promotes proliferation but not differentiation of articular chondrocytes
Freed et al. Frontiers in Tissue Engineering: In Vitro Modulation of Chondrogenesis.
Freed et al. Composition of cell‐polymer cartilage implants
Baker et al. Three-dimensional culture of bovine chondrocytes in rotating-wall vessels
Malpeli et al. Serum-free growth medium sustains commitment of human articular chondrocyte through maintenance of Sox9 expression
DE69533223D1 (de) Zusammensetzungen und verfahren zur stimulierung der proliferation und der differenzierung von menschlichen fetalen und erwachsenen pankreatischen zellen ex vivo
TR200401091T4 (tr) Gelişim faktörleri ve L-glutamin içeren hücre kültürü besiyeri
DE69420138D1 (de) Medium zur langfristige vermehrung und entwicklung von zellen
CA2237890A1 (en) In vitro chondrogenic induction of human mesenchymal stem cells
DE60017875D1 (de) Verwendung von collagenase in der zubereitung von neuralen stammzellkulturen
ATE370227T1 (de) Verfahren zur herstellung von knorpelimplantaten mittels in vitro gezüchteter chondrozyten
ATE296875T1 (de) Verfahren zur herstellung von genetisch modifizierten cd34-negativen, adhärent wachsenden hämatopoietischen stammzellen
ATE364408T1 (de) Verfahren zur kultivierung von knorpelersatz und biomatrix nach diesem verfahren hergestellt
O'Connell et al. Human chondrocyte migration behaviour to guide the development of engineered cartilage
ATE511752T1 (de) Methode zur kontrolle der proliferation und differenzierung von stamm- und vorläuferzellen
ATE219654T1 (de) Verfahren zur vermehrung von haaren
CA2646488A1 (en) Methods to maintain, improve and restore the cartilage phenotype of chondrocytes
Thompson et al. Chondrogenesis in agarose gel culture: a model for chondrogenic induction, proliferation and differentiation
Watson et al. Tissue-engineered cartilage for facial plastic surgery
WO1999043270A1 (en) Augmentation and repair of dermal, subcutaneous, and vocal cord tissue defects
CN103396982A (zh) 利用干细胞自分泌细胞外基质并诱导其成为肝细胞的方法
Fang et al. Centimeter‐Scale Self‐Assembling Tendon Organoids Drive Tissue Regeneration
Weber et al. Modulation of collagen type synthesis in organ and cell cultures of fibroblasts
FI964208A0 (fi) Menetelmä metallofosfaatin saostumisen kontrolloimiseksi fermentoinneissa, joissa solutiheys on suuri

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties